Author: tianli

Synthetic Route of 26021-57-8, Adding some certain compound to certain chemical reactions, such as: 26021-57-8, name is 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26021-57-8.

1-(6-hydroxy-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1 -one (72). Compound 54 (1 g, 6.62 mmol) was suspended in 10 mL Dl water, to which Acetic anhydride (2.5 mL, 26.46 mmol) was added dropwise. The reaction mixture was placed in an ultrasonication bath for 1 min, then was stirred in a water bath (50 C) for 10 min. The resulting solution was stirred overnight at rt. After which, the solid was collected via vacuum filtration and washed with small portions of Dl water. The product was left in the funnel and air dried overnight to afford compound 72 (1.21 g, 95%) as a white solid, which was used for the next step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; OREGON STATE UNIVERSITY; GIBBS, Summer L.; BARTH, Connor W.; ALANI, Wathah G.; SHAH, Vidhiben; WANG, Lei; (167 pag.)WO2020/33435; (2020); A1;,
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Application of 768-95-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 768-95-6 as follows.

In a four necked round bottom flask, triphosgene (9.75 g, 32.8 mmol) was dissolved in toluene (140 mL) under argon atmosphere. After cooling to 0C, pyridine (8.5 mL, 105 mmol) was added dropwise during lh and the resulting suspension stirred for further lh at 0C. 1-Adamantanol (10.0 g, 65.7 mmol) was added portion-wise. After stirring at rt for 24h, the solid was filtered-off and the solvent removed under vacuum to yield the title compound (12.3 g, 88%) as yellowish oil, which was used in the next step without further purification. FTIR (cm-1): 2913, 2854, 1780, 1455, 1354, 1152, 1038, 957, 835, 802.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,768-95-6, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; IIT – ISTITUTO ITALIANO DI TECNOLOGIA; UNIVERSITY DEGLI STUDI DI URBINO; UNIVERSITA DEGLI STUDI DI PARMA; PIOMELLI, Daniele; BANDIERA, Tiziano; MOR, Marco; TARZIA, Giorgio; BERTOZZI, Fabio; PONZANO, Stefano; WO2013/78430; (2013); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(Diethylamino)ethanol

diethylaminoethanol 11.7 g (0.1 mol) was dissolved in 10% sodium bicarbonate (200ml) and acetone (100ml). 2-(6-methoxy-2-naphthyl)propionyl chloride 24.9g (0.1mol) was added to the reaction mixture. The mixture is stirred for 3 hours at room temperature. The solvent is evaporated. The residue is suspended in ethyl acetate (500ml). 5% sodium bicarbonate (200ml) is added to the reaction mixture while stirring. The ethyl acetate layer was collected, washed with water (3 × 500ml). The resulting ethyl acetate solution was dried over anhydrous sodium sulfate. the sodium sulfate was removed by filtration. With stirring, acetic acid 6g was added to the reaction mixture. The organic solution was evaporated. After drying, the desired product 36g (89.9%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Techfields Biochem Company Limited; Yu, Chauncy; Shu, Rina; (52 pag.)JP2016/130241; (2016); A;,
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Application of 1124-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1124-63-6, name is 3-Cyclohexylpropan-1-ol, molecular formula is C9H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10 g of Fmoc-TentaGel-S-RAM resin (0.25 mmol/g, 2.5 mmol) was treated with 25% PIP in DMF for 30 min. The resin was washed with DMF (2x) , MeOH (2x) and DMF (2x) and subsequently acylated with Fmoc-gamma-Abu-OH/DIC/HOBt (3 eq) in DMF. The completeness of the reaction was assessed with Kaiser’s ninhydrine test. The Fmoc group was removed followed by resin washing as described above . The o-NBS group was introduced by treatment with o-NBS-Cl (4 eq) /collidine (6 eq) in DCM for 1 h at rt . The resin was then suspended in dry DME (15 ml) and 3- cyclohexyl-1-propanol (3.8 ml, 25 mmol, 10 eq) was added. The TPP/DIAD complex was preformed at 00C by dissolving TPP (6.55 g, 25 mmol, 10 eq) in dry DME (30 ml) and adding DIAD (4.92 ml, 25 mmol, 10 eq) . The complex was then added to the suspension and the reaction was carried out overnight. An aliquot of the resin was cleaved and analysed by HPLC (column: Vydac C18, 5mu, 250 x 4.6 mm; solvents: A-O.1% TFA (aq) , B-80% CH3CN/0.1% TFA (aq) ; a linear gradient of B was used) . The content of the non-alkylated substrate was below 2%. The o-NBS group was subsequently removed by treatment with 1 M 2-mercaptoethanol/DBU in DMF (25 ml) for 1 h (2x) . The resin was then treated with PhNCO (10.9 ml, 25 mmol, 10 eq) in DMF for 4 h. The completeness of the reaction was confirmed by a negative chloranil test. The compound was cleaved from the resin by treatment with TFA/TIS/H2O 96/2/2 (100 ml) for 1.5 h at rt . The resin was filtered off and the solvents were evaporated. The crude product was purified by preparative HPLC. The fractions containing the pure compound were combined and lyophilised. The obtained product was treated with isopropyl ether, whereby crystalline compound was provided. Yield: 442.8 mg (51%, 1.28 mmol); Mp. 104- 1060C; MS (ion spray): [M + H]+ expected 346.2, observed 346.2; 1H NMR (500 MHz, CDCl3) data was consistent with the structure of compound 17.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; FERRING B.V.; WO2006/116399; (2006); A2;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, molecular weight is 184.23, as common compound, the synthetic route is as follows.Application In Synthesis of [1,1′-Biphenyl]-4-ylmethanol

General procedure: To a flask that was charged with the benzyl alcohol (10 mmol), triethylamine (20 mmol) in THF (25 mL) cooled at 0 C, was added mesyl chloride (20 mmol) in THF (50 mL) over half an hour. Then the mixture was allowed to stir at room temperature for about 20-30 min. Cold water was added to the mixture, then the mixture was extracted with diethyl ether (125 mLx1). Triethylamine (5 mol) was added into the crude product solution to remove the unreacted mesyl chloride. Then the solution was washed with saturated aqueous NaHCO3 (10 mL), cold water (25 mL) and brine (25 mL). The solution was dried over anhydrous Na2SO4. Removal of the solvent under reduced pressure gave the benzyl mesylate products, which are used in the coupling reaction without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Wu, Guojiao; Xu, Shuai; Deng, Yifan; Wu, Chaoqiang; Zhao, Xia; Ji, Wenzhi; Zhang, Yan; Wang, Jianbo; Tetrahedron; vol. 72; 49; (2016); p. 8022 – 8030;,
Alcohol – Wikipedia,
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Reference of 96-35-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 96-35-5, name is Methyl 2-hydroxyacetate, molecular formula is C3H6O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 69: 2-Hydroxyacetohydrazide Hydrazine monohydrate (1.08 g, 22.2 mmol) was added to a solution of methyl glycolate (0.84 mL, 11.1 mmol) in methanol (10 mL) and the mixture was heated under reflux for 2 hours and stirred at room temperature for 72 hours. The reaction mixture was then concentrated in vacuo to afford the title compound as a white solid in quantitative yield. 1H NMR(400 MHz, CDCl3) delta: 4.04(s, 2H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 96-35-5, Methyl 2-hydroxyacetate.

Reference:
Patent; Pfizer Inc; US2006/160786; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 13330-96-6, 4-(Dimethylamino)butan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13330-96-6, blongs to alcohols-buliding-blocks compound. Product Details of 13330-96-6

Example 8 Synthesis of MC4 Ether MC4 Ether (Compound 15) having the structure shown below was synthesized as described below. A 50 mL RBF with stir-bar were flushed with nitrogen, and NaH (220 mg, 9 mmol), dimethylaminobutanol (1.05 g, 9 mmol) and anh. benzene (10 mL) added. After effervescence subsided, Compound 14 (440 mg, 0.75 mmol) was added and RM refluxed overnight at 90 C. TLC indicated some product formation. The reaction was diluted to 40 mL with benzene, and quenched with ethanol (25 mL). It was then washed with water (40 mL), dried and concentrated. The crude product was purified to yield product as a pale yellow oil, 145 mg, 31%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13330-96-6, its application will become more common.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS INC; Heyes, James; Wood, Mark; Martin, Alan; Lee, Amy C.H.; Judge, Adam; Robbins, Marjorie; MacLachlan, Ian; US2013/123339; (2013); A1;,
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Electric Literature of 1113-21-9, Adding some certain compound to certain chemical reactions, such as: 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol,molecular formula is C20H34O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1113-21-9.

Menadiol monoacetate (4) (30.5 g) was dissolved in toluene (150 mL) and methanesulfonic acid (2 mL) was added. While this solution was being stirred, all-trans-geranyllinalool (5) (27.7 g) was added dropwise over 45 minutes at 49 to 51 C., the reaction was then continued for 2 hours and 55 minutes at the same temperature. The reaction solution was washed with aqueous sodium chloride solution (40 mL, 5%) twice. The organic layer was washed three times with a solution prepared by the addition of sodium hydrosulfite (2 g) to aqueous potassium hydroxide solution (40 mL, 10%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1113-21-9, 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai Co., Ltd.; US2007/60761; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 6850-39-1 ,Some common heterocyclic compound, 6850-39-1, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of I [3 4.ch1oro.8methoxy- I H,2H,3 Wcyc1openta[ciquinolin7yl }oxy)propyl}pyrroiidine (Intermediate Wi) (250 mg, 0.69 mmoi, 100 eq.), i,4-dioxane (5 ml.), and t-l3uONa (331 mg, 3.45 mmol, 500 eq.) in a microwave reaction vial was purged with N2 for 5 mm. To the solution was added propan2amine (285 mg, 483 mol, 7.00 eq.), and 3rd Generation BrettPhos pre catalyst (64 mg, 007 rnmoi, 0.10 eq.). After being purged with N2 for additional 2 miii, the resultingsolution was sealed and subjected to microwave reactor (120 C, 1.5 h). The reaction mixture was allowed to cool to rt and quenched with H20 After removal of the volatiles under reduced pressure, the residue was redissoIved in DMSO, filtered and subjected to reverse preparative HPLC Prep C18, 5 mM XBndge column, 19x 150 mm, waters gradient elution of i025% MeCN in water over a 10 mm period, where both solvents contain 0.1% trifluoroacetic acid (TF A)) to provide the titlecompound as brown oil (70 ing, 15%). LCMS (ES) [[M+1]f m/z384.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Ming; LI, Zhe; (206 pag.)WO2018/119208; (2018); A1;,
Alcohol – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5333-42-6, name is 2-octyldodecan-1-ol, the common compound, a new synthetic route is introduced below. Computed Properties of C20H42O

Example 7 Preparation of 2-octyldodecyl heptanoate To a 3-neck 1000 ml round-bottomed flask was added 2-octyl-1-dodecanol (250.0 g, 837.37 mmol, 1.0 equiv.), n-heptanoic acid (141.72 g, 1088.6 mmol, 1.30 equiv.), toluene (250 ml) and p-toluenesulfonic acid monohydrate (1.5929 g, 8.374 mmol, 0.010 equiv.) at room temperature. The resulting mixture was heated at reflux with stirring in an oil bath at 134 C. under a nitrogen atmosphere for 18 hours. The water produced in the reaction was collected in a Dean-Stark trap. The cooled mixture was diluted with hexanes, washed with dilute aqueous 10% Na2CO3 solution, water, brine, dried (MgSO4), filtered, and concentrated in vacuo to afford a crude product. Excess solvent was further removed by heating the crude product with stirring in an oil bath under high vacuum for 3 hours to afford a light yellow liquid (326.7 g, 95%).

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ExxonMobil Research and Engineering Company; Ng, Man Kit; Oumar-Mahamat, Halou; Cheng, Hong; Blain, David A.; Cooper, Kathleen K.; Carey, James T.; Douglass, Michael R.; Kanga, Percy R.; Patil, Abhimanyu O.; Bodige, Satish; Lewis, Kyle G.; Hagemeister, Mark P.; (40 pag.)US2017/183595; (2017); A1;,
Alcohol – Wikipedia,
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