Author: tianli

Related Products of 81335-87-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 81335-87-7 as follows.

Sub-1 (35.0g, 255.1mmol), 3,5-dimethylacetophenone (56.7g, 382.7mmol), tris (triphenylphosphine) ruthenium (II) dichloride (2mol%) And potassium hydroxide (15.7g, 280.7mmol) and toluene (300mL) were added to the reaction flask,Heat and stir to reflux, and separate water by condensing reflux trap. When the reaction is over, drop to room temperature and filter on a pad of silica gel. The product was further purified by column (eluent: n-hexane / ethyl acetate = 2/100), and finally the intermediate Sub-3 (35.3 g, yield 56%) was obtained by crystallization from isopropanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81335-87-7, its application will become more common.

Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Zhao Xiaoyu; Hua Wanming; (31 pag.)CN110452271; (2019); A;,
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Synthetic Route of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Example 8 4-[(4-Butoxyphenyl)methyl]-1,2-dihydro-5-methyl-3 H -pyrazol-3-one The title compound was prepared in a similar manner to that described in Example 1 using 4-butoxybenzyl alcohol instead of 4-isopropoxybenzyl alcohol. 1H-NMR (500MHz, DMSO-d6) delta ppm: 0.91 (3H, t, J=7.4Hz), 1.30-1.50 (2H, m), 1.55-1.75 (2H, m), 1.98 (3H, s), 3.46 (2H, s), 3.80-3.95 (2H, m), 6.70-6.85 (2H, m), 6.95-7.10 (2H, m)

Statistics shows that 6214-45-5 is playing an increasingly important role. we look forward to future research findings about (4-Butoxyphenyl)methanol.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1213296; (2002); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. A new synthetic method of this compound is introduced below., Safety of (2-Amino-4-methylphenyl)methanol

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72995-94-9, name is 14-Bromotetradecan-1-ol, molecular formula is C14H29BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C14H29BrO

(5) A solution of n-butyl lithium (1.8 ml) was added dropwise to a 5 ml THF solution of 560 mg of 1,1-(ethylenedioxy)-4-methyl-3-(phenylsulfonyl)-cyclohexane and 4 mg of triphenylmethane under an argon stream at -78 C. The resulting mixture was stirred for 10 minutes and then reacted at room temperature for one hour. HMPT (1 ml) was added and the resulting mixture was cooled again to -78 C., followed by the dropwise addition of a 2 ml THF solution of 205 mg of 14-bromo-1-tetradecanol. After the reaction at -20 C. for 2 hours, the reaction mixture was poured into a saturated solution of ammonium chloride. The resulting mixture was extracted with diethyl ether. The organic layer was washed with water and saturated saline, dried over magnesium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column while using hexane-ethyl acetate, whereby 1,1-(ethylenedioxy)-3-(14-hydroxytetradecyl)-4-methyl-3-(phenylsulfonyl)-cyclohexane was obtained in the form of a colorless oil (yield: 98%).

With the rapid development of chemical substances, we look forward to future research findings about 72995-94-9.

Reference:
Patent; Luu, Bang; Mohier, Eliane; Yamada, Masashi; Suma, Yukie; Suzuki, Hiroto; US2004/115810; (2004); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

3-Chloro-2,2-bis (chloromethyl) propan-1-ol (15.4 g, 80.4 mmol) obtained in the above step 1 was dissolved in 98% ethanol (28 ml) and potassium hydroxide (5.0 g, mmol) was added, and the mixture was heated and refluxed for 30 minutes.The reaction solution was cooled with ice water and stirred for 10 minutes. The resulting solid was filtered off,The pH was adjusted to 7.5 with 2N aqueous hydrochloric acid solution. After removing the solvent by distillation under reduced pressure, water (100 ml) was added to the residue and extracted twice with ethyl acetate (150 ml). The obtained organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 4: 1) to obtain pure 3,3-bis (chloromethyl) oxetane (9.2 g, 74%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 813-99-0, 3-Chloro-2,2-bis(chloromethyl)propan-1-ol.

Reference:
Patent; Korea Research Institute of Chemical Technology; Eseuti Pam Co., Ltd.; Kim Bong-jin; Kim Jae-hak; Lee Il-yeong; Lee Sang-ho; Lee Jong-gyo; Kim Gyeong-jin; Kim Uk-il; Nam Hwa-jeong; (56 pag.)KR101592370; (2016); B1;,
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Electric Literature of 38584-37-1 , The common heterocyclic compound, 38584-37-1, name is 3-(Hydroxymethyl)adamantan-1-ol, molecular formula is C11H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(3) Esterification and polymerization A mixture of 1-hydroxy-3-hydroxymethyladamantane (1 mmol), acryloyl chloride (1.2 mols), triethylamine (1.2 mols) and dioxane (10 ml) was stirred at 40C for 3 hours. As a result, 1-hydroxy-3-(acryloyloxymethyl)adamantane of the following formula was obtained (yield 90%).

