Tag: M.W=100-200

Reference of 13330-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, molecular weight is 117.19, as common compound, the synthetic route is as follows.

(R)-3-[N’-(5-Acetyl-2H-pyrazole-3-carbonyl)-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-hydrazino]-2-hydroxypropionic Acid 4-dimethylaminobutyl Ester (R)-3-[N’-(5-Acetyl-2H-pyrazole-3-carbonyl)-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-hydrazino]-2-hydr oxypropionic acid (10.0 mg, 21 mumol) was combined with HOBt (17.1 mg, 126 mumol) and EDC (22 muL, 130 mumol) in DCM (0.2 mL, 3 mmol) and stirred for 10 minutes. 4-Dimethylamino-1-butanol (22.4 muL, 168 mumol) was added and the resulting mixture was stirred at room temperature and monitored for completion (?4 hours). The mixture was concentrated by rotary evaporation and the residue was purified by preparative HPLC to yield the title compound as a TFA salt (4.2 mg). MS m/z [M+H]+ calc’d for C28H33ClFN5O5, 574.22. found 574.1.

The chemical industry reduces the impact on the environment during synthesis 13330-96-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hughes, Adam D.; Fleury, Melissa; US2013/330365; (2013); A1;,
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Synthetic Route of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of the substrate (1 mmol), HMDS (1 mmol) and PC-NPs (20 mg), in acetonitrile (3 mL), was refluxed at 75 C. After completion of the reaction (monitored byTLC using a 1:1 mixture of EtOAc/n-hexane), the mixture was filtered and the residue was washed with acetonitrile (5 mL). Evaporation of the solvent gave almost the pure product(s). Further purification was proceeded by bulb-to-bulb distillation under reduced pressure or recrystallization to afford the pure silyl ether.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Article; Shirini, Farhad; Fallah-Shojaei, Abdollah; Abedini, Masoumeh; Samavi, Laleh; Journal of the Iranian Chemical Society; vol. 13; 9; (2016); p. 1699 – 1712;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929-06-6, name is 2-(2-Aminoethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(2-Aminoethoxy)ethanol

Part A A solution of 2-(2-aminoethoxy)ethanol (29.0 g, 0.276 mol) in 180 mL of tetrahydrofuran (THF), under N2, was cooled to 0 C. and treated with 140 mL of 2N NaOH solution. A solution of di-tert-butyl dicarbonate (60.2 g, 0.276 mol) in 180 mL of THF was then added dropwise over 1 h to the rapidly stirred solution. The reaction mixture was then allowed to warm to room temperature and was stirred an additional 18 h. The THF was then removed under reduced pressure and the remaining aqueous slurry was brought to pH 3 by addition of 150 mL of 1M H2SO4 solution. This was then extracted with ethyl acetate (300 mL, 100 mL) and the combined organic layers were washed with H2O (2*) and brine. The organic portion was dried over Na2SO4 and concentrated to give tert-butyl 2-(2-hydroxyethoxy)ethylcarbamate as a colorless oil (47.1 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 929-06-6, 2-(2-Aminoethoxy)ethanol.

Reference:
Patent; Crooks, Stephen L.; Griesgraber, George W.; Heppner, Philip D.; Merrill, Bryon A.; US2003/130518; (2003); A1;; ; Patent; Crooks, Stephen L.; Griesgraber, George W.; Heppner, Philip D.; Merrill, Bryon A.; Roberts, Ralph R.; Wei, Ai-Ping; US2003/139441; (2003); A1;; ; Patent; Crooks, Stephen L.; Griesgraber, George W.; Heppner, Philip D.; Merrill, Bryon A.; US2003/187016; (2003); A1;; ; Patent; 3M Innovative Properties Company; US6677347; (2004); B2;,
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Application of 3376-59-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3376-59-8, name is 2,3-Dihydroxypropyl benzoate. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred suspension of sodium hydride (0.273 g, 0.68mol, 60% in oil) in anhydrous THF (100 mL) under a nitrogenatmosphere at 0C, a solution of (¡À)-1 (33.3 g, 0.17 mol)in anhydrous THF (150 mL) was added over a period of 1 hmaintaining the internal temperature below 5C. After stirringat room temperature for 12 h, 1-bromotetradecane(187.7 g, 0.68 mol) was added at 0C over a period of 1 h.After complete addition, the reaction mixture was stirred for2 h at room temperature and this was gradually increasedwhen reaching reflux, and then stirred for 24 h. A LiOH solution(10% wt/v,100 mL) was added, and stirring and thetemperature were maintained for 12 h. The mixture was dilutedwith saturated ammonium chloride (300 mL). Theaqueous layer was extracted with dichloromethane (700 mL),washed with water (3 150 mL), and dried over Na2SO4.The unreacted 1-bromotetradeane was removed by distillationunder reduced pressure (1 mm of Hg and 125 C). Theresidue was purified by column chromatography eluting withhexane to obtain (¡À)-2 (39.5 g, 48%) as a white solid, mp.43-45 C (lit. 42.5-43.5C) [18]. 1H NMR (CDCl3, 200MHz) 0.87 (t, J = 6.7 Hz, 6H, C12-C12H3), 1.25 (br s, 44H,C11-C11H2), 1.58-1.61 (m, 4H, C10-C10H2), 3.37-3.73(m, 9H; C9-C9-C3-C2H2, C1H); 13C NMR (CDCl3,200MHz) 14.1 (C16-16), 22.8 (C15-15), 27.6 (C12-12),29.1-29.5 (C13-13), 29.7 (C11-11), 32.5 (C14-14), 32.8(C10-10), 64.3 (3C), 65.5 (C1), 71.0 (C9), 70.9(C9),72.0(C3), 78.4 (C2). EI-LR-MS, m/z, M+: 484.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3376-59-8, 2,3-Dihydroxypropyl benzoate.

Reference:
Article; Rustoy, Eduardo M; Dana, Alejandro; Letters in Organic Chemistry; vol. 13; 1; (2016); p. 71 – 75;,
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Application of 311-86-4 ,Some common heterocyclic compound, 311-86-4, molecular formula is C3H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 1-[1-(3-azetidin-3-yl-5-chloro-2-methoxy-4-methylphenyl)ethyl]-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride (20 mg, 0.04 mmol, chiral intermediate from peak 1 of Example 1, step 7) and triethylamine (19 muL, 0.13 mmol) in acetonitrile (0.6 mL) was added 2-bromo-3,3,3-trifluoropropan-1-ol (from Synquest Labs, 9.2 mg, 0.048 mmol). N,N-dimethylformamide (0.3 mL) was added, which created a clear solution that was stirred at 70 C. overnight. The mixture was diluted water and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.6 mg (30%) of the desired product. The product was isolated as a mixture of diastereomers. LCMS calculated for C22H27ClF3N6O2 (M+H)+: m/z=499.2; Found: 499.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INCYTE CORPORATION; Li, Yun-Long; Yao, Wenqing; Combs, Andrew P.; Yue, Eddy W.; Mei, Song; Zhu, Wenyu; Glenn, Joseph; Maduskuie, JR., Thomas P.; Sparks, Richard B.; Douty, Brent; US2013/59835; (2013); A1;,
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Electric Literature of 2568-33-4 , The common heterocyclic compound, 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of compound la (4 g, 38 mmol) in DMF (30 mL) was added NaH (3.3 g,8.4 mmol, 60% in mineral oil) at 0C over 10 mins. The mixture was stirred for half an hour atr.t., and then cooled to 0 C. Then compound 7-1 (6 g, 32 mmol) in DMF (20 mL) was added to5 the reaction, and the reaction was stirred at r.t. for 12 h. The reaction was poured into water(100 mL), and the resulting mixture was stirred for 10 min. The mixture was then was extractedwith EtOAc (60 mL x 3). The organic layers were combined, washed with water (60 mL), brine( 60 mL ), dried and concentrated to give crude product, which was used directly for the next stepwithout further purification. MS (ESI) m/z: 274.1.

The synthetic route of 2568-33-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
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Application of 30595-79-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3: To a solution of 2-(2,6-dichlorophenyl)ethanol (37.3 g, 195 mmol) and TEA (32.7 g, 235 mmol) in DCM (700 mL) was added MsCI (26.9 g, 235 mmol) dropwise at 0C. After addition, the solution was stirred at rt overnight, diluted with water (200 mL) and extracted with DCM (3 x 400 mL). The combined organic layer was dried over Na2S04, filtered, concentrated and purified by flash chromatography (PE/EtOAc = 5:1 ) to afford 2,6-dichlorophenethyl methanesulfonate lnt-1 c- 11. 1H-NMPi (300 MHz, CDCI3): delta 2.95 (s, 3H), 3.43 (t, J = 7.5 Hz, 2H), 4.41 (t, J = 7.5 Hz, 2H), 7.12-7.17 (m, 1 H), 7.31 (d, J = 8.4 Hz, 2H)

According to the analysis of related databases, 30595-79-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; SCHMITT, Aaron C.; GEGE, Christian; (205 pag.)WO2016/96115; (2016); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H9ClO

Example 2A4-(2-Hydroxy-2-methylpropoxy)benzaldehyde5.00 g (40.94 mmol) of 4-hydroxybenzaldehyde, 4.44 g (40.94 mmol) of 1-chloro-2-methyl-2-propanol and 6.08 g (57.32 mmol) of sodium carbonate are initially charged in 50 ml of dry DMF and stirred under reflux for 24 h.After cooling to RT, 20 ml of ethyl acetate and 20 ml of sat. aqueous sodium bicarbonate solution are added.The phases are separated, and the organic phase is dried over magnesium sulfate.After removal of the solvent, the residue is purified by column chromatography on silica gel 60 (mobile phase gradient: cyclohexane/ethyl acetate 5:1?1:1).This gives a reddish solid which is used without further purification for the subsequent step.Yield: 4.40 g (50percent of theory, 90percent purity)LC-MS (method 2): Rt=1.37 min; MS (ESIpos): m/z=195 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/130377; (2011); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C9H12O3

EXAMPLE 2 5-Chloro-3-cyclohexyl-1,3-dihydro-1-(2,4-dimethoxybenzyl)-2H-benzimidazol-2-one A solution of 0.537 g of 1-hydroxymethyl-2,4-dimethoxybenzene in 5 ml of ether is cooled to -10 C., under a nitrogen atmosphere, and a solution of 0.1 ml of phosphorus tribromide in 2 ml of ether is added dropwise. The 1-bromomethyl-2,4-dimethoxybenzene thus obtained is stored in solution at -30 C.

The synthetic route of 7314-44-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; US5661169; (1997); A;,
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Electric Literature of 46190-45-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.46190-45-8, name is Methyl 4-(2-hydroxyethyl)benzoate, molecular formula is C10H12O3, molecular weight is 180.2005, as common compound, the synthetic route is as follows.

A solution of 13 (1.16 g, 6.44 mmol) in CH2Cl2 (20 mL) was added DAST (1.56 g, 9.66 mmol) at 0 C. The mixture was warmed to ambient temperature and stirred overnight, then ethyl acetate(100 mL) was added, washed with water (50 mL), saturated Na2CO3 (50 mL), saturated NaCl (50 mL), and dried over Na2SO4.After evaporation of the solvent in vacuo, the crude product was purified by chromatography with hexane-ether (10:1) to afford 1.06 g (91%) of 15 as a colorless oil. TLC Rf 0.25 (hexane-ether10:1); 1H NMR (300 MHz, CDCl3) delta 8.01 (d, J = 8.4 Hz, 2H), 7.33(d, J = 8.1 Hz, 2H), 4.67 (dt, J = 47.1 Hz, J = 6.3 Hz, 2H), 3.93 (s,3H), 3.08 (dt, J = 24.6 Hz, J = 6.3 Hz, 2H).

The chemical industry reduces the impact on the environment during synthesis 46190-45-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Li, Aixiao; Mishra, Yogesh; Malik, Maninder; Wang, Qi; Li, Shihong; Taylor, Michelle; Reichert, David E.; Luedtke, Robert R.; MacH, Robert H.; Bioorganic and Medicinal Chemistry; vol. 21; 11; (2013); p. 2988 – 2998;,
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