Tag: M.W=100-200

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19819-98-8, name is 2-(o-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-(o-Tolyl)ethanol

General procedure: To a 1 dram vial equipped with a stir bar was added the alcohol (0.080 mmol), isopropyl (S)-2-(tert-butoxy)-2-(4?-(4,4-dimethylpiperidin- 1 -yl)-5-hydroxy-6?-methyl- [2,3?-bipyridinj-5?-yl)acetate (25 mg, 0.053 mmol), and triphenylphosphine (20.9 mg, 0.080 mmol) as a solution in THF (0.25 mL). To the solution was added DIAD (0.016 mL, 0.080 mmol) as a solution in THF (0.25 mL). The solution was stirred at r.t. for 30mm to 18 h. The reaction solution was concentrated under a N2 stream. The residue wasdissolved in EtOH (1.0 mL). To the solution was added aq. NaOH (5.0 M, 0.110 mL,0.532 mmol). The vial was capped, then placed in a 85 C heating block with stirring for4 h to 18 h. The mixture was cooled to r.t., then was filtered through a 0.4 micron syringefilter and the filtrate was directly subjected to HPLC purification to afford the purifiedproduct.

With the rapid development of chemical substances, we look forward to future research findings about 19819-98-8.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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Application of 5182-44-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5182-44-5, name is 2-(3-Chlorophenyl)ethanol, molecular formula is C8H9ClO, molecular weight is 156.6095, as common compound, the synthetic route is as follows.

In a flame-dried 250 mL round-bottom flask equipped with an argon line, the appropriate alcohol (21a-26a) (1 eq. ) was placed and was dissolved in ether/acetonitrile (3: 1). To this solution, triphenylphosphine (3 eq. ), imidazole (3 eq. ) and iodine (3 eq.) were added in this order. The reaction mixture was kept at room temperature for 1 hours and monitored by TLC. The reaction mixture was filtered and washed with ether. The organic layers were then washed with brine, dried over MgS04, filtered and concentrated in vacuo. The residue was purified via flash chromatography on silica gel eluting with 1% ethyl acetate/hexanes to give 21b-26b in 58-88% yield. m-Chlorophenethyl iodine (21b) H NMR (CDC13) : 8 7.21-7. 19 (q, 3H), 7.12 (t, 1H), 3.52 (t, 2H), 3.28 (t, 2H).’3CNMR (CDC13) : 8 140.90, 134.14, 129.69, 129.06, 127.02, 126.45, 38.69, 11,27. IR (liquid film) 2948,2879, 1598,1574, 1429 FT-ICRMS : m/z 267. 52 (M. +H).

The chemical industry reduces the impact on the environment during synthesis 5182-44-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITY OF MISSISSIPI; WO2003/95444; (2003); A1;,
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Reference of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.

For Fmoc-Leu-PABA 2j, a solution of Fmoc-Leu-OH (353 mg, 1 mmol), EEDQ (495 mg, 2 mmol) and PABA (222 mg, 1.8 mmol) in DCM (10 ml) was stirred for 10 h. All volatiles were removed on a rotovap, the residue was dissolved in Et2O (40 ml), chilled on dry ice for 2h and the solid was separated by centrifugation. The obtained crude material was purified on a column, eluent gradient of MeOH (1-2%) in CHCl3. Yield 444 mg (97%). MS: 459.4 [M+1]+.

According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARROWHEAD RESEARCH CORPORATION; CHENG, Weijun; WONG, So; ALMEIDA, Aaron, M.; ROZEMA, David, B.; BLOKHIN, Andrei, V.; CARLSON, Jeffrey, C.; WO2015/21092; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6966-10-5, name is (3,4-Dimethylphenyl)methanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 6966-10-5

General procedure: To a solution of phenylmethanols 5a-w (5 mmol) dissolved in methylene chloride (50 mL) in an ice-water bath was added phosphorus tribromide (5.5 mmol), and the mixture was stirred at the same temperature for 30 min. The mixture was washed with cool water, dried over anhydrous Na2SO4 and concentrated under reduced pressure to yield (bromomethyl)benzenes 6aew as offwhite solids or light yellow oils

With the rapid development of chemical substances, we look forward to future research findings about 6966-10-5.

Reference:
Article; Feng, Lianshun; Lv, Kai; Liu, Mingliang; Wang, Shuo; Zhao, Jing; You, Xuefu; Li, Sujie; Cao, Jue; Guo, Huiyuan; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 125 – 136;,
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Adding a certain compound to certain chemical reactions, such as: 3391-86-4, Oct-1-en-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H16O, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H16O

General procedure: A solution containing 6.4 × 10-3mmol of precatalyst and0.13 mmol of substrate (20 equiv.) in 2 mL of THF was transferred into a 5 mL glass vial which was then placed under argon into a stainless steel autoclave equipped with a magnetic stirring bar. The reaction vessel was pressurized with H2 to 30 bar and stirred for the desired time at room temperature. Then pressure was released andthe reaction vessel was stirred for the desired time at controlledtemperature under a dihydrogen atmosphere at 1 bar. Alterna-tively, after venting the H2pressure used for the catalyst activation,the residual H2was purged with argon by continuous flushingbefore continuing the reaction. The pure products were obtainedby chromatography of the reaction mixture on silica gel using dichloromethane as eluent and then analyzed by NMR spectrosopyand chiral GC for the determination of the yields and enantiomeric excesses.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3391-86-4, Oct-1-en-3-ol, and friends who are interested can also refer to it.

Reference:
Article; Titova, Ekaterina M.; Rahaman, S.M. Wahidur; Shubina, Elena S.; Poli, Rinaldo; Belkova, Natalia V.; Manoury, Eric; Journal of Molecular Catalysis A: Chemical; vol. 426; (2017); p. 376 – 380;,
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Reference of 108-16-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 108-16-7 as follows.

EXAMPLE 42 N-{5-chloro-2-[2-(dimethylamino)-1-methylethoxy]phenyl}-N’-(5-cyano-2-pyrazinyl)urea The desired product (2.9 mg, 6%) was prepared by substituting 1-(dimethylamino)-2-propanol (10.3 mg, 0.10 mmol) for 2-cyclohexen-1-ol in Example 1. MS (ESI(-)) m/z 373 (M-H)-; 1H NMR (500 MHz, DMSO-d6) delta 10.90 (s, 1H), 9.90 (br s, 1H), 8.96 (s, 1H), 8.95 (s, 1H), 8.29 (d, J=2.5 Hz, 1H), 7.28 (d, J=8.7 Hz, 1H), 7.15 (dd, J=8.7, 2.5 Hz, 1H), 3.96-4.07 (m, 1H), 3.42-3.55 (m, 2H), 2.88 (s, 6H), 1.26 (d, J=5.9 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-16-7, its application will become more common.

Reference:
Patent; Li, Gaoquan; Li, Qun; Li, Tongmei; Lin, Nan-Horng; Mantei, Robert A.; Sham, Hing L.; Wang, Gary T.; US2004/259885; (2004); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 637031-88-0, name is 3,3-Difluorocyclobutanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 3,3-Difluorocyclobutanol

370 mg 4-Fluor-5-methansulfonyl-2-methyl-benzoesaeure-methylester, 297 mg 3,3- Difluor-cyclobutanol und 1.47 [G] [CS2CO3] wurden in 10 ml wasserfreiem NMP geloest und 4 h bei [60C] geruehrt. Anschliessend wurde das Reaktionsgemisch mit 125 [ML] einer halbkonzentrierten waessrigen [NAHC03-LoeSUNG] verduennt und 3 mal mit je 100 ml EE extrahiert. Ueber [NA2SO4] wurde getrocknet und das Solvens im Vakuum entfernt. An Kieselgel wurde mit DIP chromatographiert und man erhielt 380 mg eines farblosen Oels. Rf [(DIP)] [= 0.] 21 MS [(DCI)] : 335

The synthetic route of 637031-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AVENTIS PHARMA DEUTSCHLAND GMBH; WO2003/106410; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2009-83-8, 6-Chlorohexan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2009-83-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 2009-83-8

In addition, the mixture was stirred at a stirrer, condenser, and a reaction vessel provided with a thermometer 4-hydroxy-benzoic acid 13.8g (100 mmol), potassium iodide 2.5g, 0.7g tetrabutyl ammonium bromide, and 400ml of ethanol were charged at room temperature.It was added dropwise a 25% aqueous solution of sodium hydroxide, 12g slowly.After the addition, maintaining the reaction vessel at 50 , and was added dropwise to 6-chloro-hexanol 20g (150 mmol) slowly.After the addition was completed, the reaction vessel also by heating to 70 by further reaction for 3 hours.After completion of the reaction, neutralized with 10% hydrochloric acid and subjected to extraction with ethyl acetate, dried over sodium sulfate, the solvent was concentrated to 17g to synthesize compounds shown in formula (23).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2009-83-8, its application will become more common.

Reference:
Patent; DIC Corporation; Hayashi, Masanao; Nagashima, Yutaka; Kusumotto, Tetsuo; (24 pag.)KR101523330; (2015); B1;,
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Reference of 29683-23-6, Adding some certain compound to certain chemical reactions, such as: 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol,molecular formula is C5H10OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29683-23-6.

Step 1 Tetrahydro-2H-thiopyran-4-yl-4-methylbenzenesulfonate Tetrahydro-2H-thiopyran-4-ol 23a (350 mg, 2.97 mmol, prepared by a method disclosed in EP patent application ”) was placed in a reaction flask, followed by addition of triethylamine (606 mg, 5.94 mmol), 4-dimethylaminopyridine (36 mg, 0.30 mmol), 20 mL of dichloromethane and p-toluenesulfonyl chloride (848 mg, 4.45 mmol). After reacting for 12 hours, the reaction solution was mixed with 30 mL of water, stood and layered, the aqueous phase was extracted with dichloromethane (10 mL*2). The organic phases were combined, washed with saturated sodium chloride solution (30 mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with elution system B to obtain the title compound tetrahydro-2H-thiopyran-4-yl-4-methylbenzenesulfonate 23b (556 mg, yield 68.9%) as a white solid.

According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Hengrui Pharmaceutical Co. Ltd.; Jiangsu Hengrui Medicine Co. Ltd.; LU, Hejun; SUN, Piaoyang; FEI, Hongbo; JIANG, Hongjian; WANG, Haowei; DONG, Qing; EP2894151; (2015); A1;,
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Synthetic Route of 6214-44-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6214-44-4, name is (4-Ethoxyphenyl)methanol, molecular formula is C9H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

60% NaH (300 mg, 7.5 mmol) was added in one portion to a suspension of tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2- carboxylate (1.58 g, 3.98 mmol) in DMF (30 mL) at room temperature under nitrogen. The mixture was stirred at room temperature for 20 min, then a solution of 4-ethoxybenzyl chloride in DMF (10 mL) (freshly prepared from 4-ethoxybenzyl alcohol (1.10 g, 7.23 mmol) and SOCl2 (1.0 mL) in dichloromethane at 0C) was added at room temperature, and the reaction mixture was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue was dissolved in dichloromethane and washed with water, dried over sodium sulfate. Removal of solvent gave the crude product, which was purified on silica gel (0-50% EtOAc in dichloromethane) to give the desired product (1.40 mg, 66%). MS (M+l): 532.2.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6214-44-4, (4-Ethoxyphenyl)methanol.

Reference:
Patent; AstraZeneca AB; WO2006/101434; (2006); A1;,
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