Author: tianli

Application of 346-06-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135°C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 624-95-3 , The common heterocyclic compound, 624-95-3, name is 3,3-Dimethylbutan-1-ol, molecular formula is C6H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE III; Example III illustrates the oxidation of 3, 3-dimethyl-1-butanol to 3, 3-dimethyl-1- butanal using the catalyst system of the current invention: 170 mg ofFe (N03) 3′ 9H20 (0.416mmol), 66mg 2,2′-bipyridyl (0.416mmol), 85mg TEMPO (0.536mmol) and 80mg N-bromosuccinimide (0.45mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The reactor is alternately evacuated and purged with oxygen at least five times and the temperature of the catalyst solution is raised to the target value of 45C under constant stirring of 1500RPM. When the temperature reached 45C, 8200 mg of 3, 3-dimethyl-1- butanol (76. 6mmol) are injected through the septum adapter using a gas tight syringe. The recorded oxygen uptake rate is 0. 205mmol 02/min and the GC analysis after 250min reaction time showed 95.2% conversion of the starting alcohol and 96.2% selectivity to the desired 3, 3-dimethyl-l-butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 3, NS 10 16.EXAMPLE IV Example TV represents the potential of the catalyst composition to be used at even higher alcohol concentration in direct comparison with Example III. 170 mg of Fe (N03) 3 9H20 (0. 416mmol), 66mg 2,2′-bipyridyl (0. 416mmol), 85mg TEMPO (0. 536mmol) and 80mg N-bromosuccinimide (0. 45mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The dissolution and thermostating of the catalyst solution is done as in Example III. When the temperature reached 45C, 9840 mg of3, 3-dimethyl-l-butanol (91. 9mmol) are injected through the septum adapter using a gas tight syringe. The recorded oxygen uptake rate was 0. 184mmol 02/min and the GC analysis after 420min reaction time showed 89.2% conversion of the starting alcohol and 97.4% selectivity to the desired 3, 3-dimethyl-1- butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 4, NS1027. EXAMPLE V Example V represents addition protocol in which the catalysts solution and the alcohol are charged in the reactor prior purging the reactor with oxygen and raising the temperature. 170 mg ofFe (N03) 3′ 9H20 (0. 416mmol), 66mg 2, 2′-bipyridyl (0. (d416mmol), 85mg TEMPO (0. 536mmol), 80mg N-bromosuccinimide (0. 45mmol) and 8200 mg of 3, 3-Dimethyl-l-butanol (76. 6mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The dissolution and therniostating of the catalyst solution is done as in Example III. When the temperature reached 45C the stirring rate was set to 1500RPM and at this point, monitoring of the oxygen uptake was initiated. The recorded oxygen uptake rate was 0. 220rrunol 02/min and the GC analysis after 230min reaction time showed 96.3% conversion of the starting alcohol and 98.5% selectivity to the desired 3, 3-dimethyl-1-butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 5, NS1019.

The synthetic route of 624-95-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE NUTRASWEET COMPANY; WO2005/82825; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61367-62-2, name is 4-Bromo-3,5-dimethoxybenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO3

To a round bottom flask was added (4-bromo-3,5-dimethoxyphenyl)methanol (compound 10, 0.5 g, 2.02 mmol) and NN-dimethylformamide (10 mL). The solution was cooled to 0 °C and sodium hydride (0.100 g of 60percent (w/w) in mineral oil, 2.61 mmol) was added and the reaction was stirred for 1 hour at room temperature. 1-Bromohexane (0.34 mL, 2.43 mmol) was added and the reaction was stirred overnight at room temperature. The reaction was quenched with water and concentrated in vacuo. The residue was taken up in ethyl acetate and washed using water, then brine. The organic layer was dried using sodium sulfate, filtered and concentrated in vacuo. The resulting oil was purified on silica gel using ethyl acetate and hexanes as eluent. Product 2-Bromo-5-((hexyloxy)methyl)-l,3- dimethoxybenzene (16, 0.378 g, 56percent yield) was isolated as a clear oil. LC-MS: tR=2.98 min; m/z+23=353.0, 355.0. 1H NMR (400 MHz, DMSO-d6) delta ppm 6.68 (s, 2 H) 4.43 (s, 2 H) 3.82 (s, 6 H) 3.42 (t, J=6.48 Hz, 2 H) 1.45 – 1.63 (m, 2 H) 1.16 – 1.40 (m, 6 H) 0.85 (t, J=1.00 (0438) Hz, 3 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol.

