Month: September 2021

Adding a certain compound to certain chemical reactions, such as: 117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 117087-18-0, blongs to alcohols-buliding-blocks compound. Product Details of 117087-18-0

White powder obtained in the step (3) (75 g, 0.38 mol)Soluble in N,N-dimethylformamide (1L), ice bath,Nitrogen partial protection,One copy Sodium hydrogen(15.2g, 0.38mol, 60% in mineral oil),After stirring for 1 hour, methanesulfonyl chloride (43 g, 0.375 mol) was added dropwise.The system was allowed to warm to room temperature and stirring was continued for 2 hours.Then the system is cooled to 0 C,Add one part of sodium hydrogen (15.2g, 0.38mol),The system was slowly warmed to room temperature again and stirring was continued for 3 hours.In the ice bath, adding 1M means adjusting the pH to neutral.Add 2L of water, extract ethyl acetate 300mL 5 times,The organic phases were combined, washed 3 times with water, dried and concentrated.The residue was dissolved in methanol 500 mL.Add 100 mL to the methanol phase and stir for 20 minutes.Layered,Then the lower layer was continuously added with 100 mL of petroleum ether, stirred for another 20 min, layered, and the lower layer was concentrated, and ethyl acetate and petroleum ether were crystallized 1:10.Obtained 53 g of a white solid. Yield 78%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Xinyuan Pharmaceutical Technology Co., Ltd.; Chai Teng; Lin Zengming; (12 pag.)CN108314665; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.09, as common compound, the synthetic route is as follows.HPLC of Formula: C9H11BrO

tert-Butyldimethylsilyl chloride (2.1O g, 14 mmol) was added to a mixture of 2-(4-bromophenyl)-propan-2-ol (2.0 g, 9.3 mmol) and imidazole (0.95 g 14 mmol) in DMF (30 mL) and the resultant mixture was stirred at 80 C for 24 h. The mixture was concentrated to one third of the original volume then diluted with water (50 mL) and extracted with diethyl ether (3 x 50 mL). The combined organic layer was dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The resultant residue was purified by chromatography (silica, 5Og column, Si-SPE, 0-5% diethyl ether in pentane) to afford the title compound as a colourless oil (1.39 g, 46%). 1H NMR (MeOD, 400MHz): 7.46-7.37 (m, 4H); 1.56 (s, 6H); 0.95-0.91 (m, 9H); 0.06 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2077-19-2, 2-(4-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; WO2009/151598; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 15852-73-0, (3-Bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To a solution of alcohol(1 mmol) in a mixture of MeCN and MeOH (5:1, 2.4 mL) was added TsNBr2(2.5 mmol) and K2CO3 (5 mmol) and stirred at room temperature. Aftercompletion of the reaction (TLC) sodium thiosulfate was added and thereaction mixture was stirred for 10 min. The reaction mixture was extracted indiethyl ether and hexane (1:1), dried, (Na2SO4) and concentrated. Purificationof the crude product by flash chromatography on silica gel (230?400 mesh)with petroleum ether?EtOAc as eluent gave the pure product

The synthetic route of 15852-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rajbongshi, Kamal Krishna; Sarma, Manas Jyoti; Phukan, Prodeep; Tetrahedron Letters; vol. 55; 39; (2014); p. 5358 – 5360;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73978-41-3, name is (2,4-Diaminopteridin-6-yl)methanol hydrochloride, molecular formula is C7H9ClN6O, molecular weight is 228.639, as common compound, the synthetic route is as follows.Recommanded Product: (2,4-Diaminopteridin-6-yl)methanol hydrochloride

0J 89j 4 FontWeight=”Bold” FontSize=”10″ Araino FontWeight=”Bold” FontSize=”10″ 4-deoxy-l O-A^nethyipterok Acid (APA, 2) ( raovec. I; Spencer, G.; Blair, A. H.; Mammen, M; Singh, M,; Ghose, T. J. Med Chem., 1989, 32, 2426). A mixture of 249 rag (0.59 mraol) dibromotripheaylphosphorane and 45,0 mg (0.20 tnmol) 2,4-diaraino-6-(hydr )xymethyl)pteridin.e hydrochloride (1) in 1 .5 mL of anhydrous dmieihylacetamide was stirred at room iemperatare for 24 h under an argon atmosphere. To the reaction mixture were added 41 mg (0.27 mmol) of 4-(methylamino)benzoic acid and 0,16 mL { 116 mg, 0,90 mmol) of DIPEA and the reaction mixture was stirred at room temperature for 48 h, and then at 60 ‘”‘C for 24 fi. The cooled reaction mixture was poured into 25 mL of 0.33 M aq NaOH and the precipitate was filtered. The filtrate was adjusted to H 5.5 with 10% acetic acid and the resulting precipitate was collected through filtration, washed wi h water and dried under diminished pressure at 80 C overnight to obtain 2 as an orange solid: yield 42 mg (56%); silica gel TLC – 0.47 (5:4: 1 chlorofornv-methanol-water); lH NM (DMSO-<&) o 3.19 (s, 3H), 4.76 (s, 2H), 6.61 (s, 2H>, 6.78 (d, 21i J- 8.9 Hz), 7.72 (d, 2H, J- 8.7 Hz) and 8.56 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73978-41-3, (2,4-Diaminopteridin-6-yl)methanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY; HECHT, Sidney; PAUL, Rakesh; TANG, Chenhong; MADATHIL, Manikandadas; BHATTACHARYA, Chandraball; WO2014/145109; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 769-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2.0 g, 13.1 mmol) and 6i(lH-imidazol-l-yl)methanone (4.26 g, 26.2 mmol) in 20 mL CH2CI2 was heated overnight at 50 C The reaction was quenched with water and extracted with CH2CI2, and the combined layers were dried over MgS04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2C12 gave (benzo[d][l,3]dioxol-7-yl)methyl lNo.-imidazole-l-carboxylate (2.8 g, 86%). ltt NMR (400 MHz, CDC13) 8 8.15 (t, /= 0.9 Hz, 1H), 7.44 (t, J= 1.4 Hz, 1H), 7.07 (dd, J= 1.6, 0.8 Hz, 1H), 6.95 (m, 2H), 6.84 (m, 1H), 6.01 (s, 2H), 5.33 (s, 2H).

Statistics shows that 769-30-2 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1036260-25-9, 3-Aminocyclobutanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1036260-25-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1036260-25-9

step 1: A mixture of 3-aminocyclobutanol hydrochloride (1.91 g, 15.47 mmol), isobenzofuran-1,3-dione (2.52 g, 17.01 mmol) and DIPEA (6.0 g, 46.40 mmol) in PhMe (100 mL) was stirred at 110 C. for 18 h. The reaction mixture was concentrated and purified by SiO2 chromatography eluting with PE/EA (3:1) to afford 2-(3-hydroxycyclobutyl)isoindoline-1,3-dione as white solid (2.1 g, 62.6%). LCMS (ESI): m/z=218.1 [M+1]+

The synthetic route of 1036260-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4654-39-1, name is 2-(4-Bromophenyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 4654-39-1

To a mixture of 2-(4- bromophenyl)ethanol (10.0 g, 49.7 mmol) in DCM (100 mL) were added imidazole (10.0 g, 149.2 mmol) and TBSC1 (8.2 g, 54.7 mmol) at 0 C. After stirring at room temperature for 3 h, the reaction mixture was quenched with water, extracted with DCM. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated. The crude was purified by silica gel column (PE: EA = 50: 1) to get (4-bromophenethoxy)(tert-butyl)dimethylsilane (16.2 g, 99%) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4654-39-1, 2-(4-Bromophenyl)ethanol.

Reference:
Patent; NIKANG THERAPEUTICS, INC.; LOU, Yan; FU, Jiping; HE, Yigang; (0 pag.)WO2020/14332; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.Computed Properties of C8H9BrO

The reaction kettle was charged with 4-bromophenethyl alcohol (1.0 kg, 5.0 mol) 10 times the volume of methylene chloride dissolved, Triethylamine (1.01 kg, 10.0 mol) And catalytic amount of DMAP, TBSCl (0.9 kg, 6.0 mol) was added in batches. Reaction to the disappearance of raw materials at room temperature, Washed, Saturated brine, After drying with anhydrous sodium sulfate, the liquid compound VA (1.5 kg, 95.5%) was obtained as a colorless oil. Directly into the next reaction.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4654-39-1, 2-(4-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Lide Biological Technology Co., Ltd.; Ren Guobao; Wu Yan; Li Chuanbin; (6 pag.)CN106565467; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1,2,4-Butanetriol

Example 1; Instead of PEG-400 and the para-toluenesulfonic acid catalyst used in ComparativeExample 1, dioxane and a strong acid ion exchange resin (Amberlyst 15, H+ form) containing a sulfonic acid group were used in equal amounts. Then, the reaction was conducted using a batch type reactor under conditions of atmospheric pressure and 1000C for 20 hours. The reaction yield was 96 mol%.

With the rapid development of chemical substances, we look forward to future research findings about 3068-00-6.

Reference:
Patent; SK CORPORATION; WO2007/81065; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H10N2O

First a 30mL methanol solution of salicyldehyde (30 mmol,3.66 g) was added to a 15mL methanol solution of 1,3-diamino-2-propanol (15 mmol, 1.35 g). The resulting orange solution wasthen refluxed for 1 h, and after cooling down, the solvent wasremoved under reduced pressure to afford an orange crystallinesolid which was collected as the ligand. Yield: 69%. Anal. Calc. forC17H18N2O3: C, 68.42; H, 6.09; N, 9.39. Found: C, 68.77; H, 5.73; N,9.71%.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Das, Kuheli; Massera, Chiara; Garribba, Eugenio; Frontera, Antonio; Datta, Amitabha; Journal of Molecular Structure; vol. 1199; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts