Tag: M.W=100-200

Electric Literature of 627-18-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 3,4-Dihydropyran (DHP, 15 mmol) was added slowly to a stirred solution of bromohydrin (10 mmol) and p-toluenesulfonic acid (1 mmol) in dichloromethane (20 mL) on ice bath. After stirring at room temperature overnight, the reaction mixture was diluted with water and extracted with dichloromethane. The organic layer was washed with brine and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure, and the residue was purified by flash column chromatography to afford 1-5 as a light yellow oil. 2-(3-Bromopropoxy)tetrahydro-2H-pyran (1). Yield 94.2%. 1H NMR spectrum, delta, ppm: 1.37-1.55 m (4H), 1.57-1.65 m (1H), 1.70-1.78 m (1H), 2.01-2.10 m (2H), 3.37-3.49 m (4H), 3.73-3.83 m (2H), 4.49-4.55 m (1H). 13C NMR spectrum, deltaC, ppm: 19.4, 25.4, 30.5, 30.6, 32.8, 62.1, 64.8, 98.7.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 627-18-9, 3-Bromopropan-1-ol.

Reference:
Article; Zhang; Dong; Meng; Huang; Li; Russian Journal of General Chemistry; vol. 88; 11; (2018); p. 2388 – 2393; Zh. Obshch. Khim.;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, molecular weight is 134.1736, as common compound, the synthetic route is as follows.COA of Formula: C6H14O3

A. Preparation of 1-Allyloxy-2-(2′-ethoxyethoxy) ethanol (4A) All procedures were the same as for preparation of 1A except that diethylene glycol monoethyl ether (39.0 mL, 0.288 mmoles) was used. After filtering the sodium bromide precipitate and concentrating the filtrate, the product was chromatographed on silica gel (eluents: toluene, 15% ethyl acetate in toluene, then 50% ethyl acetate in toluene) and then purified by fractional distillation to produce an 80% yield of colorless liquid, b.p. 78-79 C. at 0.2 torr. 1 H NMR:delta1.02 (t, J=7.0 Hz, –O–C–CH3); 3.28 (q, J=6.5 Hz, –O–CH2 C); 3.30 [m, W1/2 =4 Hz (CH2 CH2 O)2 ]; 3.77 (d, J=5.0 Hz, CH2 allyloxy); 4.69-5.22 (m, CH2 vinyl); 5.29-6.02 (m, CH vinyl).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-90-0, Diethylene Glycol Monoethyl Ether, and friends who are interested can also refer to it.

Reference:
Patent; Northeastern University; US4778909; (1988); A;,
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Synthetic Route of 870-72-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 870-72-4, name is Hydroxymethanesulfonic Acid Sodium Salt. This compound has unique chemical properties. The synthetic route is as follows.

(S)-(-)-(5,7-Difluoro-1,2,3,4-tetrahydronaphth-2-yl)(cyanomethyl)amine. The amine hydrochloride 8a (50.27 g, 229 mmol) was treated with a solution of NaOH (10.0 g. 250 mmol) in water (150 mL), followed by a few additional pellets of NaOH sufficient to obtain a solution. Further water (300 mL) was added and the mixture placed in a 50 C bath and treated with formaldehyde sodium bisulfite complex (30.8 g, 230 mmol). After the mixture had been stirred for 30 min, KCN (15.0 g, 230 mmol) was added. The reaction mixture was stirred for a further 1 h at 80 C, cooled to room temperature, and extracted with EtOAc to give an oil (51.3 g) which solidified. TLC (5% MeOH-CH2Cl2) showed ca. 10-15% of starting amine remained. Chromatography on silica gave the nitrile product (39.4 g) and starting free amine (7.12 g), which quickly forms the carbonate in air. Recycling this amine gave an additional 5.35 g of product. Combined yield (44.8 g, 202 mmol; 87.5%): mp 73.1-76.5 C; [alpha]25D -58.0 (c = 1.63, CHCl3); 1H NMR (CDCl3) delta 1.50 (br s, 1H), 1.70 (m, 1H), 2.05 (m, 1H), 2.55-3.04 (m, 4H), 3.22 (m, 1H), 3.70 (s, 2H), 6.62 (m, 2H); MS m/z 222 (M+). Anal. Calcd for C12H12F2N2: C, 64.85; H, 5.44; N, 12.60. Found: C, 65.07; H, 5.47; N, 12.44. The spectra for the (R)-enantiomer 9b are identical: mp 64.4-73.6 C; [alpha]25D +52.3 (c =2.12, CHCl3). Anal. Calcd for C12H12F2N2: C, 64.85; H, 5.44; N, 12.60. Found: C, 65.14; H, 5.54; N, 12.53.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt.

Reference:
Patent; Biotie Therapies, Inc.; WOIWODE, Tom; MORAN, Mark; PICKFORD, Lesley; (73 pag.)EP2182804; (2017); B1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(3-Fluorophenyl)ethanol

1 [0036] Aldehyde 14 can be prepared as shown in Scheme 3. 2-(3- Fluorophenyl)ethanol can be oxidized with Dess-Martin periodinane to give 15.Reductive amination with N-(2-hydroxyethyl)benzyl amine gives 16. Hydrogenolysis, Boc protection, and Dess-Martin oxidation gives 14 in excellent yields.Scheme 3. Synthesis of aldehyde 14 used in the synthesis of 1

With the rapid development of chemical substances, we look forward to future research findings about 52059-53-7.

Reference:
Patent; NORTHWESTERN UNIVERSITY; YANG, Sun; MEYSKENS, Frank, L.; SILVERMAN, Richard, B.; JI, Haitao; XUE, Fengtian; POULOS, Thomas, L.; WO2012/97121; (2012); A2;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.Application In Synthesis of (2-Amino-5-chlorophenyl)methanol

To 40 ml of DMS0 in the reactor, PdCl2 (dppf), organic ligand L1, potassium carbonate and an auxiliary agent, And 12 mmol of the compound of formula (I) and 18 mmol of the compound of formula (II) in the above reaction scheme, with nitrogen being inert to formAtmosphere, sealed reaction at 110 C for 5 hours, the reaction is completed by natural cooling, vacuum concentration, the use of petroleum ether and ethyl acetate(1: 2 by volume) as the eluent to give the compound of the above formula (III) in a yield of96.7%;[0053] wherein the molar amount of the PdCl2 (dppf) is 1.2% by mol of the compound of the formula (I), and the ligand LlIs used in an amount of 3% by mol based on the molar amount of the compound of formula (I), the molar amount of said potassium carbonate being a molar amount of the compound of formula (I)35% and the molar amount of said auxiliary PhSiH3 is 1.5% by mol based on the compound of formula (I).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37585-25-4, (2-Amino-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Wang, Wenming; (10 pag.)CN104557737; (2016); B;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. Quality Control of [1,1′-Biphenyl]-4-ylmethanol

In a 10 mL round bottom flask, 0.85 g of 4-hydroxymethylbiphenyl (4-phenylbenzyl alcohol) and 2 g of diethylene glycol dimethyl ether were sequentially added, and the resulting mixture was subjected to an ultrasonic reaction apparatus at 40 KHz/30 W/70. C Ultrasonic radiation was allowed to open for 35 minutes. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallized to give 0.95 g of 4-phenylbenzoic acid, yield 96%.

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Central South University; Xiao Fang; Xiao Yuanyuan; Zeng Ming; Li Na; Yin Lirong; (15 pag.)CN108467342; (2018); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6240-11-5

General procedure: To a three-necked, cylindrical Pyrex glass reaction vessel equipped with a rubber balloon, rubberseptum, and glass stopper, a N2 atmosphere was introduced by flowing via cannula for 5 min. Au(0.6 wt %)/TiO2 (117.3 mg, 0.17 mol % Au), 1a (271.5 mg, 1.99 mmol), and dehydrated ethylacetate (25 mL) were added successively to the vessel. After N2 gas was reintroduced more than 5min, the rubber balloon was connected to the vessel and the mixture was sonicated. The vessel wasimmersed in a oil bath (kept at 45 oC) and stirred for 10 h under irradiation (lambda = 300-470 nm). 1HNMR analysis of this crude mixture using mesitylene as an internal standard indicated 97%conversion of 1a and the formation of 2a in 86% yield, as determined based on the signals at delta 3.61ppm and 2.94 ppm (shifted from 2.89 ppm due to the presence of ethyl acetate), respectively. Theproduct was purified by silica gel column chromatography (n-hexane/ethyl acetate 3:1) to afford 2a(180 mg, 66% yield, with inclusion of small amounts of unidentified impurities).

With the rapid development of chemical substances, we look forward to future research findings about 6240-11-5.

Reference:
Article; Shibata, Masaki; Nagata, Ryoko; Saito, Susumu; Naka, Hiroshi; Chemistry Letters; vol. 46; 4; (2017); p. 580 – 582;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90369-75-8, name is (3-Chloro-2-methylphenyl)methanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of (3-Chloro-2-methylphenyl)methanol

Diphenylphosphoryl azide (6.00 mL, 27.80 mmol) was added to a cooled (0 C.) solution of (3-chloro-2-methyl-phenyl)-methanol (3.66 g, 23.40 mmol) in ether. The resulting mixture was stirred for a few minutes and DBU (4.20 mL, 28.00 mmol) was added slowly. The reaction mixture was stirred for 14 hours, decanted into a clean flask and the residue was washed with more ether. The combined organic phases were concentrated to give the crude title azido compound. Spectroscopic data: 1H NMR (300 MHz, CDCl3.) delta 2.41 (s, 3H), 4.36 (s, 2H), 7.11-7.26 (m, 2H), 7.35 (dd, J=7.33 Hz, 1H).

The synthetic route of 90369-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Allerghan, Inc.; US2008/194650; (2008); A1;,
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Reference of 10602-04-7 ,Some common heterocyclic compound, 10602-04-7, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Ethynylbenzyl alcohol a_(l g, 7.57 mmol) was diluted in 20 ml DCM, and cooled to 0¡ã in ice bath. Phosphorus tribromide (4.1 g, 15 mmol) was added dropwise. The reaction was allowed to warm to room temperature gradually, and stirred under nitrogen overnight. The reaction was quenched by addition of H2O in ice bath, extracted by DCM. Combined organic layers were washed with brine, dried over Na2SO4 and concentrated to dryness. The crude material was purified by chromatography (ISCO) using 100percent hexane to give pure 4-ethynylbenzyl bromide b (220 mg). M+H+ 195.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; WO2008/134679; (2008); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-95-2, name is 2-Methylbenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Methylbenzyl alcohol

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89-95-2, 2-Methylbenzyl alcohol.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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