Reference:
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; RUMINSKI, Peter, G.; MEYERS, Marvin, L.; HEIER, Richard, F.; RETTIG, Michael, P.; DIPERSIO, John; (139 pag.)WO2018/85552; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1777-82-8, (2,4-Dichlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dichlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dichlorophenyl)methanol

General procedure: Alcohol (1 mmol) was added to a mixture of MCM-41XANi(II) (0.03 g) and acetic anhydride (0.4 mL), and theresulting mixture was stirred at 50 C in solvent-free condition.After completion of the reaction (mentioned by TLC,ethylacetate: n-hexane, 3:7), dichloromethane (20 mL) wasadded and the catalyst was separated by filtration. Then, themixture was diluted with CH2Cl2.The organic phase washedwith 10% aqueous solution of sodium bicarbonate and driedover Na2SO4.Finally, the organic solvents were evaporatedand the product obtained with high to excellent yield.

The synthetic route of 1777-82-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nazarzadeh, Somayeh; Ghorbani-Choghamarani, Arash; Tahanpesar, Elham; Journal of the Iranian Chemical Society; vol. 15; 3; (2018); p. 649 – 659;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid (83) DEAD (2.1 ml, 13.65 mmol) is slowly added to a solution of 4-hydroxy-1 H-indole-2-carboxylic acid ethyl ester 79 (2 g, 9.75 mmol), triphenylphosphine (3.58 g, 13.65 mmol) and cyclobutyl-methanol (1.25 ml, 12.26 mmol) in 20 ml of THF, so that the temperature always remained below 30 OC. Stirring is continued for 2 hours and the solvent is then evaporated. The crude residue is purified by chromatography (cyclohexane : EtOAc/95: 5). Yield : 1. 86 g (70%). MS (ESI) : 274.2 [M+H] +, 1 H-NMR (CDC13) : 5 (ppm) 8.83 (s, 1 H), 7.35 (s, 1H), 7.21 (t, 1H), 6.98 (d, 1H), 6.49 (d, 1H), 4.4 (q, 2H), 4.07 (d, 2H), 2.85 (m, 1H), 2.17 (m, 2H), 1.95 (m, 4H), 1.42 (t, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2005/77932; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 599-67-7, 1,1-Diphenylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 599-67-7, blongs to alcohols-buliding-blocks compound. Computed Properties of C14H14O

General procedure: A solvent (5 mL) was placed in a 10 mL round bottom-flask equipped with a magnetic stirrerunder reflux, NXS (1.1 mmol) was then added and, after being dissolved, the substrate (1 mmol) wasadded and the solution was stirred for 4-24 h. The progress of the reaction mixture was monitoredby TLC, whilst the consumption of NXS was tested by KI (0.1 M). Upon completion of the reaction,the crude reaction mixture was cooled down at room temperature, diluted with EtOAc (15 mL),washed with aqueous Na2S2O3 (6 mL), NaHCO3 (6 mL), and water (10 mL), and dried over anhydrousNa2SO4. The solvent was evaporated under reduced pressure and the crude product obtained wasanalyzed by 1H-NMR. The pure final products were obtained after flash chromatography, columnchromatography or preparative thin layer chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,599-67-7, its application will become more common.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Molecules; vol. 21; 10; (2016);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 627-27-0, Adding some certain compound to certain chemical reactions, such as: 627-27-0, name is But-3-en-1-ol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-27-0.

