Month: August 2021

Electric Literature of 10029-04-6, Adding some certain compound to certain chemical reactions, such as: 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate,molecular formula is C6H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10029-04-6.

Phosphorus tribromide (17.16 g, 63.41 MMOL) was added to a stirred solution of the compound of example 30 (17.92 g, 138.1 MMOL) in dry ether (132 mL) at-10 C. The temperature was allowed to rise to 20 C and stirring was continued for 3h. Water (80 mL) was then added at-10 C and the mixture was extracted with hexane (3 x 45 mL). The organic extracts were washed with saturated sodium chloride solution (2 x 45 mL) and dried with anhydrous MGS04. Evaporation of solvent under vacuum gave 15.07 g (yield 56.6 %) of the crude product, which was used directly in the next reaction without any further purification. 1H NMR (CDCI3, 400MHZ) 8 6.25 (s, 1H), 5.88 (s, 1H), 4.2 (q, 2H), 4.11 (s, 2H), 1.25 (t, 3H); 13C NMR (CDCI3, 400 MHz) 5 166. 7,140. 1,125. 3,61. 1, 53.9, 14.4

According to the analysis of related databases, 10029-04-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOMEP INC.; WO2004/50620; (2004); A2;,
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Reference of 13674-16-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate, molecular formula is C10H12O3, molecular weight is 180.2, as common compound, the synthetic route is as follows.

A dichloromethane solution of methyl 2-hydroxy-3-phenylpropionate is treated with triethylamine (1.1 equiv) and methanesulfonyl chloride (1.1 equiv) at 0 C. Upon completion of reaction, the mixture is dissolved in dichloromethane/ether and washed with saturated aqueous solution of sodium chloride, dried and concentrated. Purification of crude material by flash column chromatography (40% ethyl acetate in hexane) gives methyl 2-methanesulfonyloxy-3-phenyl-propionate (1.6 g, 93%). 1 H NMR (300 MHz CDCl3): delta7.358-7.233 (m, 5H), 5.173 (dd, 4.26 Hz, 8.8 Hz, 1H), 3.793 (s, 3H), 3.301 (dd, 4.23 Hz, 14.38 Hz, 1H), 3.1295 (dd, 8.8 Hz, 14.3 Hz, 1H), 2.766 (s, 3H).

Statistics shows that 13674-16-3 is playing an increasingly important role. we look forward to future research findings about Methyl 2-hydroxy-3-phenylpropanoate.

Reference:
Patent; Merck & Co., Inc.; US5254682; (1993); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H11BrO

Using 2-norborneneA 10-mL dry sealed-tube equipped with a stir bar was charged with [RhCl(C2H4)2]2 (0.0125 mmol,4.86 mg), BIPHEP (0.0125 mmol, 6.53 mg), Li2CO3 (0.5 mmol, 36.9 mg), LiCl (0.1 mmol, 4.24 mg),and 2-norbornene (1.0 mmol, 94.1 mg) under a N2 flow. Xylene (1 mL), 2a (0.25 mmol, 53.8 mg),and furfural (0.5 mmol, 48.0 mg) were then added. After degassing the reaction mixture by the freezepump-thaw method three times, the tube was filled with N2. The mixture was then placed in an oilbath that had been preheated to 130 C for 20 h. After cooling to room temperature, the resultingsolution was filtered through a celite pad, and the filtrate was concentrated in vacuo. The resultingcrude product was purified by flash column chromatography on silica-gel to afford 6.

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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Adding a certain compound to certain chemical reactions, such as: 15833-00-8, 2-(2-Aminophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(2-Aminophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(2-Aminophenyl)propan-2-ol

EXAMPLE 4; 1-{3-[2-hydroxy-2-(6-hydroxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-ethylamino]-3-methyl-butyl}-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one; a) 4,4-dimethyl-1,4-dihydro-benzo[1,3]oxazin-2-one; 112 g (1.13 mol) phosgene are piped into 500 mL THF. Then a solution of 52 g (0.34 mol) 2-(2-amino-phenyl)-propan-2-ol, prepared from 2-aminoacetophenone and methylmagnesium iodide, in 300 mL THF is added. The reaction mixture is left to stand overnight, evaporated down and combined with 500 ml pyridine. After the pyridine has been distilled off water is added and the mixture is extracted with diethyl ether. The organic phases are washed successively with 2 N hydrochloric acid, sodium hydroxide solution and water, dried with sodium sulphate and evaporated down. The residue remaining (46 g) is further reacted directly without any more purification.

The synthetic route of 15833-00-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2005/227975; (2005); A1;,
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Related Products of 39068-94-5 ,Some common heterocyclic compound, 39068-94-5, molecular formula is C12H19NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 1 (preferred) 1-[(3,4-dimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine R1 =ethyl, R2 =R3 =methyl, R4 =phenyl, R5 =,4-dimethoxyphenyl, n=q=0, m=p=1. 39.3 grams of sodium (1.71 mol) are introduced into 300 grams of 2-phenyl-2-dimethylamino-1-butanol (1.55 mol) in solution in 3 liters of anhydrous dioxane. The mixture is refluxed with vigorous stirring to disperse the sodium. After 6 hours 434 grams of 3,4-dimethoxy-alpha-chlorotoluene (2.34 mol) in solution in 1 liter of anhydrous dioxane are introduced within 30 minutes; the mixture is maintained for 6 hours at the reflux temperature of the solvent. The suspension is filtered and the solvent of the filtrate is eliminated by distillation in vacuo. The residue is taken up with 2 liters of hydrochloric acid (2N) and extracted with diethyl ether. The ether phases are removed and the aqueous acid phase is made alkaline in the cold with sodium hydroxide solution (10N) in a quantity sufficient to obtain a pH value of 12. The oil formed is extracted with ether, the ether phases are washed with water and then dried over sodium sulphate and the ether is eliminated by distillation. The oily residue obtained is purified by fractionation in vacuo. B.p.0.2/0.5 =187-193 C., weight: 271 grams, yield 50%. The DL camphosulphonate of the product is prepared in ethanol and recrystallized in ethyl acetate. Yield=85%, M.p.=108 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39068-94-5, 2-(Dimethylamino)-2-phenylbutan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Societe Industrielle de Produits de Synthese; US4301163; (1981); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

To a dried round-bottom flask, 3,5-dimethylbenzoic acid (600 mg, 4.0 mmol) was dissolved inCH2Cl2 (14 mL) and a few drops of DMF was added. Oxalyl chloride (370 L, 4.4 mmol) wasadded dropwise resulting in gas evolution. The mixture was stirred for 30 min. 3,3,3-Trifluoropropan-1-ol (460 mg, 4.0 mmol), DMAP (10 mg, 0.080 mmol) and NEt3 (1.1 mL, 8.0mmol) were dissolved in CH2Cl2 (2.0 mL) and the CH2Cl2 solution was added to the reactionmixture. The mixture was stirred at ambient temperature overnight. To the resulting mixture, H2Owas added and extracted with Et2O three times. Combined organic extracts were washed with 1MNaOH aq., 1M HCl aq. and brine and dried over MgSO4. Concentrated mixture was purified byflash column chromatography (hexane/EtOAc = 100/1 to 20/1) to give the title compound(colorless oil, 703 mg, 71percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Article; Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto; Bulletin of the Chemical Society of Japan; vol. 90; 3; (2017); p. 332 – 342;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 41790-30-1, name is (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol

To a solution of S5 (5.24 g, 32.3 mmol) in DCM (200 mL) at 0 C was added thionyl chloride (8.45 g, 71.1 mmol). The reaction mixture was stirred at r.t. for 24 h, then solvent was removed under reduced pressure. The residue was diluted with DCM (100 mL) and quenched with ice-water (100 mL). The organic phase was washed with sat. aq. NaHCO3, dried with Na2SO4 and concentrated to give 5-(chloromethyl)-1,2,3,4-tetrahydronaphthalene (S6) as a brown oil (3.25 g, 56%). 1H NMR (CDCl3) delta 7.16-7.05 (m, 3H), 4.59 (s, 2H), 2.86 (t, J = 6.3 Hz, 2H), 2.79 (t, J = 6.4 Hz, 2H), 1.88-1.77 (m, 4H). Found: [M+H]=181.6.

With the rapid development of chemical substances, we look forward to future research findings about 41790-30-1.

Reference:
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Blaser, Adrian; Conole, Daniel; Franzblau, Scott G.; Lotlikar, Manisha U.; Cooper, Christopher B.; Upton, Anna M.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1292 – 1307;,
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Related Products of 3597-91-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, molecular weight is 184.23, as common compound, the synthetic route is as follows.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

Statistics shows that 3597-91-9 is playing an increasingly important role. we look forward to future research findings about [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
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Adding a certain compound to certain chemical reactions, such as: 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, blongs to alcohols-buliding-blocks compound. name: 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

To a solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwood, 1.5 g, 5.8 [MMOL)] in THF (25 mL) was added lithium bis (trimethyl) amide (11.6 mL of a 1.0 M solution in THF). After stirring for 10 minutes, methyl [A-BROMOPHENYLACETATE] (1.3 g, 5.8 [MMOL)] was added. The reaction mixture was stirred at room temperature for 18 h. The mixture was diluted with ethyl acetate and washed with water and brine. The organic solution was dried [(MGS04)] and concentrated in vacuo. Purification by flash chromatography (4: 1 hexanes/EtOAc) gave the free base of the title compound. A solution of the free base in CH2CI2 (20 mL) was acidified with 4N HCI in dioxane. Hexane was added and the hydrochloride salt was collected by filtration and dried to give the title compound (50 mg, 2percent). 1H NMR (DMSO-d6) [8] 7.45 (d, 2H), 7.30 (m, 5H), 6.72 (d, 2H), 5.22 (s, [1 H),] 3.62 (s, 3H). MS (ES+) [M/Z 408 (MH+).]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Bromo-3,5-dimethoxybenzyl alcohol, blongs to alcohols-buliding-blocks compound. Safety of 4-Bromo-3,5-dimethoxybenzyl alcohol

To a mixture of 4-bromo-3,5-dimethoxybenzylalcohol (44.5 g), triethylammonium benzyl chloride (2.05 g) and 20percent aqueous sodium hydroxide solution (288 g) was added diethyl sulfate (41.7 g) under ice-cooling, and the mixture was stirred overnight at 25-30°C. After stirring for 1 hour at 70°C, the mixture was cooled and extracted with toluene. The toluene layer was washed with water and saturated aqueous NaCl solution and dried over magnesium sulfate. The solvent was removed in vacuo to yield 4-bromo-3,5-dimethoxybenzyl ethyl ether (49.5 g) as colorless oil. MS (m/z): 276 (M++2), 274 (M+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2003/72536; (2003); A1;,
Alcohol – Wikipedia,
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