Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 64372-62-9, 2-Chloro-5-(trifluoromethyl)benzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 64372-62-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 64372-62-9

General procedure: A 3 M K2CO3 solution is prepared by adding solid K2C03 (31 g, 0.22 mol) to water (100 mL). Cooling is applied to keep the solution at 20-25 C. (2-chloro-5-(trifluoromethyl)phenyl)methanol (Formula VI’, X = CI, Ri = CH2OH) (17.5 g, 84 mmol), and 4-fluoro-5-isopropyl-2-methoxyphenylboronic acid (MIPB) (18.1 g, 85 mmol) are added to the K2CO3 followed by all THF (100 mL) rinse. The solution is degassed by sparging with argon gas for 20 min. The catalyst, 1 , 1-bis(di-tertbutylphosphino)ferrocene palladium dichloride (300 mg, 0.55 mol%) is added. The organic layer turns dark brown immediately. The biphasic mixture is aged at 35-45 C with vigorous stirring for 32 hours. The mixture is cooled to r. t. and water (150 mL) is added, followed by petrol ether (150 mL) and the aqueous layer is removed. The organic layer was washed with water (2×200 mL) and filtered through silica gel and the solvent is removed under reduced pressure to yield brownish oil which is crystallized from heptane to give 4′-fluoro-5′-isopropyl-2′-methoxy-4-(tnfluoromethyl)biphenyl-2-yl)methanol as a pale white solid (28.5 g, 80%). mp 93.5-95.5 C; 1H NMR (CDC ) C 1 .24 (d, J = 6.9 Hz, 6H), 1.95 (t, J = 6.1 Hz, 1 H), 3.21 (sept., J = 6.9 Hz, 1 H), 3.73 (S, 3H), 4.49 (m, 2H), 6.68 (d, J = 12.0 Hz, 1 H), 6 99 (d, J = 8.6 Hz, 1 H), 7.30 (d, J = 7.9 Hz, 1 H), 7.59 (dd, J, = 8.0 Hz, J2 = 1 .3 Hz, 1 H), 7.86 (d, J = 0.7 Hz, 1 H). According to the same procedure in various scales and different concentrations of catalyst some other biaryl of Formula VII1 and Vll2 are prepared and listed in Table 1 and Table 2, respectively.

The synthetic route of 64372-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEK PHARMACEUTICALS D.D.; HUMLJAN, Jan; MARAS, Nenad; WO2013/91696; (2013); A1;,
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Synthetic Route of 25574-11-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 100. Synthesis of l-Broiotatio-4-(3-Bromo-Propyl)-Benzene (Intermediate50150[02981 To a solution of intermediate 49 (Example 99) (4.0 g, 19 mmol) in THF (30 mL)O at 0 C under the argon atmosphere was added PPh3 (6.3 g, 24 mmol) followed by CBr4 (8.0 g, 24 mmol). The mixture was stirred at the same temperature for 15 min and then stirred at room temperature for additional 15 h. Most of the solvent was removed and the residue purified by flash chromatography on silica gel (hexane) to afford the title compound (3.5 g, 66%) as a colorless oil.[0299] 1H NMR (500 MHz, DMSOd6): delta 2.03-2.12 (m, 2H), 2.68 (t, J= 7.5 Hz, 2H), 3.49 (t, J= 6.5 Hz, 2H), 7.19 (d, J= 8.3 Hz, 2H), 7.47 (d, J= 8.3 Hz, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 25574-11-2, 3-(4-Bromophenyl)propan-1-ol.

Reference:
Patent; TARGEGEN, INC.; WO2008/8234; (2008); A1;,
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Synthetic Route of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

In a 100 mL single-necked flask,1- (3-fluoro-2,6-dichlorophenyl) ethanol 2.71g (0.013mol),15 mL of 1,4-dioxane,Ice bath in the cooling,Controlled at 1-5 C,1.2 g of sodium hydride (60% 0.03 mol) was added,About 15min,2.43 g (0.01 mol) of 4-chloro-6-bromo-quinazoline was added,After about 1 h at room temperature, the reaction solution was poured into 100 mL of H2O,With 10% hydrochloric acid transferred to neutral,filter,50% ethanol wash,3.3 g of a white solid,Yield 80%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.

Reference:
Patent; Southern Medical University; Wan Shanhe; Wang Guangfa; Wu Xiaoyun; Tian Yuanxin; Ye Ling; Li Zhonghuang; Zhang Tingting; Zhu Zhengguang; Jin Hong; Zhang Jiajie; (27 pag.)CN106565684; (2017); A;,
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Synthetic Route of 2043-47-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. A new synthetic method of this compound is introduced below.

Example 6In a 100-ml, three-necked glass reactor were placed 50 ml of methylene chloride, 10 g (38 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol, 5 g (69 mmol) of acrylic acid, 7 g (40 mmol) of benzenesulfonic acid chloride and 0.1 g of a polymerization inhibitor, Sumilizer GM. While the reactor-inside temperature was kept at 40 C. or lower, 14 g (139 mmol) of N-methylmorpholine was added dropwise. At this point, the conversion was 95% and the selectivity was 99%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2043-47-2, its application will become more common.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5333-42-6, name is 2-octyldodecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C20H42O

Into a 250 ml glass reactor fitted with an Argon purge was placed the nonanoic acid (20.5 grams, 0.2 moles), 2-octyl-1-dodecanol (29.9 grams, 0.1 moles) and p-toluene sulfonic acid monohydrate (19 grams, 0.1 moles). The mixture above was purged with Argon at room temperature for one hour. The mixture was then heated to 100 C. under Argon purge for 18 hours. The mixture was then cooled to room temperature. The residue was then dissolved into 100 ml with ethyl acetate and placed into a separatory funnel. The ethyl acetate solution was extracted once with 100 ml of distilled water. The ethyl acetate layer was washed with 250 ml 10 wt % NaHCO3 aqueous solution followed by 250 ml saturated NaCl aqueous solution. The ethyl acetate solution was dried over MgSO4 and then filtered. The ethyl acetate was removed on the rotary evaporator from the solution. The residue from the rotary evaporator was placed on a Kugelrohr vacuum distillation apparatus where the ester was distilled. 1H NMR (CDCl3): delta4.01 (d, 2H, O-CH2-), 2.31 (d, 2H, O=C-CH2-), 1.63-1.33 (m, 45H, -CH2-), 0.88 (t, 9H, CH3). IR (cm-1): 2955, 2954, 2854, 1738, 1466, 1378, 1251, 1251, 1165, 1107, 722.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5333-42-6, 2-octyldodecan-1-ol.

Reference:
Patent; ExxonMobil Chemical Patents Inc.; Patil, Abhimanyu O.; Lewis, Kyle G.; Bodige, Satish; Zushma, Stephen; US2019/62663; (2019); A1;,
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Synthetic Route of 17701-61-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-hydroxybenzaldehyde (2.7 g), benzyl hydroxypivalate (4.7 g) and triphenylphosphine (6.4 g) in tetrahydrofuran (22 mL) was added diethyl azodicarboxylate (40% toluene solution, 11 mL), and the mixture was stirred at room temperature for 2 days. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate = 6/1 – 4/1) to give the title compound (0.97 g).1H-NMR (CDCl3) delta ppm: 1.36 (6H, s), 4.07 (2H, s), 5.15 (2H, s), 6.9-7.0 (2H, m), 7 . 2-7 . 35 (5H, m), 7.75-7.85 (2H, m), 9.89 (1H, s)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17701-61-0, Benzyl 3-hydroxy-2,2-dimethylpropanoate.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1544208; (2005); A1;,
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Synthetic Route of 186020-66-6 , The common heterocyclic compound, 186020-66-6, name is tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, molecular formula is C13H26O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert-butyl 3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy) propanoate (30.20 g, 108.5 mmol, 1.0 eq.) and TsCl (41.37 g, 217.0 mmol, 2.0 eq.) in anhydrous DCM (220 mL) at 0 C was added TEA (30.0 mL, 217.0 mmol, 2.0 eq.). The mixture was stirred at room temperature overnight, and then washed with water (3 × 300 mL) and brine (300 mL), dried over anhydrous Na2SO4, filtered, concentrated and purified by SiO2 column chromatography (3:1 hexanes/ EtOAc) to give a colorless oil (39.4 g, 84.0% yield). MS ESI m/z calcd for C20H33O8S [M + H]+ 433.1818, found 433.2838.

The synthetic route of 186020-66-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUZHOU M-CONJ BIOTECH CO., LTD.; HANGZHOU DAC BIOTECH CO, LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; GAI, Shun; ZHAO, Linyao; YE, Hangbo; GUO, Huihui; TONG, qianqian; CAO, Minjun; JIA, Junxiang; YANG, Chengyu; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; LIN, Chen; GUO, Zhixiang; YE, Zhicang; (246 pag.)WO2016/59622; (2016); A2;,
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Synthetic Route of 25574-11-2, Adding some certain compound to certain chemical reactions, such as: 25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol,molecular formula is C9H11BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25574-11-2.

