Tag: M.W=100-200

Related Products of 25055-82-7, Adding some certain compound to certain chemical reactions, such as: 25055-82-7, name is 2-(3-Methyl-3H-diazirin-3-yl)ethanol,molecular formula is C4H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25055-82-7.

4-hydroxy-2-butanone (20, 1.00 g, 11.35 mmol) was pipetted into a dry flask and cooled to 0C under nitrogen atmosphere. 7N methanolic ammonia (11.2 mL, 79 mmol) was added via syringe, and the solution was allowed to stir at 0C for 3 hours. A solution of hydroxylamine-O-sulfonic acid (1.476 g, 13.05 mmol) in methanol (9.7 mL) was added dropwise, then was allowed to stir for an additional 16 hours while slowly warming to room temperature. The reaction was filtered through a sintered glass funnel, then transferred to a reaction vessel and re-cooled to 0C. Triethylamine (1.58 mL,11.35 mmol) was added, then molecular iodine (2.88 g, 11.35 mmol) was added slowly in 10 equal portions until the purple/brown color of iodine persisted in the reaction vessel. The solvent was removed under reduced pressure, and purification of the crude isolate via Kugelrohr distillation (60C, 1-3 torr) delivered the 2,2-diazirinyl intermediate as a clear oil (304 mg, 27% yield). A portion of this intermediate (300 mg, 3.00 mmol) was dissolved in dry pyridine (6 mL) and cooled to 0C in an ice bath. To this solution was added p-toluenesulfonyl chloride (628 mg, 3.30 mmol). The reaction mixture was allowed to stir for 24 hours at 0-4C, then was poured into a mixture of 37%w/v HCl (15 mL) and ice (80 mL). The resulting suspension was extracted 3x with ether, then the pooled organic layers were washed with 1N HCl solution, 1N NaOH solution, water, and brine. The organic extract was dried over MgSO4, vacuum filtered, and concentrated to a clear oil (428 mg, 15% yield over 3 steps) used without further purification. TLC Rf (2:1 hex:EtOAc) = 0.6. 1HNMR (500 MHz, CDCl3) delta 7.82 (d, J = 7.9 Hz, 2H), 7.37 (d, J= 7.9 Hz, 2H), 3.96 (t, J = 6.4 Hz, 2H), 2.46 (s, 3H), 1.68 (t, J= 6.4 Hz, 2H), 1.01 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25055-82-7, 2-(3-Methyl-3H-diazirin-3-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yestrepsky, Bryan D.; Kretz, Colin A.; Xu, Yuanxi; Holmes, Autumn; Sun, Hongmin; Ginsburg, David; Larsen, Scott D.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1538 – 1544;,
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Application of 144-19-4 ,Some common heterocyclic compound, 144-19-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 3.8 liter jacketed vessel, 424 grams of 2,2,4-trimethyl-1,3-pentanediol (TMPD Glycol) were charged and heated to a nominal temperature of 150 C. When the TMPD Glycol began to melt, the agitator was switched on to a speed of 400 rpm. In a separate vessel, 1674 grams of 2-ethylhexanoic acid (2-EH) was heated. When the temperature of the 2-EH reached 175 C., it was added to the TMPD Glycol forming a clear solution. The solution was heated until it reached 240 C. The temperature of the vessel contents was controlled by manipulating the temperature of the fluid in the vessel jacket. A sparge of nitrogen was established through a small pipe that discharged 50 cc/min of nitrogen to the base of the vessel under the impeller. Nitrogen purging was discontinued after 1 hours of operation. The pressure of the vessel was atmospheric (760 mmHg). A condenser located in the line between the vessel and the vacuum pump condensed any vapors in the gas and was collected in a receiver vessel where it separated into an aqueous and water layer. The organic layer comprising mainly 2-EH was returned to the vessel while the water layer was removed from the system. During the experiment, samples of the solution were taken at discrete intervals to monitor the progress of the reaction. The results of this experiment are shown in Table 10.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144-19-4, 2,2,4-Trimethyl-1,3-pentanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eastman Chemical Company; US7674931; (2010); B1;,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7-Bromo-1-heptanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7-Bromo-1-heptanol

A method for synthesizing cis-7-tetradecenol acetate, which is the main sex pheromone of the elm moth, comprises the following steps:(1) Preparation of (7-bromoheptyl-1 -) – 2-tetrahydropyranyl ether To a 500 ml four-necked flask equipped with an electromagnetic stirrer, a reflux condenser,Pressure dropping funnel in a 250 mL four-necked flask, 3,4-dihydropyran 8 g was added and 0.03 g of 37% hydrochloric acid was added as a catalyst with stirring. After 10 min, a solution of 7-bromo- Alcohol 17 g, control the dropping rate (the reaction is exothermic reaction, 7-bromo-1-heptanol dropping speed is accelerated, the reaction is accelerated, exothermic increase, to be ice bath cooling), keep the reaction temperature of 40 ~ 60 C, add room temperature after reaction 2 h, stop stirring, instead of distillation device, steamed unreacted 3,4-dihydropyran. After the residue was cooled, 85 g of petroleum ether was added, washed with saturated sodium hydrogencarbonate solution and saturated brine, dried over sodium sulfate for 10 to 15 hours, concentrated and evaporated to give (7-bromoheptyl-1- Tetrahydropyranyl ether 23.5 g, purity 99.2%, the yield was 96.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; Shanxi Agricultural University; Yang, Meihong; Chen, Xupeng; Liu, Jinlong; Liu, Hongxia; Zhang, Jintong; Cao, Chuanjian; Jing, Xiaoyuan; Wang, Shifei; Fan, Lihua; (8 pag.)CN105418418; (2016); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO

To a round bottom flask with stir bar was added (S)-4-(1-(tert- butoxycarbonylamino)ethyl)-2-chlorobenzoic acid (450 mg, 1.20 mmol), (lr,4r)-4- aminocyclohexanol (415 mg, 3.60 mmol), EDO HCI (460 mg, 2.40 mmol), 1-hydroxy-7-aza- benzotriazole (229 mg, 1.68 mmol) and DMF (6 mL). To this mixture was then added DIEA (629 pL, 3.60 mmol). Reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture was diluted with water and extracted with EtOAc. The organic phaseswere combined, washed with twice with water, brine, dried (Na2SO4), filtered and concentrated to a brown crystalline tert-butyl (S)- 1 -(3-chloro-4-((1 r,4S)-4- hydroxycyclohexylcarbamoyl)phenyl)ethylcarbamate (330 mg, 0.83 mmol, 69 % yield). LCMS m/z391.1 (M + H), RtO.71 mm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; SHAFER, Cynthia; SHULTZ, Michael David; WO2014/147586; (2014); A1;,
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Related Products of 2568-33-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2568-33-4, name is 3-Methylbutane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate To a solution of 3-methylbutane-l,3-diol (1.00 g, 9.60 mmol) in pyridine (10 mL) at 0 C was added -toluenesulfonyl chloride (2.014 g, 10.56 mmol). The reaction mixture was stirred for 16 h while allowing the reaction mixture to slowly warm up to room temperature by dissipation of the ice-water bath. The mixture was transferred to a separatory funnel containing ethyl acetate (100 mL). The organic layer was washed with 1 N HQ (3 x 50 mL). The organic layer was then washed with saturated aHC03 solution (50 mL), brine (50 mL), dried over MgS04, filtered, and concentrated. The product was purified by column chromatography on silica gel (30%? 50% ethyl acetate in hexanes; 220 g column) to afford 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate (2.03 g, 7.86 mmol, 82% yield) as a colorless oil: XH NMR (400MHz, CHLOROFORM- d) delta 7.85 – 7.78 (m, 2H), 7.37 (dd, J=8.5, 0.8 Hz, 2H), 4.23 (t, J=6.9 Hz, 2H), 2.47 (s, 3H), 1.88 (t, J=6.9 Hz, 2H), 1.24 (s, 6H); LC/MS: The product did not ionize, tR = 1.78 min (method 2-1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SIT, Sing-Yuen; CHEN, Yan; CHEN, Jie; SWIDORSKI, Jacob; VENABLES, Brian Lee; SIN, Ny; MEANWELL, Nicholas A.; REGUEIRO-REN, Alicia; HARTZ, Richard A.; XU, Li; LIU, Zheng; WO2015/157483; (2015); A1;,
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Synthetic Route of 7397-62-8, Adding some certain compound to certain chemical reactions, such as: 7397-62-8, name is Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7397-62-8.

175.16 g (99%) of o-cresol and 214.10 g (99%) of n-butyl glycolate,And the catalyst Mo2P5-MCM-48 (Mo2P5 and MCM-48 mass ratio of 25:100) 1.32g was put into the reaction rectification apparatus, mixed and stirred, and the temperature was raised to 120 C, and the reaction was carried out for 3 hours.When the top of the column is substantially anhydrous, the reaction is completed, the temperature is lowered to room temperature, the catalyst is filtered off, and the filtrate is distilled to recover 64.85 g of o-cresol.a mixture of 48.94 g of n-butyl glycolate, 118.54 g,The product obtained n-butyl tolyloxyacetate 223.82g, purity 98.9%,The yield was 99.2% based on phenol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Hou Yongsheng; Chi Zhilong; Zhang Liguo; Hu Yishan; (13 pag.)CN108947839; (2018); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, molecular weight is 149.1882, as common compound, the synthetic route is as follows.HPLC of Formula: C6H15NO3

A solutionof 2-[2-(2-aminoethoxy)ethoxy]ethanol (0.41 g, 2.75 mmol, 1.1 eq.) and Et3N (660 L, 4.75mmol, 1.9 eq.) in methanol (15 mL) was stirred at 30C for 1 h. NBD-Cl (0.5 g, 2.50 mmol, 1eq.) was added and the reaction was stirred in the dark for 16 h at 30C. Insoluble material wasremoved by filtration, and the filtrate was dried. The resulting solid was dissolved in H2O (5mL) and purified on a sephadex LH-20 column, eluting with H2O to give the product as anorange solid (0.33 g, 1.05 mmol, 42% yield).LRMS (ESI-): m/z calculated 311.10 ([M-H]-), found 311.18 ([M-H]-), (ESI+): m/z calculated335.27 ([M+Na]+), found 335.09 ([M+Na]+); HRMS (ESI+): m/z calculated 335.09621([M+Na]+) for C12H16N4O6Na, found 335.09650 ([M+Na]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Glenister, Alexandra; Simone, Michela I.; Hambley, Trevor W.; PLoS ONE; vol. 14; 7; (2019);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-20-8, name is Trichloroethanol. A new synthetic method of this compound is introduced below., COA of Formula: C2H3Cl3O

3alpha-Hydroxy-7-oxo-5beta-cholanoic acid (39.0 g, 100 mmol),beta,beta,beta-Trichloroethanol (16.4 g, 110 mmol)Soluble in 150 ml of methylene chlorideStir and cool to 0C.DCC (dicyclohexylcarbodiimide) (24.7 g) was slowly added dropwise.120mmol) dichloromethane solution,After dripping, the reaction was incubated for 6 hours.Filtered, concentrated under reduced pressure, recrystallized from acetonitrile, filtered,Trichloroethyl 3alpha-hydroxy-7-oxo-5beta-cholanoic acid (50.4 g, yield 86.7%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-20-8, Trichloroethanol.

Reference:
Patent; Hangzhou Heze Pharmaceutical Technology Co., Ltd.; Ni Sheng; Yang Zhenghe; Chen Jie; Cai Liefeng; Zhou Yinglei; Zhou Liang; Chen Hongxiang; (23 pag.)CN107383139; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 112513-79-8, 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol

A solution of racemic 6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol (30 mg), isopropenyl acetate (24-240 mul, 1-30 eq.) and NOV435 (30 mg) in 3.0 mL of solvent (toluene, acetonitrile, tetrahydrofuran or terc-buthyl methyl ester) was stirred gently at 35 C for 7 h in a 4 mL vial. Samples were collected after 3 and 7 h and were directly analyzed by chiral GC for ee of the product and reagent. Conversion (C) was calculated as C = eer/(eer + eep) and enantiomeric ratio (E) was calculated as E = ln[1 – C(1 + eep)]/ln[1 – C(1 – eep)].

The synthetic route of 112513-79-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Miranda, Amanda S.; Gomes, Juliana C.; Rodrigues Jr., Manoel T.; Costa, Ingrid C.R.; Almeida, Wanda P.; Lopes, Raquel De O.; Miranda, Leandro S.M.; Coelho, Fernando; De Souza, Rodrigo O.M.A.; Journal of Molecular Catalysis B: Enzymatic; vol. 91; (2013); p. 77 – 80;,
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Adding a certain compound to certain chemical reactions, such as: 505-10-2, 3-(Methylthio)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 505-10-2, blongs to alcohols-buliding-blocks compound. name: 3-(Methylthio)propan-1-ol

The 3-(methylthio)propan-l-ol 6-a (200 g, 1900 mmol, CAS 505-10-2) was dissolved in CH2C12 (2000 mL). The mixture was cooled to 0C. The w-CPBA 85% in water (970 g, 5700 mmol, CAS 937-14-4) was added portion wise keeping the temperature between 0 and 5C. After addition, the mixture was allowed to warm to 25C and stirred for 15 h. The mixture was filtered through a celite pad. The filtrate was purified by flash column (Eluent: petroleum ether: ethyl acetate = 3 : 1 and then ethyl acetate: methanol = 10: 1) to yield the intermediate 6-b (75 g, 29%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,505-10-2, its application will become more common.

Reference:
Patent; JANSSEN R&D IRELAND; COOYMANS, Ludwig Paul; DEMIN, Samuel Dominique; HU, Lili; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; WO2012/80449; (2012); A1;,
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