PPh3 (95.5 g), phthalimide (56.1 g) and 3 -Buten-l-ol (25.0 g) were suspended in dry THF (250 mL) and cooled to 0 C. Diisopropyl azodicarboxylate (75.1 mL) was then added dropwise over a period of 20 min. The resulting mixture was stirred at 0 C for 30min and then at r.t. over night. Control by LC/MS showed product. THF was removed in vacuo as far as possible. The oily residue was diluted with PE/EtOAc = 9:1 (400 mL) and stirred vigourously until a precipitate occured. The precipitated OPPh3 was filtered off and washed extensively with PE/EtOAc = 9:1. The combined filtrates were filtered through a patch of SiO 2 and then evaporated. The residue was diluted with PE (200 mL), mixed vigourously and placed in an icebath. The precipitated product was then filtered off and washed with PE to afford the product in sufficent purity as pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-27-0, But-3-en-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OMEICOS THERAPEUTICS GMBH; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MAX DELBRUeCK-CENTRUM FUeR MOLEKULARE MEDIZIN; FISCHER, Robert; KONKEL, Anne; WESSER, Tim; WESTPHAL, Philipp; SCHUNK, Wolf-Hagen; WESTPHAL, Christina; FALCK, John Russel; (121 pag.)WO2017/13265; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

General procedure: A CH3CN solution of alcohol (1 mmol), ZnBr2 (45 mg, 0.2 mmol), and chloramine-T (282 mg, 1 mmol) was placed in a three necked flask with a reflux condenser. After the mixture was stirred under reflux for 1.5-5 h. After cooling to room temperature, the solution was quenched by adding water and the resulting mixture was extracted with AcOEt. Removal of the solvent under reduced pressure gave the crude product, which was purified by column chromatography on silica gel to give the corresponding carbonyls.

According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Peng; Cai, Jin; Yang, Jiabin; Sun, Chunlong; Li, Lushen; Hu, Huayou; Ji, Min; Tetrahedron Letters; vol. 54; 6; (2013); p. 533 – 535;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75476-86-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 75476-86-7

Example 10-A. (±)-Methyl 2-(2-((6-bromo-2,3-dihydro-1 H-inden-1 -yl)oxy)phenyl)acetate DIAD (1 .165 mL, 5.99 mmol) was added dropwise to a solution of PPh3 (1 .571 g, 5.99 mmol), 6-bromo-2,3-dihydro-1 H-inden-1 -ol (CAS 75476-86-7) (1 .1 1 g, 5.21 mmol) and methyl 2-(2-hydroxyphenyl)acetate (0.996 g, 5.99 mmol) in THF (1 5 mL) at 0 C. The reaction mixture was allowed to stir for 15 minutes at 0 C and then warmed to room temperature. The reaction mixture was stirred at room temperature overnight, partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc . The combined organics were washed with brine, dried (Na2S04) and concentrated. The residue was purified by silica gel chromatography (30% EtOAc- heptane) tor provide the title compound. MS (ESI ) m/z 359.0, 361 .0 (M-H)~.

The synthetic route of 75476-86-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BELANGER, David; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; KARKI, Rajeshri Ganesh; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; MAINOLFI, Nello; POWERS, James J.; VULPETTI, Anna; (100 pag.)WO2016/88082; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 115-20-8, Trichloroethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C2H3Cl3O, blongs to alcohols-buliding-blocks compound. Formula: C2H3Cl3O

4.2.2.14 3,17beta-dimethoxy-17alpha-[2′,2′,2′-trichloroethyl-1′-N-tosylacetimidate]estra-1,3,5(10)-triene (4w) The general procedure was followed using 3,17beta-dimethoxy-17alpha-ethynyl-estra-1,3,5(10)-triene 1f and 2,2,2-trichloroethanol 3l, affording compound 4w (76 mg, 59%) as a white solid, mp 68-70 C, [alpha]D26 = +24 (? 0.98, CHCl3).

The synthetic route of 115-20-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Volkova, Yulia A.; Kozlov, Andrey S.; Kolokolova, Marya K.; Uvarov, Denis Y.; Gorbatov, Sergey A.; Andreeva, Olga E.; Scherbakov, Alexander M.; Zavarzin, Igor V.; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 694 – 706;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts