Tag: M.W=100-200

Reference of 59854-12-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59854-12-5, name is tert-Butyl 4-hydroxybutanoate, molecular formula is C8H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Hydroxy-butyric acid t-butyl ester (12.996 g) synthesized according to the reference (J. Org. Chem. 68, 6679-6684(2003)) and imidazole (5.522 g) were dissolved in dry DMF (60 mL). After the solution was cooled with an ice bath, t-butyldimethylsilyl chloride (12.227 g) was added, and the temperature of the mixture was raised gradually to room temperature (25 to 28C). After stirring for 10 hours, hexane (150 mL) was added. The organic layer was washed three times with water (100 mL). The organic layer was washed with a half-saturated aqueous ammonium chloride solution (about 10%) (100 mL), dried over anhydrous sodium sulfate, filtered off, and the filtrate was concentrated to obtain a crude product of Compound 13 as a yellow oil (20.383 g). Out of this amount, 18.232 g was distilled under reduced pressure (bp 93C/1.0 mmHg) to obtain a colorless oil 13 (15.3 g). Physicochemical property of Compound 13 ESI (LC/MS positive mode) (M+H+)275 1H-NMR Chemical shift value delta (in deuterated chloroform): 0.05 (6H, s), 0.89 (9H, s), 1.45 (9H, s), 1.74-1.84 (2H, m), 2.29 (2H, t, J=7Hz), 3.63 (2H, t, J=7Hz)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59854-12-5, tert-Butyl 4-hydroxybutanoate.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1857456; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 127-66-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.127-66-2, name is 2-Phenylbut-3-yn-2-ol, molecular formula is C10H10O, molecular weight is 146.19, as common compound, the synthetic route is as follows.

(2-Ethoxybut-3-yn-2-yl)benzene (Table 2, entry 1) [39a]:2-phenyl-3-butyn-2-ol (0.106 g, 0.728 mmol) was added to a 5-mLscrew cap vial and dissolved in CH2Cl2(1 mL). Ethanol (0.036 g,0.897 mmol) was added followed by the addition of [Fc]PF6(0.007 g, 0.022 mmol). The vial was then sealed and heated at40C for 3 days. The solvent was removed and the residue waschromatographed on a neutral alumina oxide (Aluminar®) column(2.5 × 30 cm, hexane and then CH2Cl2) to give the product as a yel-low solid (0.085 g, 0.487 mmol, 67percent). NMR (, CDCl3)1H: 7.67?7.29(m, 7H, aromatic), 3.69 (doublet of quintets, 1 H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 3.22 (doublet of quintets, 1H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 2.74 (s, 1H, C CH), 1.78 (s, 3H, CH3), 1.24 (t,3H,2JHH= 7.2 Hz, OCH2CH3) ppm.13C{1H}: 143.3 (s, aromatic ipso),128.6 (s, aromatic), 128.5 (s, aromatic), 127.9 (s, aromatic), 127.6(s, aromatic*), 126.1 (s, aromatic), 84.7 (s, C CH), 75.9 (s, CC CH),75.2 (s, C CH), 60.6 (s, OCH2), 33.2 (s, CH3), 15.6 (s, OCH2CH3)ppm. IR (ATR, Neat): 3284 (m), 3055 (w), 2973 (m), 2926(w), 1714(s), 1670 (s), 1575 (s), 1491 (s), 1335 (s), 1264 (s), 1057 (s), 997 (s)

The chemical industry reduces the impact on the environment during synthesis 127-66-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Queensen, Matthew J.; Rabus, Jordan M.; Bauer, Eike B.; Journal of Molecular Catalysis A: Chemical; vol. 407; (2015); p. 221 – 229;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 403-41-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of corresponding alcohol 1a,b,d-al (8 mmol), nitroxide 4a (0.085 g, 0.4 mmol) and compound 6d (0.097 g, 0.8 mmol) in CH2Cl2 (10 mL) was added to a vigorously stirred solution of NaHCO3 (2.016 g, 24 mmol) in water (10 mL) at 20 C. Then I2 (4.06 g, 16 mmol) powder was added in one portion to the formed reaction mixture at vigorous stirring and temperature 20-22 C. The reaction mixture was stirred at 20-22 C for appropriate time (see Table 1 in the article). Then, a saturated solution of sodium thiosulfate was added to the stirred reaction mixture for discoloration. Organic and aqueous phases were separated and the aqueous phase was then extracted with CH2Cl2 (3×5 mL). Organic phase and the extracts were combined and washed subsequently with saturated aqueous solution of NaCl (5 mL), aqueous solutionof HCl (1%) saturated with NaCl (3 mL), and then with water (5 mL). The washed extract was dried with anhydrous Na2SO4 and evaporated to dryness to give crude product, which was then purified by vacuum distillation under argon atmosphere or by recrystallization.

According to the analysis of related databases, 403-41-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kashparova, Vera P.; Klushin, Victor A.; Zhukova, Irina Yu.; Kashparov, Igor S.; Chernysheva, Daria V.; Il’chibaeva, Irina B.; Smirnova, Nina V.; Kagan, Efim Sh.; Chernyshev, Victor M.; Tetrahedron Letters; vol. 58; 36; (2017); p. 3517 – 3521;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 14426-21-2 ,Some common heterocyclic compound, 14426-21-2, molecular formula is C4H12ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into a reaction flask equipped with a stirrer, a condenser and a thermometer, 4.84 g (0.01 mol) of intermediate III-2 was added, 30mL dichloromethane to dissolve, add DCC 4. lg, stirring for some time after adding DMAP. After stirring for a period of time, bis (2-hydroxyethyl) amine hydrochloride l.lg (O.Olmol) was added to the reaction system in batches, and the reaction was continued for 2 hours. The filtrate was washed with 3 X 40 mL of water, the dichloromethane layer was separated, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness under reduced pressure. Column chromatography [eluent: nu (petroleum ether) Nu (ethyl acetate) = 90: 10] to give a white solid product of 3.818 (yield 99.8%), yield 66.8%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14426-21-2, its application will become more common.

Reference:
Patent; Tianjin Pharmaceuticals Research Institute Co., Ltd.; Liu, Ying; Liu, DengKe; Jie, xiaoshuai; Qi, haofei; Wang, jingyang; (13 pag.)CN102838652; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5339-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

From the reaction solution, 0.24 g of the catalyst was recovered. The recovered catalyst was regenerated by supporting 12 mg (5wt%) of K2 CO3. The procedures of Example 1 was repeated except that the so regenerated catalyst was used. The conversion of 2-(o-aminophenyl)ethanol was 100% and the yield of indole was 87.7%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 6966-10-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6966-10-5, name is (3,4-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.

Example 39; 3′,4′-Dimethvlphenylmethyl 2-cvanopvrazolidine-1 -carboxylate (39)3′,4′-Dimethylphenylmethyl chloroformate was prepared by dissolving 3,4-dimethylbenzyl alcohol (94.0 mg, 0.69 mmol) was in 3 ml_ dichloromethane followed by diisopropylethylamine (145 uL, 0.83 mmol). 20% Phosgene in toluene (473 uL, 0.83 mmol) was added dropwise and the reaction mixture was allowed to stir at room temperature for 2 hours.4 was prepared according to Example 4. To this was added the 4′-acetylaminophenyl chloroformate in one portion and the reaction mixture was stirred overnight at room temperature. After removal of solvent by rotary evaporation, the title compound was purified by silica gel chromatography (CombiFlash, 20% ethyl acetate in hexanes to 100% ethyl acetate over 10 minutes.) The appropriate fractions were collected, combined and evaporated to dryness to yield 39 (57.0 mg, 31.9%), ESMS 260.4 (M+H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6966-10-5, (3,4-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/94003; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (4-(Trifluoromethyl)phenyl)methanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (4-(Trifluoromethyl)phenyl)methanol

