Month: July 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-69-8, name is 1,3-Dimethoxypropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 623-69-8

Synthesis of trans-N 1 -(1 ,3-dimethoxypropan-2-yl)cyclohexane-1 ,4-diamine (IntermediateStep 1 . To NaH (0.366 g, 9.16 mmol) in THF (12 mL) at 0 °C was added 1 ,3- dimethoxy-2-propanol (1 g, 8.32 mmol) in THF (8 mL) solution. The mixture was warmed to ambient temperature and stirred for 0.5 hour. To this was added tosyl chloride (1.587 g, 8.32 mmol) in one portion. The resulting white cloudy mixture then was stirred at ambient temperature for 16 hours. LC/MS showed complete conversion to 1 ,3- dimethoxypropan-2-yl 4-methylbenzenesulfonate. The reaction mixture was poured into water and extracted with EtOAc. The organic extracts were combined, washed with brine, dried with sodium sulfate and concentrated in vacuo to yield 2 g of a colorless oil. The crude mixture was purified by Analogix system (silica gel column 80 g, gradient: 0 min, 100percentn-heptane; 5-12 min, 20percent EtOAc in Heptane; 12-15 min. 30percent EtOAc in Heptane and hold until 30 min). The pure fractions were combined and concentrated in vacuo to yield 1.25 g of the tosylate product 1 ,3-dimethoxypropan-2-yl 4- methylbenzenesulfonate as a colorless oil, which solidified upon standing.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 623-69-8, 1,3-Dimethoxypropan-2-ol.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; LIN, Xiaodong; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; RENHOWE, Paul A.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/101066; (2012); A1;,
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Electric Literature of 702-98-7, Adding some certain compound to certain chemical reactions, such as: 702-98-7, name is 2-Methyladamantan-2-ol,molecular formula is C11H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-98-7.

To a stirred mixture of 2-methyl-2-adamantanol 14 (200 mg, 1.21 mmol), triethylamine(243 mg, 2.41 mmol) and acetic anhydride (246 mg, 2.41 mmol), 4-dimethylaminopyridine (DMAP) (18 mg, 0.12 mmol) was added as the acetylation catalyst. The mixture was stirred at room temperature for 72 h (TLC minitoring,hexane/ether 3:1). Petroleum ether was added and the mixture was washed withHCl 5%, saturated NaHCO3, brine and dried (Na2SO4). After solvent evaporation the residue was chromatographed on silica gel column using hexane-ether 4:1 as eluent to afford 150 mg (60 %) of pure acetyl derivative 20 (a second fraction including 2-methylene adamantane was obtained).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-98-7, 2-Methyladamantan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kolocouris, Antonios; Koch, Andreas; Kleinpeter, Erich; Stylianakis, Ioannis; Tetrahedron; vol. 71; 16; (2015); p. 2463 – 2481;,
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Application of 19064-18-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19064-18-7, name is (2,6-Difluorophenyl)methanol, molecular formula is C7H6F2O, molecular weight is 144.12, as common compound, the synthetic route is as follows.

4.86 g of potassium tert-butoxide (43.3 mmol, 3.0 eq.) were added to a solution of 2.71 g of (2,6-difluorophenyl)methanol [CAS No.: 19064-18-7] (18.8 mmol, 1.3 eq.) in 120 ml of 1,2-dimethoxyethane, and the mixture was stirred at RT for 60 min. 2.60 g of 2-amino-3-chloro-5-methylpyrazine hydrochloride [CAS No.: 89182-14-9] (14.4 mmol, 1.0 eq.) were then added, and the mixture was stirred at 80 C. overnight. After cooling to room temperature, saturated aqueous sodium bicarbonate solution was added and the aqueous phase was extracted three times with dichloromethane. The combined organic phases were washed with saturated aqueous sodium chloride solution, dried with magnesium sulfate, filtered and concentrated. The residue was purified by Biotage Isolera (340 g silica gel cartridge, cyclohexane/ethyl acetate gradient, 10%-72% ethyl acetate). This gave 1.77 g of the title compound (39% of theory, purity 85%). (0262) LC-MS (Method 2): Rt=0.94 min (0263) MS (ESpos): m/z=252 (M+H)+ (0264) 1H-NMR (400 MHz. DMSO-d6): delta [ppm]=2.20 (s, 3H), 5.35 (s, 2H), 5.88 (s, 2H), 7.09-7.23 (m, 2H), 7.37 (s, 1H), 7.46-7.57 (m, 1H).

Statistics shows that 19064-18-7 is playing an increasingly important role. we look forward to future research findings about (2,6-Difluorophenyl)methanol.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; VAKALOPOULOS, Alexandros; BROCKSCHNIEDER, Damian; WUNDER, Frank; STASCH, Johannes-Peter; MARQUARDT, Tobias; DIETZ, Lisa; LI, Min Jian Volkhart; (30 pag.)US2018/22751; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1777-82-8, name is (2,4-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, molecular weight is 177.03, as common compound, the synthetic route is as follows.Product Details of 1777-82-8

General procedure: In a 50ml Pyrex round-bottom flask, a mixture of alcohol (1mmol), TBATB (10-20mg, 0.02-0.04mmol) in 10ml of CH3CN was exposed to blue or violet light LED irradiation at room temperature under an air atmosphere with stirring. The progress of the photocatalytic oxidation reaction was monitored by TLC on silica gel plates. The reaction mixture externally irradiated until the alcohol was completely consumed.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1777-82-8, (2,4-Dichlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Mardani, Atefeh; Heshami, Marouf; Shariati, Yadollah; Kazemi, Foad; Abdollahi Kakroudi, Mazaher; Kaboudin, Babak; Journal of Photochemistry and Photobiology A: Chemistry; vol. 389; (2020);,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C6H12O3, molecular weight is 132.16, as common compound, the synthetic route is as follows.HPLC of Formula: C6H12O3

Example 2S nthesis of 2 , 2-dimethyl-3- (nitrooxy) propanoic acid HNO3 (2.4 mL, 54 mmol) was dissolved in AC2O (7.5 mL, 80 mmol) , cooled to 0C, and methyl 3-hydroxy-2 , 2-dimethylpropanoate (4 mL, 31 mmol) was added. The mixture was stirred for 1 hour, then poured into iced aHC03 (5%) and diluted with EtOAc. The organic phase was washed with brine, dried over Na2 S C>4 and concentrated affording methyl 2 , 2-dimethyl-3- (nitrooxy) propanoate as a clear oilThe residue was dissolved in NaOH (2.5 M, 20 mL) and MeOH (20 mL) and the solution was stirred at room temperature for 6 hours, and then acidified with HC1 (5%) to pH 3-4. The aqueous phase was extracted with EtOAc and the combined organic phases were washed with brine, dried over Na2 S C>4 and concentrated affording the title compound as a pale yellow solid (5.00 g, 98%)1H-NMR (CDCI3) : 4.53 (2H,s); 1.34 (6H,s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14002-80-3, Methyl 3-hydroxy-2,2-dimethylpropanoate, and friends who are interested can also refer to it.

Reference:
Patent; NICOX S.A.; ALMIRANTE, Nicoletta; IMPAGNATIELLO, Francesco; NICOTRA, Alessia; MANDELLI, Valentino; BRAMBILLA, stefania; WO2011/101245; (2011); A1;,
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Reference of 101597-25-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101597-25-5 as follows.

Step 6; To the product in toluene from Step 5, 1 )1 -bis{4~methoxypr¾enyl)prop-2-yn-1 -ol {0.8 g), a few crystals of p-toiuene sulfonic acid were added. After stirring for one hour at room temperature, all the solvent was. evaporated. The recovered product was purified by ComfaiFlash followed by re-crystailization. from diethyl ether. White crystals {0.95 g) were obtained as the product. NMR indicated that the product had a structure consistent with 3,3- bis(4-rrtethoxyphenyl)~l 0, 12-dibromo-6,7-dimethoxy-11 ,13, 13-trimethyl-3H,l 3H- indeno^’.^^jnaphthop ,2-b]pyran as represented by the following graphic formula.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; WO2012/82506; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, molecular weight is 151.6345, as common compound, the synthetic route is as follows.Recommanded Product: 5456-63-3

a) 5-Bromo-N-((ilS,R,2RlS,)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide5-Bromo-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (75.0 g, 0.25 mol) was dissolved in DMF (850 mL). To the solution was added TBTU (91.0 g, 0.275 mol), N,N-diisopropylethyl amine (214 mL, 1.25 mol) and (7SR,2RS)-2-amino-cyclohexanol hydrochloride (41.7 g, 0.275 mol). The reaction mixture was stirred for 1.5 h at room temperature. The solvent wasevaporated in vacuo, the residue was partitioned between ethyl acetate (2500 mL) and 1 N sodium hydroxide solution (2000 mL), the water phase was separated, extracted once more with ethyl acetate (1000 mL) and the organic phases were washed 2 times with water (2×1500 mL). Organic phases were pooled, dried with MgS04 and concentrated to about 900 mL. The product precipitated upon stirring and cooling to 0C. Filtration, washing with ethyl acetate/n-heptane (1: 1) and drying in vacuo gave the title compound (81.1 g) as a white solid; MS (ISP) 397, 399 (M)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5456-63-3, trans-2-Aminocyclohexanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ROEVER, Stephan; WRIGHT, Matthew; WO2011/29827; (2011); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 37729-18-3

Under nitrogen atmosphere, to a stirred solution of 2-(4-phenylphenyl)-ethanol (0.30 g,1.41 mmol) in dry CH2C12 (15 mL), DMAP (0.014 g, 0.11 mmol) and 2-DPC (0.37 g, 1.70mmol) were added. The reaction mixture was stirred at r.t. for 16h, then diluted with CH2C12 (15mL) and sequentially washed with sat. NH4C1 solution (15 mL) and sat. NaHCO3 solution (315 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness giving an oily residue (0.46 g), as a mixture (1:1.7 ratio) of 2-(4-phenylphenyl)-ethyl-2-pyridyl carbonate and 2-(4-phenylphenyl)-ethyl-2-oxopyridine- 1 -carboxylate. The mixture of isomers was not separated and used in the next step without any further purification. R = 2.63 mm. MS (ESI)m/z: 244 [M-H], 266 [M-Na]. MS (ESI) m/z: 242 EM-Hr.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PIOMELLI, Daniele; BANDIERA, Tiziano; BERTOZZI, Fabio; NUZZI, Andrea; FIASELLA, Annalisa; PONZANO, Stefano; PAGLIUCA, Chiara; REGGIANI, Angelo Mario; WO2014/144836; (2014); A2;,
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Related Products of 2854-16-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2854-16-2 as follows.

Example 19N-(2-{[(2-hydroxy-2-methylpropyl)amino]methyl}-1-methyl-1H-indol-5-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamideN-(2-Formyl-1-methyl-1H-indol-5-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide (300 mg) obtained in Reference Example 10 and 1-amino-2-methylpropan-2-ol (143 mg) were suspended in NMP (3.0 mL), acetic acid (1.0 mL) was added at room temperature, and the mixture was stirred at the same temperature for 3 hr.Sodium triacetoxyborohydride (336 mg) was added, the mixture was stirred at room temperature for 90 hr, and diluted with ethyl acetate, and 2N aqueous sodium hydroxide solution (20 mL) was added at room temperature.The mixture was poured into THF-water, and the organic layer was washed twice with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure.The obtained solid was suspended in ethyl acetate, and the precipitate was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (323 mg, yield 90percent) as a pale-brown solid.1H NMR (300 MHz, CDCl3) delta: 1.19 (6 H, s), 1.71 – 1.88 (1 H, m), 1.90 – 2.20 (3 H, m), 2.65 (2 H, s), 2.77 (1 H, br. s.), 3.78 (3 H, s), 3.80 – 3.90 (1 H, m), 3.90 – 4.01 (3 H, m), 4.04 (2 H, d, J=4.9 Hz), 4.31 (1 H, tt, J=7.0, 5.3 Hz), 6.38 (1 H, s), 7.01 (2 H, d, J=8.7 Hz), 7.24 – 7.29 (1 H, m), 7.30 – 7.36 (1 H, m), 7.75 (1 H, s), 7.86 (2 H, d, J=9.1 Hz), 7.88 (1 H, s).melting point: 188-190°Celemental analysis (C26H33N3O4)Calculated: C, 69.16; H, 7.37; N, 9.31.Found: C, 69.02; H, 7.47; N, 9.30.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2522657; (2012); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H14O4

20 mg of Au-Co composite particle load (0.1 mol%), 13.8 mg K2CO3 (10 mol%), 198.0 mg 3,4,5-trimethoxybenzyl alcohol (1 mmol), 4 mL of methanol was sequentially added to a pressure vessel with a 25 mL glass lining. After replacing the oxygen three times, the pressure was increased to 0.1 MPa, and the reaction was carried out at 80 C for 12 h, and cooled to room temperature. The gas is depressurized, the catalyst is filtered, the filtrate is concentrated by rotary evaporation, and the residue is subjected to column chromatography.White solid productMethyl 3,4,5-trimethoxybenzoate 169.5 mg,The yield was 78%.

With the rapid development of chemical substances, we look forward to future research findings about 3840-31-1.

Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Li Guosong; Lv Ying; (9 pag.)CN109824513; (2019); A;,
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