Month: August 2021

Electric Literature of 27129-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27129-87-9, name is (3,5-Dimethylphenyl)methanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.

General procedure: A glass vial fitted with magnetic stirrer and a magnetic bar containing a reaction mixture of alcohol (0.1 mmol), NH4SCN (3 eq.), catalyst (5 mol%) and 2 ml of solvent. The vial was closed with rubber septum and O2 was bubbling for 15 minutes using needles. The reaction mixture was irradiated under a 23W CFL lamp for a certain time period. Reaction progress was monitored by TLC. After, completion of the reaction, a yellow solid was formed. The reaction mixture of three vials with the same content were combined and filter it through whatman filter paper. The mixture was evaporated under reduced pressure and purified by column chromatography using hexane/ethyl acetate as eluent. Further, the reaction mixture was run on a GC-MS instrument for characterisation. Yield, conversion and selectivity were calculated using following equations.

Statistics shows that 27129-87-9 is playing an increasingly important role. we look forward to future research findings about (3,5-Dimethylphenyl)methanol.

Reference:
Article; Sheriff Shah, Sk; Pradeep Singh; Tetrahedron Letters; vol. 59; 3; (2018); p. 247 – 251;,
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Synthetic Route of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.

A mixture of 2-(l-piperazinyl)- 5-pyrimidinecarboxylic acid, ethyl ester (0.016 mol),(2-phenylethenyl)- boronic acid (0.016 mol) and l,4-dioxane-2,5-diol (0.016 mol) inEtOH (250 ml) was stirred for 2 days at room temperature and then the solvent wasevaporated (vac.), The residue was taken up in DCM and water and the organic layerwas separated, dried (MgSO4), filtered and the solvent was evaporated. The residue waspurified by column chromatography over silica gel (15-40/xm) (eluent: DCM/MeOH97/1). The pure fractions were evaporated, yielding 4g (61%) of intermediate 1, meltingpoint 128C.Esters, corresponding to intermediate 1, can be separated by chiral chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23147-58-2, Glycerol aldehyde dimer, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/10749; (2006); A2;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 702-23-8, 2-(4-Methoxyphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(4-Methoxyphenyl)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-(4-Methoxyphenyl)ethanol

Production Example 7 Synthesis of 4-methoxyphenethyl bromide 4-Methoxyphenethyl alcohol (0.61 g) was treated as in Production Example 1 to give the title compound (0.838 g) as a pale yellow oil (yield: 97.4%). 1H-NMR (400 MHz, CDCl3): delta(ppm) 3.10(2H, t, J=7.6Hz), 3.53(2H, t, J=7.6Hz), 3.80(3H, s), 6.86(2H, d, J=8.2Hz), 7.13(2H, d, J=8.2Hz).

The synthetic route of 702-23-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; US2002/19531; (2002); A1;,
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Reference of 402-63-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.402-63-1, name is 1-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.

General procedure: In a round-bottom flask, a benzyl alcohol 2 (1.0 mmol), a sulfonamide1 (1.8 mmol) and BF3·OEt2 (151 muL, 1.2 mmol) were dissolved in CHCl3 (2.0 mL). The mixture was stirred for 2 h under reflux in air atmosphere, then the solvent was removed under reduced pressure using a rotary evaporator. The product was isolated by column chromatography of the residue on silica gel (EtOAc-PE, 1:10 to 1:2, v/v) to give the desired mono- and di-N-benzylated products 3 and 4.

The chemical industry reduces the impact on the environment during synthesis 402-63-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Pan, Jing; Li, Jia-Qiang; Huang, Ruo-Feng; Zhang, Xiao-Hui; Shen, Hang; Xiong, Yan; Zhu, Xiang-Ming; Synthesis; vol. 47; 8; (2015); p. 1101 – 1108;,
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Adding a certain compound to certain chemical reactions, such as: 454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-[3-(Trifluoromethyl)phenyl]ethanol, blongs to alcohols-buliding-blocks compound. Safety of 1-[3-(Trifluoromethyl)phenyl]ethanol

At room temperature, in a 50 ml round-bottom flask is sequentially added in 3 – trifluoromethyl -1 – phenethyl alcohol (0.19 g, 1 mmol), benzoic acid (0.183g, 1.5 mmol), NBS (0.356g, 2 mmol) and 1, 4 – dioxane (2 ml). In the 60 C stirring 1 hour, then adding DBU (0.304 g, 2 mmol), continue to reaction 4 hours (TLC detection reaction). Then, stopping the reaction, concentrated under reduced pressure, to obtain crude product. Finally petroleum ether and ethyl acetate mixed eluent flushing, rapid column chromatography (silica gel column) to obtain the corresponding product alpha – acyloxy ketone compound (white solid 0.170, yield 55%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Qufu Normal University; Wang, Hua; Wei, Wei; Zhu, Minghui; Cui, Huanhuan; (19 pag.)CN106518663; (2017); A;,
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Application of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 1 (1 eq) andtriethylamine in MeOH (10 ml) was cooled at 220C and treateddropwise with a solution of the corresponding acyl chloride (1.1 eq) intetrahydrofurane (THF) (5 ml). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was pouredinto brine and extracted with dichloromethane (3 10 ml). Thecombined organic phases were washed with brine, dried over MgSO4,and concentrated under reduced pressure. The residue was purified byflash column chromatography on silica gel using as eluent EtOAc/MeOH (10:1 to 7:1) to provide the corresponding N-acyl serinolderivatives.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Gomez de Cedron, Marta; Vargas, Teodoro; Madrona, Andres; Jimenez, Aranza; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Reglero, Guillermo; San-Felix, Ana; Ramirez de Molina, Ana; Journal of Pharmacology and Experimental Therapeutics; vol. 366; 2; (2018); p. 377 – 389;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13807-89-1, name is 2-((4-Methoxybenzyl)oxy)ethanol, molecular formula is C10H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-((4-Methoxybenzyl)oxy)ethanol

Dissolve 3.7ml of oxalyl chloride in dichloromethane (75ml) and control the temperature to -70 C.Dissolve dimethyl sulfoxide (6.4 ml) in dichloromethane (10 ml) and slowly dropwise.After completion of the dropwise addition, the reaction was performed for 1 hour.6 g (33.0 mmol) of 2- (4-methoxybenzyloxy) ethanol was dissolved in dichloromethane (5 ml) and slowly added. After two hours of reaction, triethylamine (12.5 ml) was slowly added dropwise.After 30 minutes of reaction, the temperature reduction device was removed and the temperature was raised to zero degrees.3N HCl was added slowly, extracted, and the organic layers were combined. With 1N HCl,Saturated sodium bicarbonate solution, washed with saturated brine, dried,The organic solvent was spin-dried to obtain 5 g of product.

With the rapid development of chemical substances, we look forward to future research findings about 13807-89-1.

Reference:
Patent; Nanjing Gurui Biological Technology Co., Ltd.; Mei Yan; (56 pag.)CN110734456; (2020); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.SDS of cas: 403-41-8

Dissolve 1-(4-fluorophenyl)ethanol (1.24 g, 8.85 mmol) in n-hexane (29.5 mL),CAL-B (195 mg), vinyl acetate (1.60 mL, 17.7 mmol) and triethylamine (0.0710 mL, 0.885 mmol) were added.The reaction mixture was stirred at room temperature for 12 hours. The mixture was filtered to remove impurities and reduced pressure to remove solvent. The mixture was purified by silica gel column chromatography (n-hexane / EtOAc = 8: 1, Rf = 0.25 (n-hexane / EtOAc = 4: 1)) and purified.(S)-1-(4-fluorophenyl)ethan-1-ol (574 mg, 46%) was obtained as a colorless oil (Formula 9)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Patent; ERICA Industry-University Cooperation Foundation of Hanyang University; Min Seon-jun; Kim Ju-hyeon; Chu Hyeon-a; Cho Yong-seo; Lee Jae-gyun; Bae Ae-nim; (23 pag.)KR2019/115976; (2019); A;,
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Synthetic Route of 112-27-6 , The common heterocyclic compound, 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 6-1 (235 g, 1.57 mol) was dissolved in 500 mL of tetrahydrofuran, then potassium hydroxide (41.2 g, 0.57 mmol, 82% w/w) was added, and then p-toluenesulfonyl chloride 6-2 (100 g, 0.52 mol) was added in batches, and the mixture was stirred at room temperature for 5 hours. The reaction solution was poured into 1200 mL of water, and extracted with ethyl acetate (400 mL*3). The extract liquid was combined and washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure and purified by silica gel column chromatography, with an eluent (petroleum ether:ethyl acetate=1:1), to obtain the target product 6-3 (118 g, 75%) as a colorless oil. LC-MS: m/z=305[M+H]+.

The synthetic route of 112-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen China Resources Gosun Pharmaceutical Co., Ltd.; Jiang, Xiongjie; Huang, Quanhua; Yang, Zhanao; (43 pag.)US2017/2028; (2017); A1;,
Alcohol – Wikipedia,
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Application of 946122-05-0, Adding some certain compound to certain chemical reactions, such as: 946122-05-0, name is (2-Amino-4-bromophenyl)methanol,molecular formula is C7H8BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 946122-05-0.

Step 3. A solution of (2-amino-4-bromo-phenyl)-methanol (1.53 g, 7.57 mmol) in pyridine (15 mL) was treated with 5-chloro-2-methoxybenzenesulfonyl chloride (1.85 g, 7.57 mmol) at room temperature and stirred for 72 h, then poured upon ice-cold 2 M aq. hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated to produce a gummy residue, from which the product was precipitated by addition of toluene. The precipitate was collected by filtration and dried to afford N-(5-bromo-2-hydroxy-methyl-phenyl)-5-chloro-2-methoxy-benzenesulfonamide (2.51 g, 82percent). Off-white solid, MS (ISP)=404.2 (M-H)-.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 946122-05-0, (2-Amino-4-bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ackermann, Jean; Bleicher, Konrad; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; Sander, Ulrike Obst; US2007/191603; (2007); A1;,
Alcohol – Wikipedia,
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