Author: tianli

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 221285-25-2, name is (2-Amino-6-fluorophenyl)methanol. A new synthetic method of this compound is introduced below., Computed Properties of C7H8FNO

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

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Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1.Preparation of I-(6-amino-pyridin-3-yloxy)-2-methyl-propan-2-olTo a microwave flask containing 6-aminopyridin-3-ol hydrobromide (700 mg, 3.66 mmol) and 1-chloro-2-methyl-2-propanol (597 mg, 5.5 mmol) in anhydrous dimethylformamide (17 ml) was added cesium carbonate (3.7 g, 11.4 mmol) and the material was heated in a microwave oven at 140° C. for 3 hours.The vial was cooled to ambient and the solvent was concentrated in vacuo (rotary evaporator/mechanical pump).The residue was taken up in methylene chloride and filtered to remove insolubles, rinsing well with methylene chloride.The crude material was purified by HPLC on silica gel, eluting with a gradient of 2percent to 10percent methanol/methylene chloride to provide the desired product as a orange-brown viscous oil which solidified on standing (449 mg). MS (H+)=183 m/e.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael; US2012/40949; (2012); A1;,
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Synthetic Route of 769-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 6; Method AT5; Preparation of 1-Benzof1 3]dioxol-4-yl-2-bromo-ethanone; Step 1: Preparation of starting material 1-Benzor1, 3]dioxol-4-yl-ethanone; To a solution of MeMgBr in THF (1 M, 50 mL, 50 mmol, 1.5 eq) was diluted with 50 mL THF and cooled to-10 C. A solution of benzo [1,3] dioxole-4-carboxaldehyde (5.0 g, 33.3 mmol) in 50 mL THF was slowly added, and the reaction left to stir for 1 h. The reaction mixture was then quenched by pouring into 500 mL of ice cold sat. ammonium chloride and the mixture extracted with ether. The organic layers were dried over sodium sulfate and filtered through a plug of silica gel before concentrating in vacuo, providing 4.9 g of a white solid. A mixture of this solid (2.0 g, 12.0 mmol) and MnO2 (10.5 g, 120. 4 mmol, 10.0 eq) in 75 mL diethyl ether was stirred vigorously for 48 h. The reaction mixture was then filtered first through a plug of silica gel, then through a 0. 46 um frit before concentrating in vacuo to provide 2. 1g of an off-white solid. Purification by MPLC (Biotage) using a hexane-ethyl acetate gradient provided 1.47 g (74%) of 1- benzo [1,3] dioxol-4-yl-ethanone as an off-white solid. 1H-NMR (CDC13) 6 7.35 (d, J = 8 Hz, 1H), 6.97 (dm, J = 8 Hz, 1H), 6.87 (dd, J = 8 Hz, 1H), 6.08 (s, 2 H), 2.59 (s, 3H); TLC Rf = 0.18, 25% ethyl acetate-hexanes.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromopropan-1-ol

General procedure: To a solution of DHA (10.0 mmol) and 2-bromoethanol (10.0 mmol) in CH2Cl2 (30 mL), boronfluoride ethyl ether (0.5 mL) was added dropwise at 0 C. The reaction mixture was stirred at 0 Cfor 8 h, then washed with saturated NaHCO3 solution (20 mL x 3). The organic layer was dried overanhydrous Na2SO4 and concentrated under reduced pressure. The crude products were purified bysilica gel column chromatography (PET/EtOAc = 10:1, v/v) to get the target compound 7a.The compounds 7b and 9a were synthesized by the same operation procedure of compound 7a.

With the rapid development of chemical substances, we look forward to future research findings about 627-18-9.

Reference:
Article; Tian, Ye; Liang, Zhen; Xu, Hang; Mou, Yanhua; Guo, Chun; Molecules; vol. 21; 6; (2016);,
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Electric Literature of 426831-32-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.426831-32-5, name is (5-Fluoro-2-methoxyphenyl)methanol, molecular formula is C8H9FO2, molecular weight is 156.1543, as common compound, the synthetic route is as follows.

Neat (5-Fluoro-2-methoxy-phenyl) -methanol (19.587g, 1 equiv. ) was added to neat SOC12 (42.2 mL, 4.6 equiv. ) at-78C under a nitrogen atmosphere and the solution was then allowed to warm to room temperature and stirred until evolution of gas had ceased. An equivalent volume of anhydrous toluene was added to the flask and the solution heated to 60C. On cooling the reaction solution was poured onto ice water. The toluene layer was separated and dried (MgSO4) and the solvent removed under reduced pressure. The crude material was sublimed (60-80C/0. 05 mBarr) to give the title compound as a white solid (13.40 g, 61%).’H NMR (300MHz, CDC13) : S 3.87 (s, 3H), 4.60 (s, 2H), 6.79-7. 20 (m, 3H).;

Statistics shows that 426831-32-5 is playing an increasingly important role. we look forward to future research findings about (5-Fluoro-2-methoxyphenyl)methanol.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/60949; (2005); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: (Z)-3-Methylpent-2-en-4-yn-1-ol

