Tag: M.W=200-300

Reference of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Compound 6 (100g, 0.41mol, 1eq), compound 8 (87g, 0.8eq) and Al2O3 (415g, 10eq) was put inside the reactor (connected with Dean-Stock device) containing toluene (3L). The reaction mixture was deoxygenized with the stream of nitrogen gas followed by refluxing the reaction mixture. On completion, the reaction mixture was cooled to room temperature, washed with NaOH solution and removed the toluene on rotary. After that solid product was mixed with ethyl acetate: water and organic layer was separated, removed excess solvent on rotary to afford 9 which was purified by column chromatography using hexane: ethyl acetate: toluene (5:1:1) solvent system. Fine yellow crystals of 9 were collected on mixing it with ethyl acetate [32-38]. 1H NMR (CDCl3, ppm): delta 3.09 (s, 6H), 3.76 (s, 6H), 3.9 (s, 3H), 6.09 (d, 1H), 6.79 (d, 4H), 7.05 (dd, 1H), 7.25 (d, 1H), 7.35 (d, 4H), 7.60 (dd, 2H), 7.95 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 101597-25-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kim, Moon-Hwan; Saleem, Muhammad; Seo, Ji-Su; Choi, Chang-Shik; Lee, Ki Hwan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 136; PC; (2015); p. 1291 – 1297;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H8BrNO

General procedure: A mixture of 2-aminobenzyl alcohol 1 (0.2 mmol), allylic alcohol 2(0.4 mmol), [IrCp*Cl2]2 (0.0020 mmol, 1.0 molpercent), and KOH (0.2 mmol) were dissolved in anhyd toluene (1 mL) in a 25-mL Schlenk tube. The system was flushed with N2 and allowed to react at the specified temperatureand for the specified time. The mixture was allowed to cool to r.t. and filtered through a short silica gel column (washed with EtOAc). Removal of the solvent left an oil that was separated by column chromatography (silica gel, EtOAc?hexane) to give the quinoline.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 20712-12-3, (2-Amino-5-bromophenyl)methanol.

Reference:
Article; Chen, Shu-Jie; Lu, Guo-Ping; Cai, Chun; Synthesis; vol. 47; 7; (2015); p. 976 – 984;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C20H40O

Example 75Synthesis of 1-O-(3,7,11,15-tetramethylhexadec-2-enyl)-D-glucoside 3.4 g (8.7 mmol) of 13-D-Glucose pentaacetate and 2.0 g (6.7 mmol) of phytol were dissolved in dry acetonitrile (7 mL). 1.70 mL (13.4 mmol) of boron trifluoride diethyl etherate complex was added to the solution with cooling on ice. The reaction mixture was allowed to warm up slowly to room temperature while being stirred for 18 hours before addition of 2.8 mL (20 mmol) of triethylamine at 0 C. The resulting solution was diluted with ethyl acetate, and washed with water, 1M hydrochloric acid, saturated sodium bicarbonate aqueous solution, and saturated brine, successively, and dried over sodium sulfate. After filtration, the filtrate was concentrated to obtain a crude product of 1-O-(3,7,11,15-tetramethylhexadec-2-enyl)-D-glucopyranoside tetraacetate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol.

Reference:
Patent; Chemgenesis Incorporated; US2012/264923; (2012); A1;,
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Electric Literature of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

11091] To a solution of 2-(4-aminophenyl)-1,1,1,3,3,3- hexafluoropropan-2-ol (2.50 g, 9.64 mmol) (preparation, for example, W. A. Sheppard, J Am. Chem. Soc. 1965, 87, 24 10-2420) in glacial acetic acid (40 ml) was added, at RT, N-chlorosuccinimide (2.71 g, 20.2 mmol). The mixture was stirred at 75° C. for 3 h and then at RT for 14 h. Subsequently, the mixture was added to water and extracted with EtOAc. The organic phase was washed with water and saturated aqueous NaHCO3 solution and dried over magnesium sulphate. Afier solvent had been removed, the residue was taken up in MTI3E and the solids were filtered off. The filtrate was concentrated under reduced pressure and the crude product was purified by means of column chromatography on 5i02 (n-hexane/EtOAc gradient). 2.89 g (91percent) of 2-(4-amino-3,5-dichlorphenyl)- 1,1,1 ,3,3,3-hexafluoropro- pan-2-ol were obtained.11092] HPLCMSa): log P=3.04, mass (m/z)=328 [M+H].11093] ?H NMR (400 MHz, d3-acetonitrile): oe=5.13 (br s, 2H), 6.02 (br s, 1H), 7.51 (s, 2H).

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; HALLENBACH, WERNER; SCHWARZ, HANS-GEORG; ILG, KERSTIN; GOERGENS, ULRICH; KOEBBERLING, JOHANNES; TURGERG, ANDREAS; BOEHNKE, NIELS; MAUE, MICHAEL; VELTEN, ROBERT; HARSCHNECK, TOBIAS; HAHN, JULIA JOHANNA; HORSTMANN, SEBASTIAN; (160 pag.)US2016/278379; (2016); A1;,
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Electric Literature of 19936-14-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 19936-14-2 as follows.

