Author: tianli

Reference of 13826-35-2, Adding some certain compound to certain chemical reactions, such as: 13826-35-2, name is (3-Phenoxyphenyl)methanol,molecular formula is C13H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13826-35-2.

To a solution of triphenyl phosphine (4.52 g; 17.2 mmol) and 3-phenoxybenzyl alcohol (3.44 g; 17.2 mmol) in THF (20 mL) kept in an ice bath was added a solution of 1a (4.61 g; 17.2 mmol) and diisopropyl azodicarboxylate (95%, 3.66 g; 17.2 mmol) in THF (20 mL). The reaction mixture was stirred at 0 C for 2 h and monitored by TLC. The solvent was removed on the rotary evaporator, leaving a yellow oil which was purified by flash chromatography (silica gel/ethyl acetate/hexane) to yield a white solid (6.33 g; 82% yield), mp 75-77 C. 1H NMR (CDCl3): delta 1.49 (s, 9H), 3.65 (d, 2H), 3.72 (s, 3H), 4.79 (s, 2H), 4.77 (t, J = 13.6 Hz, 1H), 6.90-7.03 (m, 4H), 7.10 (d, 2H), 7.30-7.39 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dou, Dengfeng; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.; Bioorganic and Medicinal Chemistry; vol. 20; 6; (2012); p. 2111 – 2118;,
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Application of 5343-92-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

Prepare 55g sodium hydrogen (2.3mol) under nitrogen protectionAnd a suspension of 200 ml of tetrahydrofuran,Slowly add 1,2-pentanediol 125g (1.2mol) under micro refluxa mixture with 200 ml of tetrahydrofuran,There is a constant flow of gas to produce a discharge system.No gas is produced after stirring for 10 hours.A sodium salt suspension is obtained for use.After replacing the air in the 2000 mL autoclave with nitrogen,After adding 300 ml of tetrahydrofuran under nitrogen protection,Maintain internal temperature -10 ~ 0 C into the sulfuryl fluoride 151.6g (1.48 mol),The sodium salt suspension was continuously added to the kettle, and the reaction was kept for 2 hours.After the reaction, the nitrogen blowing system removes excess sulfuryl fluoride gas.The reaction solution was filtered and then decomposed to dryness under reduced pressure.The crude product was added with 300 ml of dichloromethane, 15-crown-5 0.1 g,18-crown-6 0.1g, refluxing for 1h,After filtration, the product was dried (162.7 g) (two-step yield 85.1%)

The chemical industry reduces the impact on the environment during synthesis 5343-92-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Quzhou Kangpeng Chemical Co., Ltd.; He Li; Li Xiaoliang; Tian Zhong; Yang Jianhua; (12 pag.)CN108409708; (2018); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: 101597-25-5

10244] A propargyl alcohol compound represented by thefollowing formula was provided. 10245] 1.55 Grams (4.0 mmols) of the indenonaphthol compound obtained in Example 4 and 1.40 g (5.2 mmols) of the above propargyl alcohol compound were dissolved in 47 ml of toluene and to which was, further, added 0.03 g of camphorsulfonic acid to conduct the reaction at 100 C. for one hour.10246] After the reaction, the solvent was removed, the reaction product was refined by chromatography (solvent chloroform) using silica gel and was, thrther, recrystallized with acetonitrile to obtain 1.86 g (2.9 mmols) of a white solid material of an indenonaphthopyran represented by the following formula (ES). The yield was 73%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TOKUYAMA CORPORATION; IZUMI, Shinobu; TERANISHI, Kazuhiro; (26 pag.)US2016/130203; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 57772-50-6, (2-Amino-3-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 57772-50-6, blongs to alcohols-buliding-blocks compound. SDS of cas: 57772-50-6

Imidazole (817 mg) and tert-butyldimethylsilyl chloride (1.09 g) were added to a solution of (2-amino-3-methyl-phenyl)-methanol (823 mg) in dimethylformamide (10 mL) at room temperature. The reaction mixture was stirred at room temperature for one hour, diluted with ethyl acetate and washed with a saturated sodium hydrogen carbonate aqueous solution and brine, dried over sodium sulfate and concentrated, and 1.51 g (100%) of the title compound was obtained as a colourless transparent oil. MS(FAB) m/z:252 (M + H)+.

The synthetic route of 57772-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sankyo Company, Limited; EP1764360; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23147-58-2, name is Glycerol aldehyde dimer, molecular formula is C4H8O4, molecular weight is 120.1039, as common compound, the synthetic route is as follows.name: Glycerol aldehyde dimer

