Tag: M.W=200-300

Application of 5333-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5333-42-6, name is 2-octyldodecan-1-ol, molecular formula is C20H42O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 6 Preparation of 2-octyldodecyl pentanoate To a 3-neck 1000 ml round-bottomed flask was added 2-octyl-1-dodecanol (140.0 g, 468.92 mmol, 1.0 equiv.), n-pentanoic acid (71.838 g, 703.40 mmol, 1.50 equiv.), toluene (175 ml) and p-toluenesulfonic acid monohydrate (0.8920 g, 4.689 mmol, 0.010 equiv.) at room temperature. The resulting mixture was heated at reflux with stirring in an oil bath at 134 C. under a nitrogen atmosphere for 12 hours. The water produced in the reaction was collected in a Dean-Stark trap. The cooled mixture was diluted with hexanes, washed with dilute aqueous 10% Na2CO3 solution, water, brine, dried (MgSO4), filtered, and concentrated in vacuo to afford a crude product. Excess solvent was further removed by heating the crude product with stirring in an oil bath under high vacuum for 3 hours to afford a light yellow liquid (178.0 g, 99%).

According to the analysis of related databases, 5333-42-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ExxonMobil Research and Engineering Company; Ng, Man Kit; Oumar-Mahamat, Halou; Cheng, Hong; Blain, David A.; Cooper, Kathleen K.; Carey, James T.; Douglass, Michael R.; Kanga, Percy R.; Patil, Abhimanyu O.; Bodige, Satish; Lewis, Kyle G.; Hagemeister, Mark P.; (40 pag.)US2017/183595; (2017); A1;,
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Synthetic Route of 5208-93-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5208-93-5 as follows.

Analogously to example 11, vinylionol in DMF or NMP was reacted firstly with tBuOOH. The resulting reaction was then further reacted in accordance with the details in table 2 with a base to give the end product of the formula I (R?H). The yields are given in table 2:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5208-93-5, its application will become more common.

Reference:
Patent; BASF SE; Ernst, Hansgeorg; Puhl, Michael; Benson, Stefan; Siegel, Wolfgang; US2013/116473; (2013); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol, molecular formula is C7H8BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 20712-12-3

A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81percent), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199, found: 200, 202 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 20712-12-3.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Bifulco, Jr., Neil; DiPietro, Lucian V.; Miduturu, Chandrasekhar V.; (41 pag.)US9695165; (2017); B2;,
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Synthetic Route of 722-92-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: 28: 2-(4-(ethysulfonyl)phenyl)-A/-(2-fluoro-4-(1, 1,1,3, 3,3-hexafluoro-2-hydroxypropan-2- yl)phenyl)acetamide. To a solution of 2-(4-amino-3-fluorophenyl)-1 ,1 ,1 ,3,3,3-hexafluoropropan-2-ol, (111-12, 50 mg), 2-(4-(ethanesulfonyl)phenyl)acetic acid, IotaIota^ (41.7 mg) and DMAP (4.9 mg) in CH2CI2 (2 ml) was added drop wise at 0°C a solution of DCC (45,4 mg) in CH2CI2 (2 ml). After stirring for 17 hours at room temperature, the reaction mixture was filtered and the solvent was removed under reduced pressure. The residue was purified on S1O2 , using 20percent ethyl acetate in heptane as the eluent, to give the title compound 2^ (4-(ethvlsulfonyl)phenvl)-A/-(2-fluoro-4-(1 , , ,3,3.3-hexafluoro-2-hvdroxvpropan-2-yl) phenvDacetamide (62 mg) as a white solid. MS(ES+) m/z 488 [M+H]+. 1H NMR(500 MHz, DMSO-d6) : delta 10.30 (s, 1 H), 8.91 (s, 1 H), 8.1 1 (dd, 1 H), 7.86 (d, 2H), 7.62 (d, 2H), 7.46-7.52 (m, 2H), 3.94 (s, 2H), 3.28 (q, 2H), 1.1 1 (t, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; LEAD PHARMA CEL MODELS IP B.V.; CALS, Joseph Maria Gerardus Barbara; NABUURS, Sander Bernardus; WO2015/82533; (2015); A1;,
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Application of 1454-84-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1454-84-8, name is 1-Nonadecanol, molecular formula is C19H40O, molecular weight is 284.5203, as common compound, the synthetic route is as follows.

General procedure: Methyl 3-hydroxy-2-naphthoate (1mmol) in DMF was added to allyl bromide (1mmol) in the presence of NaH (55%), and stirred at 60 C for 1 day. The solvent was evaporated in vacuo, and the product was extracted with ether three times. The organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. After the alkaline hydrolysis, thionyl chloride was added to prepare the 2-allyloxy-3-naphthoeic acid chloride. Then, either alkyl alcohol or alkyl amine (1mmol; n = 18, 19) with triethylamine(1mmol) was reacted in THF to produce the S1-OCn or S1-NCn, respectively. The products were purified by silica gel column chromatography with CHCl3 as an eluent. The S1-OCn(S1-NCn) was heated at 160 C for 60 min under vacuum without any solvent, and following column chromatography resulted in the production of S2-OCn (S2-NCn).

Statistics shows that 1454-84-8 is playing an increasingly important role. we look forward to future research findings about 1-Nonadecanol.

Reference:
Article; Kikkawa, Yoshihiro; Ishitsuka, Manami; Omori, Kazuhiro; Kashiwada, Ayumi; Tsuzuki, Seiji; Hiratani, Kazuhisa; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 834 – 842;,
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Application of 55362-80-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55362-80-6, name is 9-Bromononan-1-ol, molecular formula is C9H19BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 9-Bromo- l-nonanol (1.50 g, 6.72 mmol) in acetone (27 ml) cooled at 0C, a satured solution of NaHCO3 (9 ml), NaBr (0.14 g, 1.34 mmol) and 2,2,6,6-Tetramethyl-l-piperidinyloxy-free radical (TEMPO) (0.10 g, 0.67 mmol) were added. Then Trichloroisocyanuric acid (3.1 g, 13.44 mmol) was added portionwise. The mixture was stirred 30 minutes at 0C and 3 hours at room temperature then was cooled at 0C and 2-Propanol (8 ml) was added slowly. The mixture was stirred at 0C for further 30 minutes then the white precipitate was filtered off and the mixture concentrated under reduced pressure. H20 (10 ml) and CH2C12 (10 ml) were added to the residue. The two phases were separated and the aqueous layer was extracted with CH2C12 (2 x 10 ml). The combined organic layers were dried on Na2SO4 and concentrated affording 1.60 g (Yield: 100%) of the title compound as a white solid. 1H NMR (300 MHz, DMSO) delta 3.49 (t, 2H), 2.23 – 2.08 (m, 2H), 1.84 – 1.68 (m, 2H), 1.57 – 1.14 (m, 10H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55362-80-6, 9-Bromononan-1-ol.

Reference:
Patent; NICOX S.A.; RONSIN, Gael; STORONI, Laura; BENEDINI, Francesca; WO2013/60673; (2013); A1;,
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Electric Literature of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kandil, Sahar; Westwell, Andrew D.; Mcguigan, Christopher; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2000 – 2004;,
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Electric Literature of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

2) 4.6 g of the product of step 1), 6 g of anhydrous potassium carbonate, 50 ml of acetone and 8.4 g of 1,3-dibromopropane were heated under reflux for 4 hours, and then cooled to room temperature and filtrated. The solvent was removed by rotation to give yellowish oil, which was passed through a column to give 5.6 g of white solid. Melting point: 72-74° C., yield: 80.1percent.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Patent; NHWA PHARMA CORPORATION; Zhang, Guisen; Chen, Yin; Xu, Xiangqing; Liu, Bifeng; Liu, Xin; Zhao, Song; Liu, Shicheng; Yu, Minquan; Zhang, Heng; Liu, Xinghua; US2014/113911; (2014); A1;,
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Reference of 2425-28-7 , The common heterocyclic compound, 2425-28-7, name is 2-Bromo-1-phenylethan-1-ol, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of the olefin (0.5-1.2mmol) in 10-16mL of acetonitrile-water (1:1) mixture was added NBS (1.05equiv) at rt. The reaction mixture was stirred until all the olefin was consumed, as monitored by TLC analysis. Subsequently, TetMe-IA (10mol%) and Oxone (1.0equiv) were introduced into the reaction mixture, and the stirring was continued. After completion of the oxidation as judged by TLC analysis, the reaction mixture was washed with saturated NaHCO3 solution. The organic matter was extracted 2-3 times with ethyl acetate or dichloromethane, and the combined organic extract was dried over anhyd Na2SO4. The solvent was removed in vacuo and the resultant residue was subjected to a short-pad silica gel column chromatography to isolate pure alpha-bromoketone.

The synthetic route of 2425-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chandra, Ajeet; Parida, Keshaba Nanda; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 73; 40; (2017); p. 5827 – 5832;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56456-51-0, name is 2-Chloro-4-(trifluoromethyl)benzyl alcohol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Chloro-4-(trifluoromethyl)benzyl alcohol

Reference Example 130 To a solution of 2-chloro-4-(trifluoromethyl)benzyl alcohol (2.23 g) and triphenylphosphine (4.17 g) in tetrahydrofuran (25 ml) was added carbon tetrabromide (5.27 g), and the mixture was stirred at room temperature for 2 hr. The reaction solution was concentrated, hexane and diethyl ether were added to the residue, and the insoluble substance was removed by filtration. The filtrate was concentrated, and the obtained residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (0:1 to 1:4, v/v) to give 2-chloro-4-(trifluoromethyl)benzyl bromide (2.90 g, yield 99%) as a colorless oil. 1H-NMR (300 MHz, CDCl3) delta:4.59 (2 H, s), 7.46 – 7.60 (2 H, m), 7.65 (1 H, s).

With the rapid development of chemical substances, we look forward to future research findings about 56456-51-0.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1829863; (2007); A1;,
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