Month: July 2021

Synthetic Route of 5339-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of Fmoc-Leu-OH, 2- (4-aminophenyl) ethanol, and EEDQ in 1: 1 toluene : ethanol is stirred at room temperature under nitrogen for 3 days. Additional 2- (4-AMINOPHENYL) ethanol, and EEDQ are added if the reaction is incomplete, and the reaction is stirred for another 24 hours. The solution is concentrated under reduced pressure, and the resulting residue is taken up in dichloromethane, and washed consecutively with 0.1 N HCI, saturated NAHG03, and saturated NACL. The organic solution is dried (MgS04) and concentrated, and the residue is purified by silica flash chromatography using a hexane: ethyl acetate mobile phase to give the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/23314; (2005); A1;,
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Electric Literature of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 3- (4-chlorophenyl) propanol (17.1 g, 0.1 mol) was addedTo DMF (170 ml)Slowly added at 0 C60% NaH (3 g, 0.1 mol),Stir for 30 minutes,Then joinN- (3-bromopropyl) piperidine (22.6 g, 0.11 mol) inDMF (30 mL).The mixture was stirred at 0 & lt; 0 & gt; C2 hours,And then reacted at 20 C for 8 hours.Then diluted with 400 ml of water,Extracted twice with 400 ml of ethyl acetate,Combine organic phase,Washed twice with 2N sodium hydroxide and brine,Dried over magnesium sulfate,filter,Room temperature into the HCl gas,Stir the solid,filter,dry,To obtain 30.7 g of a pale yellow solid product,Yield 92.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6282-88-8, its application will become more common.

Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
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Application of 1454-84-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1454-84-8, name is 1-Nonadecanol, molecular formula is C19H40O, molecular weight is 284.5203, as common compound, the synthetic route is as follows.

General procedure: Methyl 3-hydroxy-2-naphthoate (1mmol) in DMF was added to allyl bromide (1mmol) in the presence of NaH (55%), and stirred at 60 C for 1 day. The solvent was evaporated in vacuo, and the product was extracted with ether three times. The organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. After the alkaline hydrolysis, thionyl chloride was added to prepare the 2-allyloxy-3-naphthoeic acid chloride. Then, either alkyl alcohol or alkyl amine (1mmol; n = 18, 19) with triethylamine(1mmol) was reacted in THF to produce the S1-OCn or S1-NCn, respectively. The products were purified by silica gel column chromatography with CHCl3 as an eluent. The S1-OCn(S1-NCn) was heated at 160 C for 60 min under vacuum without any solvent, and following column chromatography resulted in the production of S2-OCn (S2-NCn).

Statistics shows that 1454-84-8 is playing an increasingly important role. we look forward to future research findings about 1-Nonadecanol.

Reference:
Article; Kikkawa, Yoshihiro; Ishitsuka, Manami; Omori, Kazuhiro; Kashiwada, Ayumi; Tsuzuki, Seiji; Hiratani, Kazuhisa; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 834 – 842;,
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Related Products of 3319-15-1 ,Some common heterocyclic compound, 3319-15-1, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of 1,3-dicarbonyl compound (2 mmol),alcohol or styrene derivatives (1 mmol), and 0.6 gSBNPSA, was added 2 cm3 nitromethane as solvent. Themixture was stirred under reflux conditions and the reactionwas followed by TLC. After completion, the mixture wasfiltered, and the remaining was washed with warm ethanolto separate catalyst and nitromethane was removed underreduced pressure. Then, the crude products were recrystallizedfrom mixture of dichloromethane and n-hexane.All the synthesized products were known and characterized by comparison of their spectral and physical data withthose reported in literature.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3319-15-1, 1-(4-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Karimzadeh, Morteza; Saberi Asl, Hamed; Hashemi, Hajar; Saberi, Dariush; Niknam, Khodabakhsh; Monatshefte fur Chemie; vol. 149; 12; (2018); p. 2237 – 2244;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 558-42-9, name is 1-Chloro-2-methyl-2-propanol. A new synthetic method of this compound is introduced below., name: 1-Chloro-2-methyl-2-propanol

Under an argon atmosphere, the compound 11 (41.7 mg, 0.10 mmol) was dissolved in DMF (2 mL), the solution was added with 1-chloro-2-methyl-2-propanol (103 muL, 1.0 mmol), potassium carbonate (207 mg, 1.5 mmol), and sodium iodide (249 mg, 1.5 mmol), and the mixture was stirred at 100°C for 12 hours. The reaction mixture was poured into distilled water, and the mixture was extracted three times with chloroform. The organic layers were combined, dried over anhydrous sodium sulfate, and then concentrated. Under an argon atmosphere, the obtained crude product was dissolved in dichloromethane (2 mL), the solution was added with a solution of boron tribromide in dichloromethane (1.0 mol/L, 0.5 mL, 0.50 mmol) under ice cooling, and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was added with 6 M aqueous ammonia (10 mL) under ice cooling, and the mixture was stirred at room temperature for 30 minutes, and extracted three times with chloroform. The organic layers were combined, dried over anhydrous sodium sulfate, and then concentrated. The obtained crude product was purified by preparative TLC to give the title compound 29 as white amorphous (29.7 mg, 63percent). [0191] The obtained compound 29 was treated with a 20percent solution of hydrogen chloride in methanol to give the hydrochloride of the compound 29. Compound 29 (free base) 1H NMR (CDCl3, 300MHz): delta 0.63-1.29 (m, 2.2H), 1.15 (s, 6H), 1.43-1.57 (m, 0.8H), 1.60-1.84 (m, 2H), 1.91-2.12 (m, 1H), 2.33-2.73 (m, 4H), 2.92-3.17 (m, 3H), 3.24-3.37 (m, 1H), 3.61 (dd, J=5.7, 12.6Hz, 0.8H), 3.78-3.92 (m, 1H), 4.18-4.29 (m, 0.4H), 4.86-5.00 (m, 1.6H), 5.03 (t, J=6.0Hz, 0.2H), 6.50 (d, J=2.4Hz, 0.2H), 6.60 (dd, J=2.7, 8.4Hz, 0.2H), 6.67 (dd, J=2.4, 8.1Hz, 0.8H), 6.72 (d, J=2.4Hz, 0.8H), 6.90 (d, J=8.1Hz, 0.2H), 6.91 (d, J=8.1Hz, 0.8H), 7.30-7.53 (m, 5H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; The Kitasato Institute; Nippon Chemiphar Co., Ltd.; NAGASE, Hiroshi; FUJII, Hideaki; NAKATA, Eriko; WATANABE, Yoshikazu; TAKAHASHI, Toshihiro; EP2774926; (2014); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7N3O

(2) The hydroxymethyl benzotriazole 7.4g added to a single-necked flask,Dropping 25ml SOCl2,After the dropwise addition and stirring 30min,80 reflux 3h;Excess amount of SOCl2 was distilled off by a rotary evaporator,Get white crystals,Namely chloromethyl benzotriazole;

With the rapid development of chemical substances, we look forward to future research findings about 28539-02-8.

Reference:
Patent; Henan Zhong Medical School; Wang Xia; Song Ning; Yuan Juan; Zhang Chao; Zhang Shuling; Yang Huaixia; (10 pag.)CN106188103; (2016); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.COA of Formula: C8H7F3O

Complex 2 (8.3 mg, 10 mmol), CsOHH2O (0.84 g, 5 mmol),alcohol (5 mmol) was added to a 25 mL schlenk tube and the solutionwas heated at 150 C (oil bath) for 24 h in an open systemunder argon. After cooling to room temperature, the degassedwater (5 mL)was added and the mixturewas extracted with diethylether (3 10 mL). A sample of ether phasewas subjected to the GCMSanalysis and the residual solution was evaporated, then subjected to the NMR analysis. The aqueous phase was acidifiedwith 6 M HCl and extracted with ethyl acetate (5 20 mL). Thecombined organic phasewaswashed with brine (25 mL), dried overanhydrous Na2SO4, and evaporated under reduced pressure, thepure carboxylic acid was collected and weighed for calculating theyield, which was further characterized by its 1H NMR which isconsist with the standard sample.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Dai, Zengjin; Luo, Qi; Meng, Xianggao; Li, Renjie; Zhang, Jing; Peng, Tianyou; Journal of Organometallic Chemistry; vol. 830; (2017); p. 11 – 18;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, the common compound, a new synthetic route is introduced below. Computed Properties of C8H8Cl2O

