Tag: 200-300

《Phenazine-Based Covalent Organic Framework Cathode Materials with High Energy and Power Densities》 was written by Vitaku, Edon; Gannett, Cara N.; Carpenter, Keith L.; Shen, Luxi; Abruna, Hector D.; Dichtel, William R.. Formula: C9H6O6 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Redox-active covalent organic frameworks (COFs) are promising materials for energy storage devices because of their high d. of redox sites, permanent and controlled porosity, high surface areas, and tunable structures. However, the low electrochem. accessibility of their redox-active sites has limited COF-based devices either to thin films (<250 nm) grown on conductive substrates or to thicker films (1 μm) when a conductive polymer is introduced into the COF pores. Elec. energy storage devices constructed from bulk microcrystalline COF powders, eliminating the need for both thin-film formation and conductive polymer guests, would offer both improved capacity and potentially scalable fabrication processes. Here we report on the synthesis and electrochem. evaluation of a new phenazine-based 2D COF (DAPH-TFP COF), as well as its composite with poly(3,4-ethylenedioxythiophene) (PEDOT). Both the COF and its PEDOT composite were evaluated as powders that were solution-cast onto bulk electrodes serving as current collectors. The unmodified DAPH-TFP COF exhibited excellent elec. access to its redox sites, even without PEDOT functionalization, and outperformed the PEDOT composite of our previously reported anthraquinone-based system. Devices containing DAPH-TFP COF were able to deliver both high-energy and high-power densities, validating the promise of unmodified redox-active COFs that are easily incorporated into elec. energy storage devices. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Formula: C9H6O6) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Formula: C9H6O6

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《Nanoparticle Size-Fractionation through Self-Standing Porous Covalent Organic Framework Films》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Dey, Kaushik; Kunjattu H., Shebeeb; Chahande, Anurag M.; Banerjee, Rahul. Name: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The article mentions the following:

Covalent organic frameworks (COFs) have attracted attention due to their ordered pores leading to important industrial applications like storage and separation Combined with their modular synthesis and pore engineering, COFs could become ideal candidates for nanosepns. However, the fabrication of these microcrystalline powders as continuous, crack-free, robust films remains a challenge. Herein, we report a simple, slow annealing strategy to construct centimeter-scale COF films (Tp-Azo and Tp-TTA) with micrometer thickness. The as-synthesized films are porous (SABET = 2033 m2 g-1 for Tp-Azo) and chem. stable. These COFs have distinct size cut-offs (ca. 2.7 and ca. 1.6 nm for Tp-Azo and Tp-TTA, resp.), which allow the size-selective separation of gold nanoparticles. Unlike, other conventional membranes, the durable structure of the COF films allow for excellent recyclability (up to 4 consecutive cycles) and easy recovery of the gold nanoparticles from the solution In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Name: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Name: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydePhloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

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Xiao, Haiwen; Shen, Haigen; Zhu, Lin; Li, Chaozhong published an article in Journal of the American Chemical Society. The title of the article was 《Copper-Catalyzed Radical Aminotrifluoromethylation of Alkenes》.Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The author mentioned the following in the article:

We report herein an unprecedented protocol for aminotrifluoromethylation of alkenes. With Cu(OTf)2 as the catalyst, the reaction of alkenes, (bpy)Zn(CF3)2, and N-fluorobis(benzenesulfonyl)imide (NFSI) at room temperature provides the corresponding aminotrifluoromethylation products in satisfactory yields with high regioselectivity opposite to those driven by CF3 radical addition The method exhibits a broad substrate scope and wide functional group compatibility. A mechanism involving N-radical addition to alkenes followed by trifluoromethylation of alkyl radicals is proposed. The experimental part of the paper was very detailed, including the reaction process of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

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Sashidhara, Koneni V.; Kumar, Manoj; Khedgikar, Vikram; Kushwaha, Priyanka; Modukuri, Ram K.; Kumar, Abdhesh; Gautam, Jyoti; Singh, Divya; Sridhar, Balasubramaniam; Trivedi, Ritu published an article on January 10 ,2013. The article was titled 《Discovery of Coumarin-Dihydropyridine Hybrids as Bone Anabolic Agents》, and you may find the article in Journal of Medicinal Chemistry.SDS of cas: 153759-59-2 The information in the text is summarized as follows:

The concept of mol. hybridization led us to discover a novel series of coumarin-dihydropyridine hybrids that have potent osteoblastic bone formation in vitro and that prevent ovariectomy-induced bone loss in vivo. In this context, among all the compounds screened for alk. phosphatase activity, four compounds 10, 14, 18, and 22 showed significant activity at picomolar concentrations A series of other in vitro data strongly suggested compound 18 as the most promising bone anabolic agent, which was further evaluated for in vivo studies. From these studies compound 18 proved to be useful, which at low oral dose of 1 (mg/kg)/day body weight increased bone mass d. and volume, expression of osteogenic genes (RUNX2, BMP-2, and ColI), bone formation rate (BFR), and mineral apposition rate (MAR), improved the trabecular microarchitecture, and decreased bone turn over markers in an ovariectomized rodent model for postmenopausal osteoporosis. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2SDS of cas: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.SDS of cas: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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In 2019,Angewandte Chemie, International Edition included an article by Ling, Liang; He, Yuan; Zhang, Xue; Luo, Meiming; Zeng, Xiaoming. Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. The article was titled 《Hydrogenation of (Hetero)aryl Boronate Esters with a Cyclic (Alkyl)(amino)carbene-Rhodium Complex: Direct Access to cis-Substituted Borylated Cycloalkanes and Saturated Heterocycles》. The information in the text is summarized as follows:

The authors herein report the hydrogenation of substituted aryl- and heteroaryl boronate esters for the selective synthesis of cis-substituted borylated cycloalkanes and saturated heterocycles. A cyclic (alkyl)(amino)carbene-ligated Rh complex with two di-Me groups at the ortho-alkyl scaffold of the carbene showed high reactivity in promoting the hydrogenation, thereby enabling the hydrogenation of (hetero)arenes with retention of the synthetically valuable boronate group. This process constitutes a clean, atom-economic, as well as chemo- and stereoselective route for the generation of cis-configured, diversely substituted borylated cycloalkanes and saturated heterocycles that are usually elusive and difficult to prepare In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Gupta, Sampa; Maurya, Pooja; Upadhyay, Akanksha; Kushwaha, Pragati; Krishna, Shagun; Siddiqi, Mohammad Imran; Sashidhara, Koneni V.; Banerjee, Dibyendu published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents》.Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde The author mentioned the following in the article:

DNA replication and repair are complex processes accomplished by the concerted action of a network of enzymes and proteins. DNA ligases play a crucial role in these processes by catalyzing the nick joining between DNA strands. As compared to normal cells, elevated levels of human DNA ligase I (hLigI) is reported in some cancers. The authors studied the inhibition of hLigI mediated DNA nick sealing activity followed by the antiproliferative activity of novel indole-chalcone based benzopyran compounds on cancer cells. One mol. called compound 27 ((E)-2-amino-8-(tert-butyl)-4-(2-methyl-1H-indol-3-yl)-6-(3-oxo-3-(thien-2-yl)prop-1-en-1-yl)-4H-chromene-3-carbonitrile) showed a notable preference for inhibition of hLigI as compared to other ligases and showed enhanced cytotoxicity against colon cancer (DLD-1) cells as compared to normal cells. Mechanistic studies showed that compound 27 directly interacts with hLigI in a competitive manner and did not interact with the DNA substrate during ligation. This novel and potent hLigI inhibitor showed significant inhibition of both monolayer culture as well as 3D culture of DLD-1 cells that mimic solid tumor. It also affected the migration of DLD-1 cells indicating the potential anti-metastatic activity. This novel hLigI inhibitor could therefore serve as a promising lead for anticancer drug development. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehydeDeprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Recommanded Product: 401797-00-0On March 9, 2016, Zhang, Teng; Manna, Kuntal; Lin, Wenbin published an article in Journal of the American Chemical Society. The article was 《Metal-Organic Frameworks Stabilize Solution-Inaccessible Cobalt Catalysts for Highly Efficient Broad-Scope Organic Transformations》. The article mentions the following:

New and active earth-abundant metal catalysts are critically needed to replace precious metal-based catalysts for sustainable production of commodity and fine chems. We report here the design of highly robust, active, and reusable cobalt-bipyridine- and cobalt-phenanthroline-based metal-organic framework (MOF) catalysts for alkene hydrogenation and hydroboration, aldehyde/ketone hydroboration, and arene C-H borylation. In alkene hydrogenation, the MOF catalysts tolerated a variety of functional groups and displayed unprecedentedly high turnover numbers of ∼2.5 × 106 and turnover frequencies of ∼1.1 × 105 h-1. Structural, computational, and spectroscopic studies show that site isolation of the highly reactive (bpy)Co(THF)2 species in the MOFs prevents intermol. deactivation and stabilizes solution-inaccessible catalysts for broad-scope organic transformations. Computational, spectroscopic, and kinetic evidence further support a hitherto unknown (bpy•-)CoI(THF)2 ground state that coordinates to alkene and dihydrogen and then undergoing σ-complex-assisted metathesis to form (bpy)Co(alkyl)(H). Reductive elimination of alkane followed by alkene binding completes the catalytic cycle. MOFs thus provide a novel platform for discovering new base-metal mol. catalysts and exhibit enormous potential in sustainable chem. catalysis. The results came from multiple reactions, including the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Recommanded Product: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Recommanded Product: 401797-00-0

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HPLC of Formula: 20880-92-6On March 23, 2022, Wang, Xuyong; Tong, Wen-Yan; Huang, Bing; Cao, Si; Li, Yunlong; Jiao, Jingchao; Huang, Hang; Yi, Qiu; Qu, Shuanglin; Wang, Xi published an article in Journal of the American Chemical Society. The article was 《Convergent Synthesis of 1,4-Dicarbonyl Z-Alkenes through Three-Component Coupling of Alkynes, α-Diazo Sulfonium Triflate, and Water》. The article mentions the following:

A general protocol for the convergent synthesis of 1,4-dicarbonyl Z-alkenes RC(O)C(R1)=CHR2 (R = Ph, 4-methoxyphenyl, thiophene-2-yl, 2-chloropyridin-4-yl, etc.; R1 = Me, t-Bu, cyclohexyl, etc.; R2 = acetyl, ethoxycarbonyl, benzoyl, etc.) form alkynes RCCR1 using α-diazo sulfonium triflate (CH3)2S+C(=N2)(R2)O-S(O)2CF3 and water was reported. The C=O, C=C, and C-H bonds are formed under mild conditions with a wide range of functional groups tolerated. The reaction exhibits excellent Z-selectivity and complete regioselectivity. The resulting 1,4-dicarbonyl Z-alkenes can smoothly undergo follow-up conversion to a variety of heteroaromatic scaffolds e.g., I. Moreover, the reaction also provides a facile access to the corresponding deuterated Z-alkenes RC(O)C(R1)=CDR2 and deuterated heteroarenes II with a high level of deuterium incorporation (90-97% D-inc.) by directly using D2O, thus rendering the method highly valuable. The comprehensive mechanistic studies indicate that a free carbyne radical intermediate is formed via the photocatalytic single electron transfer process, and KH2PO4 plays a crucial role in significant improvements on yield and selectivity based on d.-functional theory calculations, providing a new direction for radical coupling reactions of diazo compounds In the experiment, the researchers used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6HPLC of Formula: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.HPLC of Formula: 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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Formula: C13H18BFO3On October 1, 2019 ,《Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats》 was published in European Journal of Medicinal Chemistry. The article was written by Ouach, Aziz; Vercouillie, Johnny; Bertrand, Emilie; Rodrigues, Nuno; Pin, Frederic; Serriere, Sophie; Boiaryna, Liliana; Chartier, Agnes; Percina, Nathalie; Tangpong, Pakorn; Gulhan, Zuhal; Mothes, Celine; Deloye, Jean-Bernard; Guilloteau, Denis; Page, Guylene; Suzenet, Franck; Buron, Frederic; Chalon, Sylvie; Routier, Sylvain. The article contains the following contents:

In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with com. available and home-made boron derivatives The exploration of SAR required the preparation of uncommon boron derivatives Forty final drugs were tested for their ability to bind the target and nine of them exhibited Ki values below nanomolar concentrations The best scores were always obtained when the 5-phenyl-2-thiophenyl core was attached to the triazole. The selectivity of these compounds towards the nicotinic α4β2 and serotoninergic 5HT3 receptors was assessed and their brain penetration was quantified by the preparation and in vivo evaluation of two [18F] radiolabeled derivatives It can be expected from our results that some of these compounds will be suitable for further developments and will have effects on cognitive disorders. The results came from multiple reactions, including the reaction of (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2Formula: C13H18BFO3)

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Formula: C13H18BFO3

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《Ultrathin Two-Dimensional Membranes Assembled by Ionic Covalent Organic Nanosheets with Reduced Apertures for Gas Separation》 was written by Ying, Yunpan; Tong, Minman; Ning, Shoucong; Ravi, Sai Kishore; Peh, Shing Bo; Tan, Swee Ching; Pennycook, Stephen John; Zhao, Dan. Related Products of 34374-88-4This research focused onultrathin membrane assembled ionic covalent organic nanosheet aperture gas. The article conveys some information:

Covalent organic frameworks (COFs) are a promising category of porous materials possessing extensive chem. tunability, high porosity, ordered arrangements at a mol. level, and considerable chem. stability. Despite these advantages, the application of COFs as membrane materials for gas separation is limited by their relatively large pore apertures (typically >0.5 nm), which exceed the sieving requirements for most gases whose kinetic diameters are less than 0.4 nm. Herein, we report the fabrication of ultrathin two-dimensional (2D) membranes through layer-by-layer (LbL) assembly of two kinds of ionic covalent organic nanosheets (iCONs) with different pore sizes and opposite charges. Because of the staggered packing of iCONs with strong electrostatic interactions, the resultant membranes exhibit features of reduced aperture size, optimized stacking pattern, and compact dense structure without sacrificing thickness control, which are suitable for mol. sieving gas separation One of the hybrid membranes, TpEBr@TpPa-SO3Na with a thickness of 41 nm, shows a H2 permeance of 2566 gas permeation units (GPUs) and a H2/CO2 separation factor of 22.6 at 423 K, surpassing the recent Robeson upper bound along with long-term hydrothermal stability. This strategy provides not only a high-performance H2 separation membrane candidate but also an inspiration for pore engineering of COF or 2D porous polymer membranes. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Related Products of 34374-88-4) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Related Products of 34374-88-4

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