Author: tianli

Electric Literature of 5182-44-5 ,Some common heterocyclic compound, 5182-44-5, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Dissolved e1 – e3 (1.0 equiv) completely in dry DMF, then added NaH (2.2 equiv) to the reaction slowly at 0 C and the resulting mixture was stirred for 20 minutes, and then corresponding R2(CH2)nOH or g1 – g5 (1.2 equiv) was added and the reaction mixture was stirred for 1 h at room temperature. Then it was quenched by H2O, washed with brine and extracted with ethyl acetate. The combined organic layers were dried over anhydrous Na2SO4 and concentrated under vacuum. The residue was purified by chromatography on a silica gel chromatography (petroleum ether/ ethyl acetate = 8:1 to 4:1) to give corresponding products h1 – h22 (yield 75% – 89%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5182-44-5, 2-(3-Chlorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cheng, Kai; Li, Shiyu; Lv, Xiao; Tian, Yongbin; Kong, Haiyan; Huang, Xufeng; Duan, Yajun; Han, Jihong; Xie, Zhouling; Liao, Chenzhong; Bioorganic and Medicinal Chemistry Letters; vol. 29; 8; (2019); p. 1012 – 1018;,
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Application of 6338-55-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6338-55-2 as follows.

To a 1 L three-necked flask, 23.5 g of a compound BP103a03 (1.0 eq), 68.6 g (Boc)2O (2.0 eq), and a mixture of methanol and triethylamine (9:1) (500 ml) were added, and the mixture was stirred and refluxed for 1 h. After completion of the reaction was monitored by TLC, methanol was evaporated triethylamine, dissolved in water and extracted three times with dichloromethane, and the combined organic layers were washed with water once, dried over anhydrous sodium sulfate, the solvent was distilled off, and dried to give a solid BP103a04 of 34.8g

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.

Reference:
Patent; Borui Bio-pharmaceutical (Suzhou) Co., Ltd.; Yuan Jiandong; Huang Yangqing; Song Yunsong; (20 pag.)CN109771658; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7541-49-3, blongs to alcohols-buliding-blocks compound. COA of Formula: C20H40O

Product obtained by hydrogenating phytol. [1234] To a solution of phytol (30.00 g, 101.20 mmol) in THF (450 mL) in argon is added platinum dioxide (PtO2, 1.15 g, 6.61 mmol). The medium is placed under 1 bar of dihydrogen then stirred for 4 h at ambient temperature. After filtering on celite by rinsing with THF, a black oil of molecule 47 is obtained after concentration at reduced pressure. [1235] Yield: 29.00 g (96%) [1236] 1H NMR (CDCl3, ppm): 0.84 (6H); 0.86 (6H); 0.89 (3H); 1.00-1.46 (22H); 1.46-1.68 (3H); 3.61-3.73 (2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7541-49-3, its application will become more common.

Reference:
Patent; ADOCIA; CHAN, You-Ping; GEISSLER, Alexandre; NOEL, Romain; ROGER, Walter; CHARVET, Richard; LAURENT, Nicolas; (75 pag.)US2019/275156; (2019); A1;,
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Electric Literature of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

EXAMPLE 84-(4-Fluorobenzyloxy)- 1-[4-(3 -hydroxy-3 -methylbutoxy)-3 -methoxyphenyl]pyridin-2-( lH)-oneTo a solution of 4-[(4-fluorobenzyloxy)-l-(4-hydroxy-3-methoxyphenyl) pyridin-2(lH)- one (25 mg, 0.073 mmol), 3-methylbutane-l, 3-diol (11 mg, 0.11 mmol) and triphenylphosphine (19 mg, 0.073 mmol) in anhydrous THF (0.5 mL) under N2 atmosphere at 0C, diisopropyl azodicarboxylate (14 mg, 0.080 mmol) was added. After stirring at rt overnight, the volatiles were removed under reduced pressure, and the residue was purified with preparative HPLC eluting with water /acetonitrile (containing 0.1%TFA, 37 % to 67 %) to afford the title compound. 1HNMR (400MHz, CDC13, delta ppm): 7.39-7.53 (3H, m), 7.12 (2H, t, J= 8.8Hz), 7.04-7.09 (IH, m), 6.88-6.97 (IH, m), 6.78-6.86 (IH, m), 6.20-6.28 (IH, m), 6.05-6.09 (IH, m), 5.12 (2H, s), 4.12- 4.21 (2H, m), 3.84 (3H, s), 1.99 (2H, t, J= 6.8 Hz), 1.26 (6H, s). LCMS: m/e 428 [M+H]+.

According to the analysis of related databases, 2568-33-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIN, Linus; SOLL, Richard; DONG, Jingchao; WU, Hao; SUZUKI, Takao; HU, Bin; LIU, Dejun; HAO, Jinglai; XU, Ming; WO2011/127643; (2011); A1;,
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Synthetic Route of 627-27-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

To a suspension of 8.0 g NaH (333.32 mmol, 60 % w/vdispersion in mineral oil, 4.0 eq) in 100 cm3, anhydrousTHF was added drop wise to a solution of 6.0 g 3-buten-1-ol 8 (83.33 mmol, 1.0 eq) at 0 C. To this mixture, 0.150 gTBAI and 11.9 cm3 benzyl bromide (99.99 mmol, 1.2 eq)were added, and stirring was continued for 2 h at the sametemperature and overnight at 25 C. The reaction mixturewas quenched by small crushed ice flakes until a clearsolution (biphasic) had formed. The reaction mixture wasextracted with ether and the extract was washed with water(1 9 100 cm3), brine (1 9 100 cm3) and dried over anhydrousNa2SO4. Evaporation of the solvents followed bycolumn chromatography (silica gel, 60-120 mesh, 5 %EtOAc in pet. ether) afforded the pure product 9 (12.2 g,91 % yield) as a colorless liquid.

Statistics shows that 627-27-0 is playing an increasingly important role. we look forward to future research findings about But-3-en-1-ol.

Reference:
Article; Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Hatti, Islavathu; Venkata Basaveswara Rao, Mandava; Raju, Rudraraju Ramesh; Monatshefte fur Chemie; vol. 146; 11; (2015); p. 1921 – 1926;,
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Reference of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate P1082-phenyl-4,6-dihydro-2H-furo [3 ,4-c]pyrazol-31006951 Step A: Preparation of 4-oxotetrahydrofuran-3-carbonitrile: To a suspension of KOtBu (996.6 mg, 8.88 1 mmol) in THF (640.4 mg, 8.88 1 mmol) cooled to 0 C was added dropwise methyl 2-hydroxyacetate (675.7 jiL, 8.881 mmol) and stirred for 10 minutes. The acrylonitrile (589.1 jiL, 8.881 mmol) was then added and the reaction stirred at ambient temperature. After 3 hours, the reaction was diluted with 1120 (50 mL), then extracted with Et20 (25 mL) to remove any starting ester. The basic aqueous phase was acidified with 2M HC1 (5 mL), then extracted with Et20 (2 x 50 mL). The combined organic phases were dried with MgSO4, filtered, and concentrated to afford a light brown oil (446 mg, 45.2% yield). ?H NMR (CDC13) 4.63 (t, 111), 4.24 (t, 111), 4.14 (d, 1H), 4.02 (d, 1H), 3.57 (t, 111).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96-35-5, Methyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; BLAKE, James F.; BRANDHUBER, Barbara J.; HAAS, Julia; NEWHOUSE, Brad; THOMAS, Allen A.; WINSKI, Shannon L.; WO2014/78331; (2014); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate, the common compound, a new synthetic route is introduced below. Application In Synthesis of Ethyl 2-(hydroxymethyl)acrylate

To a stirred solution of 2-hydroxymethyl-acrylic acid ethyl ester (260 mg, 2 mmol) and imidazole (163 mg, 2.4 mmol) in dry DMF (5 ml) was added tert- butyldimethylsilyl chloride (362 mg, 2.4 mmol). The reaction mixture was stirred overnight and diluted with ether, washed with water three times and dried over MgSO4. Solvent was removed under reduced pressure to provide a crude product that was purified by column chromatography using a solution of ethyl acetate in hexanes (1:6) to obtain the title product (463 mg, 95%).

The synthetic route of 10029-04-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2007/70398; (2007); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 63478-76-2, name is 6-Heptyn-1-ol. A new synthetic method of this compound is introduced below., Quality Control of 6-Heptyn-1-ol

Following a reported procedure,9 hept-6-yn-1-ol (50) (5.00 g, 44.6 mmol, 1.00 equiv.) was dissolved intetrahydrofuran (150 mL) and the solution was cooled down at – 78 C. A cooled 2.5 M solution of nbutyllithiumin hexanes (nBuLi, 39.2 mL, 98.0 mmol, 2.20 equiv.) was added dropwise, followed by 4-(dimethylamino)pyridine (DMAP, 1.36 g, 11.1 mmol, 0.25 equiv.). After stirring for 1 hour at thistemperature, trimethylsilyl chloride (TMS-Cl, 20.4 mL, 156 mmol, 3.50 equiv.) was added dropwise. Themixture was then allowed to warm to room temperature. After 2 hours of stirring, the reaction wasquenched with a 1.0 N aqueous hydrochloric acid (50 mL) and vigorously stirred at room temperatureover 30 minutes. The mixture was then diluted with ethyl acetate (200 mL) and the layers wereseparated. The aqueous phase was extracted with additional portions of ethyl acetate (3 x 50 mL). Thecombined organic layers were collected, washed with a solution of saturated aqueous sodiumbicarbonate (100 mL), brine (50 mL), dried over magnesium sulfate, filtered and concentrated in vacuo.After purification by column chromatography (SiO2, Pentane:Ethyl acetate 4:1), 7-(trimethylsilyl)hept-6-yn-1-ol (51) (6.58 g, 35.7 mmol, 80% yield) was obtained as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 63478-76-2, 6-Heptyn-1-ol.

Reference:
Article; Tessier, Romain; Ceballos, Javier; Guidotti, Nora; Simonet-Davin, Raphael; Fierz, Beat; Waser, Jerome; Chem; vol. 5; 8; (2019); p. 2243 – 2263;,
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Reference of 124-68-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 124-68-5 as follows.

1) N-Benzyl-2-amino-2-methyl-1-propanol A solution of 2-amino-2-methyl-1-propanol (10.0 g), benzaldehyde (11.98 mL) and p-toluenesulfonic acid (10 mg) in benzene (300mL) was heated to reflux for 4 hours using a Dean-Stark dehydrating apparatus. After air cooling, the reaction solvent was evaporated under reduced pressure, and a residue thus obtained was dissolved in methanol (200 mL). Under ice cooling, sodium cyanoborohydride (8. 89 g) was added to the solution, and the mixture was stirred for 1. 5 hours. The reaction solvent was evaporated under reduced pressure, then a saturated aqueous solution of sodium hydrogen carbonate and ethyl acetate were added to the residue thus obtained, and the resultant mixture was partitioned. The organic layer was washed with saturated brine, and then was dried over anhydrous magnesium sulfate. After separating the organic layer by filtration, the solvent was evaporated under reduced pressure, and a residue thus obtained was purified by silica gel column chromatography (dichloromethane-methanol-aqueous ammonia), to obtain N-benzyl-2-amino-2-methyl-1-propanol (10. 36 g, 52%) as a solid. 1H-NMR (400MHz, CDCl3) delta: 1.15 (6H, s), 1.86 (2H, br s), 3.35 (2H, s), 3.68 (2H, s), 7.30 (5H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1803719; (2007); A1;,
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Reference of 2807-30-9, Adding some certain compound to certain chemical reactions, such as: 2807-30-9, name is 2-Propoxyethanol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2807-30-9.

Diisopropyl azodicarboxylate (14.2mL, 70MMOL) was added to an ice-cooled solution OF 4-NITRO-1 H-PYRAZOLE-3, 5-DICARBOXYLIC acid dimethyl ester (EP 1241170, prep 10) (15g, 60MMOL), 2-propoxyethanol (8.2mL, 70MMOL) and TRIPHENYLPHOSPHINE (18. 9g, 70MMOL) in tetrahydrofuran (150ML), and the reaction stirred at 0C for 2.5 hours, then allowed to stir at room temperature for a further 18 hours. The reaction was concentrated in vacuo and the residue purified by column chromatography on silica gel using ethyl acetate: pentane as eluant, and then re-columned using DICHLOROMETHANE as eluant to afford the title compound as a solid, 14g. 1H NMR (CD30D, 400MHZ) 5 : 0.82 (t, 3H), 1.47 (m, 2H), 3.34 (t, 2H), 3.78 (t, 2H), 3.91 (s, 6H), 4.76 (t, 2H). LRMS: m/z APCI+ 316 [MH] +

According to the analysis of related databases, 2807-30-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/96810; (2004); A1;,
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