The compound (209.3 mg) obtained in Example 89-2 was dissolved in anhydrous methanol (8.4 ml). Then, the solution was added with [1,4]dioxan-2,5-diol (54.0 mg) and sodium cyanoborohydride (56.6 mg) and adjusted to pH 5 with acetic acid, followed by stirring at room temperature for 19.5 hours. After the reaction, the solvent was distilled off. Subsequently, the residue was added with a 1 mol/l sodium hydroxide aqueous solution (1.0 ml), followed by extraction with chloroform. The extract was dried with magnesium sulfate and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol) and then treated with hydrochloric acid, thereby obtaining hydrochloride (175.8 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=510[M+H]+1H-NMR(500MHz,DMSO-d6+D2O):delta=0.92(6H,t,J=7.1Hz),1.64-1.68(6H,m),1.78-1.82(2H,m),3.00-3.08(10H,m),3.71(3H,s),3.74(4H,s),4.09(2H,s),4.17(2H,s),4.30 (2H,q,J=13.9Hz),7.41(2H,d,J=7.8Hz),7.48(4H,d,J=5.6Hz),7.61(2 H,s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
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Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of (2-bromo-5-fluorophenyl) methanol (5g, 0.02 mol) in 1,4-dioxane (60 mL), bis(pinacolato)diboron (5.6 g, 0.022 mol) and potassium acetate (5.6 g, 0.06 mol) were added. The resulting mixture was degassed using a stream of nitrogen and to this was added [U’-bis(diphenylphosphino) ferrocene]dichloropalladium(ll) (250 mg, 0.34 mmol). The reaction mixture was then heated at 80 °C for 10 hrs. The mixture was cooled to room temperature, diluted with H20 and extracted with EtOAc. The organic layer was dried over Na2S04 and evaporated in vacuum to yield (5-fluoro-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)methanol (5) that was used in the next reaction step without further purification. Yield-95percent; Purity-99.9percent.

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; PULLAGURLA, Manik Reddy; NANDA KUMAR, Mecheril Valsan; PITTA, Bhaskar Reddy; RANGISETTY, Jagadeesh Babu; (55 pag.)WO2017/183043; (2017); A1;,
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Reference of 162358-05-6, Adding some certain compound to certain chemical reactions, such as: 162358-05-6, name is 2-(4-Octylphenyl)ethanol,molecular formula is C16H26O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162358-05-6.

(1) 2-(4-Octylphenyl)ethyl iodide To a solution of 2-(4-octylphenyl)ethanol (25 g) in ether (200 ml)-acetonitrile (100 ml), imidazole (11 g) and triphenylphosphine (36 g) were added and the mixture was stirred at 0 C. for an hour. Iodine (38 g) was added to the solution and the whole mixture was stirred at 0 C. for 2 hours. Silica gel was added to the reaction solution and the mixture was filtered off. The precipitate was washed with a mixed solution of hexane-ethyl acetate (2:1). The filtrate and the solvent employed at washing were combined and concentrated. The residue was purified by silica gel chromatography (eluent; hexane-ethyl acetate=2:1) to give the subject compound (37 g). Rf value: 0.85 (hexane-ethyl acetate=4:1) MS: 344(M+) 1 H-NMR(400 MHz, CDCl3) delta: 0.88 (3H, t, J=8 Hz), 1.10-1.40 (10H, m), 1.50-1.65 (2H, m), 2.57 (2H, t, J=8 Hz), 3.14 (2H, t, J=8 Hz), 3.33 (2H, t, J=8 Hz), 7.09 (2H, d, J=8 Hz), 7.13 (2H, d, J=8 Hz)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162358-05-6, 2-(4-Octylphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5948820; (1999); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H11NO2

General procedure: The product S1 was dissolved in CHCl3. Then pyridine (1.2 equiv) and 4-toluenesulfonyl chloride (1.2 equiv) were added to the solution. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction mixture was quenched with saturated ammonium chloride, and the mixture was extracted with ethyl acetate and dried over Na2SO4. After removal off the solvent, the crude product S2 was used directly without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55414-72-7, (2-Amino-5-methoxyphenyl)methanol.

Reference:
Article; Sun, Bing-Bing; Hu, Qing-Xian; Hu, Jia-Ming; Yu, Jie-Qiang; Jia, Jun; Wang, Xing-Wang; Tetrahedron Letters; vol. 60; 30; (2019); p. 1967 – 1970;,
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Synthetic Route of 7250-55-7 ,Some common heterocyclic compound, 7250-55-7, molecular formula is C7H12O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of scheme 5-8 compound S1 (24 g, 0.136 mol) and benzyl 2,2,2-trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 mL) at room temperature was added trifluoromethanesulfonic anhydride (cat.1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHCO3 and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (35 g, 93.3% yield) as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-55-7, its application will become more common.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (508 pag.)WO2017/35409; (2017); A1;,
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Synthetic Route of 3973-18-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3973-18-0 as follows.

2-(Prop-2-ynyloxy)ethyl-lflr,l^,27/,2^-perfluorodecane-l-sulfonate (20); In a 25 mL round bottomed flask, distilled triethylamine (0.24 mL, 1.7 mmol) followed by lH,lH,2H,2H-perfluorodecane sulfonyl chloride (273 mg, 0.5 mmol) were added to a solution of 2-(prop-2-ynyloxy)ethanol (140 mg, 1.4 mmol) in DCM (3.0 mL) at 0C under a nitrogen atmosphere. The mixture was allowed to stir for 3 hours before being quenched with NaHCO3, extracted with DCM, and the organic phases dried over MgSO4. The solvent was removed under reduced pressure to give a crude solid product. Purification by column chromatography on silica gel (15% Et2O in hexane) afforded the target product as a white solid (71 mg, 0.12 mmol, 23% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3973-18-0, its application will become more common.

Reference:
Patent; ISIS INNOVATION LIMITED; GOUVERNEUR, Veronique; BEJOT, Romain; WO2010/7363; (2010); A2;,
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