Tag: M.W=100-200

Synthetic Route of 10602-04-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10602-04-7, name is (4-Ethynylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(4-{3-Bromo-5-[2-(4-chloro-phenyl)-ethoxy]-phenylsulfanyl}-2-methyl-phenoxy)- acetic acid ethyl ester (270 mg; 0.46 mmol), (4-ethynyl-phenyl)-methanol (296 mg; 2.2 mmol), bis(triphenylphosphine) palladium (II) chloride (31.4 mg; 0.045 mmol) and copper iodide (6.4 mg; 0.034 mmol) were dissolved in a mixture of triethylamine (2 mL) and DMF (2 mL) under an atmosphere of nitrogen. The reaction mixture was reacted in a microwave oven at 110 °C for 1.5 h. The reaction mixture was evaporated to dryness, and 5percent aqueous citric acid (30 mL) and ethyl acetate (30 mL) was added. The two phases were separated and the aqueous phase was extracted with ethyl acetate (30 mL). The combined organic phases were dried and evaporated to dryness and purified by preparative HPLC (method B). Yield: 270 mg (83percent). HPLC-MS: m/z: 587.1 (M+H)+; Rt: 2.96 min.

According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVO NORDISK A/S; WO2007/3581; (2007); A1;,
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Application of 39590-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39590-81-3 as follows.

[1-(Hydroxymethyl)cyclopropyl]methanol obtained from Step A (0.2 g, 1.96 mmol), 4-bromo-2,6-difluoro-phenol (0.314 g, 1.5 mmol) and triphenylphosphine (0.393 g, 1.5 mmol) were dissloved in 24 mL of THF. Diisopropyl azocarboxylate (0.3 mL, 1.5 mmol) was added thereto, and the reaction mixture was stirred for 16 hours at room temperature. The mixture was concentrated under reduced pressure and purified by column chromatography to obtain the title compound (0.307 g, 70 %). 1H NMR (CDCl) delta 7.08 (2H, m), 4.08 (2H, s), 3.68 (2H, d), 1.84 (1H, t, OH), 0.62 (4H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39590-81-3, its application will become more common.

Reference:
Patent; LG LIFE SCIENCES LTD.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; WO2014/209034; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 13674-16-3

EXAMPLE 112 (R)-2-[2,6-Dibromo-4-(6-methoxy-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenoxy]-3 -phenyl-propionic acid, methyl ester Prepared from 2,6-dibromo-4-(6-methoxy-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenol (Example 63) and (S)-2-hydroxy-3-phenylpropionic acid, methyl ester (Example 96) according to the procedure of Example 107. White solid (0.608 g, 96%): NMR (THF-d8); delta8.29-8.26 (m, 1 H), 7.87 (d., J=8 Hz, 1 H), 7.72 – 7.68 (dd, 2 H, J=4, 2 Hz), 7.60 – 7.56 (m, 2 H), 7.48-7.37 (m, 4 H), 7.32 – 7.28 (m, 2 H), 7.25-7.23 (m, 2 H), 7.20 – 7.15 (m, 2 H), 6.85 – 6.82 (m, 1 H), 5.22(dd, 1 H, J=14, 2, Hz), 4.17 (s, 1 H), 3.71 (s, 1 H), 3.58(s, 6 H),; MS (FAB+): [M+], 2 bromine isotope pattern, 674 (40%), 676 (66%), 678 (45%); Anal. Calc. for C33H24Br2O4S: C, 58.60, H, 3.58, N, 0.00. Found: C, 58.11, H, 3.53, N, 0.19.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13674-16-3, Methyl 2-hydroxy-3-phenylpropanoate.

