Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. SDS of cas: 3597-91-9

(A) 4-Phenylbenzyl Bromide Triphenylphosphine (1.58 g) and N-bromosuccinimide (1.07 g) were added to a stirred solution of 4-hydroxymethylbiphenyl (1.01 g) in dichloromethane (10 mL) under nitrogen. The mixture was stirred at room temperature for 15 hr and evaporated in vacuo. The residue was diluted with chloroform, and washed with saturated sodium hydrogencarobonate, and brine. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=1:100 to 1:50, v/v) to give the titled compound (1.26 g) as colorless crystals: 1H-NMR (400 MHz, CDCl3) delta 4.55 (s, 2H), 7.33-7.38 (m, 1H), 7.41-7.49 (m, 4H), and 7.54-7.60 (m, 4H).

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Microcide Pharmaceuticals, Inc.; US6399629; (2002); B1;,
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Application of 5259-98-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5259-98-3, name is 5-Chloropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Under a nitrogen atmosphere, 7.0 g of a compound represented by the formula (D-9-6)0.7 g of pyridinium p-toluenesulfonate,70 mL of dichloromethane was added.5.8 g of 3,4-dihydro-2H-pyran was added dropwise while cooling with ice, and the mixture was stirred at room temperature for 8 hours.After washing successively with a 5percent aqueous sodium hydrogencarbonate solution and brine,Purification by column chromatography (silica gel, dichloromethane) gave 10.6 g of a compound represented by the formula (D-9-7).

According to the analysis of related databases, 5259-98-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; (134 pag.)JP2018/70546; (2018); A;,
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Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

34.9 g (0.1 mol) of 4-[l-(5,6,7,8 -tetrahydro- 3,5,5,8,8-pentamethyl -2-naphthalenyl) ethenyl] benzoic acid (bexarotene, Targretin ) was dissolved in 300 ml of chloroform. 20.6 g of N, N’-Dicyclohexylcarbodiimide was added into the reaction mixture. 11.6 g of dimethylaminoethanol was added into the reaction mixture. The mixture was stirred for 3 hours at RT. The solid was removed by filtration. The chloroform solution was washed with 5% NaHCO (2 x 100 ml) and water (3 x 100 ml). The organic solution was dried over anhydrous sodium sulfate. Sodium sulfate was removed by filtration. 3.6 g of HCl gas in ether (100 ml) was added into the reaction mixture with stirring. The solid product was collected by filtration. After drying, it yielded 40 g of the desired product (85.8%). Hygroscopic product; Elementary analysis: C H ClNO ; MW: 484.11. Calculated % C: 74.43; H: 8.74; Cl:30 42 27.32; N: 2.89; O: 6.61; Found % C: 74.39; H: 8.76; Cl: 7.29; N: 2.91, O: 6.65.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; YU, Chongxi; WO2008/87493; (2008); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H5F3O

Tert-butyl [(lr,4r)-6′-bromo-4-methoxy-5″-methyl-3’H-dispiro[cyclohexane-l,2′-indene- ,2″- imidazol]-4″-yl]carbamate (Intermediate 12, 715 mg, 1.50 mmol), allylpalladium(II) chloride (21.95 mg, 0.06 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl-2- yl)phosphine (70.3 mg, 0.15 mmol) and CS2CO3 (733 mg, 2.25 mmol) were placed in a MW- vial. Toluene (8 mL) was added and the head space was evacuated and refilled with argon. 3,3,3- Trifluoropropan-l-ol (684 mg, 6.00 mmol) was added and the mixture was heated to 100 C in a MW apparatus for 2 h. 2 M methanolic ammonia (8.57 mL, 60.0 mmol) and water (1.08 mL, 60.0 mmol) was added and the mixture was heated to 80 C for 12 h. The reaction mixture was cooled to r.t. The organic solvents were evaporated and the aqueous residue was extracted with DCM. The combined extracts were concentrated and the residue was purified by reverse phase preparative chromatography providing the title compound (410 mg, 67% yield). 1H MR (500 MHz, DMSO-de) delta 0.90 (td, 1 H), 1.08 – 1.27 (m, 2 H), 1.34 – 1.49 (m, 3 H), 1.80 (d, 2 H), 2.15 (s, 3 H), 2.69 (tt, 2 H), 2.82 – 2.99 (m, 3 H), 3.15 – 3.22 (m, 3 H), 4.00 – 4.10 (m, 2 H), 6.08 (d, 1 H), 6.51 (br. s., 2 H), 6.75 (dd, 1 H), 7.18 (d, 1 H); MS (APCI+) m/z 410 [M+H]+.

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; KARLSTROeM, Sofia; CSJERNYIK, Gabor; SWAHN, Britt-Marie; SANDBERG, Lars; KOLMODIN, Karin; SOeDERMAN, Peter; OeHBERG, Liselotte; WO2013/190298; (2013); A1;,
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Related Products of 56456-49-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56456-49-6, name is 4-Chloro-2-fluorobenzyl alcohol, molecular formula is C7H6ClFO, molecular weight is 160.5733, as common compound, the synthetic route is as follows.

To a solution of (4-chloro-2-fluorophenyl)methanol (222 mg) in MeCN (20 mL) was added MnC>2 (480 mg). The mixture was stirred for 24h. The mixture was filtered over celite, the org. layer was dried over MgS04 and evaporated in vacuo. The crude aldehyde was used without purification in the next step. LC-MS (A): tR = 0.76 min; [M+H]+: not visible.

Statistics shows that 56456-49-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-fluorobenzyl alcohol.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; NAYLER, Oliver; REMEN, Lubos; VERCAUTEREN, Magali; WELFORD, Richard; WO2015/75023; (2015); A1;,
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Application of 928-51-8, Adding some certain compound to certain chemical reactions, such as: 928-51-8, name is 4-Chlorobutan-1-ol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 928-51-8.

Example 6 Synthesis of 4-(nitrooxy)butyl 4-phenyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa- 1 ,4-dienyl)butanoate (Compound 6) Step 1 : Synthesis of 4-chlorobutyl 4-nitrobenzoate To a solution of 4-Chlorobutanol (1.09 g; 10.04 mmol) and TEA (1.7 ml; 12.05 mmol) in CH2C12 (25 ml) cooled at 0C, 4-Nitrobenzoyl chloride (2.23 g; 12.05 mmol) was added portionwise. The mixture was stirred 2 hours at room temperature then was washed with NaH2P04 (25 ml), H20 and brine. The residue was purified by flash chromatography (Biotage SPl instrument, SNAP cartridge silica 100 g, n-Hexane/EtOAc 9: 1, 10 CV) affording the title compound (2.48 g; Yield: 96%) 1H NMR (300 MHz, CDC13) delta 8.38-8.25 (m, 2H), 8.25-8.14 (m, 2H), 4.55-4.33 (m, 2H), 3.73-3.53 (m, 2H), 2.13-1.85 (m, 4H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 928-51-8, 4-Chlorobutan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NICOX SCIENCE IRELAND; ALMIRANTE, Nicoletta; STORONI, Laura; RONSIN, Gael; BASTIA, Elena; WO2014/170264; (2014); A1;,
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Reference of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.

(9-1) Synthesis of 3-bromopropylcyclohexane (compound 9-1) [Show Image] 3-Cyclohexyl-1-propanol (5.00 g) was dissolved in methylene chloride (50 ml), triphenylphosphine (10.2 g) and N-bromosuccinimide (6.90 g) were added under ice-cooling, and the mixture was stirred under ice-cooling for 1 hr, and further at room temperature for 1 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. Diethyl ether (100 ml) was added, and the precipitated triphenylphosphine oxide was filtered off. The concentrate of the filtrate was purified by silica gel column chromatography (hexane alone) to give the object product (7.17 g) as a colorless oil. 1H-NMR(CDCl3) delta (ppm): 0.81-0.96(2H, m), 1.10-1.45(6H, m), 1.60-1.78(5H, m), 1.82-1.92(2H, quint, J=7.0Hz), 3.39(2H, t, J=7.0Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
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Reference of 56239-26-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To tert-butyl 3-(5-chloro-2-fluoropyridin-4-yl)phenyl((tetrahydro-2H-pyran-4- yl)methyl)carbamate (440 mg, 1.045 mmol) was added DMSO (4 ml), TEA (0.729 ml, 5.23 mmol), and (ls,4s)-4-aminocyclohexanol hydrochloride (476 mg, 3.14 mmol) . The reaction was stirred at 95-100 °C for 40 hr. The reaction was followed by LCMS. The reaction was let cool, added 250 ml of ethyl acetate, washed with saturated sodium bicarbonate, water (2x), filtered and concentrated to constant mass. The crude was purified by silica gel chromatography using 12g column eluting with 30-85percent ethyl acetate with heptane. The desired fractions were concentrated to constant mass, giving 363 mg of the titled compound as free base used without further purification. LCMS (m/z): 516.2 (MH+), rt = 0.80 min.

According to the analysis of related databases, 56239-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/66065; (2012); A1;,
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Electric Literature of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.

A solution of 5-methoxy-l-indanone (500 mg, 3.08 mmol) in methanol (10 mL) was treated with 10% palladium on carbon (53 mg) followed by glycoaldehyde dimer (370 mg, 3.08 mmol) and 0.5M sodium methoxide in methanol (1.3 mL, 0.65 mmol). The mixture was placed under a hydrogen atmosphere (balloon) and stirred vigorously at room temperature for 65 hours. After purging with nitrogen, the mixture was filtered through a 0.45 mum Acrodisc and the disk was rinsed with methanol (2 mL). The filtrate was diluted with EtOAc (25 mL), washed with 0. IN HCl (15 mL) and brine (15 mL), dried over MgSOphi filtered, and evaporated under vacuum to a solid. LC-MS of this material showed a mixture of starting material (major) and product. The mixture was purified by chromatography on a Biotage Flash 12M KP-SiI column (12 mm x 15 cm). The column was eluted with 3:2 EtOAc-hexanes, collecting 6 mL fractions every 30 sec. EPO Fractions 20-36 were concentrated under vacuum and flashed with benzene to afford 2-(2-hydroxyethyl)- 5-methoxy-l-indanone as an oil. 1H NMR (CDCl3, 500 MHz) delta 1.80 and 2.05 (two m, CH2CH2OH), 2.79 and 3.35 (two dd, 3-CH2), 2.83 (m, H-2), 3.77-3.90 (m, CH2CH2OH), 3.87 (s, OCHj), 6.86 (d, H-4), 6.89 (dd, H-6), and 7.67 (d, H- 7).

According to the analysis of related databases, 23147-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2006/50399; (2006); A2;,
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Application of 13674-16-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate. This compound has unique chemical properties. The synthetic route is as follows.

[0177] Example 18: Synthesis of 2-(4 -AMINO-BIPHENYL-4-YLOXY)-3-PHENYL-PROPIONIC acid methyl ester.; [0178] Step 1: 2- (4 -NITRO-BIPHENYL-4-YLOXY)-3-PHENYL-PROPIONIC acid methyl ester. A mixture OF 4 -HYDROXY-4-NITRO-BIPHENYL (4.12 g, 19.1 mmol), prepared in step 2 of Example 16, 2-hydroxy-3-phenyl-propionic acid methyl ester (3.35 g, 18. 5 mmol) and triphenylphosphine (4.12 g, 19.1 MMOL.) in diethyl ether was cooled under nitrogen to 0C. Diisopropyl azodicarboxylate (6.09 mL, 30.96 mmol) was then added and the reaction allowed to come to room temperature and then stirred overnight at room temperature. The reaction was concentrated under reduced pressure. Purification of the residue on silica gel using 15% ethyl acetate hexanes as the eluent gave 2- (4 -NITRO-BIPHENYL-4-YLOXY)-3-PHENYL-PROPIONIC acid methyl ester.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13674-16-3, Methyl 2-hydroxy-3-phenylpropanoate.

Reference:
Patent; WYETH; WO2005/30702; (2005); A1;,
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