The synthetic route of 38584-37-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Daichel Chemical Industries Ltd; EP1000924; (2000); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 81335-87-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. A new synthetic method of this compound is introduced below.

Sub-1 (35.0g, 255.1mmol), 3′-methylacetophenone (51.4g, 382.7mmol), tris (triphenylphosphine) ruthenium (II) dichloride (2mol%) and Potassium hydroxide (15.7g, 280.7mmol) and toluene (300mL) were added to the reaction flask, heated and stirred to reflux, and water was separated by a reflux reflux condenser. When the reaction is over, drop to room temperature and filter on a pad of silica gel. The product was further purified by column (eluent: n-hexane / ethyl acetate = 2/100), and finally the intermediate Sub-2 (35.1 g, yield 59%) was obtained by crystallization from isopropanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81335-87-7, its application will become more common.

Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Zhao Xiaoyu; Hua Wanming; (31 pag.)CN110452271; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 626-95-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-95-9, name is 1,4-Pentanediol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a typical experiment, a round bottom flask containing 4-6mL of acetonitrile/water mixture (1:1) was charged with 0.5-1.0mmol of the diol, 5mol% of TetMe-IA, and oxone (2equiv). The resulting mixture was stirred at rt for benzylic diols and at 45C for aliphatic diols. At the end of the reaction, as judged from TLC analysis, little water was added to dissolve the inorganic salts, and the organic matter was extracted with EtOAc at least two times. The combined extract was dried over anhydrous Na2SO4, concentrated in vacuo to obtain the crude product, which was subjected to silica-gel column chromatography using ethyl acetate/pet ether to isolate the pure product.

According to the analysis of related databases, 626-95-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 70; 13; (2014); p. 2286 – 2293;,
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Reference of 14426-21-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14426-21-2, name is Diethanolamine hydrochloride, molecular formula is C4H12ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirring solution of 57 (500 mg, 3.33 mmol) in DCM (100 mL) was added CSI (290 tL, 471 mg, 3.33 mmol). After 20 mi Et3N (1.4 mL, 1.0 g, 10 mmol) and a solution of diethanolamine.HC1 (571 mg, 4.0 mmol) in DMF (5 mL) were added subsequently. After an additional 45 mm., the reaction mixture was concentrated under reduced pressure and the residue was purified by gradient column chromatography (0 -* 15% MeOH in DCM).Product 66 was obtained as colorless thick oil (767 mg, 2.13 mmol, 64%). ?H NIVIR (400IVIFIz, CDC13) (ppm) 4.26 (d, J= 8.2 Hz, 2H), 3.87 (t, J= 4.9 Hz, 4H), 3.55 (t, J = 4.9Hz, 4H), 2.37-2.16 (m, 6H), 1.65-1.45 (m, 2H), 1.39 (quintet, J = 8.6 Hz, 1H), 1.05-0.92 (m, 2H)

According to the analysis of related databases, 14426-21-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; WIJDEVEN, Maria Antonia; VAN DE SANDE, Petrus Josephus Jacobus Maria; VAN BERKEL, Sander Sebastiaan; VAN DELFT, Floris Louis; (150 pag.)WO2016/53107; (2016); A1;,
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Synthetic Route of 15963-47-0 , The common heterocyclic compound, 15963-47-0, name is (3-Chlorocyclobutyl)methanol, molecular formula is C5H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(A) [[(3-Chlorocyclobutyl)methoxy]methyl]benzene A mixture of 3-chlorocyclobutanemethanol (17.3 g, 0.143 mole) and benzylbromide (29.96 g, 0.1576 mole) in dry dimethylformamide (123 ml) was stirred at room temperature under an argon atmosphere and a 60% suspension of sodium hydride (6.31 g) was added. The reaction was stirred at ambient temperature for 22.5 hours. The reaction mixture was poured into 600 ml of water and the aqueous mixture extracted with ethyl acetate (4*500 ml). The ethyl acetate extracts were combined and dried over anhydrous sodium sulfate and the ethyl acetate evaporated in vacuo yielding the crude product as a yellow oil. The material was purified on a 2-liter Merck silica gel column eluding with 3 liters of hexane, followed by 5% ethyl acetate/hexane. The fractions containing the desired product were combined and the volatiles evaporated in vacuo yielding 28.6 g of the title compound as a pale yellow oil.

The synthetic route of 15963-47-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4855466; (1989); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts