Tag: M.W=100-200

Application of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2: This example illustrates the preparation of 3,3-dimethyl-1 -pyrrolo[1 ,2-b]pyridazin- 3-yl-4H-isoquinolinea) Preparation of 1 ,3,3-trimethyl-4H-isoquinolineAcetonitrile (1.5 g, 37 mmol) was slowly added to 98% sulfuric acid (50 g, 0.5 mol) at 0 00. Then 2-methyl-i -phenyl-propan-2-ol (5.0 g, 33 mmol) was added to this solution at 0 00 The reaction mixture was allowed to reach room temperature, stirred for 1 h at this temperature and poured on aqueous sodium hydroxide solution of pH 9. The mixture was extracted withethyl acetate, the organic layer washed with water and brine, dried over sodium sulfate and evaporated under reduced pressure to obtain 1 ,3,3-trimethyl-4H-isoquinoline (4.3 g, 25 mmol, 74 %), which was pure enough to be directly used in the next step. 1H-NMR (400 MHz, 0D013): oe (ppm) = 1.20 (s, 6H), 2.37 (s, 3H), 2.69 (s, 2H), 7.14 (d, 1H), 7.27-7.36 (m, 2H), 7.48 (d, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-86-7, 2-Methyl-1-phenyl-2-propanol.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA (CHINA) INVESTMENT CO., LTD.; BOU HAMDAN, Farhan; QUARANTA, Laura; TRAH, Stephan; LAMBERTH, Clemens; LU, Long; LU, Qiang; WO2015/117563; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 28539-02-8 , The common heterocyclic compound, 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

7.4 g of hydroxymethylbenzotriazole was added to a single-necked flask, 25 ml of S0C12 was added dropwise,After the end of the mixing, the mixture was stirred for 30 min and refluxed at 80 C for 3 h. The excess S0C12 was distilled off with a rotary evaporator, To give a white crystal, i. EforChloromethyl benzotriazole

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Henan College of Traditional Chinese Medicine; Wang, Xia; Zhang, Chao; Ceng, Dai; Cheng, Di; Song, Ning; Yang, Huai Xia; (11 pag.)(2016);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 3068-00-6, Adding some certain compound to certain chemical reactions, such as: 3068-00-6, name is 1,2,4-Butanetriol,molecular formula is C4H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3068-00-6.

General procedure: To a solution of CoCl2 (0.6 mmol) in anhyd MeCN (4 mL), the selecteddialkyl acetal (1 mmol), TMSCl (1.1 mmol), and butane-1,2,4-triol (3 mmol) were added, with stirring, at r.t. At the end ofthe reaction, the mixture was extracted with EtOAc and the combinedextracts were washed with 5% NaHCO3. The organic layerwas dried (anhyd Na2SO4) and filtered, and the solvent was evaporatedunder vacuum. The oils obtained were purified by flash chromatographyto give the desired compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3068-00-6, 1,2,4-Butanetriol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Battisti, Umberto Maria; Sorbi, Claudia; Franchini, Silvia; Tait, Annalisa; Brasili, Livio; Synthesis; vol. 46; 7; (2014); p. 943 – 946;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.Application In Synthesis of 3,3,3-Trifluoropropan-1-ol

To a solution of 3,3,3-trifluoropropan-1-ol (5.0 g, 43.8 mmol) in CH2Cl2 (25 mL) and pyridine (25 mL) was added 4-(dimethylamino)pyridine (0.27 g, 2.2 mmol) followed by p-toluenesulfonyl chloride (8.4 g, 43.8 mmol). The mixture was allowed to stir at ambient temperature for 72 h then was quenched with 5percent aqueous HCl (20 mL). The layers were separated and the aqueous phase was extracted with CH2Cl2 (3.x.7 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 75percent hexanes in EtOAc) afforded the title compound (8.0 g, 29.8 mmol, 68percent yield). MS (DCI/NH3) m/z 286 (M+NH4)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 7218-43-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol. A new synthetic method of this compound is introduced below.

A suspension of Intermediate B (190 mg, 0.297 mmol), 2-(2-(prop-2-yn-1-yloxy)ethoxy) ethanol [King-Underwood et al., WO2011/048111] (257 mg, 0.890 mmol), PdCI2(PPh3)2 (208 mg, 0.297 mmol) and copper(l) iodide (57 mg, 0.30 mmol) in a mixture of Et2NH and DMF (4: 1 v/v, 7.5 ml_) was degassed with N2 and was then heated to 60C for 16 hr. The reaction mixture was cooled to RT and was evaporated in vacuo onto silica gel and purified by flash column chromatography (Si02, 12 g, MeOH in DCM, 0-5%, gradient elution) to afford the title compound, Compound (la), as a pale tan solid (30 mg, 14%); Rt 1.88 min, m/z 704 (M+H)+ (ES+); 1 H NMR delta: 3.36-3.50 (6H, overlapping m), 3.61-3.63 (2H, overlapping m), 4.37 (2H, s), 4.58 (1 H, m), 5.48 (2H, s), 5.76 (2H, s), 6.41 (1 H, d), 6.64 (1 H, m), 6.72 (1 H, d), 6.78 (1 H, s), 7.14 (1 H, t), 7.27 (1 H, t), 7.52 (1 H, d), 7.65-7.71 (2H, overlapping m), 7.82 (1 H, t), 8.13 (1 H, s), 10.19 (1 H, br s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.

Reference:
Patent; RESPIVERT LIMITED; ONIONS, Stuart Thomas; COPMANS, Alex Herman; BROECKX, Rudy Laurent Maria; SMITH, Alun John; TADDEI, David Michel Adrien; WO2014/140597; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, molecular weight is 120.15, as common compound, the synthetic route is as follows.name: 1,3-Dimethoxypropan-2-ol

To a solution of 1, 3-dimethoxy-2-hydroxypropane (3.84g, 0. 032mol) in DCM (70ml) cooled at 5 C was added triethylamine (Sml, 0. 036mol) followed by slow addition of methanesulphonyl chloride (2. 72ml, 0. 035mol). The mixture was then stirred at ambient temperature for 24 hours. The mixture was then absorbed onto silica gel and purified by flash silica chromatography DCM: isohexane (3: 1) to give the title compound (3.74g, 59percent). NMR 3.15 (s, 3H), 3.28 (s, 6H), 3.52 (d, 4H), 4.78 (q, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-69-8, 1,3-Dimethoxypropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/76436; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 111-46-6 ,Some common heterocyclic compound, 111-46-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Protocole 2 To a solution of diethylene glycol (31.83 g ; 300.0 mmol ; 7.0 eq) in CH2Cl2 (90 mL) was added Et3N (4.77 g ; 47.1 mmol ; 1.1 eq). The mixture was stirred vigorously. A solution of p-toluenesulfonyl chloride (8.17 g ; 42.8 mmol ; 1.0 eq) in CH2Cl2 (108 mL) was added dropwise. Following the addition, the reaction mixture was stirred for 24 h at room temperature. Then a 1.0 M solution of HCl (50 mL), water (50 mL) and saturated solution of brine (60 mL) were added. The resultant aqueous layers were further extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The product was purified by flash column chromatography on silica gel (99% CH2Cl2/MeOH) to give the desired compound 3b as a colorless oil in 67% yield (7.48 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-46-6, 2,2′-Oxybis(ethan-1-ol), other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ricco, Christophe; Abdmouleh, Fatma; Riccobono, Charlotte; Guenineche, Lena; Martin, Frederique; Goya-Jorge, Elizabeth; Lagarde, Nathalie; Liagre, Bertrand; Ali, Mamdouh Ben; Ferroud, Clotilde; Arbi, Mehdi El; Veitia, Maite Sylla-Iyarreta; Bioorganic Chemistry; vol. 96; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 15852-73-0, Adding some certain compound to certain chemical reactions, such as: 15852-73-0, name is (3-Bromophenyl)methanol,molecular formula is C7H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15852-73-0.

General procedure: 1 mmol of the substrate (alcohol, phenol or amine) wasadded to a mixture of RHA/TiO2(30percent) (20 mg) and aceticanhydride (1.5 mmol per OH/NH2 group) and the resulting mixture was stirred at room temperature. After completionof the reaction (mentioned by TLC), dichloromethane(20 mL) was added and the catalyst was separated byfiltration. The organic phase was washed with 10percent aqueoussolution of sodium bicarbonate (2 20 mL) and dried overNa2SO4. The solvent was removed under reduced pressureto afford the desired product in good to high yields. Thespectral (IR, 1H and 13C NMR) data of new compounds arepresented below:

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Seddighi, Mohadeseh; Shirini, Farhad; Goli-Jolodar, Omid; Comptes Rendus Chimie; vol. 19; 8; (2016); p. 1003 – 1010;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 765-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 765-04-8, name is Undecane-1,11-diol, molecular formula is C11H24O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 250 mL round bottom flask, 1,11-undecanediol (2.62 g, 14 mmol) was suspended in toluene (50 mL). Glacial acetic acid (8.41 g, 140 mmol), water (2.5 mL), and concentrated sulfuric acid (82 mg, 0.84 mmol) were added, and the reaction mixture was heated to reflux temperature. The progress of the reaction was monitored by GC-MS. After 4 hours of reflux, the flask was removed from the heating bath and allowed to cool to room temperature. The contents of the flask were transferred to a separatory funnel and washed with water (25 mL), 10% sodium bicarbonate (2×25 mL), water (25 mL), and brine (25 mL). The organic phase was dried over sodium sulfate, filtered, and the solvent was removed under reduced pressure to yield 3.08 g (96% yield) of a water-clear liquid, which crystallized on standing at room temperature overnight. Analysis of the final product by gas chromatography-flame ionization detector (GC-FID) (Varian 3600) confirmed the product composition as 73% monoacetate, 14% diol, and 13% diacetate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 765-04-8, Undecane-1,11-diol.

Reference:
Patent; Wicki, Markus A.; Nielsen, Kent E.; US2005/143599; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50595-15-8, name is tert-Butyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below., Safety of tert-Butyl 2-hydroxyacetate

A 100 mL round bottom flask, equipped with a magnetic stir bar, was charged with tert- butyl 2-hydroxyacetate (1.07 g, 8.10 mrnol) and 4,5-dichloro-2-(2,2,2-trifluoroethyl)pyridazin- 3(2H)-one (FCH Group; CAS: 97137-16-1 ; 2 g, 8.10 mrnol). The flask contents were placed under a dry nitrogen atmosphere and tetrahydrofuran (THF) (16 mL) was introduced via syringe. The resulting solution was stirred at ambient temperature as lithium bis(trimethylsilyl)amide (1.0 M in THF; 8.10 mL, 8.10 mrnol) was added dropwise. The reaction mixture was stirred at ambient temperature for 65 hours. The reaction mixture was diluted with ethyl acetate (30 mL) and washed with dilute aqueous citric acid (2 x 10 mL) and with brine (1 x 10 mL). The organic layer was dried over anhydrous MgSC , filtered and concentrated under reduced pressure to give a crude mixture that was purified via column chromatography (Si(, 10-35percent ethylacetate/heptanes) to give the earlier eluting title compound A (577 mg, 1.7 mrnol, 21percent yield) and the later eluting title compound B (768 mg, 2.2 mrnol, 28percent yield). Title compound A:JH NMR (400 MHz, CDC13) delta ppm 7.77 (s, 1H), 5.21 (s, 2H), 4.71 (q, J = 8.3 Hz, 2H), 1.45 (s, 9H); MS (ESI+) m/z 343 (M+H)+. Title Compound B:JH NMR (400 MHz, CDC13) delta ppm 7.68 (s, 1H), 4.80 (q, 8.3 Hz, 2H), 4.80 (s, 2H), 1.50 (s, 9H); MS (ESI+) m/z 343 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50595-15-8, tert-Butyl 2-hydroxyacetate.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; BROWN, Brian, S.; MURAUSKI, Kathleen; (673 pag.)WO2019/90069; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts