Tag: M.W=100-200

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromopropan-1-ol

General procedure: To a solution of DHA (10.0 mmol) and 2-bromoethanol (10.0 mmol) in CH2Cl2 (30 mL), boronfluoride ethyl ether (0.5 mL) was added dropwise at 0 C. The reaction mixture was stirred at 0 Cfor 8 h, then washed with saturated NaHCO3 solution (20 mL x 3). The organic layer was dried overanhydrous Na2SO4 and concentrated under reduced pressure. The crude products were purified bysilica gel column chromatography (PET/EtOAc = 10:1, v/v) to get the target compound 7a.The compounds 7b and 9a were synthesized by the same operation procedure of compound 7a.

With the rapid development of chemical substances, we look forward to future research findings about 627-18-9.

Reference:
Article; Tian, Ye; Liang, Zhen; Xu, Hang; Mou, Yanhua; Guo, Chun; Molecules; vol. 21; 6; (2016);,
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Synthetic Route of 769-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 6; Method AT5; Preparation of 1-Benzof1 3]dioxol-4-yl-2-bromo-ethanone; Step 1: Preparation of starting material 1-Benzor1, 3]dioxol-4-yl-ethanone; To a solution of MeMgBr in THF (1 M, 50 mL, 50 mmol, 1.5 eq) was diluted with 50 mL THF and cooled to-10 C. A solution of benzo [1,3] dioxole-4-carboxaldehyde (5.0 g, 33.3 mmol) in 50 mL THF was slowly added, and the reaction left to stir for 1 h. The reaction mixture was then quenched by pouring into 500 mL of ice cold sat. ammonium chloride and the mixture extracted with ether. The organic layers were dried over sodium sulfate and filtered through a plug of silica gel before concentrating in vacuo, providing 4.9 g of a white solid. A mixture of this solid (2.0 g, 12.0 mmol) and MnO2 (10.5 g, 120. 4 mmol, 10.0 eq) in 75 mL diethyl ether was stirred vigorously for 48 h. The reaction mixture was then filtered first through a plug of silica gel, then through a 0. 46 um frit before concentrating in vacuo to provide 2. 1g of an off-white solid. Purification by MPLC (Biotage) using a hexane-ethyl acetate gradient provided 1.47 g (74%) of 1- benzo [1,3] dioxol-4-yl-ethanone as an off-white solid. 1H-NMR (CDC13) 6 7.35 (d, J = 8 Hz, 1H), 6.97 (dm, J = 8 Hz, 1H), 6.87 (dd, J = 8 Hz, 1H), 6.08 (s, 2 H), 2.59 (s, 3H); TLC Rf = 0.18, 25% ethyl acetate-hexanes.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
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Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1.Preparation of I-(6-amino-pyridin-3-yloxy)-2-methyl-propan-2-olTo a microwave flask containing 6-aminopyridin-3-ol hydrobromide (700 mg, 3.66 mmol) and 1-chloro-2-methyl-2-propanol (597 mg, 5.5 mmol) in anhydrous dimethylformamide (17 ml) was added cesium carbonate (3.7 g, 11.4 mmol) and the material was heated in a microwave oven at 140° C. for 3 hours.The vial was cooled to ambient and the solvent was concentrated in vacuo (rotary evaporator/mechanical pump).The residue was taken up in methylene chloride and filtered to remove insolubles, rinsing well with methylene chloride.The crude material was purified by HPLC on silica gel, eluting with a gradient of 2percent to 10percent methanol/methylene chloride to provide the desired product as a orange-brown viscous oil which solidified on standing (449 mg). MS (H+)=183 m/e.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael; US2012/40949; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 221285-25-2, name is (2-Amino-6-fluorophenyl)methanol. A new synthetic method of this compound is introduced below., Computed Properties of C7H8FNO

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 221285-25-2, (2-Amino-6-fluorophenyl)methanol.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2612-28-4, name is 2-Propylpropane-1,3-diol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-Propylpropane-1,3-diol

3rd Step 2-Propyl-1,3-propanediol 17.4 g (147 mol) and the above 3-(4-trifluoromethylphenyl)propanal 20.0 g (98.9 mmol) were dissolved in toluene 200 ml, and PTS 1 g was added, and the mixture was refluxed with heating for 3 hours while removing water formed with Dien-Stark. The reactant was washed with a saturated sodium bicarbonate aqueous solution, and then with saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate, and the solvent was distilled off. The residue was purified by silica gel column chromatography (eluent: toluene), and recrystallized twice from ethanol to obtain 5-propyl-2-(2-(4-trifluoromethylphenyl)ethyl)-1,3-dioxane 10.8 g (35.7 mmol). The yield was 36.1% from 3-(4-trifluoromethylphenyl) propanal. 1H-NMR(CDCl3) delta(ppm): 7.41 (dd,4H), 4.41(t,1H), 4.18-4.00(m,2H), 3.41-3.16(m,2H), 2.88-2.70(m,2H), 2.14-1.80(m,3H), 1.35-0.81(m,7H)

The synthetic route of 2612-28-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chisso Corporation; US6235355; (2001); B1;,
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Related Products of 675580-49-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 675580-49-1, name is (6-Chloroimidazo[1,2-b]pyridazin-3-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(6-Chloroimidazo[1,2-b]pyridazin-3-yl)methanol 72 (1 mmol) and the alkyl iodide (1.1 mmol) were dissolved in dry DMF (2 mL) and sodium hydride (60% disp, 1.1 mmol) added. After 2 h the mixture was poured into water and extracted (2×) with ethyl acetate. The combined organic layers were washed with 5% lithium chloride solution (5×), dried, concentrated and the residue purified by column chromatography (12 g ISCO column eluting with methylene chloride and a methanol/ammonia mixture (10:1); gradient 100% methylene chloride to 80% methylene chloride over 30 min at 25 mL/min) to provide the desired product 8.8a 6-Chloro-3-(methoxymethyl)imidazo[1,2-b]pyridazine was obtained as a yellow oil (100 mg, 51%); Rf=0.90 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CD3OD) delta 8.05 (d, J=9.5 Hz, 1H), 7.81 (s, 1H), 7.34 (d, J=9.5 Hz, 1H), 4.85 (s, 2H), 3.41 (s, 3H).8b 6-Chloro-3-(ethoxymethyl)imidazo[1,2-b]pyridazine was obtained as a yellow oil (111 mg, 53%); Rf=0.90 (CH2Cl2/MeOH/NH4OH, 160:18:2); 1H NMR (500 MHz, CD3OD) delta 8.01 (d, J=9.5 Hz, 1H), 7.80 (s, 1H), 7.34 (d, J=9.5 Hz, 1H), 4.87 (s, 2H), 3.63 (quart, J=7.0 Hz, 2H), 1.21 (t, J=7.0 Hz, 3H).

According to the analysis of related databases, 675580-49-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALCON MANUFACTURING, LTD.; US2008/153813; (2008); A1;,
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Related Products of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

cyclopentane methanol (119a) (500 mg) was dissolved in pyridine (5 mL), under ice cooling, added TsCl (1.43 g), and the reaction was stirred at room temperature for 36 hours. After concentrating the solvent under reduced pressure, the residue ethyl acetate(50 mL) was added to the organic layer saturated aqueous sodium hydrogen carbonate solution (50 mL), washed with saturated brine (50 mL), and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reducedpressure, the residue was purified by silica gel flash column chromatography (developing solvent nhexane:ethyl acetate =50: 1) to obtain a colorless cyclopentylmethyl tosylate (120a) (864 mg, 68% yield) to give an oil.

Statistics shows that 3637-61-4 is playing an increasingly important role. we look forward to future research findings about Cyclopentanemethanol.

Reference:
Patent; Nagoya City University; Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Ida, Shinsuke; Rie, Masaki; (47 pag.)JP5725475; (2015); B2;,
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Synthetic Route of 15258-73-8 ,Some common heterocyclic compound, 15258-73-8, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 3-e (320 mg, 1.818 mmol) was obtained in an ice bath.Diisopropyl azodicarboxylate (400 mg, 2.00 mmol) was slowly added dropwise to a solution of 2-nitrophenol (250 mg, 1.818 mmol), triphenylphosphine (520 mg, 2.00 mmol) in tetrahydrofuran (5 mL). After stirring overnight at room temperature, the solvent was distilled off under reduced pressure, and the residue was purified by Prep-TLC (petroleum ether/ethyl acetate = 1:1) to give compound 3-d (0.30 g, 55%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15258-73-8, its application will become more common.

Reference:
Patent; SHANGHAI KAIHUI TECHNOLOGY DEVELOPMENT CO;LTD; XU, ZUSHENG; Kaihui Science And Technology Development (Shanghai) Co., Ltd.; Xu Zusheng; (100 pag.)CN103304571; (2018); B;,
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Adding a certain compound to certain chemical reactions, such as: 34626-51-2, 5-Bromopentan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 5-Bromopentan-1-ol, blongs to alcohols-buliding-blocks compound. name: 5-Bromopentan-1-ol

Condensation of a-bromo aldehyde with 2,4-diamino-4-oxo-pyrimidine 19 is the key step in the synthesis of compounds 9-11 as outlined in Scheme 1 and Scheme 2. Commercially available alcohol 14 was coupled to the corresponding phenyl esters and oxidized to the corresponding aldehydes 17a and 17b (Scheme 1).-? Alcohol 24 was coupled to the appropriate phenyl ester to afford the aldehyde 25 (Scheme 2). The aldehydes were reacted with Br2 in dioxane to give the desired a-bromoaldehydes?2 18a, 18b (Scheme 1) and 26 (Scheme 2) and immediately reacted with 2,4-diamino-6-hydroxypyrimidine 19 to cyclize to the 5-substituted pyrrolo[2,3-d]pyrimidines 20a, 20b (Scheme 1) and 27 (Scheme 2).? Hydrolysis of the esters provided the free acids 21 a, 2 lb and 28. Subsequent peptide coupling with diethyl L-glutamate using the activating agents N-methyl morpholine and 2,4-dimethoxy-6-chlorotriazine, afforded the diesters 22a, 22b and 29. Saponification of the diesters yielded the final compounds 9-11 of this invention.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,34626-51-2, 5-Bromopentan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; DUQUESNE UNIVERSITY OF THE HOLY SPIRIT; WAYNE STATE UNIVERSITY; GANGJEE, Aleem; MATHERLY, Larry H.; (43 pag.)WO2016/22881; (2016); A1;,
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Related Products of 144-19-4, Adding some certain compound to certain chemical reactions, such as: 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol,molecular formula is C8H18O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144-19-4.

238. 5g of 2, 2, 4-trimethyl-1, 3-pentanediol was placed (TMPD, 1.631 mol) in a 2-13- neck round-bottom flask. To this was added 205.7g DMC (2.283 mol, 40% excess) and 2.2g zinc stearate. The reaction flask was equipped with a thermocouple temperature probe, magnetic stirbar, and a 1″wide, 10″long vacuum-jacketed, silvered column packed with HastelloyG) B, atop which was placed a variable reflux K-head and condenser. The system was purged by bubbling nitrogen into the reaction mixture for 45 minutes prior to being heated. While under an atmosphere of nitrogen, the mixture was heated slowly to 100- 105C. After 30 minutes of heating, the boiling mixture began to reflux at an overhead temperature of 62-64C. The methanol byproduct/DMC azeotrope (typically a 70/30 wt/wt mixture of methanol/DMC) was removed at a reflux to takeoff ratio of between 3: 1 and 8: 1. After 2 hours of continuous heating, the temperature of the reaction mixture slowly began to rise, reaching 150-155C over the course of the next 15.5 hours as methanol was removed from the system. At this point, 37.9g DMC and 79.2g methanol (75.9% of total expected) had been removed from the reaction. The reaction mixture was then cooled to 60C and a vacuum was slowly introduced in order to remove unreacted DMC and additional methanol by-product. During this time, the temperature of the mixture was slowly increased. After 3 hours, the reaction mixture had been warmed to 90-95C and the system pressure had been reduced to 1.0-2. 0 mmHg. The system pressure was then further reduced to 0.5-1. 0 mmHg and the temperature of the mixture increased to 130C. Unreacted TMPD was preferentially removed from the reaction at an overhead temperature of 80-95C followed by distillation of the carbonate product 4-isopropyl-5, 5-dimethyl-1, 3-dioxan-2-one at an overhead temperature of 95-110C. Several cuts were taken during the distillation and analyzed by GC with the following results; Based on the above results (assuming actual wt. % is approximately equal to GC area %), reaction yield = 73.5%.

According to the analysis of related databases, 144-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HUNTSMAN PETROCHEMICAL CORPORATION; WO2003/89424; (2003); A1;,
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