Category: alcohols-buliding-blocks

Related Products of 37585-16-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of (2-amino-4-chlorophenyl)methanol (5.9 g) in ethyl acetate (100 mL) was heated until the former dissolved. Acetic anhydride (8 mL) was added and the mixture removed from the heat. The precipitate was filtered to give a white solid and the filtrate was concentrated and slurried with hexane and filtered to give further white solid. The two batches were combined to give 5.3 g of the alcohol intermediate. The first phase of the experiment was repeated on 3x the scale described above. 21 g of the combined products was dissolved in DCM (650mL) and added to a solution of thionyl chloride (23 mL) in DCM (225 mL) at room temperature under argon. The mixture was stirred for 30 minutes and concentrated to give a yellow/red solid. The solid was dissolved in DCM (500 mL), washed with saturated sodium bicarbonate (200 mL) and dried over magnesium sulfate. Removal of the solvent gave the 22 g of the title compound as a yellow/brown solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 37585-16-3, (2-Amino-4-chlorophenyl)methanol.

Reference:
Article; Smethurst, Chris A.; Bevan, Nicola; Emmons, Amanda; Mookherjee, Claudette; Moores, Kitty; Peace, Simon; Piercy, Val; Watson, Steve P.; Zippoli, Mara; Brooks, Carl; Gough, Peter J.; Philp, Joanne; Bioorganic and medicinal chemistry letters; vol. 22; 23; (2012); p. 7252 – 7255,4;; ; Article; Smethurst, Chris A.; Bevan, Nicola; Brooks, Carl; Emmons, Amanda; Gough, Peter J.; Mookherjee, Claudette; Moores, Kitty; Peace, Simon; Philp, Joanne; Piercy, Val; Watson, Steve P.; Zippoli, Mara; Bioorganic and Medicinal Chemistry Letters; vol. 22; 23; (2012); p. 7252 – 7255;,
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Synthetic Route of 558-42-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, molecular weight is 108.5667, as common compound, the synthetic route is as follows.

[00351j Step 1: methyl 3-chloro-4-(2-hydroxy-2-methylpropoxy)benzoate [00352j A 500 ml 3 neck RB flask was fitted with a mechanical stirrer,a J-Kem temperature probe/controller, an addition funnel, a water cooled reflux condenser and a nitrogen inlet/outlet. The vessel was charged under a nitrogen atmosphere with methyl 3-chloro-4-hydroxy-benzoate (10 g, 53.6 mmol) and methylalcohol (40 ml) which provided a clear pale yellow solution. Stirring was commenced and the pot temperature was recorded at 19 °C. The vessel was then charged with potassium carbonate (30 g, 0.21 mol) added as a solid in one portion which resulted in an exotherm to 23 °C. Note: The potassium carbonate was ground to a fine powder prior to use. The resulting suspension was continued to stir at rt for 15 mm and thentreated with 1-chloro-2-methyl-propan-2-ol (11.6 g, 0.11 mol) added neat dropwise via addition funnel over 10 mm. The resulting reaction mixture/suspension was then heated to 70 °C and stirred for 20 h. The reaction mixture was cooled to rt and diluted with ethyl acetate (250 ml). The mixture was filtered through a glass fit Buchner funnel with a 10 mm layer of Celite. The filter cake was washed with ethyl acetate (2 x100 ml). The filtrate was transferred to a separatory funnel and partitioned with 1 M aqueous NaOH (250 ml). The organic was removed and washed with 1 M aqueous NaOH (2 x 150 ml), saturated aqueous sodium chloride (150 ml), dried over sodium sulfate (250 g) and filtered through a glass frit Buchner funnel. The filtrate was concentrated under reduced pressure to provide methyl 3-chloro-4-(2-hydroxy-2-methylpropoxy)benzoate (9.0 g, 65percent) as a clear pale yellow oil. The material was used without further purification in the next synthetic step. ESI-MS mlz caic. 258.7, found 259.2 (M+1) Retention time: 1.46 mm (3 mm run).

The chemical industry reduces the impact on the environment during synthesis 558-42-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; DENINNO, Michael, Paul; ANDERSON, Corey; CONROY, Erica, Lynn; FRIEMAN, Bryan, A.; GROOTHENHUIS, Peter, Diederik Jan; HADIDA-RUAH, Sara, Sabina; HURLEY, Dennis, James; PIERRE, Fabrice Jean, Denis; SILINA, Alina; UY, Johnny; ZHOU, Jinglan; WO2015/6280; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

A mixture of 2-hydroxy-4-({[3-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonyl}amino)benzoic acid (26 mg, 67 mumol), 4-(dimethylamino)-1-butanol (78 mg, 0.67 mmol), 4-dimethylaminopyridine (2.4 mg, 20 mumol) and N,N’-dicyclohexylcarbodiimide (41 mg, 0.20 mmol) was stirred in THF (1 ml) overnight at room temperature and further at 60 C. for 3 h. The solvent was evaporated and the residue dissolved on MeOH. The compound was purified by preparative HPLC (acidic system). The title compound was obtained in 6% yield (2.5 mg). MS (ESI+) calcd for C23H27N3O5S2: 489.139212. found 489.140522.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13330-96-6, 4-(Dimethylamino)butan-1-ol.

Reference:
Patent; Martinsson, Jessica; Faernegardh, Katarina; Joensson, Mattias; Ringom, Rune; US2015/25068; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal, the common compound, a new synthetic route is introduced below. Product Details of 597-31-9

The hydroxypivalaldehyde and sodium hydroxide solution obtained in the step (3) were added to a four-necked flask, heated and refluxed for 2 hours with stirring at 85 to 95 C,The weight ratio of the BaO / SiO2 core-shell microsphere catalyst was 27: 5: 270: 15, the weight ratio of the catalyst was 4: Stirring to 60 C while adding ammonia to keep the pH of the reaction solution 7-9, 8 hours after the stop reaction, the reaction solution suction filter, the filtrate concentration adjusted with concentrated hydrochloric acid ph value 3-4, extracted with acetone , After evaporation of acetone standing, precipitation crystallization is hydroxy pivalic acid, the yield was 91%

The synthetic route of 597-31-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Suzhou Yi Dike Pharmaceutical Chemical Co; Hu, Haiwei; Ding, Jing; Yan, Yongping; Zheng, Hui; Yan, Hui; (7 pag.)CN105753684; (2016); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Preparation of (3-tert-Butoxycarbonylamino-2-hydroxy-propyl)-carbamic Acid Tert-Butyl Ester: To a solution of 1,3 diamino-2-hydroxypropane (10 g, 0.11 mol) in methanol (500 ml) was added di-tert-butyl dicarbonate (48 g, 0.22 mumol) and the reaction stirred for 2 hours at room temperature under a N2 atmosphere. The mixture was concentrated to afford the product as a light yellow oil (31.9 g, 100%). 1H-NMR (CD3OD) delta 1.44 (s, 18H), 3.10 (m, 4H), 3.63 (m, 1H).

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.; US2004/19058; (2004); A1;,
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Reference of 78573-45-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.

In a 500 ml reaction flask, 15 g of m-trifluoromethylbenzenepropanol,8.2 g of triethylamine and 150 ml of methylene chloride was added, stirred and cooled down to -5 C. Methanesulfonyl chloride (10 g of methanesulfonyl chloride + 30 ml of methylene chloride) was added dropwise and the temperature was controlled at -5 C. for about 0.5 hour. 1 hour. Plus 8.2g triethylamine, the control temperature -5 , the reaction 0.5 hours. 100 ml of ice water was added and the mixture was stirred for 10 minutes. The layers were separated and the organic layer was separated. The aqueous layer was extracted once with 100 ml of dichloromethane. The organic layers were combined, washed once with 100 ml of saturated sodium chloride solution and dried over 20 g of anhydrous sodium sulfate for 2 hours. The sodium sulfate was filtered off and concentrated under reduced pressure until no fractions were distilled off. 100 ml of isopropyl acetate was added to dissolve and concentrated under reduced pressure No distillate distillate, the product, yield 97.9%, purity 99.5% (W / W).

Statistics shows that 78573-45-2 is playing an increasingly important role. we look forward to future research findings about 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.

Reference:
Patent; Shandong Xinhua Pharmaceutical Co., Ltd.; He Xinheng; Zheng Zhonghui; Jiang Tao; He Weihao; Jiang Zeyu; (5 pag.)CN107473993; (2017); A;,
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Application of 623-50-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-50-7, name is Ethyl 2-hydroxyacetate, molecular formula is C4H8O3, molecular weight is 104.1045, as common compound, the synthetic route is as follows.

Example 34[0196] Preparation of allyloxy-acetic acid ethyl ester. EMI61.2[0197] A round-bottom flask was charged with NaH (1.76 g, 44 mmol, 60% dispersion in mineral oil) and flushed with argon. Hexane (10 ml x 2) was added and decanted. DMF (10 ml) was added into the flask and the resulting solution was cooled to 0 C. Ethyl glycolate (4.16 g, 40.0 mmol) was added over 10 min. The solution was allowed to gradually warm to 25 C and was maintained at that temperature for 2 h. The solution was cooled to 0 C and allyl bromide (5. 32 g, 44.0 mmol) was added over 10 min. The solution was allowed to gradually warm to 25 C and stirred at that temperature for 2h. Aqueous solutionNH4Cl(10 ml) was added to the reaction and the mixture was diluted with EtOAc (60 ml). The organic layer was separated and washed withH20 (20 ml x 2), dried overNa2S04 and concentratedin vacuo. The crude product was purified by distillation under reduced pressure. [0198] Yield = 4.29 g, 75%; colorless liquid; bp = 38-39 C, 2 mmHg. IR (neat): 1985,1756, 1724,1203, 1130 cm-l. IH NMR (CDC13, 400 MHz): 6 5.90-5. 70 (m, 1H), 5.25-5. 00 (m, 2H), 4.10-4. 20 (m, 2H), 3.92-4. 05 (m, 4H), 1.21 (t, J = 7Hz, 3H). 13C NMR (CDCl3, 100 MHz): 8 170.09 (C), 133.62 (CH), 117.78 (CH2), 72.10 (CH2), 66.99 (CH2), 60.53 (CH2), 13. 94 (CH3). MS (m/z, relative intensity): 144 (M+, 14), 115 (22), 103 (100), 83 (85); HRMS: calculated for C7HI203 (M+): 144.0786 ; found 144.0783.

Statistics shows that 623-50-7 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-hydroxyacetate.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2005/49582; (2005); A1;,
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Application of 83647-43-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of (2-methyl-3 -(4,4,5,5 -tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenyl)methanol (1.728 g, 6,96 mmol), (3-bromo-2-methylphenyl)methanol (1.40 g, 6.96 mmol), Pd(dppf)C12CH2C12(0.5 09 g, 0.696 mmol) and potassium carbonate (1.922 g, 13.93 mmol) under N2 was added a mixture of solvents (20 mL dioxane and 5 mL water) and heated to 85 C in a heating block for 2h, at which time all SM was consumed by LCMS. After cooling to room temperature, the reaction was diluted with EtOAc and water. The organic layer was separated, dried with Na2504 and concentrated. Purified by silica gel chromatography (eluting with EtOAc-Hex) to provide (2,2?-dimethyl-[1,1?-biphenylj-3,3?-diyl)dimethanol as a light oil that crystallized on standing. [M-OHj = 225. ?H NMR (400 MI-Tz, DMSO-d6) 7.37 (dd, J = 7.6, 1.3 Hz, 2H), 7.19 (t, J = 7.5 Hz, 2H), 6.92 (dd, J = 7.6, 1.4 Hz, 2H), 5.10 (t, J = 5.4 Hz, 2H), 4.52 (d, J = 5.4 Hz, 4H), 1.88 (s, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83647-43-2, (3-Bromo-2-methylphenyl)methanol.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
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Synthetic Route of 14320-38-8 , The common heterocyclic compound, 14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add ieri-butylchlorodiphenylsilane (36.66 g, 133.38 mmol) to 3-cyclopenten-l-ol (10.2 g, 121.26 mmol) and lH-imidazole (18.16 g, 266.77 mmol) in dry DMF (100 mL) drop wise at -20 C. After complete addition, allow the reaction temperature to gradually warm to ambient temperature and stir under nitrogen overnight. Add water, ammonium chloride, and EtOAc to the reaction mixture and stir the mixture for 1 hour. Separate the organic layer and wash with ammonium chloride (5x) until pH is acidic, water (2x), and brine, dry over sodium sulfate, filter, and concentrate under reduced pressure to give the title compound (40.22 g, 93%). ES/MS (m/z): 405.2 (M+2 MeCN+H).

The synthetic route of 14320-38-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; BROOKS, Harold Burns; DALLY, Robert Dean; DURHAM, Timothy Barrett; FALES, Kevin Robert; FRIMPONG, Kwame; MCCOWAN, Jefferson Ray; NJOROGE, Frank George; SHEPHERD, Timothy Alan; SI, Chong; THRASHER, Kenneth Jeff; TOTH, James Lee; WU, Zhipei; (106 pag.)WO2016/89670; (2016); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 623-50-7, name is Ethyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Ethyl 2-hydroxyacetate

EXAMPLE 10(i) N-(1-azabicyclo[2.2.1]hept-3-yl)-furo[2,3-b]pyridine-2-carboxamide: Ethyl glycolate (35.5 mL, 375 mmol) is slowly added (over 20 minutes) to a slurry of NaOH (15.8 g, 394 mmol) in 1,2-dimethoxyethane (400 mL) under N2 with the flask being in an ice bath. The mixture is allowed to warm to rt, is stirred for 30 min, and ethyl 2-chloronicotinate (27.84 g, 150 mmol) in 1,2-dimethoxyethane (50 mL) is added over 10 minutes. The reaction is warmed to 65 C. for 15 h in an oil bath. The mixture is concentrated to dryness, the residue is dissolved in H2O (500 mL), washed with hexane (500 mL), acidified to pH 3 with 5% HCl, and extracted with CHCl3 (4*400 mL). The combined organic layer is dried over MgSO4, filtered, and concentrated to a yellow solid. The solid is suspended in ether (200 mL) and heated on a steam bath until concentrated to a volume of 40 mL. The material is allowed to crystallize overnight, then filtered to afford ethyl 3-hydroxyfuro[2,3-b]pyridine-2-carboxylate (C40) as a pale orange solid (41% yield). Additional material is obtained by concentrating the filtrate.

With the rapid development of chemical substances, we look forward to future research findings about 623-50-7.

Reference:
Patent; Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Reitz, Steven Charles; Groppi JR., Vincent E.; US2003/153595; (2003); A1;,
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