Reference:
Patent; American Home Products Corporation; US6110962; (2000); A;,
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Related Products of 3597-91-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, molecular formula is C13H12O, molecular weight is 184.23, as common compound, the synthetic route is as follows.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

Statistics shows that 3597-91-9 is playing an increasingly important role. we look forward to future research findings about [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 41790-30-1, name is (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol

To a solution of S5 (5.24 g, 32.3 mmol) in DCM (200 mL) at 0 C was added thionyl chloride (8.45 g, 71.1 mmol). The reaction mixture was stirred at r.t. for 24 h, then solvent was removed under reduced pressure. The residue was diluted with DCM (100 mL) and quenched with ice-water (100 mL). The organic phase was washed with sat. aq. NaHCO3, dried with Na2SO4 and concentrated to give 5-(chloromethyl)-1,2,3,4-tetrahydronaphthalene (S6) as a brown oil (3.25 g, 56%). 1H NMR (CDCl3) delta 7.16-7.05 (m, 3H), 4.59 (s, 2H), 2.86 (t, J = 6.3 Hz, 2H), 2.79 (t, J = 6.4 Hz, 2H), 1.88-1.77 (m, 4H). Found: [M+H]=181.6.

With the rapid development of chemical substances, we look forward to future research findings about 41790-30-1.

Reference:
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Blaser, Adrian; Conole, Daniel; Franzblau, Scott G.; Lotlikar, Manisha U.; Cooper, Christopher B.; Upton, Anna M.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1292 – 1307;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

To a dried round-bottom flask, 3,5-dimethylbenzoic acid (600 mg, 4.0 mmol) was dissolved inCH2Cl2 (14 mL) and a few drops of DMF was added. Oxalyl chloride (370 L, 4.4 mmol) wasadded dropwise resulting in gas evolution. The mixture was stirred for 30 min. 3,3,3-Trifluoropropan-1-ol (460 mg, 4.0 mmol), DMAP (10 mg, 0.080 mmol) and NEt3 (1.1 mL, 8.0mmol) were dissolved in CH2Cl2 (2.0 mL) and the CH2Cl2 solution was added to the reactionmixture. The mixture was stirred at ambient temperature overnight. To the resulting mixture, H2Owas added and extracted with Et2O three times. Combined organic extracts were washed with 1MNaOH aq., 1M HCl aq. and brine and dried over MgSO4. Concentrated mixture was purified byflash column chromatography (hexane/EtOAc = 100/1 to 20/1) to give the title compound(colorless oil, 703 mg, 71percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Article; Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto; Bulletin of the Chemical Society of Japan; vol. 90; 3; (2017); p. 332 – 342;,
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Reference of 16369-21-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16369-21-4, name is 2-(Propylamino)ethanol, molecular formula is C5H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-(bis{2-[(methylsulfonyl)oxy]ethyl}amino)-3,5-dinitrobenzoic acid (43) (333 mg, 0.7 mmol) and MgO (341 mg, 8.5 mmol) in CH2Cl2 ( 5 mL) was cooled to 0 C and treated with oxalyl chloride (364 muL, 4.2 mmol ) and DMF (3 drops). The mixture was stirred at 15 0C for 1 h, filtered and then treated with a solution of 2-(propylamino)ethanol (105 muL, 0.9 mmol) and triethyl amine (160 muL, 1.1 mmol) in CH2Cl2 (5 niL) The mixture was stirred at 0 C for 40 min, diluted with CH2Cl2, washed with water and aqueous solution of methane sulfonic acid. The organic layers were dried with Na2 SO4 and then concentrated under reduced pressure. The residue was then purified by flash column chromatography on silica gel eluting with CH2Cl2/MeOH (99:1) to provide 2-(2-{[(2- hydroxyethyl)(propyl)amino]carbonyl} {2-[(methylsulfonyl)oxy]ethyl}-4,6-dinitroanilino)ethyl methanesulfonate (20) (230 mg, 58 %) as a yellow gum; 1H NMR [(CDO2SO] (mixture of rotamers) 6 8.71, 8.69 (2dJ = 2.8 Hz, IH), 8.38, 8 25 (2d, / = 2.8 Hz, IH), 4.85, 4.82 (2t, J = 5.2 Hz, IH), 4.32-4.27 (m, 4H), 3.68-3.50 (m, 5H), 3.45-3.39 (m, 3H), 3.34-3.19 (m, 2H), 3.14 (2s, 6H), 1.70-1.60 (m, 2H), 0.93, 0.73 (2tJ = 7.4 Hz, 3H) HRMS(ESI) calcd for C18H29N4O12S2 [M+H]+ »/?* 557.1218: found 557.1202.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 16369-21-4, 2-(Propylamino)ethanol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; PATTERSON, Adam, Vorn; SMAILL, Jeffrey, Bruce; DENNY, William, Alexander; WILSON, William, Robert; SYDDALL, Sophie; ASHOORZADEH, Amir; WO2010/44685; (2010); A1;,
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Electric Literature of 5182-44-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5182-44-5, name is 2-(3-Chlorophenyl)ethanol. A new synthetic method of this compound is introduced below.

(c) 2-(3-Chlorophenyl)ethanol (48.2 g) and paraformaldehyde (10.8 g) were mixed and warmed to 70 on an oil bath. A stream of hydrogen chloride gas was passed vigorously through the suspension for about 7 hr. The reaction mixture was then allowed to stand at room temperature overnight. Aqueous sodium hydroxide solution (100 g/100 ml) was added cautiously to the reaction mixture. After the initial reaction subsided the rest of the alkali solution was run in fast and the resulting mixture was heated at reflux on an oil bath for 2 hr. The reaction mixture was cooled and extracted into ether (3*100 ml). The ether layer was dried (sodium sulphate) and evaporated in vacuo to give the 6-chloroisochroman as an oil (46 g), which was purified by distillation in vacuo (25.1 g, b.pt. 76-80/0.6 mmHg), characterised by its nmr spectrum.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5182-44-5, 2-(3-Chlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Burroughs Wellcome Co.; US4801593; (1989); A;,
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Electric Literature of 41175-50-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, molecular formula is C12H15NO, molecular weight is 189.2536, as common compound, the synthetic route is as follows.

A mixture of 8-hydroxyjulolidine (300 mg, 1.59 mmol) and ethyl 4-chloroacetoacetate (260 ul, 1.90 mmol) was stirred at ?90 C. under argon atmosphere. To this mixture was added a solution of aluminum chloride (420 mg, 3.2 mmol) in nitrobenzene (5 ml) and the whole reaction mixture was stirred at ?130 C. for 3 hours. After the reaction mixture was cooled to room temperature, it was purified by column chromatography over silica gel eluting first with 5% ethyl acetate in hexane and then with chloroform to obtain the desired product as a yellow-brown solid (200 mg, 43% yield). TLC: Rf=0.56 (silica gel, 1:1 hexane/ethyl acetate). 1NMR (DMSO-d6): chemical shift (ppm) 7.21 (s, 1H, ArH), 6.15 (s, 1H, ArH), 4.86 (s, 2H, CH2), 3.28-3.25 (m, 4H, CH2), 2.76-2.69 (m, 4H, CH2), 1.90-1.87 (m, 4H, CH2). absorption maximum: 405 nm in methanol, emission maximum: 493 nm in methanol. MS: m/e 290.20.

The chemical industry reduces the impact on the environment during synthesis 41175-50-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Life Technologies Corporation; Kang, Hee Chol; Gee, Kyle; Johnson, Iain; Janes, Michael; US8981100; (2015); B2;,
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Reference of 7218-43-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol, molecular formula is C7H12O3, molecular weight is 144.1684, as common compound, the synthetic route is as follows.

General procedure: Freshly ground potassium hydroxide (2 eq.) was added to a cooled (0 C) solution of S1 inanhydrous DCM under a nitrogen atmosphere. The mixture was then stirred at this temperature for an hour before the slow addition of p-toluene sulfonylchloride (1.1 eq.). The reaction mixture was thenstirred at room temperature overnight before being concentrated in vacuo to give a beige oily solid.The crude product was then taken up in EtOAc (25 mL) and the resulting suspension stirred at roomtemperature for 30 minutes. The insoluble solid was removed by filtration and the filtrate concentratedin vacuo to afford S2.

The chemical industry reduces the impact on the environment during synthesis 7218-43-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Tran, Fanny; Odell, Anahi V.; Ward, Gary E.; Westwood, Nicholas J.; Molecules; vol. 18; 9; (2013); p. 11639 – 11657;,
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