Tag: M.W=200-300

Reference of 13826-35-2 ,Some common heterocyclic compound, 13826-35-2, molecular formula is C13H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a. 3-Phenoxybenzaldehyde Chromium trioxide (3.00 g.) was added to a stirred solution of pyridine (4.75 g.) in dry methalene chloride (75 ml.), and stirring was continued for a further 15 minutes. 3-Phenoxybenzyl alcohol (1 g.) in methylene chloride (5 ml.) was added, the mixture stirred for a further 15 minutes, decanted and the residue washed with diethyl ether (100 ml.). The filtrate was washed with 55 sodium hydroxide solution (3 * 50 ml), 2.5 NHCl (50 ml.) and 5% sodium carbonate solution (50 ml.) and dried over Na2 SO4 to give 3-phenoxy-benzaldehyde. Alternatively the alcohol can be oxidized using Jones’ reagent, a similar yield of aldehyde being obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; National Research Development Corporation; US4024163; (1977); A;,
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Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1)Synthesis of 5-bromo-2-fluoro-4-(hydroxymethyl)benzaldehydeTetramethylpiperidine (0.68 g, 4.87 mmol) was dissolved in tetrahydrofuran (4.5 mL).To the resultant solution was added n-butyllithium (1.0 M n-hexane solution, 4.88 mL) at 0¡ã C., and this solution was stirred for 15 minutes.The resultant mixture was cooled to -78¡ã C. and a solution of (2-bromo-5-fluorophenyl)methanol (0.50 g, 2.43 mmol) in tetrahydrofuran (2.5 mL) was added dropwise thereto.The temperature of the solution was raised over 2 hours to -40¡ã C.The solution was again cooled to -78¡ã C., and then dimethylformamide (0.47 mL, 6.07 mmol) was added thereto.The temperature of the solution was raised to room temperature, and the solution was stirred for 30 minutes.Saturated aqueous ammonium chloride was then added thereto, and the resultant mixture was extracted with ethyl acetate.The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (604.3 mg, quantitative).1H-NMR (CDCl3) delta: 4.78 (2H, s), 7.46 (1H, d, J=10.6 Hz), 8.01 (1H, d, J=6.2 Hz), 10.29 (1H, s).

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; US2011/275703; (2011); A1;,
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Electric Literature of 83647-43-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(3-Bromo-2-methylphenyl)methanol (24 g, 119 mmol) was dissolved in dichloromethane (240 mL) and manganese (IV) oxide (103 g, 1.2 mol) was added. After stirring overnight, TLC showed no starting material. Reaction mixture was evaporated with silica gel and loaded on a small silica gel column. The product was eluted with hexane:ethyl acetate (10:1) to afford the pure aldehyde 3-bromo-2-methylbenzaldehyde (18.6 g) after evaporation. 1H NMR (600 MHz, CDCl3): 10.25 (s, 1H), 7.78 (m, 2H), 7.23 (t, 1H, J=7.7Hz), 2.75 (s, 3H). 13C NMR (150 MHz, CDCl3): 191.84, 137.72, 130.93, 130.20, 127.61, 127.37, 126.82, 18.13.

According to the analysis of related databases, 83647-43-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; KURA ONCOLOGY, INC.; GREMBECKA, Jolanta; CIERPICKI, Tomasz; BORKIN, Dmitry; POLLOCK, Jonathan; MIAO, Hongzhi; SUN, Duxin; LI, Liansheng; WU, Tao; FENG, Jun; REN, Pingda; LIU, Yi; (317 pag.)WO2016/40330; (2016); A1;,
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Synthetic Route of 109240-30-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109240-30-4, name is 1-(4-Bromophenyl)cyclopropanol. A new synthetic method of this compound is introduced below.

General procedure: An argon-degassed solution of cyclopropanol 1 (2 equiv) in t-BuOH (0.0625 M) was added dropwise over 3 h to an argondegassed,stirred solution of acrylamide 4 (1 equiv) and manganese(III) acetylacetonate (2.2 equiv) in t-BuOH (0.114 M) at 26C. The resulting solution (0.03 M with respect to the cyclopropanol)was stirred for an additional 5 min before the solventwas removed under reduced pressure and the resulting residuepurified by flash chromatography to yield the desired oxindole.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109240-30-4, its application will become more common.

Reference:
Article; Davis, Dexter C.; Haskins, Christopher W.; Dai, Mingji; Synlett; vol. 28; 8; (2017); p. 913 – 918;,
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Application of 100751-63-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, the compound obtained in the second step to the reactor (T-3) was charged (23.6 g, 99.6 mmol) and methylene chloride (250ml). The solution was cooled to 0 , and Dess-Martin periodinane; was added in portions (DMP 42.2g, 99.6mmol) to 3 times. The mixture was stirred for a further 2 hours while returning to room temperature. The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (300 ml), then was subjected to filtration, the filtrate was extracted with ethyl acetate. The organic layers were washed with water, aqueous sodium sulfite, and washed sequentially with water and saturated brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure, the residue was purified by silica gel chromatography (eluent: toluene) to give the compound (T-4) (19.05g, 81.0mmol; 81%) was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100751-63-1, 6-Bromo-2-naphthylmethanol.

Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; GOTO, MAYUMI; TANAKA, HIROYUKI; (104 pag.)JP2016/37458; (2016); A;,
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Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

Similarly, the reaction of 4-nitrophthalonitrile (1.00 g, 5.78 mM) with 7-hydroxy-4-trifluoromethylcoumarin(1.33 g, 5.78 mM) was initiated in 30 mL of DMF in the presence of K2CO3 (2.30 g, 16.6 mM). The reaction mixture was heated with stirring at 90 ¡ãC under an inert nitrogen atmosphere for 24 h. Thereafter, the reaction mixture was cooled to room temperature, poured into 60 mL water, and extracted with CH3CN. The combined organic extracts were dried over sodium sulfate and filtered. The solvent was evaporated under reduced pressure and the remaining residue was added to 30percent HCl to induce precipitation. The precipitate was then repeatedly washed with water and added to hot methanol (MeOH), filtered, and dried under P2O5. Yield: 41percent; m.p. (¡ãC): 180.0?181.8; FT-IR (numax/cm?1): nu(C=O) 1729, nu(C?N) 2235, nu(C?O?C) 990, 1129; 1H NMR (ppm): 7.06 (s, 1H, H1), 7.99 (s, 1H, H2), 7.64 (d, 1H, J = 8.73 Hz, H3), 8.19 (d, 1H, J = 8.74 Hz, H4), 7.43 (s, 1H,H5), 7.28 (d, 1H, J = 8.80 Hz, H6), 7.80 (d, 1H, J = 9.01 Hz, H7); 13C NMR (ppm): 159.78, 158.74, 158.42, 156.01, 146.85, 137.01, 127.37, 124.64, 124.38, 123.44, 117.57, 117.21, 116.26, 116.11, 115.69, 110.82, 110.40, 109.04; UV?Vis [DMF, lambdamax (epsilon, M?1 cm?1)]: 443 nm (90), 318 nm (29875), 307 nm (33370). Molecular mass (m/z): Calcd: 356.25. Found: 379.03 [M + Na]+. Anal. Calcd for C18H7F3N2O3 (percent): C, 60.68; H, 1.98;N, 7.86. Found: C, 60.48; H, 2.30; N, 7.86.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chohan, Sumayya; Booysen, Irvin Noel; Mambanda, Allen; Akerman, Matthew Piers; Journal of Coordination Chemistry; vol. 68; 10; (2015); p. 1829 – 1846;,
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Related Products of 261723-32-4 ,Some common heterocyclic compound, 261723-32-4, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To an ice-cold solution of Compound II (500 mg) in THF (5.0 mL) were added sodium hydride (160 mg, 55% contents) and methyl iodide (608 muL), and the resulting mixture was stirred at room temperature overnight. To the reaction mixture was added water, and the mixture was concentrated under reduced pressure. The residue was diluted with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1) to give Compound III (426 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 261723-32-4, (3-Bromo-2-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAINIPPON SUMITOMO PHARMA CO., LTD.; US2012/225876; (2012); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

[91] A solution of diisopropylazodicarboxylate (DIAD, 0.52 mL, 2.8 mmol) prepared in 2 mL anhydrous THF) was slowly added to a stirred mixture of benzyl 3-hydroxy-2,2- dimethylpropanoate (590 mg, 2.8 mmol), triphenylphosphine (820 mg, 3.1 mmol) and N- hydroxyphthalimide (510 mg, 3.1 mmol) prepared in 20 mL anhydrous THF at 0 C. After stirring the mixture at room temperature under a nitrogen atmosphere for 24 h, THF was removed under reduced pressure and the residue re-dissolved in 40 mL of ethyl acetate. The ethyl acetate mixture was washed with water (10 mL) three times, brine and dry-loaded onto a 40-g silica column. The final product was obtained in 73% yield (730 mg) as a white solid after FCC purification (hexane/ethyl acetate). [92] NMR (CDCh, 400 MHz): 5 7.84 (m, 2H), 7.76 (s, 2H), 7.39 (m, 5H), 5.19 (s, 2H), 4.32 (s, 2H), 1.42 (s, 6H); 13C NMR (CDC13, 100 MHz): 5 175.0, 163.1, 136.0, 134.4, 129.0, 128.5, 128.1, 123.5, 83.6, 66.7, 43.2, 22.2, MS (ESI+): m/z (intensity), 354.4 ([M+H]+, 100%).

The synthetic route of 17701-61-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; HU, Longqin; ALOYSIUS, Herve; (59 pag.)WO2018/144880; (2018); A1;,
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Reference of 13362-52-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13362-52-2, name is Tridecane-1,13-diol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Under an atmosphere of N2, a 97% H3PO4 solution (8.7 equiv) was prepared by adding P2O5 (300 mg, 2.10 mmol, 1.4 equiv) to 85% H3PO4 (0.6 mL, 0.85 g H3PO4, 8.67 mmol, 5.8 equiv). To this solution was added KI (1.44 g, 8.70 mmol) and then 1,15-pentadecanediol (367 mg, 1.50 mmol, 1 equiv). The reaction mixture was stirred at ?115 C for 4 h, cooled to rt, diluted with Et2O (20 mL), and water (20 mL) was added. The organic layer was separated, and the aqueous phase extracted with an additional 50 mL of Et2O. The combined organic extracts were washed with brine (20 mL), washed with a concentrated aqueous solution of Na2S2O3 (10 mL), dried (Na2SO4), and then concentrated. High-vacuum drying gave 1,15-diiodopentadecane (683 mg, 1.47 mmol, 70%) as a white solid;

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13362-52-2, Tridecane-1,13-diol.

Reference:
Article; Vlahakis, Jason Z.; Mitu, Simona; Roman, Gheorghe; Rodriguez, E. Patricia; Crandall, Ian E.; Szarek, Walter A.; Bioorganic and Medicinal Chemistry; vol. 19; 21; (2011); p. 6525 – 6542;,
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Related Products of 756520-66-8 , The common heterocyclic compound, 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 1,3-dichloro-2-(1-bromoethyl)-4-fluorobenzene To a solution of triphenylphosphine (27.8 g, 0.106 mol) in CH2Cl2 (200 mL), liquid bromine (16.8 g, 0.105 mol) was added slowly under stirring at 0C. Upon completion of the addition, the resultant was stirred for 10 minutes, and then to which 1-(2,6-dichloro-3-fluorophenyl)ethanol (20.9 g, 0.10 mol) was added. Upon completion of the addition, the resultant was stirred for 30 minutes. The reaction was quenched with ethanol. and the reaction liquid was poured into saturated sodium bicarbonate solution, and extracted with CH2Cl2. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and purified by silica gel column chromatography to give 1,3-dichloro-2-(1-bromoethyl)-4-fluorobenzene (25.8 g, 95% yield). 1H-NMR (400 MHz, CDCl3): delta = 7.28 (m, 1H), 7.05 (t, 1H), 5.97 (q, 1H), 2.16 (d, 3H).

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co.,Ltd; Centaurus BioPharma Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XIAO, Dengming; XU, Xinhe; LIU, Xijie; HU, Yuandong; YU, Honghao; LIU, Zhihua; PENG, Yong; SUN, Yinghui; LUO, Hong; KONG, Fansheng; HAN, Yongxin; SUN, Jian; EP2952510; (2015); A1;,
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