General procedure: To a stirred solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.88 g, 9.2 mmol) in dry THF (20 mL)wascooled to 78 °C under an atmosphere of argon. n-Butyl lithium (7.7 mL, 18.4 mmol, 2.4 Min hexane) was then added slowly, via syringe. The mixture was allowed to stir at 78 °C for 1 h,after which, 6-methoxy-2,2-dimethyl-2,3-dihydronaphthalene-1,4-dione 9b (2 g, 9.2 mmol), dissolvedin dry THF (10 mL) was added. The mixture was stirred for a further 1 h at 78 °C, and then thecold bath was removed. The reaction mixture was stirred at r.t. for a further 16 h. The reactionwas quenched by addition of a saturated aqueous solution of NH4Cl. The mixture was stirred for10 min and extracted with ethyl acetate (3 50 mL), washed with water (2 30 mL) and driedover anhydrous Na2SO4. Evaporation of the solvent yielded the desired alcohol as a yellowishoil. The residue was subjected to silica gel chromatography using PE and EtOAc (4:1) as eluentto afford (Z)-(10-hydroxy-30,30-dimethyl-40-oxo-70-methoxy-tetrahydronaphthalene-one-yl)-3-methylpentyl-2-em-4-yn-1-ol 18b (2.37 g, 82percent) as a yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6153-05-5, (Z)-3-Methylpent-2-en-4-yn-1-ol.

Reference:
Article; Wan, Chuan; Wang, Mingan; Yang, Dongyan; Han, Xiaoqiang; Che, Chuanliang; Ding, Shanshan; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 22; 12; (2017);,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31775-67-4, name is trans-2-Aminocyclopentanol hydrochloride, the common compound, a new synthetic route is introduced below. COA of Formula: C5H12ClNO

To a solution of 1-(4-bromobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (0.83 g) known from a document (Journal of Medicinal Chemistry, 2007, 50, 5471) in DMF (20 mL) were added (1,2-trans)-2-aminocyclopentanol hydrochloride (0.38 g), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (1.1 g) and triethylamine (0.80 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the precipitate was collected by filtration and dried to give the title compound (1.0 g) as a pale-yellow solid. 1H NMR (300MHz, DMSO-d6) delta 1.37-1.94 (5H, m), 2.00-2.17 (1H, m), 3.88-4.10 (2H, m), 5.77 (2H, s), 5.86 (1H, s), 7.13-7.30 (2H, m), 7.44-7.97 (5H, m), 8.29-8.44 (1H, m), 9.08 (1H, s), 10.03 (1H, d, J = 7.4 Hz).

The synthetic route of 31775-67-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SAKAMOTO, Hiroki; SUGIMOTO, Takahiro; EP2821401; (2015); A1;,
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Related Products of 4704-94-3 , The common heterocyclic compound, 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2 The allylation reaction was carried out as in Example 1 except using 42.07 g of 1,1,1-tri(methylol)methane, 40.43 g of tetrabutylammonium bromide and 95.79 g of allyl chloride. After the allylation reaction, the product was separated and purified as in Example 1. As a result, 59.80 g of 1,1,1-tri(allyloxymethyl)methane was obtained. The yield was 100% and the purity was 99%.

The synthetic route of 4704-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Matsumura, Yasufumi; Komiyama, Hiromi; US2003/135059; (2003); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4720-29-0, name is 3-(Benzylamino)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Benzylamino)-1-propanol

3-(N-tert-Butoxycarbonyl-N-phenylmethylamino)-propan-1-ol (4f) (R3=H, q=1, x=2, R1=BOC) from 3f (method B). 1H-NMR (CDCl3): 7.37-7.15 (m, 5H, Ar); 4.38 (s, 2H, CH2 -Ar); 3.58-3.50 (m, 2H, CH2OH); 3.40-3.30 (m, 2H, N-CH2); 3.10 (bs, 1H, OH); 1.70-1.55 (m, 2H, CH2-CH2-CH2); 1.40 (s, 9H, t.Bu).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4720-29-0, 3-(Benzylamino)-1-propanol.

Reference:
Patent; Zambon Group S.p.A.; US6214833; (2001); B1;,
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Related Products of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device, 14.6 g (0.1 mol) of adipic acid, 35.1 g (0.3 mol) of N, N-diethylaminoethanol, (0.2mol) of water, filtered to remove the catalyst (direct reuse), the filtrate transferred to another 250ml of three bottles, vacuum distillation (20ml), the reaction mixture was heated to 150 C, After recovery of the solvent, recovery of excess diethylaminoethanol and recovery of the low boiling point matter, 3.0 g of activated clay was added and stirred for 30 minutes to lower the temperature to 80C or lower.And the filtrate afforded 31.10 g of a di-ethylaminoethyl adipate as a yellow oily liquid in a yield of 90.4%.And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed with stirring heated to120 C,The citric acid is melted and then cooled and crystallized with stirring to form a salt, thereby obtaining a white powdery solid product of adipic acid bis diethylaminoethanol citrate. Its melting point: 117 C.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
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