Category: alcohols-buliding-blocks

Synthetic Route of 1992-09-2, Adding some certain compound to certain chemical reactions, such as: 1992-09-2, name is 2-(4-Amino-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C10H9F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1992-09-2.

2.73 g of 2-(3′-methyl-4′-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanolCompound of formula VAnd 4.89 g of cesium carbonate was added to the dried reaction flask,Add in 20 ml of DMF and stir at room temperature for 30 minutes.1.70 g of methyl iodide was slowly added to the reaction flask with a syringe,Stirring was continued at room temperature and TLC was detected until the conversion of the starting material was complete.After the reaction was completed, it was extracted with a saturated aqueous solution of ammonium chloride and ethyl acetate.The organic phase was dried over anhydrous sodium sulfate and dried under reduced pressure.The crude oily intermediate VIa was obtained for subsequent reaction.

According to the analysis of related databases, 1992-09-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China University of Science and Technology; Cao Song; Zhao Xianghu; He Jingjing; Li Jialu; Liu Yisen; Li Chunmei; Xu Sixue; Huang Qingchun; (19 pag.)CN110272361; (2019); A;,
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Electric Literature of 23147-58-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23147-58-2, name is Glycerol aldehyde dimer. A new synthetic method of this compound is introduced below.

Compound I-ee was prepared using the method of Example 7. To a solution of compound I-ee (0.1 mmol) in methanol (1 mL) was added the aldehyde or ketone (0.2 mmol) and acetic acid (0.4 mmol), followed by sodium cyanoborohydride (0.2 mmol). The solution was stirred at 20 to 25 C (for reactive aldehydes) or 50 to 60 C (for less reactive aldehydes and ketones) until all of Compound I-ee was consumed. The reaction mixture was concentrated on a rotary evaporator, re-dissolved in a mixture of water-acetonitrile, filtered through a one-gram plug of C-18 silica gel, and purified by reversed-phase HPLC, eluted using a gradient of acetonitrile in water containing 0.1% acetic acid. The product was obtained as a white solid after lyophilization of desired fractions. EPO [00182] Compound I-nn (5S,6R)-5-[N-(2-hydroxyethyl)methylamino]polyangi-l ,6- diol) was synthesized using glycolaldehyde dimer at room temperature. ESI-TOF-MS m/z 518.3839, calcd for C31H52NO5 ([M + H]+) 518.3840.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; KOSAN BIOSCIENCES INCORPORATED; WO2006/66147; (2006); A2;,
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Related Products of 83647-43-2, Adding some certain compound to certain chemical reactions, such as: 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83647-43-2.

Step B: 5-Bromo-4-methyl-2-benzofuran-l(3H)-one To a flask charged with (3-bromo-2-methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M trifluoroacetic acid solution of thallium trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added palladium(II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and methanol (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a diatomaceous earth pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford 5-bromo-4-methyl-2-benzofuran-l(3H)-one. 1H-NMR (500 MHz, CDC13) delta ppm 7.71 (d, J= 8.0 Hz, 1H), 7.58 (d, J 2H), 2.37 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83647-43-2, (3-Bromo-2-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H10N2O

First a 30mL methanol solution of salicyldehyde (30 mmol,3.66 g) was added to a 15mL methanol solution of 1,3-diamino-2-propanol (15 mmol, 1.35 g). The resulting orange solution wasthen refluxed for 1 h, and after cooling down, the solvent wasremoved under reduced pressure to afford an orange crystallinesolid which was collected as the ligand. Yield: 69%. Anal. Calc. forC17H18N2O3: C, 68.42; H, 6.09; N, 9.39. Found: C, 68.77; H, 5.73; N,9.71%.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Das, Kuheli; Massera, Chiara; Garribba, Eugenio; Frontera, Antonio; Datta, Amitabha; Journal of Molecular Structure; vol. 1199; (2020);,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1,2,4-Butanetriol

Example 1; Instead of PEG-400 and the para-toluenesulfonic acid catalyst used in ComparativeExample 1, dioxane and a strong acid ion exchange resin (Amberlyst 15, H+ form) containing a sulfonic acid group were used in equal amounts. Then, the reaction was conducted using a batch type reactor under conditions of atmospheric pressure and 1000C for 20 hours. The reaction yield was 96 mol%.

With the rapid development of chemical substances, we look forward to future research findings about 3068-00-6.

Reference:
Patent; SK CORPORATION; WO2007/81065; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.Computed Properties of C8H9BrO

The reaction kettle was charged with 4-bromophenethyl alcohol (1.0 kg, 5.0 mol) 10 times the volume of methylene chloride dissolved, Triethylamine (1.01 kg, 10.0 mol) And catalytic amount of DMAP, TBSCl (0.9 kg, 6.0 mol) was added in batches. Reaction to the disappearance of raw materials at room temperature, Washed, Saturated brine, After drying with anhydrous sodium sulfate, the liquid compound VA (1.5 kg, 95.5%) was obtained as a colorless oil. Directly into the next reaction.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4654-39-1, 2-(4-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Lide Biological Technology Co., Ltd.; Ren Guobao; Wu Yan; Li Chuanbin; (6 pag.)CN106565467; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4654-39-1, name is 2-(4-Bromophenyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 4654-39-1

To a mixture of 2-(4- bromophenyl)ethanol (10.0 g, 49.7 mmol) in DCM (100 mL) were added imidazole (10.0 g, 149.2 mmol) and TBSC1 (8.2 g, 54.7 mmol) at 0 C. After stirring at room temperature for 3 h, the reaction mixture was quenched with water, extracted with DCM. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated. The crude was purified by silica gel column (PE: EA = 50: 1) to get (4-bromophenethoxy)(tert-butyl)dimethylsilane (16.2 g, 99%) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4654-39-1, 2-(4-Bromophenyl)ethanol.

Reference:
Patent; NIKANG THERAPEUTICS, INC.; LOU, Yan; FU, Jiping; HE, Yigang; (0 pag.)WO2020/14332; (2020); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1036260-25-9, 3-Aminocyclobutanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1036260-25-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1036260-25-9

step 1: A mixture of 3-aminocyclobutanol hydrochloride (1.91 g, 15.47 mmol), isobenzofuran-1,3-dione (2.52 g, 17.01 mmol) and DIPEA (6.0 g, 46.40 mmol) in PhMe (100 mL) was stirred at 110 C. for 18 h. The reaction mixture was concentrated and purified by SiO2 chromatography eluting with PE/EA (3:1) to afford 2-(3-hydroxycyclobutyl)isoindoline-1,3-dione as white solid (2.1 g, 62.6%). LCMS (ESI): m/z=218.1 [M+1]+

The synthetic route of 1036260-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
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Related Products of 769-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2.0 g, 13.1 mmol) and 6i(lH-imidazol-l-yl)methanone (4.26 g, 26.2 mmol) in 20 mL CH2CI2 was heated overnight at 50 C The reaction was quenched with water and extracted with CH2CI2, and the combined layers were dried over MgS04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2C12 gave (benzo[d][l,3]dioxol-7-yl)methyl lNo.-imidazole-l-carboxylate (2.8 g, 86%). ltt NMR (400 MHz, CDC13) 8 8.15 (t, /= 0.9 Hz, 1H), 7.44 (t, J= 1.4 Hz, 1H), 7.07 (dd, J= 1.6, 0.8 Hz, 1H), 6.95 (m, 2H), 6.84 (m, 1H), 6.01 (s, 2H), 5.33 (s, 2H).

Statistics shows that 769-30-2 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73978-41-3, name is (2,4-Diaminopteridin-6-yl)methanol hydrochloride, molecular formula is C7H9ClN6O, molecular weight is 228.639, as common compound, the synthetic route is as follows.Recommanded Product: (2,4-Diaminopteridin-6-yl)methanol hydrochloride

0J 89j 4 FontWeight=”Bold” FontSize=”10″ Araino FontWeight=”Bold” FontSize=”10″ 4-deoxy-l O-A^nethyipterok Acid (APA, 2) ( raovec. I; Spencer, G.; Blair, A. H.; Mammen, M; Singh, M,; Ghose, T. J. Med Chem., 1989, 32, 2426). A mixture of 249 rag (0.59 mraol) dibromotripheaylphosphorane and 45,0 mg (0.20 tnmol) 2,4-diaraino-6-(hydr )xymethyl)pteridin.e hydrochloride (1) in 1 .5 mL of anhydrous dmieihylacetamide was stirred at room iemperatare for 24 h under an argon atmosphere. To the reaction mixture were added 41 mg (0.27 mmol) of 4-(methylamino)benzoic acid and 0,16 mL { 116 mg, 0,90 mmol) of DIPEA and the reaction mixture was stirred at room temperature for 48 h, and then at 60 ‘”‘C for 24 fi. The cooled reaction mixture was poured into 25 mL of 0.33 M aq NaOH and the precipitate was filtered. The filtrate was adjusted to H 5.5 with 10% acetic acid and the resulting precipitate was collected through filtration, washed wi h water and dried under diminished pressure at 80 C overnight to obtain 2 as an orange solid: yield 42 mg (56%); silica gel TLC – 0.47 (5:4: 1 chlorofornv-methanol-water); lH NM (DMSO-<&) o 3.19 (s, 3H), 4.76 (s, 2H), 6.61 (s, 2H>, 6.78 (d, 21i J- 8.9 Hz), 7.72 (d, 2H, J- 8.7 Hz) and 8.56 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73978-41-3, (2,4-Diaminopteridin-6-yl)methanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY; HECHT, Sidney; PAUL, Rakesh; TANG, Chenhong; MADATHIL, Manikandadas; BHATTACHARYA, Chandraball; WO2014/145109; (2014); A1;,
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