Example A.4: Synthesis of 3-(4-bromophenyl)propanal (10*) Alcohol 4* (4.71g, 21.8mmol) was dissolved in DCM, treated with Dess-Martin periodinane (9.71g, 20.9mmol) and stirred at rt for 2h. The mixture was quenchedwith 2M NaOH, the phases were separated the aqueous layer extracted with DCM. The combined organic phases were dried on Mg504, filtered and evaporated in vacuo. The crude was purified by flash chromatography on silica gel using a gradient of DCM in cHex to yield the desired product 10* (4.46g, 96%) as a colourless liquid.1H NMR (400MHz, CDCI3) 6 9.81 (5, 1H), 7.41 (d, 2H), 7.07 (d, 2H), 2.91 (t, 2H),2.79-2.74 (m, 2H).MS (ES) C9H9BrO requires: 211/213, (Mi-H) not found, 100%.

According to the analysis of related databases, 25574-11-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LEAD DISCOVERY CENTER GMBH; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; WALDMANN, Herbert; DI LUCREZIA, Raffaella; NUSSBAUMER, Peter; KOCH, Uwe; MENNINGER, Sascha; CHOIDAS, Axel; KLEBL, Bert M.; WO2015/181272; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 329218-12-4, blongs to alcohols-buliding-blocks compound. Formula: C7H6BrClO

Example 12 4-Aminomethyl-cyclohexanecarboxylic acid {1-[3-(3-amino-1H-indazol-6-yl)-4-chloro-phenyl]-2-phenyl-ethyl}-amide 12A. 3-Bromo-4-chloro-benzaldehyde: To a cooled (0 C.), clear, colorless solution of 3-bromo-4-chlorobenzoic acid (1.0 g, 4.25 mmol) in THF (43 mL) was added dropwise a 1.0 M borane-THF complex (12.7 mL, 12.7 mmol). After 15 min, the reaction was warmed to rt and then to reflux. After 2 h, the reaction was cooled to rt, then to 0 C., and then quenched with MeOH (10 mL). The reaction was warmed to rt and after 15 min., the reaction was concentrated. The residue was dissolved in EtOAc and washed with 1.0 N HCl, sat. NaHCO3, brine, dried over Na2SO4, filtered and concentrated to give a clear, colorless liquid. The liquid was dissolved in CH2Cl2 (17 mL) and cooled to 0 C. Next Dess-Martin periodinane (2.16 g, 5.10 mmol) was added. The resulting cloudy pale orange suspension was stirred for 30 min. and then diluted with Et2O (50 mL). The reaction was filtered through a plug of silica gel and the filtrate was concentrated to give an off-white solid. Column chromatography on silica gel (gradient elution 0-25% EtOAc in Hex) gave 0.815 g (87%) of the aldehyde as a white solid. 1H NMR (400 MHz, CDCl3) delta: 9.94 (s, 1H), 8.13 (d, J=1.8 Hz, 1H), 7.77 (dd, J=8.1, 2.0 Hz, 1H), 7.63 (d, J=7.9 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,329218-12-4, its application will become more common.

Reference:
Patent; Corte, James R.; Quan, Mimi L.; Smallheer, Joanne M.; Pinto, Donald J.; US2006/154915; (2006); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3344-77-2, name is 12-Bromododecan-1-ol. A new synthetic method of this compound is introduced below., Safety of 12-Bromododecan-1-ol

Tetrahydro-2-(12-bromododecanoxy)-2H pyran To a solution of 12-bromo-1-dodecanol (1 mole) in dichloromethane containing pyridinium p-toluenesulfonate (P-TSA) is added dihydropyran (2 moles). The reaction mixture is stirred for 24 hours and then washed twice with water and dried over anhydrous MgSO4. The dichloromethane is removed under reduced pressure. If necessary the resulting product is purified by chromatography on silica gel. Coupling of polyethylene glycol to the terahydropyran derivative The tetrahydropyran derivative described above, dissolved in dry benzene, is added to a solution of polyethylene glycol (1 mole) in dry benzene containing NaH (1 mole).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3344-77-2, 12-Bromododecan-1-ol.

Reference:
Patent; Protein Delivery, Inc.; US6191105; (2001); B1;; ; Patent; Protein Delivery, Inc.; US5681811; (1997); A;,
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