(viii) To sodium hydride (144 mmol, 4.32 g, 80% oil dispersion) in anhydrous ethylene glycol dimethyl ether (80 mL) was added a solution of 2,6-dichlorophenethyl alcohol (27.65 g, 144 mmol) in anhydrous ethylene glycol dimethyl ether (80 mL). The resulting mixture was stirred at room temperature under argon atmosphere for 4 hours.(ix) (1R,2R)/(1S,2S)-2-[1,4-Dioxa-7-azaspiro[4,4]non-7-yl]-1-(2,6-dichlorophenethoxy)cyclohexane: The mesylate (vi) in anhydrous ethylene glycol dimethyl ether (80 mL) was added quickly to the alkoxide mixture (viii) and the resulting mixture was readily refluxed for 66 hours. The cooled reaction mixture was poured into water (200 mL) and the organic solvent was evaporated in vacuo. The residual aqueous solution was diluted with more water to a volume of 700 mL, acidified to pH 0.5 with 6M HCI aqueous solution and extracted with diethyl ether (2 x 600 mL). The pH of the aqueous layer was adjusted to pH 5.9 and then the aqueous solution was extracted with diethyl ether (700 mL). The organic extract was dried over sodium sulfate and the solvent was evaporated in vacuo to yield 34.0 g of the title compound (70% yield).

The synthetic route of 30595-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nortran Pharmaceuticals Inc.; EP1087934; (2004); B1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, the common compound, a new synthetic route is introduced below. Safety of (2-(Trifluoromethyl)phenyl)methanol

(2) To a 250 mL four-neck round bottom flask (mechanically stirred,Thermometer, reflux condenser) was added 2-trifluoromethylbenzyl alcohol (88.1 g, 0.5 mol), Then heated to 10 ° C,A solution of thionyl chloride (71.4 g, 0.6 mol)After the dropwise addition, the temperature was raised to 60 ° C, and the reaction was allowed to proceed.Keep T ? 55 ~ 65 /P ? 0.09 MPa The remaining SOCl2 was distilled off under reduced pressure,And then distillation at 75-80 ° C / -0.09 MPa under reduced pressure to give colorless transparent liquid 2-trifluoromethylbenzyl chloride purity> 99percent yield 95percent.

The synthetic route of 346-06-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jin Kai (Liaoning) Chemical Co., Ltd.; Fu, Limin; Wang, Yongcan; Jia, Tiecheng; Yang, Xiaoge; Wang, Xiuying; Wu, Jingrui; (8 pag.)CN106588673; (2017); A;,
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Synthetic Route of 722-92-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: 28: 2-(4-(ethysulfonyl)phenyl)-A/-(2-fluoro-4-(1, 1,1,3, 3,3-hexafluoro-2-hydroxypropan-2- yl)phenyl)acetamide. To a solution of 2-(4-amino-3-fluorophenyl)-1 ,1 ,1 ,3,3,3-hexafluoropropan-2-ol, (111-12, 50 mg), 2-(4-(ethanesulfonyl)phenyl)acetic acid, IotaIota^ (41.7 mg) and DMAP (4.9 mg) in CH2CI2 (2 ml) was added drop wise at 0°C a solution of DCC (45,4 mg) in CH2CI2 (2 ml). After stirring for 17 hours at room temperature, the reaction mixture was filtered and the solvent was removed under reduced pressure. The residue was purified on S1O2 , using 20percent ethyl acetate in heptane as the eluent, to give the title compound 2^ (4-(ethvlsulfonyl)phenvl)-A/-(2-fluoro-4-(1 , , ,3,3.3-hexafluoro-2-hvdroxvpropan-2-yl) phenvDacetamide (62 mg) as a white solid. MS(ES+) m/z 488 [M+H]+. 1H NMR(500 MHz, DMSO-d6) : delta 10.30 (s, 1 H), 8.91 (s, 1 H), 8.1 1 (dd, 1 H), 7.86 (d, 2H), 7.62 (d, 2H), 7.46-7.52 (m, 2H), 3.94 (s, 2H), 3.28 (q, 2H), 1.1 1 (t, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; LEAD PHARMA CEL MODELS IP B.V.; CALS, Joseph Maria Gerardus Barbara; NABUURS, Sander Bernardus; WO2015/82533; (2015); A1;,
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