Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 15852-73-0, (3-Bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To a solution of alcohol(1 mmol) in a mixture of MeCN and MeOH (5:1, 2.4 mL) was added TsNBr2(2.5 mmol) and K2CO3 (5 mmol) and stirred at room temperature. Aftercompletion of the reaction (TLC) sodium thiosulfate was added and thereaction mixture was stirred for 10 min. The reaction mixture was extracted indiethyl ether and hexane (1:1), dried, (Na2SO4) and concentrated. Purificationof the crude product by flash chromatography on silica gel (230?400 mesh)with petroleum ether?EtOAc as eluent gave the pure product

The synthetic route of 15852-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rajbongshi, Kamal Krishna; Sarma, Manas Jyoti; Phukan, Prodeep; Tetrahedron Letters; vol. 55; 39; (2014); p. 5358 – 5360;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.09, as common compound, the synthetic route is as follows.HPLC of Formula: C9H11BrO

tert-Butyldimethylsilyl chloride (2.1O g, 14 mmol) was added to a mixture of 2-(4-bromophenyl)-propan-2-ol (2.0 g, 9.3 mmol) and imidazole (0.95 g 14 mmol) in DMF (30 mL) and the resultant mixture was stirred at 80 C for 24 h. The mixture was concentrated to one third of the original volume then diluted with water (50 mL) and extracted with diethyl ether (3 x 50 mL). The combined organic layer was dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The resultant residue was purified by chromatography (silica, 5Og column, Si-SPE, 0-5% diethyl ether in pentane) to afford the title compound as a colourless oil (1.39 g, 46%). 1H NMR (MeOD, 400MHz): 7.46-7.37 (m, 4H); 1.56 (s, 6H); 0.95-0.91 (m, 9H); 0.06 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2077-19-2, 2-(4-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; WO2009/151598; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 117087-18-0, blongs to alcohols-buliding-blocks compound. Product Details of 117087-18-0

White powder obtained in the step (3) (75 g, 0.38 mol)Soluble in N,N-dimethylformamide (1L), ice bath,Nitrogen partial protection,One copy Sodium hydrogen(15.2g, 0.38mol, 60% in mineral oil),After stirring for 1 hour, methanesulfonyl chloride (43 g, 0.375 mol) was added dropwise.The system was allowed to warm to room temperature and stirring was continued for 2 hours.Then the system is cooled to 0 C,Add one part of sodium hydrogen (15.2g, 0.38mol),The system was slowly warmed to room temperature again and stirring was continued for 3 hours.In the ice bath, adding 1M means adjusting the pH to neutral.Add 2L of water, extract ethyl acetate 300mL 5 times,The organic phases were combined, washed 3 times with water, dried and concentrated.The residue was dissolved in methanol 500 mL.Add 100 mL to the methanol phase and stir for 20 minutes.Layered,Then the lower layer was continuously added with 100 mL of petroleum ether, stirred for another 20 min, layered, and the lower layer was concentrated, and ethyl acetate and petroleum ether were crystallized 1:10.Obtained 53 g of a white solid. Yield 78%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Xinyuan Pharmaceutical Technology Co., Ltd.; Chai Teng; Lin Zengming; (12 pag.)CN108314665; (2018); A;,
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Application of 171011-37-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol. A new synthetic method of this compound is introduced below.

Step 2: Synthesis of (5-bromo-2-(chloromethyl)phenyl)methanol A flask was charged with (4-bromo-1,2-phenylene)dimethanol (4.00 g, 18.4 mmol, 1.00 equiv) and hydrochloric acid (25 mL). The resulting solution was stirred for 15 min at 70 C and quenched with water (50 mL). The mixture was extracted with EtOAc (2 x 80 mL) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was chromatographed on a silica gel column with EtOAc/petroleum ether (1/8) to provide 2.70 g (62% yield) of (5-bromo-2-(chloromethyl)phenyl)methanol as an off-white solid.1H NMR (300 MHz, DMSO-d6) ^ 7.64- 7.66 (m, 1H), 7.45- 7.49 (m, 1H), 7.36 (d, J = 8.1 Hz, 1H), 5.40- 5.45 (m, 1H), 4.78 (s, 2H), 4.66 (d, J = 4.5 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, and friends who are interested can also refer to it.

Reference:
Patent; ABIDE THERAPEUTICS, INC.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; CISAR, Justin S.; GRICE, Cheryl A.; JONES, Todd K.; WEBER, Olivia D.; (277 pag.)WO2017/197192; (2017); A1;,
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Synthetic Route of 1124-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1124-63-6, name is 3-Cyclohexylpropan-1-ol, molecular formula is C9H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 125 5-(3-Cyclohexyl-propoxy)-1-(4-nitro-phenyl)-1H-tetrazole Cyclohexylpropyl alcohol (237 mL, 1.58 mol) was added to a suspension of NaH (66.0 g, 1.65 mol) in tetrahydrofuran (1.40 L). A solution of 5-Chloro-1-(4-nitro-phenyl)-1 H-tetrazole (320 g, 1.42 mol) in tetrahydrofuran (900 mL) was added dropwise over 1.5 hours. The reaction was allowed to cool to room temperature and stirred overnight. The mixture was concentrated in vacuo to a solid. The solid was dissolved in ethyl acetate, washed with saturated aqueous sodium chloride solution (2x), dried (Na2SO4), and filtered through silica gel (700 g). The red filtrate was concentrated in vacuo until product began to precipitate from solution. Hexane was added and the slurry filtered to provide a tan solid (320 g, 64 %). Mp 82-88C (dec); 1H NMR (CDCl3, 300 MHz) delta 8.43 (d, 9.2 Hz, 2 H), 8.04 (d, 9.2 Hz, 2 H), 4.70 (t, 7.0 Hz, 2 H), 1.96 (m, 2 H), 1.75-1.64 (m, 5 H), 1.39-1.13 (m, 6 H), 0.97-0.87 (m, 2 H); MS (CI) mlz 332 (MH+); Anal. calcd for C16H21N5O3: C, 57.99; H, 6.39; N, 21.13. Found: C, 57.80; H, 6.35; N, 21.02; Rf = 0.43 (N).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; BAYER CORPORATION; EP1054881; (2008); B1;,
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Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Application of 5391-88-8, Adding some certain compound to certain chemical reactions, such as: 5391-88-8, name is 1-(4-Bromophenyl)ethanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5391-88-8.

l-(4-bromo-phenyl)-ethanol is stirred in aq. HCl at room temperature for 20 h. The excess acid is evaporated under vacuum to give the expected product in quantative yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5391-88-8, 1-(4-Bromophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS NV; MENET, Christel Jeanne Marie; BLANC, Javier; JOUANNIGOT, Nolwenn; HODGES, Alastair James; VAN ROMPAEY, Luc Juliaan Corina; FLETCHER, Stephen Robert; WO2010/10189; (2010); A1;,
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Related Products of 42514-50-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 4: (3-Hydroxy-1,1-dimethyl-propyl)-carbamic acid tert-butyl ester. 3-Amino-3-methyl-butan-1-ol(5.0 g, 0.04 mol) was dissolved in 150 mL CH2Cl2 and treated with di-tert-butyl dicarbonate(11.12 g, 0.05 mol). The resulting mixture was stirred for 18 h at 25 C. The mixture was concentrated to the desired material as an amber oil(9.8 g, 100%); 1H NMR (DMSO-d6) delta 3.55 (s,1H), delta 4.43 (t, J=5 Hz, 1H), delta 3.46 (m, 2H), delta 1.71 (t, J=7 Hz, 2H), delta 1.37(s, 9H), delta 1.12(s, 6H).

According to the analysis of related databases, 42514-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kim, Kyoung S.; Lu, Songfeng; Sheng, X. Christopher; Crews JR., Alvin Donald; US2004/242596; (2004); A1;,
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Electric Literature of 612-16-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of benzyl alcohol (1a, 0.3244 g, 3.0 mmol,1.5 equiv.), 2-aminopyridine (6a, 0.1882 g, 2.0 mmol), and NaOH (0.0400 g, 1.0 mmol, 50 mol%)was sealed under air in a 20 mL Schlenk tube and then stirred at 150 oC for 24 h. After completion,the reaction was monitored by TLC and/or GC-MS (>99% GC conversion) and the crude productwas purified by column chromatography using ethyl acetate and petroleum ether as eluent. Thetarget product 7a was obtained in 89% isolated yield. White solid. 1H NMR (500 MHz, CDCl3): delta 8.10 (dd,J = 5.0 Hz, J = 1.0 Hz, 1H), 7. 39-7.36 (m, 1H), 7.31 (d, J = 7.5 Hz, 1H), 7.26-7.23 (m, 1H),6.92-6.87 (m, 2H), 6.56-6.54 (m, 1H), 6.39 (d, J = 7.5 Hz, 1H), 5.01 (b, 1H), 4.48 (d, J = 6.0 Hz,2H), 3.85 (s, 3H). 13C NMR (125.4 MHz, CDCl3): delta 158.9, 157.4, 148.2, 137.3, 128.8, 128.3, 127.1,120.5, 112.8, 110.2, 106.7, 55.3, 41.7. MS (EI): m/z (%) 214 (60), 183 (92), 136 (45), 121 (35), 105(31), 91 (100), 78 (48), 65 (25), 51 (14).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Article; Li, Xiaohui; Li, Shuangyan; Li, Qiang; Dong, Xu; Li, Yang; Yu, Xiaochun; Xu, Qing; Tetrahedron; vol. 72; 2; (2016); p. 264 – 272;,
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Electric Literature of 2615-15-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2615-15-8 as follows.

1005671 A solution of hexaethylene glycol (10 g, 35.46 mmol) in DCM (100 mL) was charged with Ag20 (12.34 g, 53.19 mmol), KI (1.17 g, 7.04 mmol) and stirred at room temperature for 15 mm. This solution was charged with tosyl chloride (7.35 g, 38.68 mmol)and stirred at room temperature for 6 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 2% methanol in DCM to give 8.80 g, 57% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.9 Hz, 2H), 7.48 (d, J= 7.7 Hz, 2H), 4.56 (t, J= 5.4 Hz, 1H), 4.11 (t, J= 4.3 Hz, 2H), 3.563.32 (m, 22H), 2.42 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2615-15-8, its application will become more common.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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