Author: tianli

Reference of 50411-26-2, Adding some certain compound to certain chemical reactions, such as: 50411-26-2, name is 1-Amino-3-phenylpropan-2-ol,molecular formula is C9H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50411-26-2.

To a stirring solution of 1-amino-3-phenyl-propan-2-ol (0.51 g, 3.3 mmol) and triethylamine (0.45 mL, 3.3 mmol) in 20 mL dichloromethane was added (0.92 g, 2.6 mmol) 2-chloro-3-methyl-5-naphthalen-2-yl-6-pyridin-4-yl-3H-pyrimidin-4-one. The solution was stirred for 18 h at room temperature. The solution was diluted with ethyl acetate and washed with 5% sodium bicarbonate. The organic layer was dried over magnesium sulfate and purified on 10 g silica eluting product with 0 to 5% methanol/dichloromethane to give a pale yellow solid. M+1=463.2.

According to the analysis of related databases, 50411-26-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Amgen Inc.; US2005/43301; (2005); A1;,
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Electric Literature of 14320-38-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows.

Cyclopent-3-enol (2.1 g, 24.97 mmol) was dissolved in CH2CI2 (30 ml,). TIPS-Cl (10.58 mL, 49.9 mmol) was added, followed by imidazole (3.40 g, 49.9 mmol). The mixture was stirred at room temperature for 2 days. White solid was filtered out and washed with small amount of DCM. The organic solution was evaporated and the residue was purified by silica gel chromatography (80 g silica gel column, 0-50% EtOAc/hexane gradient). Removing solvent gave (cyclopent-3-en-l -y]oxy)triisopropylsilane (4.92 g, 20.46 mmol, 82 % yield) as a colorless oil. NMR (400 MHz, CDCb): delta ppm 5.67 (2 H, s), 4.63 (1 H, t, ./ 3.63 Hz), 2.62 (2 H, dd, ./ 14.97. 6.82 Hz), 2.20 – 2.45 (2 H, m), 1.00 – 1.13 (21 H, m).

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FU, Qinghong; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (184 pag.)WO2018/13770; (2018); A1;,
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Application of 179811-63-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 179811-63-3, name is 2-Amino-2-(3-chlorophenyl)ethanol, molecular formula is C8H10ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a mixture of 20 (2.60 mmol) and corresponding amine (2.60 mmol) in MeOH (10 mL) was added Et3N (540.00 mul, 3.90 mmol). The mixture was refluxed for 6h. After completion, the mixture was cooled to 0 oC, and stirred for 30 min, the precipitate was filtered to obtain corresponding product. 2.16.1. 2-(1-(3-chlorophenyl)-2-hydroxyethyl)-6-(2-(methylsulfonyl) pyrimidin-4-yl) isoi-ndolin-1-one (21a) Yield 65%. m.p. 166~167 oC. 1H NMR (300 MHz, CDCl3) delta (ppm): 9.01 (d, J = 5.30 Hz, 1H, ArH), 8.49 (s, 1H, ArH), 8.44 (dd, J = 8.00, 1.50 Hz, 1H, ArH), 8.01 (d, J = 5.30 Hz, 1H, ArH), 7.58 (d, J = 8.00 Hz, 1H, ArH), 7.50-7.31 (m, 3H, ArH), 7.28-7.26 (m, 1H, ArH), 5.40 (dd, J = 7.90, 4.40 Hz, 1H, CHCH2OH), 4.63 (d, J = 17.80 Hz, 1H, CH2), 4.43 – 4.32 (m, 2H, HOCH2CH), 4.28 (dd, J = 11.90, 4.40 Hz, 1H, CH2), 3.49 (s, 3H, SO2CH3 ).

According to the analysis of related databases, 179811-63-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ji, Dezhong; Zhang, Lingzhi; Zhu, Qihua; Bai, Ying; Wu, Yaoyao; Xu, Yungen; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 334 – 341;,
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Synthetic Route of 78573-45-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 78573-45-2 as follows.

(e) p-Toluenesulfonic acid [3-(3-trifluoromethylphenyl)propyl] ester 125 g of p-toluenesulfonic acid [3-(3-trifluoromethylphenyl)propyl] ester are obtained as a yellow oil from 71.5 g of 3-(3-trifluoromethylphenyl)propan-1-ol, 83 g of p-toluenesulfonic acid chloride and 54 ml of pyridine in 160 ml of chloroform by the procedure described in Example 5e.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,78573-45-2, its application will become more common.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung; US4324796; (1982); A;,
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Reference of 5020-41-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.1904, as common compound, the synthetic route is as follows.

To a stirred mixture of 3-methoxyphenethylalcohol (1.18 g, 7.8 mmol) and pyridine (0.75 ml, 9.3 mmol) in dry dichloromethane (10 ml) was added bromine (0.47 ml, 18.0 mmol) dropwise under nitrogen at 0 C. The orange solution was stirred at room temperature for 4 hr. The reaction mixture was quenched by the addition of 10% sodium bisulfite aqueous solution., and extracted with dichloromethane. The organic extracts were washed with brine, dried over magnesium sulfate, and concentrated to give crude products, which were purified by silica-gel column chromatography eluted with gradient of hexane and ethyl acetate (10:1, 8:1, 5:1) to give the title compound as a colorless oil (1.5 g, 83.2%). [0141] 1H-NMR (CDCl3): 7.43 (d, J=8.8 Hz, 1H), 6.83 (d, J=3.3 Hz, 1H), 6.67 (dd, J=8.8, 3.3 Hz, 1H), 3.91-3.81 (m, 2H), 3.78 (s, 3H), 2.99 (t, J=6.6 Hz, 2H)

Statistics shows that 5020-41-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Methoxyphenyl)ethanol.

Reference:
Patent; Pfizer Inc.; US2003/208079; (2003); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 5-(Benzyloxy)pentan-1-ol

To a solution of triphenylphosphine (6.8 g, 25.7 mmol) in dichloromethane (100 mL) at 0 C was added bromine (1.3 mL, 25.7 mmol) and the mixture stirred for 30 minutes. A solution of the alcohol 33 (5.0 g, 25.7 mmol) in dichloromethane (20 mL) and pyridine (2.1 mL, 25.7 mmol) were added and the mixture was warmed to room temperature and stirred for 4 hours. The volatiles were removed and the residue suspended in water (200 mL), extracted with diethyl ether (3 x 100 mL) and dried over anhydrous magnesium sulfate. The ethereal extracts were concentrated (to ~100 mL) and hexane (100 mL) was added. The resulting precipitate was removed by filtration and the filtrate was aged at -30 C for 24 hours. The large crystals of triphenylphosphine oxide were removed by filtration and the filtrate concentrated to obtain the title compound 34 (5.8 g, 88%) as a colourless oil, the spectroscopic data of which corresponded to previously described. Rf: 0.34 (1:19 ethyl acetate, hexane).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4541-15-5, 5-(Benzyloxy)pentan-1-ol.

Reference:
Article; Moir, Michael; Lane, Samuel; Lai, Felcia; Connor, Mark; Hibbs, David E.; Kassiou, Michael; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 291 – 309;,
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Synthetic Route of 2968-93-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2968-93-6, name is 2-(4-(Trifluoromethyl)phenyl)ethanol, molecular formula is C9H9F3O, molecular weight is 190.16, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.

Statistics shows that 2968-93-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-(Trifluoromethyl)phenyl)ethanol.

Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
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Synthetic Route of 702-82-9 , The common heterocyclic compound, 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 2(41 mg, 0.25 mmol) was dissolved in THF (15 ml). To the solution Et3N(69 mul, 0.50 mmol), indazole-3-carboxylic acid (27 mg, 0.16 mmol) and TBTU (79mg, 0.25 mmol) were added. The reaction mixture was left to stir overnight atroom temperature. Concentrated and purified on silica using a mobile phasesystem of EtOAc/n-heptane (4:1) to give compound 3 (41.5 mg, yield 81%).

The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wallgren, Jakob; Vikingsson, Svante; Johansson, Anders; Josefsson, Martin; Green, Henrik; Dahlen, Johan; Wu, Xiongyu; Konradsson, Peter; Tetrahedron Letters; vol. 58; 15; (2017); p. 1456 – 1458;,
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Adding a certain compound to certain chemical reactions, such as: 107-75-5, 7-Hydroxy-3,7-dimethyloctanal, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 107-75-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 107-75-5

Compounds 46: 7-hyroxycitronellal (140 mu, 0.75 mmol), Cu(OTf)2 (2.2 mg, 2.5 mol %), ethanethiol (108 mu, 1.5 mmol) and 1,3,5- trimethoxybenzene (42 mg, 0.25 mmol) were reacted according to method B. The mixture was stirred for 2 h at rt. After the addition of Et3SiH (116 mu, 0.75 mmol) the reaction was stirred for 1 h at room temperature. The residual material was purified by column chromatography (silica gel 40-60, hexane / ethyl acetate 80:20) affording compound 46 (64 mg, 79% yield) as a thick oil. Characterization data of compound 46: lH NMR (CDCl3/400 MHz): delta 6.13 (s, 2H), 3.80 (s, 3H), 6.79 (s, 6H), 2.60 – 2.48 (m, 2H), 1.49 – 1.24 (m, 9H), 1.21 (s, 6H), 0.93 (d, J = 6.2, Hz, 3H); 13C NMR (CDCl3/100 MHz): 6 159.0, 158.7, 112.3, 90.6, 71.1, 55.7, 55.3, 44.4, 37.3, 36.6, 32.9, 29.3, 29.2, 21.6, 20.1, 19.7; HRMS (ESI): m/z calcd for Ci9H3204 [M+H]+ 325.2373 found 325.2363.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107-75-5, its application will become more common.

Reference:
Patent; B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY; PAPPO, Doron; PARNES, Regev; (87 pag.)WO2016/132355; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2077-19-2

(2E)-3-(4-(1-Methyl-1H-pyrazol-4-yl)pyridin-3-yl)-N-phenylacrylamide A mixture of (2E)-3-(4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)acrylamide (266 mg), 2-(4-bromophenyl)propan-2-ol (276 mg), Xantphos (67 mg), Pd2(dba)3 (53 mg), sodium tert-butoxide (157 mg) and toluene (5 mL) was stirred at 120 C. for 45 minutes under microwave irradiation. The reaction mixture was filtered through Celite, and water was added to the filtrate, followed by extraction with ethyl acetate. The organic layer was washed with brine and then dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to obtain (2E)-N-(4-(2-hydroxypropan-2-yl)phenyl)-3-(4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)acrylamide (101 mg) and (2E)-3-(4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-N-phenylacrylamide (6 mg). 1H NMR (300 MHz, DMSO-d6) delta 1.41 (6H, s), 3.94 (3H, s), 4.94 (1H, s), 6.85 (1H, d, J=15.6 Hz), 7.42 (2H, d, J=8.7 Hz), 7.49 (1H, d, J=5.2 Hz), 7.62 (2H, d, J=8.7 Hz), 7.64-7.80 (2H, m), 8.08 (1H, s), 8.53 (1H, d, J=5.2 Hz), 8.77 (1H, s), 10.23 (1H, s). 1H NMR (300 MHz, DMSO-d6) delta 3.94 (3H, s), 6.86 (1H, d, J=15.7 Hz), 7.02-7.15 (1H, m), 7.35 (2H, t, J=7.9 Hz), 7.49 (1H, d, J=4.8 Hz), 7.66-7.80 (4H, m), 8.09 (1H, s), 8.53 (1H, d, J=5.2 Hz), 8.78 (1H, s), 10.29 (1H, s).

The synthetic route of 2077-19-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; HIRAYAMA, Takaharu; FUJIMOTO, Jun; CARY, Douglas Robert; OKANIWA, Masanori; HIRATA, Yasuhiro; (147 pag.)US2017/44132; (2017); A1;,
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