General procedure: Aq ammonia (28%, 0.5 mmol), the appropriate alcohol 10 (3.4mmol), the catalyst 3 (1 mol% Ir), and the phthalate pH standard solution(0.5 mL, pH 4.01) were mixed in a microwave vial tube at 23 C under air. The vial was sealed with a cap, and the reactionmixture was stirred at 150 C for 24 h in a microwave reactor (25-32 W). After cooling to 23 C, aq NaOH (0.1 M, 1 mL) was addedto the mixture and extracted with EtOAc (3 × 2 mL). The combinedorganic layers were concentrated. The crude product was purifiedby column chromatography over silica gel eluting with hexane-EtOAc (98:2 to 9:1) or CHCl3 to afford the corresponding N-alkylatedamine 11l,o-s

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-95-1, (4-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Yamada, Yoichim. A.; Ohta, Hidetoshi; Yuyama, Yoshinari; Uozumi, Yasuhiro; Synthesis; vol. 45; 15; (2013); p. 2093 – 2100;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1805-32-9

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 3,4- dichlorobenzyl alcohol ( 212mg, 1.2mmol) and water (1ml) were successively added to the reaction flask 25mlSchlenk.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.Heavy precipitate precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 92%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 770-71-8, Adding some certain compound to certain chemical reactions, such as: 770-71-8, name is Adamantan-1-ylmethanol,molecular formula is C11H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 770-71-8.

To a solution of adamantan-1-ylmethanol (1.0 g, 6.1 mmol) in DCM (20 mL), methanesulfonyl chloride (1.0 g, 9.0 mmol) and triethylamine (1.8 g, 18 mmol) were added. After stirring at room temperature over night, the reaction mixture was washed with aqueous sodium bicarbonate (10 mL) and brine (10 mL), dried over anhydrous sodium sulfate, filter and concentrated to give adamantan-1-ylmethyl methanesulfonate (1.4 g, 96%) as a white solid. 1H-NMR (500 MHz, CDCl3): delta 3.78 (s, 2H), 3.00 (s, 3H), 2.02 (s, 3H), 1.75-1.64 (m, 6H), 1.58-1.57 (m, 6H)

According to the analysis of related databases, 770-71-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 111-45-5, Adding some certain compound to certain chemical reactions, such as: 111-45-5, name is 2-(Allyloxy)ethanol,molecular formula is C5H10O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111-45-5.

A solution of 2-allyloxiethanol (112 g; 1.1 mol) in THF (100 ml) was dripped in a suspension of sodium hydride (60% in oil) (88 g; 2.2 mol) in THF (250 ml) under mechanic stirrer. After 20 h at room temperature, a solution of bromoacetic acid (138.9 g; 1.0 mol) in THF (150 ml) was added dropwise, causing the spontaneous reflux of the solvent. The solution was kept under reflux for 2 hours, then diluted with ethanol (50 ml) and, after 30 min, the suspension was concentrated. The residue was solved on water (400 ml) and the solution was washed with ethyl ether (3*100 ml), dichloromethane (2*100 ml); the aqueous phase was acidified to pH 1 with hydrochloride acid 37% and the product was extracted with dichloromethane (300 ml+4 50 ml). The organic phase was washed with water (4*50 ml), brine (40 ml) and evaporated to a liquid residue that was distilled under vacuum, at a pressure of 67 Pa, to obtained 3,6-dioxa-8-nonenoic acid (I) as colourless liquid (119.5 g; 0.746 mol). Yield 75%. p.eb67-pa 98-100 C. Title 93.5%.

According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRACCO IMAGING S.P.A.; AIME, Silvio; DELLI CASTELLI, Daniela; FEDELI, Franco; LONGO, Dario Livio; TERRENO, Enzo; UGGERI, Fulvio; (37 pag.)US2019/209713; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts