Category: alcohols-buliding-blocks

Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 100mL 1-neck round bottom flask[A-1] (Benzenesulfonate Dichlorosulfofluorescein) (3 g, 7.40 mmol, 1 eq), [A-2] (2-(Ethylamino)ethanol) (5.28g, 59.22mmol, 8eq) and 50 g of DI-water were added thereto, followed by stirring at 100 C. Then stirred for 20 hours. The reaction was terminated by quenching in 1M HCl Solution, and the reaction was precipitated by the addition of sodium chloride (NaCl).The resulting precipitate was filtered under reduced pressure and dried at 80 C Oven. After drying, the resultant was dissolved in DMF (Dimethylformamide) to remove NaCl between the products, filtered, and the filtrate was quenched with diethyl ether, filtered under reduced pressure, and dried to obtain Compound [A] (2.98 g, 5.84 mmol, 78.9%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Lee Da-mi; Choi Sang-a; Yang Seung-jin; Lee Jae-yong; Kim Hye-jin; Kim Ji-seon; Kim Yeong-ung; Park Jong-ho; (27 pag.)KR2020/7157; (2020); A;,
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Application of 486460-26-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 486460-26-8, name is (4-Bromo-2,5-difluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

NaH (210 mg, 8.8 mmol) was added to a solution of XLVII-3 (446 m g, 2 mmol) in DMF (10 mL) at 0 C. The reaction mixture was stirred at 0 C. for 30 mins. A solution of XLVII-3A (366 mg, 2 mmol) in DMF (5 mL) was added dropwise. The reaction mixture was stirred at 0 C. for 4 h. Water (5 mL) was added. The reaction mixture was diluted with brine and EtOAc. The aqueous layer was extracted with EtOAc. The combined organic layer was washed with brine, dried over MgSO4 and concentrated. The crude product was purified by column (PE/EA=2/1) to afford XLVII-4 (200 mg, yield 30.7%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 486460-26-8, (4-Bromo-2,5-difluorophenyl)methanol.

Reference:
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 27129-87-9, (3,5-Dimethylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H12O, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H12O

Step 1 1-(2-Aminoethyl)-3-(3,5-dimethylbenzyl)-2-imidazolidinylidenepropanedinitrile (Compound (IXa)): 1-(2-Aminoethyl)-2-imidazolidinylidenepropanedinitrile (9.7 g) obtained by a known process (JP92-279581), 5.0 g of 3,5-dimethylbenzyl alcohol, 12 g of triphenylphosphine, and 10 g of di-tert-butyl azodicarboxylate were allowed to react in 500 ml of tetrahydrofuran as described in Example 23 to give 3.6 g (34%) of Compound (IXa) as a pale yellow oily substance. 1H NMR (270 MHz, CDCl3) delta: 6.89 (1H, s), 6.81 (2H, s), 4.62 (2H, s), 3.62-3.55 (4H, m), 3.42-3.34 (2H, m), 2.98 (2H, t), 2.25 (6H, s). The signal which corresponds to primary amine was not observed.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27129-87-9, (3,5-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US6469002; (2002); B1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1219019-22-3, name is cis-3-Aminocyclobutanol hydrochloride, molecular formula is C4H10ClNO, molecular weight is 123.58, as common compound, the synthetic route is as follows.Product Details of 1219019-22-3

To a solution of cis-3-aminocyclobutanol hydrochloride (900 mg, 7.3 mmol, 1.0 eq) in ethanol (5 mL) and Et3N (5 mL) at 0 C. was added Boc2O (800 mg, 3.7 mmol, 0.5 eq) and the mixture was allowed to warm to RT and stirred for 3 h. The mixture was concentrated under reduced pressure, diluted with water (50 mL) and extracted with EtOAc (40 mL*3). The combined organic layers were washed with brine (50 mL), dried over Na2SO4 and concentrated under reduced pressure to afford the title compound (1.2 g, 88%) as a yellow solid, which was used for the next step without further purification. LCMS: [M+H]+ 188.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1219019-22-3, cis-3-Aminocyclobutanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Ribon Therapeutics Inc.; Schenkel, Laurie B.; Vasbinder, Melissa Marie; Kuntz, Kevin Wayne; Swinger, Kerren Kalai; (179 pag.)US2019/194174; (2019); A1;,
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Electric Literature of 1805-32-9, Adding some certain compound to certain chemical reactions, such as: 1805-32-9, name is 3,4-Dichlorobenzyl alcohol,molecular formula is C7H6Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1805-32-9.

Under nitrogen, 4-aminobenzenesulfonamide (172 mg, 1 mmol), [Cp * IrCl2] 2 (8 mg, 0.01 mmol,1 mol%), cesium carbonate (65 mg, 0.2 mmol), 3,4-dichlorobenzyl alcohol (212 mg, 1.2 mmol)The alcohol (1.0 mL) was added sequentially to a 25 mL Schlenk reaction flask. The mixture was reacted at 120 C for 12 hoursAfter cooling to room temperature, the solvent was removed under vacuum. And then purified by column chromatography (developing solvent: ethyl acetate / n-hexane)The pure title compound was obtained in a yield of 92%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1805-32-9, 3,4-Dichlorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY; LI, FENG; LU, LEI; MA, JUAN; (16 pag.)CN106146358; (2016); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 623-69-8, name is 1,3-Dimethoxypropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H12O3

To a solution of 3-bromophenol (6g, 34.7mmol) and 1,3-dimethoxypropan-2-ol (5.OOg,41.6mmol) in THE (l5OmL) was added triphenylphosphine (13.64g, 52.Ommol) and the reaction mixture cooled to 0C followed by dropwise addition of DIAD (6.74mL, 34.7mmol). The reaction was allowed to warm to room temperature, then stirred for 12h. The reaction mixture was concentratedvacua. The obtained residue was dissolved in EtOAc (SOmL), washed with water (SOmL) and brine(SOmL), dried over Na24, concentrated in vacua and subjected to silica column chromatography(SOg column), eluting with 20% EtOAc in petroleum ether. The relevant fractions were combined andconcentrated in vacua affording the title compound (4.Og, 42%) as a yellow liquid: MS ES+ve m/z275, 277 (M–H).

With the rapid development of chemical substances, we look forward to future research findings about 623-69-8.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ANDERSON, Niall Andrew; CAMPBELL-CRAWFORD, Matthew Howard James; HANCOCK, Ashley Paul; LEMMA, Seble; PRITCHARD, John Martin; PROCOPIOU, Panayiotis Alexandrou; REDMOND, Joanna Mary; SOLLIS, Steven Leslie; (77 pag.)WO2017/162572; (2017); A1;,
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Related Products of 2516-33-8 ,Some common heterocyclic compound, 2516-33-8, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The gas-phase selective oxidation of alcohols on these catalysts with molecular oxygen was carried out on a fixed-bed quartz tube reactor (i.d., 16 mm) under atmospheric pressure as described previously [14,15,26,27]. Circular chips (16.1 mm diameter) of the microfibrous-structured Au/Ni-fiber catalysts were punched down from their large sheet sample and packed layer-up-layer into the tube reactor with total mass of 0.3 g. Note that the diameter of 0.1 mm larger than the i.d. of the tubular reactor was retained deliberately to avoid the appearance of the gap between the reactor wall and the edges of the catalyst chips thereby preventing the gas bypassing. Alcohols were fed continuously using a high-performance liquid pump, in parallel with O2 (oxidant) and N2 (diluted gas) feeding using the calibrated mass flow controllers, into the reactor heated to the desired reaction temperature. The organic phase of the liquid effluent was collected for analyzing by an HP 5890 gas chromatography-flame ionization detector (GC-FID) with a 60-m HP-5 ms capillary column. The gas-phase products such as H2, COx, and C1-C3 hydrocarbons were analyzed by an HP-5890 GC with thermal conductivity detector (TCD) and a 30-m AT-plot 300 capillary column. Reaction temperature, WHSV, and alcoholic hydroxyl (O2/ol) were varied in range from 220 to 380 C, 10 to 70 h-1, and 0.4 to 1.2, respectively. Prior to the reaction testing, as-prepared catalysts were all activated by performing the benzyl alcohol oxidation at a high temperature of 380 C for 1 h, using molar ratio of O2 to O2/ol = 0.6 and WHSV = 20 h-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2516-33-8, its application will become more common.

Reference:
Article; Zhao, Guofeng; Deng, Miaomiao; Jiang, Yifeng; Hu, Huanyun; Huang, Jun; Lu, Yong; Journal of Catalysis; vol. 301; (2013); p. 46 – 53;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one, molecular formula is C9H7NO3, molecular weight is 177.1568, as common compound, the synthetic route is as follows.Recommanded Product: 79418-41-0

A portion of 7-diethylaminocoumarin-3-aldehyde (247 mg, 1 mmol) and 3-amino-7-hydroxycoumarin (195 mg, 1.1 mmol) were combined in hot absolute ethanol (20 mL) to yield a scarlet precipitate for a moment. The solution was stirred under reflux conditions for 6 h, and the precipitate was filtrated, washed with hot absolute ethanol three times, then recrystallized with DMF/H2O (v/v, 1/3) to get scarlet crystal L (347 mg, 0.86 mmol) in 86% yield. IR (KBr, cm-1): 2966, 2927, 1718, 1620, 1349, 1506, 1456, 1420, 845, 811, 770, 729, 693. 1H NMR (DMSO-d6, 400 MHz, delta): 10.54(s, 1H, OH), 9.04(s, 1H, NCH), 8.56(s, 1H, ArH), 7.81(s, 1H, ArH), 7.70(d, 1H, J = 12 Hz, ArH), 7.58(d, 1H, J = 8 Hz, ArH), 6.81 (t, 1H, J = 8 Hz, ArH), 6.77 (s, 1H, ArH), 6.61(s, 1H, ArH), 3.49(q, 4H, J = 8 Hz, CH2CH3), 1.16(t, 6H, J = 8 Hz, CH2CH3). Anal. Calcd for C23H20N2O5: C 68.31%, H 4.98%, N 6.93%, Found: C 68.55%, H 5.04%, N 6.66%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,79418-41-0, 3-Amino-7-hydroxy-2H-chromen-2-one, and friends who are interested can also refer to it.

Reference:
Article; Wang, Lingyun; Ye, Decheng; Cao, Derong; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 90; (2012); p. 40 – 44;,
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Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 26021-57-8, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H9NO2

General procedure: To a mixture of 9 (100mg, 0.74mmol) (the general procedure for the synthesis of intermediate 9 was presented in supporting information), 3-chlorobenzaldehyde (104mg, 0.74mmol) and ethyl 2-cyanoacetate (83muL, 0.78mmol) in anhydrous EtOH (5mL) was added piperdine (136muL, 1.48mmol). The reaction mixture was stirred for 16hat 80C under N2 atmosphere. The resulting reaction mixture was evaporated to dryness under reduced pressure. The residue was purified by flash column chromatography eluting with CH2Cl2/MeOH (200:1-100:1, v/v) to afford the title compound (9a) as a slight yellow solid (210mg, 77% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26021-57-8, its application will become more common.

Reference:
Article; Zhang, Huijun; Fang, Xiong; Meng, Qian; Mao, Yujia; Xu, Yan; Fan, Tingting; An, Jing; Huang, Ziwei; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 380 – 396;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3279-95-6, name is 2-(Aminooxy)ethanol, molecular formula is C2H7NO2, molecular weight is 77.08, as common compound, the synthetic route is as follows.Formula: C2H7NO2

Step C Preparation of 2-(2-chloro-4-iodo-phenylamino)-3,4-difluoro-N-(2-hydroxy-ethoxy)-benzamide To a solution of the product of Example 6, Step B, 2-(2-chloro-4-iodophenylamino)-3,4-difluorobenzoic acid pentafluorophenyl ester (10.0 g, 17.4 mmol), in anhydrous dimethylformamide (36 mL) was added 2-(aminooxy)-ethanol [prepared by the literature procedure: Dhanak, D.; Reese, C. B. J. Chem. Soc., Perkin Trans. 1 1987, 2829] (1.6 g, 20.8 mmol) and N,N-diisopropylethylamine (6.0 mL, 34.8 mmol). The resultant solution was stirred at ambient temperature for 16 h. The reaction mixture was concentrated to 20% volume then diluted with ethyl acetate (360 mL). The resultant solution was washed with water (6*60 mL) and brine (2*60 mL). The organics were dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford a white solid that was purified on silica gel. Elution with ethyl acetate-methanol (9:1) afforded 2-(2-chloro-4-iodo-phenylamino)-3,4-difluoro-N-(2-hydroxy-ethoxy)-benzamide (7.31 g, 90%) as a white solid. Recrystallization from methanol afforded analytically pure material: m.p. 173-175 C.; 1H NMR (400 MHz, DMSO-d6) delta 11.93 (br s, 1H), 8.85 (br s, 1H), 7.76 (d, J=1.7 Hz, 1H), 7.48 (dd, J=8.6, 1.7 Hz, 1H), 7.44 (dd, J=8.5, 6.2 Hz, 1H), 7.25 (dt, J=8.5, 9.3 Hz, 1H), 6.58 (dd, J=8.5, 6.4 Hz, 1H), 4.70 (br s, 1H), 3.86 (br s, 2H), 3.56 (br d, J=3.9 Hz, 2H); MS (APCI+)=469.0; MS (APCI-)=467.0; Anal. Calcd/found for C15H12ClF21N2O3: C, 38.45/38.60; H, 2.58/2.53; N, 5.98/5.91; F, 8.11/8.08; I, 27.08/27.43. aa0-5aa

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3279-95-6, 2-(Aminooxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Barrett, Stephen Douglas; Kaufman, Michael David; Rewcastle, Gordon William; Spicer, Julie Ann; US2003/232889; (2003); A1;,
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