To a solution of 5.66 g of 1-(4-bromophenyl)-cyclobutanol (24.92 mmol, described in example S2-A) in 70 ml DCM were added 4.23 g of (diethylamino)sulfur trifluoride (95%, 24.92 mmol) at 0 C. The reaction mixture was stirred at 0 C. for 35 min, then sat. NaHCO3- solution was added and the resulting mixture was extracted with DCM. The combined organic extracts were washed with brine, dried (MgSO4), filtered, and concentrated in vacuo to give a residue which was purified by flash column chromatography (100% pentane) to give 1-bromo-4-(1-fluoro-cyclobutyl)-benzene (3.66 g, 64%) as a colorless liquid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19936-14-2, its application will become more common.

Reference:
Patent; Conte, Aurelia; Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe; US2007/185058; (2007); A1;,
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Reference of 2077-19-2, Adding some certain compound to certain chemical reactions, such as: 2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol,molecular formula is C9H11BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2077-19-2.

In a 250ml 2 necked round-bottom flask equipped with a condenser and under argon were dissolved 5.3g of N4,N4′-di(naphthalen-1 -yl)-N4,N4′- diphenylbiphenyl-4,4′-diamine (NPD) and 4.2g of 2(4-bromophenyl-2- propanol) in 65ml of dichloromethane. Then 3.15ml of BF3, Et.20 were added dropwise under stirring at room temperature. The reaction was monitored by thin layer chromatography (TLC). After completion, the reaction medium was filtered through a silica gel plug. The plug was rinsed by 25ml of dichloromethane. After removal of the solvent under reduced pressure crude product was recovered and purified by flash chromatography over silica gel using a mixture of 50/50 v/v hexane/dichloro methane as the eluent. 8.1 g of pure N4,N4′-bis(4-(2-(4- bromophenyl)propan-2-yl)phenyl)-N4,N4′-di(naphthalen-1 -yl)biphenyl-4,4′- diamine was obtained. Structure was confirmed by NMR.

According to the analysis of related databases, 2077-19-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SOLVAY SA; CAILLE, Jean, Raphael; MAUNOURY, Jonathan; WO2013/98175; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 83647-43-2, (3-Bromo-2-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9BrO, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9BrO

To a flask charged with (3-bromo-2- methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M TFA solution of Thallium Trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at rt overnight. Analysis by TLC showed no starting material remaining. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added Palladium(II) Chloride (529 mg, 2.98 mmol), Lithium Chloride (2.53 g, 59.7 mmol), Magnesium Oxide (2.41 g, 59.7 mmol), and MeOH (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a CELITE pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford title compound. 1H-NMR (500 MHz, CDCI3) delta ppm 7.71 (d, J= 8.0 Hz, 1H), 7.58 (d, J= 8.0 Hz, 1H), 5.25 (s, 2H), 2.37 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,83647-43-2, (3-Bromo-2-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DEJESUS, Reynalda, K.; FU, Qinghong; JIANG, Jinlong; TANG, Haifeng; (84 pag.)WO2016/122994; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20017-67-8, name is 3,3-Diphenyl-1-propanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portion wise with stirring to a solution of difluroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3, [3-DIPHENYL-1-] propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 [ML)] at [0-5 C.] The reaction mixture is allowed to warm up to r. t. , and stirred at r. t. overnight. Precipitated urea by-product is filtered off and washed with excesses of ethyl ether. Combined filtrates are removed under vacuum, and the title compound is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). [HPLC] Rt = 7.2. MS (m/z) : 291 [[M+H] +.]

The synthetic route of 20017-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/33449; (2004); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol, molecular formula is C7H8BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

Synthesis of 6-bromo-2-(3,5-dimethylphenyl)quinoline(2-Amino-5-bromophenyl)methanol (22 g, 109 mmol), 3,5-dimethylacetophenone (24.2 g, 163 mmol), RuCl2(PPh3)3 (1.05 g, 1.09 mmol), KOH (11.0 g, 196 mmol) were refluxed in 270 mL of toluene for 18 h.Water was collected from the reaction using a Dean-stark trap.The reaction mixture was allowed to cool to room temperature and filtered through a silica gel plug and eluted with 5percent ethyl acetate in hexanes.The product was further purified by Kugelrohr distillation and crystallization from methanol.

With the rapid development of chemical substances, we look forward to future research findings about 20712-12-3.

Reference:
Patent; Universal Display Corporation; US2012/217868; (2012); A1;,
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Electric Literature of 75476-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75476-86-7 as follows.

A mixture of 15A (11 g, 51.6 mmol) and Ph3P-HBr (17.7 g, 51.6 mmol) in benzene (35 ml_) was heated at 90 9C overnight. After cooling to RT, the solid was filtered and dried in vacuo. The solid was washed with Et2O and acetone, and then vacuum dried to afford 15B (18.9 g, 68%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; WO2008/100480; (2008); A1;,
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