Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1074-61-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1074-61-9

Using a reaction scheme adapted from literature [32] , phosphorous tribromide (18.4 g, 6.4 mL, 68 mmol) dissolved in diethyl ether (10 mL) was added to alcohol 1 (5.9 g, 44.3 mmol) in Et2O (500 mL) at 0 C under N2. After 1 h, additional phosphorous tribromide (18.4 g, 6.4 mL, 68 mmol) was added. The reaction mixture was stirred for 1 h at room temperature and subsequently cooled to 0 C. Water (100 mL) was slowly added. The solution was extracted with Et2O, and the Et2O layer was washed with saturated NaHCO3, brine and dried over MgSO4. The crude product was purified by silica gel column chromatography using a hexane:EtOAc, (70:30) elutant system to obtain product vinyl benzyl bromide 2. 1H NMR (CDCl3, 500 MHz) delta: 4.48 (s, 2H), 5.26 (dd, J = 11.0, 1.0 Hz, 1H) 5.76 (dd, J = 17.6, 1.0 Hz, 1H) 6.69-6.75 (dd, J = 17.6, 11.0 Hz, 1H), 7.32 (d, J = 8.0 Hz, 2H) 7.41 (d, J = 8.0 Hz, 2H). UV-Vis [chloroform, lambdamax(epsilon)]: 215 nm, 260 nm.

The synthetic route of 1074-61-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Balami, Uddhav; Taylor, Darlene K.; Reactive and functional polymers; vol. 81; 1; (2014); p. 54 – 60;,
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Synthetic Route of 6966-10-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6966-10-5, name is (3,4-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: General procedure for the synthesis of phenanthridines 3: To a 25 mL tube containing a magnetic stir bar, was added 2-isocyanobiphenl 1 (0.2mmol, 1.0 equiv), Fe(acac)2 (20% mmol, 25.4mg), 4 AMS (100mg), TBHP (5.5M in nonane, 0.15ml, 0.8mmol, 4.0 equiv), benzyl alcohol 2 (0.8mmol, 4.0 equiv), and MeCN (2ml). The resulting mixture was heated under O2 at 100C for 24h. The solvent was removed under vacuum, and the residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=1:10) to provide the desired products 3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6966-10-5, (3,4-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Nie, Ziyi; Ding, Qiuping; Peng, Yiyuan; Tetrahedron; vol. 72; 50; (2016); p. 8350 – 8357;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4415-73-0, name is 1,1-Cyclobutanedimethanol, the common compound, a new synthetic route is introduced below. Formula: C6H12O2

B. Preparation of cis-1, 2-bis-(bromomethyl) cyclobutane (XXI) To 44 g of phosphorous tribromide (-10 C.) was added dropwise 10.7 g of distilled XX over a 1 hour period. The reaction mixture was warmed to 25 C. and stirred for 2 hours, then heated to 80-85 C. for 18 hours. The reaction mixture was cooled in ice and cold water added. The layers were separated and the aqueous layer was extracted with methylene chloride. The organic extracts were combined, washed with 5% aqueous sodium carbonate and water, then distilled to yield 13.8 g of the title compound XXI as a purple oil, bp 86 (vacuum pump): ir (CHCl3) 3.4, 7.0-8.1mu (no OH signal observed); nmr delta 1.3-2.5 (m, 4), 2.8 (m, 2), and 3.5 (m, 2).

The synthetic route of 4415-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Miles Laboratories, Inc.; US4206127; (1980); A;,
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Application of 13330-96-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Tetramethylazodicarboxamide (0.4 mmol) was added to an ice-cooled solution of phenol (24, 0.2 mmol), alcohol (0.3 mmol) and tributylphosphine (0.4 mmol) in anhydrous benzene (1 mL). The reaction mixture was then heated at 90 C for 12 hours. The reaction mixture was concentrated and the residue was purified by column chromatography (SiO2, Methanol: DCM, 2:98) to afford a white amorphous solid (56%). The product was dissolved in MeOH/THF (1:1) and palladium on carbon (10% w/w, 20 mg) was added to the solution under inert atmosphere. The resulting mixture was then stirred under hydrogen atmosphere overnight. The reaction mixture was filtrated through celite and concentrated to get phenol (~100%). Diisopropylazodicarboxylate (0.2 mmol) was added to an ice-cooled solution of phenol (0.1 mmol), N-methyl-4-hydroxy-piperidine (0.15 mmol) and triphenylphosphine (0.2 mmol) in anhydrous THF (1 mL) and resulting solution was then allowed to stir at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by prep-TLC (SiO2, Methanol:DCM:NH4OH, 1:10:0.1) to afford a white amorphous solid (30%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13330-96-6, 4-(Dimethylamino)butan-1-ol.

Reference:
Article; Garg, Gaurav; Zhao, Huiping; Blagg, Brian S.J.; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. S1 – S58;,
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Application of 100-37-8, Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol,molecular formula is C6H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8.

(2R,6S)-tert-Butyl 4-(7-bromo-6-chloro-2-(2-(diethylamino)ethoxy)-8-fluoroquinazolin-4-yl)-2,6-dimethylpiperazine-1-carboxylate To a stirred solution of 2-(diethylamino)ethanol (276 mg, 2.36 mmol) in DMF (20 mL) at RT, NaH (94 mg, 2.36 mmol) was added and the resulting mixture was stirred for 30 min. (2R,6S)-tert-butyl 4-(7-bromo-2,6-dichloro-8-fluoroquinazolin-4-yl)-2,6-dimethylpiperazine-1-carboxylate (600 mg, 1.18 mmol) was added to the reaction mixture and stirred at RT for 2 h. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (MeOH/dichloromethane=40:1) to afford the desired product (140 mg, 20% yield) as a solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-37-8, 2-(Diethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Araxes Pharma LLC; Liu, Yi; Li, Liansheng; Ren, Pingda; (176 pag.)US2018/15087; (2018); A1;,
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Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

DIPEA (0.061 mL, 0.348 mmol) and l-chloro-2-methylpropan-2-ol (0.018 mL, 0.174 mmol) were added to (S)-l-(6-methoxy-5-methylpyridin-3-yl)-3-(piperidin-3-ylmethoxy)-4,5,7,8- tetrahydro-lH-oxepino[4,5-c]pyrazole (48 mg, 0.116 mmol) in EtOH (1 mL). The reaction mixture was heated to 90 °C for 1 h in a microwave. l-Chloro-2-methylpropan-2-ol (0.018 mL, 0.174 mmol) was added to the reaction mixture which was heated in a microwave for a further 2 h at 90 °C. 1-Chloro- 2-methylpropan-2-ol (0.018 mL, 0.174 mmol) was added to the reaction mixture which was heated in a microwave for a further 5 h. The reaction mixture was concentrated under a stream of nitrogen and purified using MDAP (Method A) to give the title compound (44.5 mg, 86percent). LCMS (Method C) : Rt = 1.31 min, MH+ = 445. 1H NMR (400 MHz, CDCb) delta ppm 7.92 (d, 2=2 Hz, 1H), 7.46 – 7.40 (m, 1H), 4.17 (dd, J=10, 3 Hz, 1H), 4.06 (dd, J=10, 6 Hz, 1H), 3.98 (s, 3H), 3.85 (t, J=5 Hz, 2H), 3.79 (t, J=5 Hz, 2H), 3.70-3.19 (m, 2H), 2.91 – 2.71 (m, 4H), 2.72-2.44 (m, 5H), 2.22 (s, 3H), 1.97 – 1.76 (m, 3H), 1.41 – 1.20 (m, 7H)

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BAXTER, Andrew; BERTRAND, Sophie Marie; CAMPBELL, Matthew; DOWN, Kenneth David; HAFFNER, Curt Dale; HAMBLIN, Julie Nicole; HENLEY, Zoe Alicia; MILLER, William Henry; TALBOT, Eric Philippe Andre; TAYLOR, Jonathan Andrew; (325 pag.)WO2018/192864; (2018); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1467-84-1

REFERENCE SYNTHETIC EXAMPLE 19 4-{[trans-4-(Hydroxymethyl)cyclohexyl]amino}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide To a solution of 4-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (680 mg, 2.09 mol) obtained in Reference Synthetic Example 7 in N,N-dimethylacetamide (1.1 mL), N,N-diisopropylethylamine (1.1 mL) and (trans-4-aminocyclohexyl)methanol (945 mg, 7.31 mmol) obtained in Reference Synthetic Example 12 were added, and the mixture was stirred at 130C for 3 hours. The reaction mixture was allowed to cool to room temperature, mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=5/1) (v/v)) to obtain the title compound as a white solid (781 mg, yield: 89%).

With the rapid development of chemical substances, we look forward to future research findings about 1467-84-1.

Reference:
Patent; Nissan Chemical Industries, Ltd.; TAKAHASHI, Keiji; WATANABE, Tsuneo; HAYASHI, Keishi; KURIHARA, Kazunori; NAKAMURA, Takanori; YAMAMOTO, Akio; NISHIMURA, Takuya; KAMIYAMA, Toshihiko; HIDAKA, Yuuki; EP2955181; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 702-98-7, 2-Methyladamantan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C11H18O, blongs to alcohols-buliding-blocks compound. Formula: C11H18O

A reactor made of glass was charged with 110 g of toluene, 50 g of n-undecane, 80 g of 2-methyladamantanol, 4.1 g of methacrylic acid and 0.92 g of p-toluenesulfonic monohydrate. The resulting mixture was heated until the reflux of toluene occurred, followed by reflux for 2 hours while distilling off water, whereby 2-methyleneadamantane was prepared it was then cooled to 0 C. A methacrylate forming reaction was carried out by adding 103.6 g of methacrylic acid and 13.7 g of boron trifluoride ethyl ether to it and stirring the resulting mixture for 2 hours. The reaction mixture was washed with 1275.5 g of a 10% aqueous sodium carbonate solution, followed by washing three times with 160 g of deionized water. Toluene was then distilled off at 70 C. under reduced pressure, whereby 148.8 g of crude 2-methyladamantan-2-yl methacrylate was obtained. The resulting product contained 59.9 wt. % of 2-methyladamantan-2-yl methacrylate and 7.6 wt. % of 2-methyleneadamantane.

The synthetic route of 702-98-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Chemical Corporation; US2008/51597; (2008); A1;,
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Related Products of 558-42-9, Adding some certain compound to certain chemical reactions, such as: 558-42-9, name is 1-Chloro-2-methyl-2-propanol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 558-42-9.

5 g (40.94 mmol) of 4-hydroxybenzaldehyde were initially charged in 50 ml of DMF. 4.45 g (40.94 mmol) of 1-chloro-2-methylpropan-2-ol and 6.08 g (57.32 mmol) of sodium carbonate were added, and the mixture was then stirred at 130° C. overnight. Saturated aqueous sodium bicarbonate solution/ethyl acetate were added to the reaction mixture. The precipitate was filtered off and discarded. The two phases were separated from one another, and the aqueous phase was extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and concentrated using a rotary evaporator. The residue was purified by column chromatography on silica gel 60 (mobile phase: cyclohexane/ethyl acetate 5/1?1/2). Yield: 8.6 g (82percent of theory, 76percent pure) LC-MS (Method 4): Rt=1.17 min; MS (ESIpos): m/z=195 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta=9.87 (s, 1H), 7.86 (d, 2H), 7.12 (d, 2H), 4.70 (s, 1H), 3.84 (s, 2H), 1.21 (s, 6H).

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Vakalopoulos, Alexandros; Meibom, Daniel; Nell, Peter; Sussmeier, Frank; Albrecht-Kupper, Barbara; Zimmermann, Katja; Keldenich, Joerg; Schneider, Dirk; Krenz, Ursula; US2013/210795; (2013); A1;,
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Application of 7589-27-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred suspension of pyridinium chlorochromate (6.9 g, 21.4 mmol) in CH2Cl2 (100 ml) was added a solution of 2-(4-fluorophenyl)ethanol (3.0 g, 21.4 mmol) in CH2Cl2 (10 ml). The resulting suspension was stirred for 2 hours at room temperature and was then diluted with ether. The resulting suspension was filtered through a pad of Celite and washed with ether. The solvents were removed under reduced pressure to yield the crude title compound as a green oil (2.6 g, 86%), which was used as such for further reaction.1H NMR (300 MHz, CDCl3, 25 C.): delta=9.75 (s, 1H, CH), 7.19-7.22 (m, 2H, PhH), 7.06 (t, J=8.5 Hz, PhH), 3.68 (s, 2H, CH2) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7589-27-7, 2-(4-Fluorophenyl)ethanol.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D; US2012/46278; (2012); A1;,
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