Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 456-47-3, name is 3-Fluorobenzyl alcohol, the common compound, a new synthetic route is introduced below. name: 3-Fluorobenzyl alcohol

General procedure: A solution of benzyl alcohol (1 mmol), SCC (1 mol %), 70% TBHP (1 mmol or 3 mmol),and 4-methylpyridine (1.0 mmol) in H2O (2 mL) was stirred at 60 C (or 80 C) for 10 h (or 15 h).The reaction mixture was quenched with a saturated solution of sodium thiosulfate (5 mL) andextracted using dichloromethane (3 10 mL). The combined organic layers were dried over anhydrous Na2SO4, filtrated, and then the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel with petroleum ether/ethyl acetate as the eluent to obtain the desired product.

The synthetic route of 456-47-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Shi-juan; Zhang, Miao; Lu, Rong; Li, Xiu-ying; Che, Guang-bo; Molecules; vol. 23; 8; (2018);,
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Synthetic Route of 50438-75-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50438-75-0, name is 2-(4-(Dimethylamino)phenyl)ethanol, molecular formula is C10H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2- [4- (N,] N-dimethylaminophenyl] ethanol (2.05 g, 17.4 mmol), phthalimide (2.19 g, 14.9 mmol) and [PPH3] (3.93 g, 14.9 mmol) (Aldrich) are mixed in 100 mL of THF maintained at [0C.] The mixture is then treated with DIAD (2.68 mL) (Aldrich) which was added dropwise. After stirring overnight, the solvent is removed under reduced pressure to give a pale yellow solid. The solid is triturated with EtOAc three times. The combined EtOAc layers are treated with gaseous HC1 to precipitate the product, and the desired product is isolated through filtration.

According to the analysis of related databases, 50438-75-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELIAN PHARMACEUTICALS INC; WO2004/33436; (2004); A1;,
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Application of 33036-62-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33036-62-3, name is 4-Bromo-1-butanol. A new synthetic method of this compound is introduced below.

After dissolving 4-bromobutanol (5 g, 32.67 mmol) in DMSO (200 mul), the mixture was cooled to 0 C and SO 3 Py (26 g, 163.4 mmol) was added. DIPEA (45 mul, 261.365 mmol) And stirred for 3 hours. The reaction solution was diluted with EtOAc and washed with water. The organic solvent was dried over anhydrous MgSO4, filtered, concentrated by evaporation under reduced pressure, and the resulting residue was purified by silica gel chromatography (n-Hex / EtOAc = 4/1)4-Bromobutane (2.41 g, 49%) was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33036-62-3, 4-Bromo-1-butanol, and friends who are interested can also refer to it.

Reference:
Patent; Chungnam National University Foundation of Research & Business; International Medicine Co., Ltd.; Kim Eun-hui; Gu Tae-seong; Jang Gi-hong; Kim Yeong-hun; Lee Ju-hui; Park Chang-min; Oh Se-hwan; Bae Hyeon-ju; Kim Yeong-gwan; (72 pag.)KR2018/56603; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 62037-46-1, 1-Amino-3-chloropropan-2-ol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 62037-46-1, blongs to alcohols-buliding-blocks compound. Formula: C3H9Cl2NO

To a suspension of 1-amino-3-chloropropan-2-ol hydrochloride (175.2 mg, 1.2 mmol, 1.0 eq) and pyridine (0.49 mL, 6.0 mmol, 5.0 eq) in DCM (3 mL) at 0 C was added the crude acid chloride 16 from the above reaction. The reaction mixture was allowed to warm to 23 C over 2 h, and then stirred overnight at rt. The resultant mixture was partitioned between DCM (3 mL) and water (5 mL). The organic layer was washed with saturated NaHCO3 (aq, 5 mL) and brine (5 mL), dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The crude material was purified by column chromatography on silica gel, using a mobile phase gradient of 15 to 40% of EtOAc/hexanes to yield the acrylamide 17 (172.2 mg, 0.49 mmol, 41% from 15) as a white solid. 1H NMR (500 MHz, DMSO-d6) delta 7.44 – 7.39 (m, 4H), 7.37 (t, J= 5.6 Hz, 1H), 7.24 (d, J= 8.6 Hz, 2H), 7.21 – 7.17 (m, 2H), 6.99 (d, J= 8.7 Hz, 2H), 5.35 (d, J= 5.3 Hz, 1H), 3.83 – 3.74 (m, 1H), 3.58 (dd, J= 11.2, 4.4 Hz, 1H), 3.47 (dd, J= 11.2, 6.0 Hz, 1H), 3.34 – 3.28 (m, 1H), 3.19 (ddd, J = 13.4, 6.7, 5.6 Hz, 1H); 13C NMR (126 MHz, DMSO-d6) delta 167.32, 137.21, 135.65, 133.96, 132.78, 132.71, 131.30, 129.40, 129.07, 128.27, 128.23, 69.06, 47.88, 43.19; HRMS m/z calcd. for C18H18Cl2NO2 [M+H]+ 350.07091, found 350.06477.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62037-46-1, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS; RETTIG, Matthew; JUNG, Michael, E.; RALALAGE, D. Elshan Nakath, G.; AN, Jiabin; (162 pag.)WO2018/136792; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23147-58-2, name is Glycerol aldehyde dimer, molecular formula is C4H8O4, molecular weight is 120.1039, as common compound, the synthetic route is as follows.Application In Synthesis of Glycerol aldehyde dimer

Example 17 (S)-N-((S)-5-((6-Bromo-2-methoxynaphthalen-l-yl)methyl)-4-oxo-2′,3′,4,5,5′,6′- hexahydro-3H-spiro[benzo[b][l,4]oxazepine-2,4′-pyran]-3-yl)-2-(2- hydroxyethylamino)propanamide Sodium cyanoborohydride (5.14 mg, 81.8 muetaiotaomicron, Eq: 1.50) was added to a solution of (S)- N-((S)-5-((6-bromo-2-methoxynaphthalen-l-yl)methyl)-4-oxo-2′,3′,4,5,5′,6′-hexahydro-3H- spiro[benzo[b][l,4]oxazepine-2,4′-pyran]-3-yl)-2-amino-propanamide (31 mg, 54.5 mumol, Eq: 1.00), glycolaldehyde dimer (3.6 mg, 30.0 muetaiotaomicron, Eq: 0.55) and acetic acid (3.27 mg, 3.15 mu, 54.5 muetaiotaomicron, Eq: 1.00) in MeOH (1 mL) and the mixture was stirred at RT overnight. The mixture was diluted with 1 N HC1 and H20/1 N NaOH was added to adjust the pH to ~ 8 – 9. The mixture was extracted with EtOAc, the combined extracts were washed with brine, dried over Na2S04 and concentrated. The resulting material was purified by flash chromatography to afford the title compound (30 mg, 90 % yield). MS m/z 613.8 (MH+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DONNELL, Andrew F.; HAN, Xiaochun; KESTER, Robert Francis; KONG, Norman; LE, Kang; LOU, Yan; MICHOUD, Christophe; MOLITERNI, John Anthony; REMISZEWSKI, Stacy; RUPERT, Kenneth Carey; YUN, Weiya; WO2014/23708; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 111-46-6, 2,2′-Oxybis(ethan-1-ol), can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,2′-Oxybis(ethan-1-ol), blongs to alcohols-buliding-blocks compound. Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

A solution of diethylene glycol (5.01 g, 47.21 mmol), / olucncsulfonyl chloride (4.50 mg, 23.6 mmol) and triethylamine (8.55 mL, 61.37 mmol) in DCM (200 mL) was stirred at 25 C for 16 h. The reaction was added to FLO (30 mL) and extracted with DCM (2 x 50 mL). The organic layer was separated, dried with over Na2S04 and concentrated under vacuum. The residue was purified by silica gel chromatography (petroleum ether :EtO Ac 10:1 to 1 : 1) to afford 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate (2.95 g, 40%) as a light yellow oil; LC-MS 283.0 [M+Na]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-46-6, 2,2′-Oxybis(ethan-1-ol), and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BENZ, Joerg; GRETHER, Uwe; HORNSPERGER, Benoit; KOCER, Buelent; KUHN, Bernd; RICHTER, Hans; TSUCHIYA, Satoshi; BELL, Charles; WU, Xiang; YAN, Xiaofei; GOBBI, Luca; (188 pag.)WO2019/105915; (2019); A1;,
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Electric Literature of 22436-06-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection,Add to a 1L three-neck glass bottle54g of (±)-2-methyl-3-phenyl-1-propanol,64g of phthalic anhydride,1.38 g of pyridine,540 g of tetrahydrofuran.The reaction was stirred at 0 C – 20 C for 30 hours.Concentrated to give 122 g of crude material.After crystallization with ethyl acetate as a solvent,Obtained 103g of (±)-2-methyl-3-phenyl-1-propanol- phthalic acid monoester,The purity of the liquid chromatography is ?98%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22436-06-2, (S)-2-Methyl-3-phenylpropan-1-ol.

Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Diao Bozhen; Zhang Limeng; Kang Jie; (13 pag.)CN109534957; (2019); A;,
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Application of 22348-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22348-44-3, name is trans-4-(Methylamino)cyclohexanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 17 trans 1-(4-Hydroxy-cyclohexyl)-3-(4-methoxy-7-[1,4]dioxepan-6-yl-benzothiazol-2-yl)-1-methyl-urea Using 7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine, phenyl chloroformate and trans-4-methylamino-cyclohexanol, the title compound was prepared as off-white solid. MS: m/e=452(M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22348-44-3, trans-4-(Methylamino)cyclohexanol.

Reference:
Patent; Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger David; Riemer, Claus; US2004/235915; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6850-39-1, name is 3-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.17, as common compound, the synthetic route is as follows.Product Details of 6850-39-1

C. tert-butyl(3-Hydroxycyclohexyl)carbamate To a solution of 3-aminocyclohexanol (3.0 g, 26.0 mol) in THF (30 mL) was added di-tert-butyl dicarbonate (6.74 g, 31.2 mmol). The resulting mixture was stirred at 50 C. for 16 h. Then the reaction mixture was concentrated in vacuum and purified by silica gel column chromatography (30% ethyl acetate in petroleum ether) to afford the desired compound (4.40 g, 20.46 mmol, 78% yield). MS (ESI) m/z 216.1 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6850-39-1, 3-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Papa, Patrick; Cathers, Brian Edwin; CALABRESE, Andrew Antony; WHITEFIELD, Brandon Wade; BENNETT, Brydon; CASHION, Daniel; MORTENSEN, Deborah; HUANG, Dehua; TORRES, Eduardo; PARNES, Jason; SAPIENZA, John; HANSEN, Joshua; LEFTHERIS, Katerina; CORREA, Matthew; DELGADO, Maria Mercedes; RAHEJA, Neil; BAHMANYAR, Sami; HEGDE, Sayee; NORRIS, Stephen; PLANTEVIN-KRENITSKY, Veronique; US2015/175557; (2015); A1;,
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Application of 4720-29-0 ,Some common heterocyclic compound, 4720-29-0, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of N-benzylpropanolamine (3.3 g) and benzyl(S)-(+)-glycidyl ether (3.6 g) in ethanol (40 mL) was heated at 40 C. for 18 h. The solvent was evaporated under reduced pressure to give the subtitled compound as a colourless oil (6.8 g, 100%), which was used without further purification. 1H NMR (400 MHz, DMSO-d6): delta 7.29 (m, 10H), 4.54 (m, 1H), 4.45 (s, 2H), 4.36 (t, 2H), 3.76 (m, 1H), 3.44 (m, 5H), 2.47 (m, 4H), 1.57 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4720-29-0, 3-(Benzylamino)-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; LONN, Hans Roland; CONNOLLY, Stephen; SWALLOW, Steven; KARLSSON, Staffan PO; AURELL, Carl-Johan; PONTEN, John Fritiof; DOYLE, Kevin James; VAN DE POEL, Amanda Jane; JONES, Graham Peter; WATSON, David Wyn; MACRITCHIE, Jaqueline Anne; PALMER, Nicholas John; US2015/210655; (2015); A1;,
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