Month: December 2022

Zhang, H.-L. published the artcileEnantioselective synthesis of enantiopure chiral alcohols using carbonyl reductases screened from Yarrowia lipolytica, Recommanded Product: 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, the publication is Journal of Applied Microbiology (2019), 126(1), 127-137, database is CAplus and MEDLINE.

Aims : We aimed to explore Yarrowia lipolytica carbonyl reductases as effective biocatalysts and to develop efficient asym. reduction systems for chiral alc. synthesis. Methods and Results : Yarrowia lipolytica carbonyl reductase genes were obtained via homologous sequence amplification strategy. Two carbonyl reductases, YaCRI and YaCRII, were identified and characterized, and used to catalyze the conversion of 2-hydroxyacetophenone (2-HAP) to optically pure (S)-1-phenyl-1,2-ethanediol. Enzymic assays revealed that YaCRI and YaCRII exhibited specific activities of 6·96 U mg^-1 (99·8% e.e.) and 7·85 U mg^-1 (99·9% e.e.), resp., and showed moderate heat resistance at 40-50°C and acid tolerance at pH 5·0-6·0. An efficient whole-cell two-phase system was established using reductase-expressing recombinant Escherichia coli. The conversion of 2-HAP (20·0 g l^-1) conversion with the solvent of di-Bu phthalate was approx. 70-fold higher than in water. Furthermore, the two recombinant E. coli displayed biocatalyst activity and enantioselectivity towards several different carbonyl compounds, and E. coliBL21 (DE3)/pET-28a-yacrII showed a broad substrate spectrum. Conclusions : A new whole-cell recombinant E. coli-based bioreduction system for enantiopure alc. synthesis with high enantioselectivity at high substrate concentrations was developed. Significance and Impact of the Study : We proposed a promising approach for the efficient preparation of enantiopure chiral alcs.

Journal of Applied Microbiology published new progress about 1310357-40-4. 1310357-40-4 belongs to alcohols-buliding-blocks, auxiliary class Benzenes, name is 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, and the molecular formula is C24H12, Recommanded Product: 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ting published the artcileSelective hydroconversion of 2-methylfuran to pentanols on MWNT-supported Pt catalyst at ambient temperature, Application In Synthesis of 111-29-5, the publication is Rare Metals (Beijing, China) (2022), 41(3), 889-900, database is CAplus.

The selective hydrogenolysis of C-O bond in furfural and its derivatives provides a sustainable route for transforming biomass-derived feedstocks into valued chems. Currently, the development of efficient catalysts which can effectively cleavage C-O bond under mild conditions remains a critical challenge. The present work reports Pt catalysts supported on multi-walled carbon nanotubes (MWNT) which are active in 2-methylfuran (2-MF) hydrogenolysis to form pentanols in liquid phase under mild conditions. The impact of various catalyst supports, active metals and reaction conditions in terms of metal loadings, solvent, time, pressure, etc. were explored. The 5 wt% Pt/MWNT catalyst demonstrated an excellent activity and selectivity with 100% 2-MF conversion and 53% pentanols (POLs) yield under 1 MPa H2 at an exceptional low temperature of 25°C. The reaction mechanism was studied combing both the reactivity tests and characterization results, and it is found that the better catalytic performances of Pt/MWNT were correlated closely to the size of Pt nanoparticles and their interactions with the underlying MWNT support. Accordingly, a reaction pathway involving the adsorption of 2-MF parallel to the Pt nanoparticles and its subsequently selective C-O hydrogenolysis was proposed. This work showcases a promising catalyst for room-temperature biofuel production

Rare Metals (Beijing, China) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C13H10N2S, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Pianpian published the artcileMass production of a single-atom cobalt photocatalyst for high-performance visible-light photocatalytic CO₂ reduction, Formula: C9H21NO3, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2021), 9(46), 26286-26297, database is CAplus.

The photocatalytic reduction of carbon dioxide (CO₂RR) into value-added chem. products is a promising way to enrich energy supply and reduce CO₂ emission. The proposal of a high-efficiency, low-cost and easy-to-operate photocatalyst is an essential segment for promoting the CO₂RR from small-scale laboratory examination to large-scale industrial application. Herein, we first come up with a Co photocatalyst with isolated Co single atoms anchored on a com. super conductive carbon black (Co-SA@SP-800) and employ it to effectively boost the photocatalytic CO₂ reduction reaction. Large scale production of the Co-SA@SP-800 catalyst can be achieved by a simple and practical adsorption-pyrolysis method. The as-prepared Co-SA@SP-800 catalyst presents remarkable photoactivity and CO selectivity with a CO production yield of 1.64 x 104μmol g^-1 and a CO selectivity of 84.2% after 2 h of UV illumination in a heterogeneous system, and significantly outperforms other reference samples and most of the other efficient photocatalysts reported recently toward the conversion of CO₂. In situ diffuse reflectance IR Fourier transform (DRIFT) spectroscopy was carried out to investigate the reaction intermediates during the photocatalytic CO₂RR. Control experiments and theor. calculations revealed that the isolated single at. Co-N₄ sites greatly lower the energy barrier for the desorption of CO* during CO₂-to-CO conversion, while suppressing H₂ evolution in the competing water splitting reaction. This work provides valuable new insights for rationally designing and synthesizing high-performance single atom catalysts for photocatalytic CO₂ reduction with ease of large-scale production

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C5H6N2O2, Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Rongchang published the artcileOscillographic titration with sodium tetraphenylboron for pharmaceutical and metallurgical analyses, Computed Properties of 3818-50-6, the publication is Fenxi Ceshi Xuebao (2002), 21(2), 39-41, database is CAplus.

An oscillog. titrimetric method with sodium tetraphenylboron was described for pharmaceutical and metallurgical analyses. Since the proposed method was based on the visual display of a sharp oscillog. end-point and was not affected by the colors of the solution, precipitate and excipient, it can be used to replace gravimetric anal., non-aqueous titration, and extraction-photometric anal. The method was used in the determination of alkaloid and quaternary ammonium salt with the RSD 0.03-0.06% and the results consistent with those obtained by pharmacopoeia method. Some metallurgical samples were determined with the RSD 0.15- 0.40%, the recovery 98.7-100% and the results consistent with those obtained by standard method. The method was accurate, rapid, simple and cheap, and hence had large potential for extensive application.

Fenxi Ceshi Xuebao published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C7H11N, Computed Properties of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajesh, Sarigama published the artcileSynthetic ionizable aminolipids induce a pH dependent inverse hexagonal to bicontinuous cubic lyotropic liquid crystalline phase transition in monoolein nanoparticles, Recommanded Product: 2-Morpholinoethanol, the publication is Journal of Colloid and Interface Science (2021), 85-95, database is CAplus and MEDLINE.

A prospective class of materials for drug delivery is lyotropic liquid crystalline (LLC) nanoparticles, such as cubosomes and hexosomes. Efforts are being made to generate a pH dependent system, which exhibits slow release hexosomes (H2) at physiol. pH and relatively fast release cubosomes (Q2) at acidic disease sites such as in various cancers and bacterial infection (pH ∼ 5.5-6.5). Herein, we report the synthesis of nine ionizable aminolipids, which were doped into monoolein (MO) lipid nanoparticles. Using high throughput formulation and synchrotron small angle X-ray scattering (SAXS), the effects of aminolipid structure and concentration on the mesophase of MO nanoparticles at various pHs were determined As the pH changed from neutral to acidic, mesophases, could be formed in an order L2 (inverse micelles) → H2 → Q2. Specifically, systems with heterocyclic oleates exhibited the H2 to Q2 transition at pH 5.5-6.5. Furthermore, the phase transition pH could be fine-tuned by incorporating two aminolipids into the nanoparticles. Nanoparticles with a pH dependent phase transition as described in this study may be useful as drug delivery carriers for the treatment of cancers and certain bacterial infection.

Journal of Colloid and Interface Science published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nageswara Rao, Desaboini published the artcileDiscovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants, Recommanded Product: 1-Methylcyclobutan-1-ol, the publication is Journal of Medicinal Chemistry (2021), 64(16), 11972-11989, database is CAplus and MEDLINE.

The three pan-genotypic HCV NS3/4A protease inhibitors (PIs) currently in clin. use-grazoprevir, glecaprevir, and voxilaprevir-are quinoxaline-based P2-P4 macrocycles and thus exhibit similar resistance profiles. Using our quinoxaline-based P1-P3 macrocyclic lead compounds as an alternative chem. scaffold, we explored structure-activity relationships (SARs) at the P2 and P4 positions to develop pan-genotypic PIs that avoid drug resistance. A structure-guided strategy was used to design and synthesize two series of compounds with different P2 quinoxalines in combination with diverse P4 groups of varying sizes and shapes, with and without fluorine substitutions. Our SAR data and cocrystal structures revealed the interplay between the P2 and P4 groups, which influenced inhibitor binding and the overall resistance profile. Optimizing inhibitor interactions in the S4 pocket led to PIs with excellent antiviral activity against clin. relevant PI-resistant HCV variants and genotype 3, providing potential pan-genotypic inhibitors with improved resistance profiles.

Journal of Medicinal Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Recommanded Product: 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smirnov, Vladimir I. published the artcileCrystal and molecular structures of Si-(iodomethyl)silatranes with methyl substituents in β-position relative to the nitrogen atom, COA of Formula: C9H21NO3, the publication is Mendeleev Communications (2018), 28(3), 278-280, database is CAplus.

Crystal and mol. structures of two silatranes, 1-iodomethyl-3-methyl- and 1-iodomethyl-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecanes, were determined by X-ray anal. Comparison of their structural and geometrical characteristics with those of other silatranes shows that the presence of Me substituents β-positioned to nitrogen atoms increases the length of the dative Si←N bond, whereas the introduction of iodine into the axial position of the silatrane slightly decreases the length of the Si←N bond.

Mendeleev Communications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C16H20N2, COA of Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Savela, Risto published the artcileIron-Catalyzed Chlorination of Silanes, Category: alcohols-buliding-blocks, the publication is Organometallics (2012), 31(8), 3199-3206, database is CAplus.

A simple and highly efficient Fe-catalyzed method for the chlorination of silanes was developed. Using 0.5-2% of the Fe(III)-based catalyst FeCl₃ or Fe(acac)₃ in the presence of 1-1.5 equiv of acetyl chloride as the Cl donor, a large number of silanes, alkoxysilanes, and silanols were converted to the corresponding chlorosilanes in 50-93% yields. In contrast to earlier reported methods often suffering from expensive catalysts or use of stoichiometric metal salts, hazardous reagents, and reaction conditions, the presently described methodol. allows benign reaction conditions and simple workup while using only catalytic amounts of a readily available and economically viable Fe catalyst.

Organometallics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jaskowska, Jolanta published the artcileNew pharmaceutical salts of trazodone, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Molecules (2021), 26(3), 769, database is CAplus and MEDLINE.

New pharmaceutically acceptable salts of trazodone (trazodone hydrogen bromide and trazodone 1-hydroxy-2-naphthonic acid) for the treatment of central nervous system disorders are synthesized and described. Although trazodone salts are poorly crystalline, single-crystal X-ray diffraction data for trazodone 1-hydroxy-2-naphthonic acid were collected and analyzed as well as compared to the previously described crystal structure of com. available trazodone hydrochloride. The powder samples of all new salts were characterized by Fourier transform IR spectroscopy, X-ray diffraction and ¹³C solid-state NMR spectroscopy. Spectroscopic studies were supported by gauge including projector augmented wave (GIPAW) calculations of carbon chem. shielding constants The main goal of our research was to find salts with better physicochem. properties and to make an attempt to associate them with both the anion structure and the most prominent interactions exhibited by the protonated trazodone cation. The dissolution profiles of trazodone from tablets prepared from various salts with lactose monohydrate were investigated. The studies revealed that salts with simple anions show a fast release of the drug while the presence of more complex anion, more strongly interacting with the cation, effects a slow-release profile of the active substance and can be used for the preparation of the tables with a delay or prolonged mode of action.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiaoxu published the artcileTargeted Delivery of Dasatinib to Deplete Tumor-Associated Macrophages by Mannosylated Mixed Micelles for Tumor Immunotherapy, Formula: C13H15NO6S, the publication is ACS Biomaterials Science & Engineering (2020), 6(10), 5675-5684, database is CAplus and MEDLINE.

Tumor-associated macrophages (TAMs) are abundant in tumors and predominately show protumor M2-type fostering tumor progression. Specific depletion of TAMs is conceivably favorable for antitumor therapy. In this study, mannosylated mixed micelles (DAS-MMic) were developed to specifically deliver dasatinib (DAS) to eliminate TAMs for tumor immunotherapy. In vitro and in vivo results showed that DAS-MMic could effectively eradicate TAMs, decrease angiogenesis, reprogram the immunosuppressive tumor microenvironment, and finally suppress tumor progression. These data suggest the potential of direct elimination of TAMs by DAS-MMic for tumor immunotherapy.

ACS Biomaterials Science & Engineering published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C20H40O2, Formula: C13H15NO6S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts