Author: tianli

Synthetic Route of 140373-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4,6-dichloropyrimidine (240 mg, 1.61 mmol) and 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol (250.00 mg, 1.61 mmol) in isopropanol (3 mL) was added DIPEA (0.84 mL, 4.83 mmol). The solution was stirred for 5 h at 50 C. H2O (50 mL) was added to the cooled solution and extracted with 10% IPA/DCM (3×50 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated in vacuo to afford 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol compound 18 (365 mg, 85%) as thick yellow liquid. MS (ESI): Calcd. for C12H11ClFN3O: 267, found 268 (MH+).

According to the analysis of related databases, 140373-17-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346450; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-70-8, name is 2-Amino-2-ethylpropane-1,3-diol. A new synthetic method of this compound is introduced below., COA of Formula: C5H13NO2

(19-1) Synthesis of [1,1-bis(hydroxymethyl)propyl]carbamic acid t-butyl ester (compound 19-1) To a solution of 2-amino-2-ethyl-1,3-propanediol (22.0 g) in methanol (500 ml) and N,N-diisopropylethylamine (64.3 ml) was added di-t-butyl dicarbonate (60.5 g) under ice-cooling, and the mixture was stirred for 40 min under ice-cooling and further at room temperature for 16 hr. 1M aqueous sodium hydroxide solution (184 ml) was added to the reaction mixture under ice-cooling and the mixture was stirred for 40 min. Methanol was removed under reduced pressure. Water was added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (41.0 g) as a colorless oil. 1H-NMR(CDCl3)delta(ppm): 0.90(3H, t, J=7.5Hz), 1.45(9H, s), 1.59(2H, q, J=7.5Hz), 3.45(2H, brs), 3.60(2H, dd, J=6.9, 11.6Hz), 3.84(2H, dd, J=4.8, 11.6Hz), 4.89(1H, brs).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-70-8, 2-Amino-2-ethylpropane-1,3-diol.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1961734; (2008); A1;,
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Application of 506-43-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 506-43-4, name is (9Z,12Z)-Octadeca-9,12-dien-1-ol, molecular formula is C18H34O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of methanesulfonic acid octadeca-9,12-dienyl ester 2To a solution of the alcohol 1 (26.6 g, 100 mmol) in dichloromethane (100 mL), triethylamine (13.13 g, 130 mmol) was added and this solution was cooled in an ice-bath. To this cold solution, a solution of mesyl chloride (12.6 g, 110 mmol) in dichloromethane (60 mL) was added dropwise and after the completion of the addition, the reaction mixture was allowed to warm to ambient temperature and stirred overnight. The TLC of the reaction mixture showed the completion of the reaction. The reaction mixture was diluted with dichloromethane (200 mL), washed with water (200 mL), satd. NaHCO3 (200 mL), brine (100 mL) and dried (NaSO4). The organic layer was concentrated to get the crude product which was purified by column chromatography (silica gel) using 0-10% Et2O in hexanes. The pure product fractions were combined and concentrated to obtain the pure product 2 as colorless oil (30.6 g, 89%). 1H NMR (CDCl3, 400 MHz) delta=5.42-5.21 (m, 4H), 4.20 (t, 2H), 3.06 (s, 3H), 2.79 (t, 2H), 2.19-2.00 (m, 4H), 1.90-1.70 (m, 2H), 1.06-1.18 (m, 18H), 0.88 (t, 3H). 13C NMR (CDCl3) delta=130.76, 130.54, 128.6, 128.4, 70.67, 37.9, 32.05, 30.12, 29.87, 29.85, 29.68, 29.65, 29.53, 27.72, 27.71, 26.15, 25.94, 23.09, 14.60. MS. Molecular weight calculated for C19H36O3S, Cal. 344.53. Found 343.52 (M-H-).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 506-43-4, (9Z,12Z)-Octadeca-9,12-dien-1-ol.

Reference:
Patent; Tekmira Pharmaceuticals Corporation; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil G.; Eltepu, Laxman; Ansell, Steven; Chen, Jianxin; US9186325; (2015); B2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 756520-66-8

A slurry of l-(2,6-dichloro-3-fluorophenyl)ethanol (4.6 g, 22 mmol) and P2O5 (17.5 g, 0.12 mol) in DCM (200 mL) was stirred at rt for 16 hours. The solid was filtered off through a pad of CELITE, and washed with DCM (200 mL) for several times. The filtrate was washed with saturated Na2C03 aqueous solution (100 mL x 2). The separated organic layer was dried over anhydrous Na2S04, and concentrated in vacuo. The white solid precipitated during concentration was discarded. The remained oil was dried in vacuo, and used directly in the next step without further purification (3.5 g, 83%). MS (ESI, pos. ion) m/z: 191.0 (M+l); 1H NMR (400 MHz, DMSO- e): delta 7.60-7.50 (m, 1H), 7.45-7.35 (m, 1H), 6.75-6.63 (m, 1H), 5.90-5.75 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Xiaobo; WO2014/193647; (2014); A2;,
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Electric Literature of 186020-66-6 , The common heterocyclic compound, 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, molecular formula is C13H26O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Tosyl chloride (22.3 g, 117 mmol) was added in portions to a stirring solution of 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester (16.3 g, 58.6 mmol) and pyridine 60 mL in (240 mL) and the mixture was stirred overnight. The reaction was quenched with water (300 mL) and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (2*100 mL). The combined organic layer was washed with HCl (1N, 100 mL), water (100 mL), and dried over Na2SO4 and the solvent was removed in vacuo to give an oil which corresponds to the title compound that would be used as is for the next step. (M+1)=433.

The synthetic route of 186020-66-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bradshaw, Curt; Bhat, Abhijit; Lai, Jing Yu; Doppalapudi, Venkata; US2008/166364; (2008); A1;,
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Related Products of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

Procedure 1, Step A. To a solution of 2-(4-aminophenyl)-l, l,l,3,3,3-hexafluoropropan-2- ol (4) (15 g, 1.0 equiv) in DMF (120 mL) was added a solution of NaN02(4.4 g, 1.1 equiv) in 30 mL water. The mixture was cooled to 0C for 15 min. 6 N HC1 (29 mL, 3.0 equiv) was added dropwise to the reaction mixture for over 15 min at 0C. The resulting mixture was stirred at 0C for lh. KI (10.1 g, 1.05 equiv) was added with portions (over 15 mins). The reaction mixture was stirred at 0C for lh, and then at room temperature overnight. The reaction was diluted with water (-500 mL) and extracted with EtOAc/hexane (2: 1, 3 x 150 mL). The combined organic phase was washed with NaHS03, water, and brine. The crude mixture was purified on a silica gel column to afford l, l,l,3,3,3-hexafluoro-2-(4-iodophenyl)propan-2-ol (Intermediate 1) (18.85 g, yield 88%) as a pale yellow oil.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ESCALIER BIOSCIENCES B.V.; MOHAN, Raju; NUSS, John; HARRIS, Jason; YUAN, Shendong; (144 pag.)WO2019/177996; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H8O3

Imidazole (3.39 mmol, 0.23 g) was added to the solution of (-)-methyl-L-lactate (2.16 mmol, 0.20 mL) in anhydrous CH2Cl2 (6.5 mL) at 0C. After 10 min of stirring at 0C, tert-butyldimethylsilyl chloride (2.59 mmol, 0.40 g) was added and reaction mixture was stirred at room temperature for 6 h. Then cold water (25 mL) was added and the mixture was extracted with CH2Cl2 (3×20 mL). The combined organic phases were washed with brine (20 mL), dried over Na2SO4 and concentrated to afford (S)-methyl 2-(tert-butyldimethylsilyloxy)propanoate 1a (0.46 g, 97%) as clear oil; [alpha]D23 = -27 (c 1, CHCl3); 1H NMR (CDCl3): delta = 0.07 (s, 3H), 0.10 (s, 3H), 0.90 (s, 9H), 1.40 (d, J = 6.8 Hz, 3H), 3.72 (s, 3H), 4.33 (q, J = 6.8 Hz, 1H); 13C NMR (CDCl3): delta = -5.3, -5.0, 18.3, 21.3, 25.7, 51.8, 68.4, 174.5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27871-49-4, (S)-Methyl 2-hydroxypropanoate.

Reference:
Article; Sivak, Ivan; Vaclav, Jakub; Berke?, Du?an; Kolarovi?, Andrej; Tetrahedron; vol. 71; 47; (2015); p. 8871 – 8875;,
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Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To THF (2 mL) in microwave reaction vessel were added ethanol (0.059 mL, 1.0 mmol) and sodium hydride (32 mg, 1.3 mmol). After stirring for 30 min at room temperature, 2,6-dichloropyrazine (100 mg, 0.671 mmol) was added to the reaction mixture. The reaction mixture was heated in the microwave reactor at power 100 W and 50 C for 10 min. After solvents were removed under reduced pressure, the residue was dissolved in ethyl acetate. Organic layer was washed with water and dried over MgSO4.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; More, Kunal N.; Jang, Hyo Weon; Hong, Victor S.; Lee, Jinho; Bioorganic and Medicinal Chemistry Letters; vol. 24; 11; (2014); p. 2424 – 2428;,
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Application of 929-06-6 ,Some common heterocyclic compound, 929-06-6, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Di-tert-butyl dicarbonate (4.973 g, 22.8 mmol) in CHC13 (100 mL) was added dropwise to a solution of 2-(2-aminoethoxy)ethanol (2.4 mL, 22.8 mmol) in CHCI3 (100 mL) and stirred o/n. Water was added and the layers separated. The aqueous layer was extracted once with CH2CI2. The combined organics were dried (MgS04), filtered, and concentrated to provide the title compound. 1H NMR (CDCI3) delta 4.95 (br s, 1 H), 3.78-3.70 (m, 2H), 3.60-3.52 (m, 4H), 3.38-3.28 (m, 2H), 2.22 (br s, 1H), 1.45 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,929-06-6, its application will become more common.

Reference:
Patent; MYREXIS, INC.; HOLCOMB, Ryan; SUZUKI, Kazuyuki; HALTER, Robert J.; SEBAHAR, Paul R.; MCLEOD, Donald A.; SHENDEROVICH, Mark D.; YAGER, Kraig M.; BURSAVICH, Matthew Gregory; YUNGAI, Ashantai J.; RICHARDS, Burt; BARTEL, Paul L.; WETTSTEIN, Daniel A.; WO2011/46970; (2011); A1;,
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Related Products of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a 50 mL Schlenk tube equipped with a stir bar was added 0.5 mmol of benzylic alcohol followed by 0.05 mmol of CuF2 (0.1 equiv). The mixture of DMSO (1.5 mL) and H2O (1.5 mL) was added, followed by 6 mmol of TBHP(12 equiv). The glass tube was vacuumed and purged with argon three times before it was tightly screw-capped. The reaction mixture was stirred at 120 Cfor 12 h, cooled to room temperature, poured into brine and extracted with EtOAc. The combined extracts were dried over MgSO4, filtered, and evaporated. The residue was purified by column chromatography (petroleumether/EtOAc) to afford the methyl ester

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1805-32-9, 3,4-Dichlorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Pan; Zhao, Jingjing; Lang, Rui; Xia, Chungu; Li, Fuwei; Tetrahedron Letters; vol. 55; 2; (2014); p. 390 – 393;,
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