Month: July 2021

Synthetic Route of 5020-41-7, Adding some certain compound to certain chemical reactions, such as: 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5020-41-7.

Preparation B 2-(3-Methoxyphenyl)ethylbromide 114.1 g (750 mmol) of 2-(3-methoxyphenyl)ethanol was dissolved in 500 mL of benzene and cooled to 0 C. 35.5 mL (375 mmol) of PBr3 was slowly added to the stirring reaction and the reactin then heated to reflux under a nitrogen atmosphere for three hours. The reaction was quenched by the addition of water and the organic layer separated. The aqueous layer was washed twice with benzene and all the benzene extracts were combined. The benzene extract was washed twice with brine, dried with Na2 SO4, and evaporated to an oil. The oil was distilled and the fraction at 115-124 C. a 4 mm Hg was taken. This yielded 131.7 g of the title compound as a clear oil. PMR: Consistent with the proposed structure. MS: m/e=214, 216 (M) FD EA: Calc: C, 50.26; H, 5.16 Fd: C, 50.22; H, 5.02 C9 H11 BrO

According to the analysis of related databases, 5020-41-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US5952350; (1999); A;,
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Related Products of 2043-47-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. A new synthetic method of this compound is introduced below.

Example 5In a 200-ml, three-necked glass reactor were placed 80 ml of toluene, 10 g (38 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol, 5 g (69 mmol) of acrylic acid, 7 g (61 mmol) of methanesulfonic acid chloride and 0.1 g of a polymerization inhibitor, Sumilizer GM. While the reaction temperature was kept at 40 C. or lower, 15 g (149 mmol) of triethylamine was added dropwise. After the completion of the dropwise addition, stirring was conducted at room temperature for 1 hour. At this point, the conversion was 98% and the selectivity was 99%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, and friends who are interested can also refer to it.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32328-03-3, name is Diethyl 3-hydroxyglutarate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C9H16O5

Diethyl 3-hydroxy glutarate (6, 25g, 122.4 mmol) in TetaF (100 mL) was added dropwise to a IM solution OfLiAlH4 in THF (400 mL) at 0 0C under argon atmosphere with vigorous stirring. After addition, reaction mixture was allowed to reach r. t. (~4 h) and stirred for overnight. The reaction mixture was cooled to -78 0C (acetone/dry ice bath) and quenched by dropwise addition of saturated NH4Cl solution (50 rnL) giving white precipitate. The reaction mixture was diluted with another 500 mL of THF and white precipitate was filtered through Celite. The precipitate was treated with boiling THF (250 mL) and filtered. The combined organic solution was dried over anhydrous MgSO4 and solvent removed by rotoevaporation. The residue was purified on a silica gel flash column chromatography using DCM/EtOAc/methanol (6:3:1) affording triol 7 (11.4 g, 95.5 mmol, 78%) as a colorless oil. %). 1H-NMR (DMSO-d6, 400 MHz): deltal.39-1.54 (m, 4H, -CH2CH(OH)CH2-), 3.47 (t, J= 6.6, 4eta, 1 & 5 -CH2-), 3.61-3.68 (m, 1eta, -CH(HO)-) and 4.23 (bs, 3H, 1,3 & 5-OH).

With the rapid development of chemical substances, we look forward to future research findings about 32328-03-3.

Reference:
Patent; IDERA PHARMACEUTICALS, INC.; WO2008/73959; (2008); A2;,
Alcohol – Wikipedia,
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Reference of 145691-59-4 ,Some common heterocyclic compound, 145691-59-4, molecular formula is C7H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirring cloudy solution of 2.41 g (9.04 mmol) of (3,5-dibromophenyl)methanol in 40 mL of CH2Cl2 at r.t. was added 1.4 mL of Et3N and 62.7 mg of DMAP. The solution was cooled to 0 0C and 1.0 mL of MsCl was added, and the solution was gradually allowed to warm to r.t. After 24.5 h, the organic layer was washed with water (20 mL) and brine (15 mL), dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (5% EtOAc/hexanes) provided 1.88 g of l,3-dibromo-5- (chloromethyl)benzene as a yellow oil in 73 % yield and 476 mg of the mesylate (35% EtOAc/hexanes) as a pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 145691-59-4, (3,5-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7397-62-8, name is Butyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H12O3

a1 n-Butyl (t-butyl-dimethyl-silanyloxy)-acetate n-Butyl glycolate (231 g; 1.75 mol) and imidazole (345.1 g; 5.07 mol) are placed together at 0 C. The suspension obtained was treated portionwise with t-butyldimethylchlorosilane (303 g; 2.01 mol) during 1.5 hours. After 20 hours at room temperature the reaction mixture was diluted with ether/n-hexane 1:1 (1 l) and suction filtered. The crystals were rinsed thoroughly with ether/n-hexane 1:1 (200 ml). The filtrate was washed in succession with water (2*700 ml) and saturated aqueous sodium chloride solution (500 ml), dried over magnesium sulphate and concentrated. The oil obtained was distilled over a Vigreux column (7.5 cm). Yield: 405 g (94%) as a colourless oil (b.p. 78 C./0.98 mmHg). IR (film): 1760, 1225, 1206, 1148, 838, 780 cm-1 MS (EI): (M+H)+ 247

With the rapid development of chemical substances, we look forward to future research findings about 7397-62-8.

Reference:
Patent; Hoffmann-La Roche Inc.; US5464617; (1995); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 756520-66-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 756520-66-8

To a solution of A5 (219g, 1.05mol) in 1,2-dichloroethane (3500mL) was added Boc-D-Pro (141g, 0.65mol) followed by EDCI (163g, 0.85mol) and DMAP (21.57g, 0.18mol) at 0 C. The resulting mixture was stirred at r.t. overnight and then water (3500mL) was added and separated, the water phase was extracted withDCM(1500mLx3), dried over MgS04, concentrated and purified by column chromatography to (PE:EA=30:1) to give Bl (55.96g, yield: 51.1%)

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48259; (2012); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 889884-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 889884-94-0, name is 7-Fluoronaphthalen-2-ol, molecular formula is C10H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirred solution of naphthol 35 (100 mg, 0.57 mmol) and azido acetate 13 (300 mg, 1.15 mmol) and 4 A molecular sieves in methylene chloride (40 mL) was added tin(IV) chloride (3.5 mL,1Min DCM, 3.5 mmol) at -78 C. The reaction mixture was stirred at -78 C for 10 min and then the temperature was gradually increasedto -35 C and kept overnight. The reaction was quenched with saturated sodium sulfate and the mixture was extracted with methylene chloride. The organic phase was dried and concentrated and purified by flash column chromatography (using 20% EtOAc/hexanes as eluent) to obtain 39 (43 mg, 20%) as yellow semisolid.

According to the analysis of related databases, 889884-94-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Mitra, Prithiba; Mandal, Subhajit; Chakraborty, Soumen; Mal, Dipakranjan; Tetrahedron; vol. 71; 34; (2015); p. 5610 – 5619;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 109-83-1, 2-(Methylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 109-83-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: 109-83-1

EXAMPLE 207 2-N-methyl-benzyloxycarbonylaminoethanol To N-methyl ethanolamine (149 mmol) in methylene chloride (100 ml) at 0 C. was added benzyl chloroformate (70 mmol). The mixture was stirred at 0 C. for 30 min, then at room temperature for 1 h, poured into ethyl acetate, washed with 2M HCl, saturated NaHCO3 solution and then brine, then dried over Na2 SO4 and evaporated to provide the desired compound. NMR (CDCl3) 3.01 (s, 3H), 3.47 (m, 2H), 3.78 (m, 2H), 5.14 (s, 2H), 7.36 (m, 5H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; Abbott Laboratories; US5032577; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 34145-05-6 ,Some common heterocyclic compound, 34145-05-6, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 96-a (1.00 g, 5.65 mmol, 1.00 eq) and CDI (2.75 g, 16.95 mmol, 3.00 eq) was dissolved in tetrahydrofuran (20 mL), and stirred at 20C for 1 hour. Compound 7-a (1.78 g, 11.30 mmol, 1.74 mL, 2.00 eq) and triethylamine (1.72 g, 16.95 mmol, 2.35 mL, 3.00 eq) were then added to the above solution, and stirred at 80C for another 15 hours. After the reaction was completed, the reaction solution was added with 100 mL of water, and separated. The aqueous phase was further extracted with dichloromethane (200 mL 3 2). The organic phases were combined, and washed with saturated sodium hydrogen carbonate solution (150 mL) and saturated brine (100 mL). The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and separated by column chromatography (petroleum ether : ethyl acetate = 10:1?6:1) to give the product of compound 96-b (1.9 g, yield: 93%). 1HNMR (400MHz, CHLOROFORMd) delta= 7.38 (d, J=2.4Hz, 1H), 7.34-7.28 (m, 1H), 7.26-7.22 (m, 1H), 5.21 (br. s., 2H), 4.17 (q, J=7.2 Hz, 4H), 3.09-2.89 (m, 2H), 2.50 (s, 1H), 1.99-1.89 (m, 2H), 1.76-1.64 (m, 2H), 1.28 (t, J=7.1 Hz, 3H). LCMS m/z = 360.0 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 34145-05-6, (2,5-Dichlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; HE, Haiying; WU, Songliang; LUO, Zhi; MOU, Jianfeng; GUO, Fengying; WANG, Chuan; LI, Guoqing; ZENG, Minggao; CHEN, Shuhui; (199 pag.)EP3456711; (2019); A1;,
Alcohol – Wikipedia,
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Application of 53066-19-6, Adding some certain compound to certain chemical reactions, such as: 53066-19-6, name is 1-(2,6-Dichlorophenyl)ethanol,molecular formula is C8H8Cl2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53066-19-6.

A solution of 1- (2,6-dichlorophenyl) ethanol (9.0 g, 47.11 mmol)Of tetrahydrofuran (200 mL)The solution was cooled to 0 C,Sodium hydride (60% dispersion in mineral oil, 2.45 g, 61.24 mmol) was added thereto in portions.When no bubbles are generated,A solution of 3-fluoro-2-nitropyridine (6.69 g, 47.11 mmol)In tetrahydrofuran (50 mL).The reaction was stirred at room temperature overnight, cooled to 0 C,Water (10 mL) was quenched and concentrated under reduced pressure. The residue was diluted with water (200 mL) and extracted with ethyl acetate(150 mL x 3). The combined organic phases were washed successively with saturated sodium bicarbonate solution (200 mL), brine (200 mL), anhydrous sulfurSodium sulfate, filtered, and concentrated under reduced pressure,The title compound was

According to the analysis of related databases, 53066-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Ruyong; Wang Liang; (112 pag.)CN104016979; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts