Month: November 2020

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1589-47-5, name is 2-Methoxypropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. 1589-47-5

The bottom product of example 3 was fed continuously to the middle of a glass column with a length of 3000 mm packed with 3 mm stainless steel coils at a feed rate of 55 [G/H.] Heating was adjusted to obtain 33 g/h distillate at a reflux ratio of 6,2. Simultaneously, 22 g/h of bottom product were removed from the distillation column. The obtained 1-methoxy-2-propanol is essentially free of water and only a trace of 2-methoxy-l-propanol was present.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1589-47-5, 2-Methoxypropan-1-ol.

Reference:
Patent; DEGUSSA AG; UHDE GMBH; WO2004/773; (2003); A1;,
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3973-18-0 ,Some common heterocyclic compound, 3973-18-0, molecular formula is C5H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 175 mL of dichloromethane, 1,2-bis(diphenylphosphino)ethane (1.73 g, 4.40 mmol), cobalt bromide (0.865 g, 4.00 mmol), and zinc iodide (4.2 g, 13.15 mmol) were dissolved, followed by stirring at 30 C. for 30 minutes. Then, 2-(propynyloxy)ethanol (8.94 g, 91.0 mmol) and butadiene (20% by weight toluene solution) (36.8 ml, 136.5 mmol) were added thereto, and then Bu4NBH4 (1.1 g, 4.3 mmol) was added. After stirring at 45 C. for 1 hour, the solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=5/1). Thus, 11.7 g of the title compound, an alcohol, was obtained as a colorless oily substance. Yield: 85.0%. [0149] 1H NMR (CDCl3, 300 MHz): delta 5.80-5.60 (m, 3H), 3.92 (s, 1H), 3.72 (t, 2H), 3.48 (t, 2H), 2.75-2.60 (m, 4H), 2.22 (brs, 1H)

According to the analysis of related databases, 3973-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; Touge, Taichiro; Hakamata, Tomohiko; Nara, Hideki; US2014/39220; (2014); A1;,
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440-60-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.440-60-8, name is (Perfluorophenyl)methanol, molecular formula is C7H3F5O, molecular weight is 198.09, as common compound, the synthetic route is as follows.

General procedure: Liquid-phaseoxidation of 1-phenylethanol was performed in glass flaskequipped with a magnetic stirrer, reflux condenser, andthermometer. In a typical experiment, a mixture of the1-phenylethanol (2mmol), toluene (10 mL), and the catalyst(0.3 g) was transferred in a glass three-necked roundbottomedflask (100 mL); the resulting mixture was thenheated to desired temperature with vigorous stirring. Theoxidation experiment was started by bubbling oxygen gas ata flow rate of 20 mL/min into the reaction mixture. After thereaction, the solid catalyst was filtered off by centrifugationand the liquid productswere analyzed by gas chromatographyto determine the conversion of the alcohol and productselectivity by GC, 7890A,Agilent Technologies Inc., equippedwith a flame ionization detector (FID) and a 19019S-001 HPPONAcolumn.

Statistics shows that 440-60-8 is playing an increasingly important role. we look forward to future research findings about (Perfluorophenyl)methanol.

Reference:
Article; Assal, Mohamed E.; Kuniyil, Mufsir; Shaik, Mohammed Rafi; Khan, Mujeeb; Al-Warthan, Abdulrahman; Siddiqui, Mohammed Rafiq H.; Adil, Syed Farooq; Journal of Chemistry; vol. 2017; (2017);,
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110-73-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below.

Compounds 1 and 2 were prepared by the following procedure: 2-(4-chloro-3-nitrophenyl)-2-oxoethyl 2-aminobenzoate or 2-(4-amino-3-nitrophenyl)-2-oxoethyl 2-aminobenzoate (44.8 mmol) was suspended in polyphosphoric acid (167.3 g). The reaction mixture was heated to 100 C and stirred for 90 min. The mixture was then poured into H2O/crushed ice (700 ml). The precipitated product was filtered, washed with H2O, dried and recrystallized from 2-methoxyethanol. Compounds 3-17 were prepared by the following general procedure: quinolinone 1 (200 mg, 0.63 mmol) was added to a solution of amine (6.3 mmol) and N-methylpyrrolidone (1.0 ml) and the mixture was stirred at 110 C for 2 h. After cooling to room temperature, H2O (20 ml) was added and the pH adjusted to 7 with dilute HCl (1:3). The precipitated solid was collected by suction, washed thoroughly with H2O and dried at 80 C. The crude product was recrystallized from 2-methoxyethanol.

Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.

