Author: tianli

Application of 671802-00-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.671802-00-9, name is tert-Butyl 3-(2-hydroxyethoxy)propanoate, molecular formula is C9H18O4, molecular weight is 190.24, as common compound, the synthetic route is as follows.

To a solution of Compound (g-2) (0.20 g, 1.1 mmol) and triethylamine (0.31 g, 3.2 mmol) in THF (15 mL) was added p-toluenesulfonyl chloride (0.30 g, 1.6 mmol) at 0 C. over 10 minutes, and then the reaction mixture was stirred at at room temperature 16 hours. The solvent was removed in vacuo, and the residue was purified by preparative TLC (pentane:ethyl acetate=4:1) to give Compound (h-1) (0.20 g, 55% yield). (1098) 1H-NMR (CDCl3, 400 MHz) delta: 7.71 (d, J=8.2 Hz, 2H), 7.27 (d, J=8.2 Hz, 2H), 4.07-4.05 (m, 2H), 3.55-3.54 (m, 4H), 2.39-2.33 (m, 5H), 1.36 (s, 9H).

Statistics shows that 671802-00-9 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 3-(2-hydroxyethoxy)propanoate.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; WATANABE, Hitoshi; ISOBE, Yoshiaki; KIMURA, Hidenori; FUJIWARA, Yuji; US2019/16711; (2019); A1;,
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Synthetic Route of 16700-55-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16700-55-3, name is (2,6-Dimethoxyphenyl)methanol, molecular formula is C9H12O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

iv) Production of 1-(4-chloro-6-methyl-2-pyridinyl)ethanone O-[(2,6-dimethoxyphenyl)methyl] oxime 1.86 g (11.1 mmol) of 2,6-dimethoxybenzyl alcohol was dissolved in 15 ml of benzene, and the resultant solution was cooled to 5 C. The solution was then added with 1.55 g (13.0mmol) of thionyl chloride at the same temperature. The mixture was subjected to temperature elevation up to a room temperature, then stirred for 70 min. to complete a reaction. The reacted solution was condensed under reduced pressure to thereby obtain a crude product of 2,6-dimethoxybenzyl chloride.

According to the analysis of related databases, 16700-55-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nippon Soda Co. Ltd.; US6589967; (2003); B1;,
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Reference of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Compound 6 (100g, 0.41mol, 1eq), compound 8 (87g, 0.8eq) and Al2O3 (415g, 10eq) was put inside the reactor (connected with Dean-Stock device) containing toluene (3L). The reaction mixture was deoxygenized with the stream of nitrogen gas followed by refluxing the reaction mixture. On completion, the reaction mixture was cooled to room temperature, washed with NaOH solution and removed the toluene on rotary. After that solid product was mixed with ethyl acetate: water and organic layer was separated, removed excess solvent on rotary to afford 9 which was purified by column chromatography using hexane: ethyl acetate: toluene (5:1:1) solvent system. Fine yellow crystals of 9 were collected on mixing it with ethyl acetate [32-38]. 1H NMR (CDCl3, ppm): delta 3.09 (s, 6H), 3.76 (s, 6H), 3.9 (s, 3H), 6.09 (d, 1H), 6.79 (d, 4H), 7.05 (dd, 1H), 7.25 (d, 1H), 7.35 (d, 4H), 7.60 (dd, 2H), 7.95 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 101597-25-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kim, Moon-Hwan; Saleem, Muhammad; Seo, Ji-Su; Choi, Chang-Shik; Lee, Ki Hwan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 136; PC; (2015); p. 1291 – 1297;,
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Related Products of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

DMSO (7.88 mL, 0.11 mol) was added at -78 oC to a solution of oxalyl chloride (7.24 mL, 0.08 mol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the monobenzylated alcohol 19 (10 g, 55.55 mmol) in CH2Cl2 (50 mL), was added drop wise at -78 oC over 30 min. After the solution had been stirred for an additional 30 min, Et3N (46.37 mL, 0.33 mol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4, and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification. To a stirred solution of aldehyde (8.9 g, 50.0 mmol) in C6H6 (100 mL), was added (ethoxycarbonylmethylene)triphenylphosphorane (19.2 g, 55.0 mmol) and the mixture was heated at reflux for 4 h. After completion of the reaction, solvent was removed in vacuo then purified by column chromatography to afford 20 (11.78 g, 85% over two steps) as a light yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Article; Bujaranipalli, Sheshurao; Das, Saibal; Tetrahedron Letters; vol. 57; 25; (2016); p. 2800 – 2802;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56456-51-0, name is 2-Chloro-4-(trifluoromethyl)benzyl alcohol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Chloro-4-(trifluoromethyl)benzyl alcohol

Reference Example 130 To a solution of 2-chloro-4-(trifluoromethyl)benzyl alcohol (2.23 g) and triphenylphosphine (4.17 g) in tetrahydrofuran (25 ml) was added carbon tetrabromide (5.27 g), and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, hexane and diethyl ether were added to the residue, and the insoluble substance was removed by filtration. The filtrate was concentrated, and the obtained residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (0:1 to 1:4, v/v) to give 2-chloro-4-(trifluoromethyl)benzyl bromide (2.90 g, yield 99%) as a colorless oil. 1H-NMR (300 MHz, CDCl3) delta:4.59 (2 H, s), 7.46 – 7.60 (2 H, m), 7.65 (1 H, s).

With the rapid development of chemical substances, we look forward to future research findings about 56456-51-0.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1829863; (2007); A1;,
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Application of 629-41-4 ,Some common heterocyclic compound, 629-41-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: DHP (3.46 ml, 37.9 mmol) and a catalytic amount of PPTS were added to a solution of 1,8-octanediol (Compound 7, 5.85 g, 40.0 mmol) in CHCl3 (100 ml) in a stream of argon at room temperature, and the mixture was stirred for 16 hours. The reaction solution was stirred for 5 minutes after addition of H2O. The organic layer was separated, and the aqueous layer was extracted with EtOAc. The combined organic layer was washed with a saturated aqueous NaHCO3 solution then with a saturated aqueous NaCl solution, and was dried over Na2SO4. After evaporation of the solvent, the residue was purified by column chromatography on silica gel (Hexane:EtOAc = 3:1 to 2:1) to yield the corresponding THP ether (4.95 g, 54%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,629-41-4, its application will become more common.

Reference:
Patent; aRigen Pharmaceuticals, Inc.; SAIMOTO, Hiroyuki; KITA, Kiyoshi; YABU, Yoshisada; YAMAMOTO, Masaichi; EP2636663; (2013); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4442-79-9, name is 2-Cyclohexylethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Cyclohexylethanol

General procedure: The N-substituted phthalimides were prepared according to literature.30 A mixture of phthalimide (2.21 g, 15 mmol), triphenylphosphine (3.93 g, 15 mmol), and appropriate alcohol (15 mmol) in 20 mL of dry THF was cooled to 0 C. Diethyl azodicarboxylate (DEAD) (2.61 g, 15 mmol) in 15 mL of dry THF was slowly added dropwise (1 h). The reaction mixture was then allowed to warm to room temperature and stirred overnight. Solvent was evaporated under reduced pressure and the residue suspended in Et2O. After the precipitate was filtered, the solvent was evaporated and the residue purified by column chromatography [eluent CH2Cl2] to afford appropriate N-substituted phthalimide.

The synthetic route of 4442-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wicek, Ma?gorzata; Kottke, Tim; Ligneau, Xavier; Schunack, Walter; Seifert, Roland; Stark, Holger; Handzlik, Jadwiga; Kie?-Kononowicz, Katarzyna; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 2850 – 2858;,
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Reference of 2425-28-7 , The common heterocyclic compound, 2425-28-7, name is 2-Bromo-1-phenylethan-1-ol, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of the olefin (0.5-1.2mmol) in 10-16mL of acetonitrile-water (1:1) mixture was added NBS (1.05equiv) at rt. The reaction mixture was stirred until all the olefin was consumed, as monitored by TLC analysis. Subsequently, TetMe-IA (10mol%) and Oxone (1.0equiv) were introduced into the reaction mixture, and the stirring was continued. After completion of the oxidation as judged by TLC analysis, the reaction mixture was washed with saturated NaHCO3 solution. The organic matter was extracted 2-3 times with ethyl acetate or dichloromethane, and the combined organic extract was dried over anhyd Na2SO4. The solvent was removed in vacuo and the resultant residue was subjected to a short-pad silica gel column chromatography to isolate pure alpha-bromoketone.

The synthetic route of 2425-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chandra, Ajeet; Parida, Keshaba Nanda; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 73; 40; (2017); p. 5827 – 5832;,
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Electric Literature of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

2) 4.6 g of the product of step 1), 6 g of anhydrous potassium carbonate, 50 ml of acetone and 8.4 g of 1,3-dibromopropane were heated under reflux for 4 hours, and then cooled to room temperature and filtrated. The solvent was removed by rotation to give yellowish oil, which was passed through a column to give 5.6 g of white solid. Melting point: 72-74° C., yield: 80.1percent.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Patent; NHWA PHARMA CORPORATION; Zhang, Guisen; Chen, Yin; Xu, Xiangqing; Liu, Bifeng; Liu, Xin; Zhao, Song; Liu, Shicheng; Yu, Minquan; Zhang, Heng; Liu, Xinghua; US2014/113911; (2014); A1;,
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Reference of 30379-58-9 ,Some common heterocyclic compound, 30379-58-9, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A previously dried round bottom flask fitted with a magnetic stirrer was charged with NaH (19 mg, 0.81 mmol) and then benzyl glycolate (230 muIota, 1 .62 mmol) in anhydrous THF (3 ml) were added in dropwise. Immediately after the addition was complete, a solution of 2-methanesulfonyl-3-(4-trifluoromethoxy-benzyl)-3H-imidazo[4,5-b]pyridine (90 mg, 0.24 mmol) in anhydrous THF (3 ml) was added. Reaction was left stirring under N2 at r.t. over the weekend. The reaction was quenched with water and a white solid crashed out of solution. This solid was filtered off and dried to afford the title compound (76 mg, 69%). [00355] LCMS Method: 1 , RT: 5.51 min, Ml: 458 [M+1] [00356] 1H NMR, Method 1 : (DMSO) 8.17 (dd 1 H), 7.84 (dd 1 H), 7.43 (d 2H), 7.40 – 7.36 (m 1 H), 7.32 (s 4H), 7.27 (d 2H), 7.22 (dd 1 H), 5.34 (s 2H), 5.29 (s 2H), 5.22 (s 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30379-58-9, Benzyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; STOCKLEY, Martin Lee; MACDONALD, Ellen Catherine; PRITOM, Shah; JORDAN, Allan; HITCHIN, James; HAMILTON, Niall; (217 pag.)WO2016/124939; (2016); A1;,
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