Reference:
Article; Motyka, Kamil; Hlava?, Jan; Soural, Miroslav; Hradil, Pavel; Krej?i, Petr; Kvapil, Lubomir; Weiss, Milo?; Tetrahedron Letters; vol. 52; 6; (2011); p. 715 – 717;,
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The common heterocyclic compound, 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, molecular formula is C11H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 2050-25-1

Step 1. 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)acetonitrile. To a stirring solution of diethylene glycol benzyl ether (1.0 g, 5.1 mmol) in THF (10 mL) at 0 C, was added in small portions NaH (408 mg, 10.2 mmol), then the reaction mixture was warmed to rt and stirred for 30 mins. The reaction mixture was cooled to 0 C, and bromoacetonitrile (0.39 mL, 5.6 mmol) was added dropwise and stirred for 3h. The reaction was quenched with saturated ammonium chloride, and extracted with EtOAc (3 x 50 mL). The combined organic phase was washed with brine, dried over magnesium sulfate, filtered and concentrated. The crude residue was further purified by silica gel chromatography using 25% acetone/hexanes eluent to afford 2-(2-(2-(benzyloxy)ethoxy)ethoxy)acetonitrile as a colorless oil (437 mg, 37%): XH NMR (500MHz, CDC13) delta ppm 7.35 (d, J= 4.9 Hz, 4H), 7.27 – 7.32 (m, 1H), 4.57 (s, 2H), 4.33 (s, 2H), 3.76 – 3.80 (m, 2H), 3.67 – 3.74 (m, 4H), 3.62 – 3.66 (m, 2H).

The synthetic route of 2050-25-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORTHEASTERN UNIVERSITY; MALAMAS, Michael; MAKRIYANNIS, Alexandros; SUBRAMANIAN, Kumara Vadivel; WHITTEN, Kyle M.; ZVONOK, Nikolai M.; WEST, Jay Matthew; MCCORMACK, Michael; PAVLOPOULOS, Spiro; WO2015/179190; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound. 558-42-9

EXAMPLE 121 4-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-(2-hydroxy-2-methylpropyl)-N-methylthiophene-2-carboxamide (Compound 121) Step 1; 1-Chloro-2-methyl-2-propanol (103 muL, 1.00 mmol) was dissolved in a 40percent methylamine methanol solution (0.5 mL), and the mixture was stirred at 100¡ãC for 15 minutes at 100 W in a microwave-assisted chemical synthesis instrument (CEM Discover). After the mixture was left to cool to room temperature, the solvent was evaporated under reduced pressure. Then, acetonitrile (3 mL) was added to the residue, and the precipitated solid was removed by filtration. After an aqueous sodium hydrogen carbonate solution (10 drops) was added to the filtrate, the solvent was evaporated under reduced pressure to give a roughly purified product of 2-methyl-1-(methylamino)propan-2-ol. The roughly purified product was used in the subsequent step as such without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2090570; (2009); A1;,
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1777-82-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1777-82-8 as follows.

General procedure: To a mixture of alcohol (1mmol) and electrospun PVA/Fe2O3/MoSB nanocomposite (0.005g), 0.6mmol t-BuOOH (57muL) was added under solvent free conditions and the reaction mixture was stirred at 80C for 6h.

The chemical industry reduces the impact on the environment during synthesis 1777-82-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Noghi, Sedighe Abbaspour; Naeimi, Atena; Hamidian, Hooshang; Polymer; vol. 149; (2018); p. 229 – 237;,
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100-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below.

25 g of 4-cyano-4-(thiobenzylthio) pentanoic acid (89.6 mmol) were dissolved in 100 g of tetrahydrofurane anhydride. Under a nitrogen atmosphere, 15.726 g of 10-hydroxy benzotriazole (0.116 mol) were added thereto and stirred for 30 minutes. 22.72 g ethyldimethylaminocarboimide (0.116 mol) were added and stirred for 15 minutes, followed by the addition of 11.98 g of dimethylaminoethanol (0.134 mol) and stirring at room temperature for 6 hours. After completing the reaction, the resultant was extracted with water and diethyl ether and dried over magnesium sulfate. The organic solvent was vacuum distillated. It was purified with a column to obtain 21.95 g of 4-cyano-4-(thiobenzylthio)pentanoic dimethylamino ethyl ester (70% yield). 16.9 g of the obtained 4-cyano-4-(thiobenzylthio) pentanoic acid (48.4 mmol) were dissolved in 100 g of tetrahydrofurane anhydride. Under a nitrogen atmosphere, 8.496 g of 10-hydroxy benzotriazole (0.0629 mol) were added thereto, and stirred for 30 minutes. 12.26 g of ethyldimethylaminocarboimide (0.0629 mol) were added and stirred for 15 minutes, followed by addition of 11.47 g of diethylaminoethanol (0.0981 mol). The stirring was continued at room temperature for 12 hours. After completing the reaction, the resultant was extracted with water and diethyl ether, and dried over magnesium sulfate. The organic solvent was distillated in a vacuum, then purified with a column to obtain 12.8 g of 4-cyano-4-(thiobenzylthio)pentanoic diethylamino ethyl ester (70% yield). 12.7 g of the obtained 4-cyano-4-(thiobenzylthio) pentanoic acid (36.39 mmol) were dissolved in 60 g tetrahydrofurane anhydride. Under a nitrogen atmosphere, 6.36 g of 10-hydroxy benzotriazole (0.0473 mol) were added thereto and stirred for 30 minutes. 9.22 g of ethyldimethylaminocarboimide (0.0473 mol) were added and stirred for. 15 minutes, followed by the addition of 7.9 g of diisopropylene diamine (0.0546213 mol) and stirring at room temperature for an additional 12 hours. After completing the reaction, the resultant was extracted with water and diethyl ether, and dried over magnesium sulfate. The organic solvent was distillated under vacuum, and purified with a column to obtain 10.35 g of 4-cyano-4-(thiobenzylthio)pentanoic diisopropyl amino ethyl ester (70% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-37-8, 2-(Diethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kim, Hee-Jung; Kim, Dong-Ryul; US2004/138492; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.110-73-6

2-(ethyl(2-hydroxyethyl)amino)benzenesulfonamideTo the solution of 2-fluorobenzenesulfonamide (1051 mg, 6 mmol) in 2-(ethylamino)ethanol (2.93 mL, 30.0 mmol) was heated with microwave irradiation at 130 C for 30 min, heated again with microwave at 130 C for 30 min (71-1), heated again with microwave at 150 C for 30 min. To the reaction mixture was added DMSO (2 mL) and water (0.2 mL) then heated with microwave irradiation at 130 C for 2 h, heated again with microwave at 140 C for 1 h, heated again with microwave at 150 C for 1 h, heated again at 150 C for 5 h. The reaction mixture was diluted with H20 (30 mL), adjusted pH to ~5 with HCI (6 N then 1 N), extracted with EtOAc (3 x 30 mL). The organic layer was washed with brine (30 mL), dried over MgSO4, filtered, concentrated under reduced pressure, purified by silica gel chromatography, to afford the desired product 2-(ethyl(2-hydroxyethyl)amino)benzenesulfonamide (923.0 mg, 3.78 mmol, 63.0 % yield). LC-MS m/z 245 (M + H)+, 0.94 (ret. time).

Statistics shows that 110-73-6 is playing an increasingly important role. we look forward to future research findings about 2-(Ethylamino)ethanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; BOEHM, Jeffrey Charles; DAVIES, Thomas Glanmor; WOOLFORD, Alison Jo-anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; NORTON, David; SAXTY, Gordon; HEIGHTMAN, Thomas Daniel; LI, Tindy; KERNS, Jeffrey K.; DAVIS, Roderick S.; YAN, Hongxing; WO2015/92713; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.4654-39-1

Under ice cooling, Et3N (1.3 mL) and methanesulfonyl chloride (0.64 mL) were sequentially added to a solution of 2-(4-bromophenyl)ethanol (1.5 g) in CHCl3 (10 mL), followed by stirring at room temperature for 2 hours. Under ice cooling, water was added thereto, followed by extraction with CHCl3. The organic layer was filtered through a phase separator, and the filtrate was concentrated under reduced pressure. A mixture of the residue (light brown oil), 3-oxa-8-azabicyclo[3.2.1]octane (904 mg), 2,2,6,6-tetramethylpiperidine (2.0 mL), and MeCN (10 mL) was stirred at an outside temperature of 95 C. for 4 days. After cooling, water was added thereto, followed by extraction with CHCl3. The organic layer was filtered through a phase separator, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (SNAP Cartridge HP-Sil: 50 g, mobile phase: EtOAc/MeOH=99/1 to 90/10 (v/v)) to yield the title compound (1.47 g, light brown solid). MS (ESI pos.) m/z: 296, 298 ([M+H]+).

Statistics shows that 4654-39-1 is playing an increasingly important role. we look forward to future research findings about 2-(4-Bromophenyl)ethanol.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD; Kuwada, Takeshi; Yoshinaga, Mitsukane; Ishizaka, Tomoko; Wakasugi, Daisuke; Shirokawa, Shin-ichi; Hattori, Nobutaka; Shimazaki, Youichi; Miyakoshi, Naoki; US2013/197217; (2013); A1;,
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