Tag: 100-200

《Imaging mitochondria and plasma membrane in live cells using solvatochromic styrylpyridines》 was published in Journal of Photochemistry and Photobiology, B: Biology in 2020. These research results belong to Mukherjee, Tarushyam; Aravintha Siva, M.; Bajaj, Komal; Soppina, Virupakshi; Kanvah, Sriram. Reference of 3-Bromopropan-1-ol The article mentions the following:

In this study, we have synthesized four fluorescent styrene derivatives, a neutral styrylpridine, three cationic styrylpyridinium probes with and without cholesterol tether, and investigated their absorption, emission, and cellular imaging properties. The fluorophores show solvatochromic emission attributed to intramol. charge transfer from donor to acceptor with an emission range of 500-600 nm. The fluorescent cholesterol conjugate labels plasma membrane effectively while the fluorophores devoid of the cholesterol tether label mitochondria. Cholesterol conjugate also shows strong interaction with liposome membrane. Furthermore, the fluorophores alsotrack the mitochondria in live cells with high specificity. Cell viability assay showed overall non-toxic nature of the probes even at higher fluorophore concentrations Through sidearm modifications, keeping the fluorescent core intact, we successfully targeted specific subcellular compartments of neuronal (N2a) and non-neuronal (HeLa) mammalian cell lines. This strategy of using a single mol. scaffold with subtle substitutions could be ideal in generating a variety of fluorophores targeting other subcellular compartments. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

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In 2022,Hassan, Ahmed H. E.; Kim, Hyeon Jeong; Gee, Min Sung; Park, Jong-Hyun; Jeon, Hye Rim; Lee, Cheol Jung; Choi, Yeonwoo; Moon, Suyeon; Lee, Danbi; Lee, Jong Kil; Park, Ki Duk; Lee, Yong Sup published an article in Journal of Enzyme Inhibition and Medicinal Chemistry. The title of the article was 《Positional scanning of natural product hispidol′s ring-b: discovery of human monoamine oxidase-b inhibitor downregulating neuroinflammation for neurodegenerative diseases》.HPLC of Formula: 26153-38-8 The author mentioned the following in the article:

Multifunctional mols. might offer better treatment of complex multifactorial neurol. diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorders. Aiming to target these diseases, polypharmacol. agents modulating both monoaminergic pathways and neuroinflammatory were addressed. A library of analogs of the natural product hispidol was prepared and evaluated for inhibition of monoamine oxidases (MAOs) isoforms. Several mols. emerged as selective potential MAO B inhibitors. The most promising compounds were further evaluated in vitro for their impact on microglia viability, induced production of proinflammatory mediators and MAO-B inhibition mechanism. Amongst tested compounds, was a safe potent competitive reversible MAO-B inhibitor and inhibitor of microglial production of neuroinflammatory mediators; NO and PGE2. In-silico study provided insights into mol. basis of the observed selective MAO B inhibition. This study presents compound as a promising lead compound for management of neurodegenerative disease. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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The author of 《New adsorption indicators for argentometric titrations of halides and thiocyanates》 were Aliotta, Guillermo; Casal, Alberto R.. And the article was published in Anales de la Asociacion Quimica Argentina (1921-2001) in 1964. Related Products of 2525-05-5 The author mentioned the following in the article:

Bromochlorophenol blue (I), bromophenol red (II), o-cresol red (III), and m-cresol purple (IV) are proposed as new adsorption indicators for application in Cl-, Br-, I-, and SCN- argentometric titrations at different pH values. In some tests it was found necessary to adjust the pH for satisfactory results. I can be employed for all anions, II for Br-, I-, and SCN-, while III and IV only for I- and SCN- determinations The reproducibility and accuracy obtained by using these indicators are discussed. 16 references. In the part of experimental materials, we found many familiar compounds, such as 4-Butylbenzene-1,2-diol(cas: 2525-05-5Related Products of 2525-05-5)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Related Products of 2525-05-5

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In 2021,Journal of Materials Chemistry B: Materials for Biology and Medicine included an article by Jiang, Bowen; Hao, Dengyuan; Li, Chaonan; Lu, Shaojin; Pei, Qing; Xie, Zhigang. Quality Control of 3,3,3-Trifluoropropan-1-ol. The article was titled 《Fluorinated paclitaxel prodrugs for potentiated stability and chemotherapy》. The information in the text is summarized as follows:

Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy. The experimental part of the paper was very detailed, including the reaction process of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Quality Control of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Quality Control of 3,3,3-Trifluoropropan-1-ol

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The author of 《Crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one》 were Suchojad, Kamil; Dolega, Anna; Adamus-Grabicka, Angelika; Budzisz, Elzbieta; Malecka, Magdalena. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. Safety of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

The synthesis and crystal structures of (E)-3-(4-hydroxybenzylidene)chroman-4-one, C16H12O3, I, and (E)-3-(3-hydroxybenzylidene)-2-phenylchroman-4-one, C22H16O3, II, are reported. These compounds are of interest with respect to biol. activity. Both structures display intermol. C-H···O and O-H···O hydrogen bonding, forming layers in the crystal lattice. The crystal structure of compound I is consolidated by π-π interactions. The lipophilicity (logP) was determined as it is one of the parameters qualifying compounds as potential drugs. The logP value for compound I is associated with a larger contribution of C···H interaction in the Hirshfeld surface.3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Safety of 3-Hydroxybenzaldehyde

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The author of 《New perylenebisimide decorated cyclotriphosphazene heavy atom free conjugate as singlet oxygen generator》 were Okutan, Elif; Eserci, Hande; Senkuytu, Elif. And the article was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2019. Recommanded Product: 6-Aminohexan-1-ol The author mentioned the following in the article:

Perylenebisimide-cyclotriphosphazene based inorganic-organic system was synthesized by a multistep procedure. The substitution reaction of asym. perylenebisimide (PBI) derivative with the hexachloroyclotriphosphazene (trimer) resulted in the formation of fully PBI decorated cyclotriphosphazene (5). The identity of newly synthesized compound (5) was confirmed by using 31P, 1H and 13C NMR spectroscopies and mass spectrometry. The photophys. (UV- Vis absorption, fluorescence emission, fluorescence lifetime and fluorescence quantum yield) and photochem. (the singlet oxygen generation, and photostability) properties of this conjugate were investigated as novel heavy atom free triplet photosensitizer. The singlet oxygen quantum yield of the PBI-cyclotriphosphazene (5) was calculated to be 0.86 which is good for a heavy atom free triplet photosensitizer. These results will add to the development of cyclotriphosphazene based heavy atom free singlet oxygen triplet photosensitizer systems for applications in organic oxygenation reactions.6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Recommanded Product: 6-Aminohexan-1-ol

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《Synthesis and application of a novel 5-hydroxymethyl resorcinol diglycidyl ether-terminated polyurethane》 was published in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. These research results belong to Li, Shuan; Sun, Mingming; Liu, Caizhao; Zhang, Xugang; Li, Jianhui; Wang, Weiping; Zhang, Bin. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Epoxy resin containing active hydroxymethyl group, 5-hydroxymethyl resorcinol diglycidyl ether, was synthesized to produce 5-hydroxymethyl resorcinol diglycidyl ether-terminated polyurethane (ETPU1000). The synthesized epoxy resin is a small monomer mol., and no polymer is produced during the synthesis process. A monomer contains one hydroxyl group, and more flexible polyurethane segments can be introduced into the main chain when synthesizing the epoxy-terminated polyurethane. The synthesis process of ETPU1000 was investigated by FT-IR spectroscopy. The disappearance of NCO peak in the FT-IR spectrum showed that diisocyanate has completely reacted to form ETPU1000. Then, a series of epoxy cured systems were prepared by changing the mass ratio of ETPU1000 and the diglycidyl ether of bisphenol A (DGEBA), and cured with 4,4′-diaminodiphenyl methane (DDM). The effect of the content of ETPU1000 on the thermal properties, mech. properties and fracture morphol. of epoxy cured systems were investigated. The results showed that when the DGEBA/ETPU1000 blends with 75 wt% ETPU1000, impact strength of the cured systems reached 29.6 kJ·m-2, which significantly increased by 176.6% compared to that of neat epoxy. SEM was used to observe the fracture surfaces of cured DGEBA/ETPU1000 blends, which showed obvious ductile fracture characteristics. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

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Song, Liya; Chen, Pengfei; Yu, Jin; Han, Xiaolu; Hua, Yabing; Liu, Shan; Pang, Bo; Gao, Jing; Ma, Jiahua; Xu, Liang published their research in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2021. The article was titled 《A novel cyanoacrylate-based matrix excipient in HPMCP capsules forms a sustained intestinal delivery system for orally administered drugs with enhanced absorption efficiency》.HPLC of Formula: 4048-33-3 The article contains the following contents:

Patients prefer oral drug delivery due to its convenience and noninvasiveness. Nevertheless, a multitude of potentially clin. important drugs will not reach the market or achieve their full potential, due to their low bioavailability and instability in gastric acid. In this study, a novel oral drug delivery system based on poly-cyanoacrylate [a polymer of 2-(2-methoxyethoxy)ethyl-2-cyanoacrylate (MECA)] and hydroxypropyl methylcellulose phthalate (HPMCP) was developed and shown to permit intestinal targeting and sustained drug release. Aspirin [acetylsalicylic acid (ASA)] was selected as a model drug for atherosclerosis treatment. It was phys. dissolved in liquid MECA, and the ASA-MECA matrix was then polymerized into a solid drug-loading depot in an HPMCP shell. The delivery of the drug depot in the intestine was achieved with the HPMCP shell; then the polymerized MECA (polyMECA) provided sustained drug release. The polyMECA excipient was not absorbed by the intestine due to its high mol. weight; a fluorescein-labeled assay indicated that it was excreted completely in feces after drug release. The formulation, ASA-polyMECA-HPMCP, showed good intestinal targeting and sustained drug release in vitro and in vivo. Pharmacokinetic studies indicated that this formulation improved the bioavailability of ASA relative to com. available controls. ASA-polyMECA-HPMCP showed desirable anti-atherosclerosis efficacy in a rabbit model, with significant enhancement of atheromatous lesion stability. Biosafety tests proved the low toxicity of ASA-polyMECA-HPMCP and the polyMECA matrix. We believe that this work has provided a practical and biocompatible system for sustained intestinal drug delivery that can be applied broadly with various drugs for specific therapeutic aims.6-Aminohexan-1-ol(cas: 4048-33-3HPLC of Formula: 4048-33-3) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.HPLC of Formula: 4048-33-3

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Category: alcohols-buliding-blocksOn September 28, 2020 ,《Electronic decay through non-linear carbon chains》 was published in Journal of Physics B: Atomic, Molecular and Optical Physics. The article was written by Mullenix, John B.; Despre, Victor; Kuleff, Alexander I.. The article contains the following contents:

A multielectron wave-packet propagation method was used to calculate the electronic decay of oxygen and fluorine 2s vacancies for a group of trifluoroalkyl alcs., HOCnH(2n-1)F3, with n between 1 and 5. Whether ionizing O2s or F2s orbitals, it is shown that an electron can be emitted non-locally from the opposite terminus of the mol. The decay of the O(2s-1) state is found to be about 2-3 times faster than that of the F(2s-1), but in both cases the process takes only a few femtoseconds, demonstrating a highly efficient energy transfer through the carbon bridge. A comparison to the previously reported non-local decay in linear difluorocumulenone systems shows that the non-linearity of the trifluoroalkyl alcs. does not appear to dramatically influence the decay efficiency. These results shed light onto the nature of the scaling of electron correlation and open the door to the potential design of mols. that take advantage of this mechanism. The results came from multiple reactions, including the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Category: alcohols-buliding-blocks)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Category: alcohols-buliding-blocks

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Application of 4048-33-3In 2022 ,《POSS-containing polynorbornene with pendant perylene diimide: from a unique supramolecular structure to tunable luminescence properties》 appeared in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. The author of the article were Liu, Jie; Gao, Si-Yu; Zhang, Xin-Yi; Feng, Yakai; Wu, Han-Chun; Chen, Zhijian; Bermeshev, Maxim V.; Ren, Xiang-Kui. The article conveys some information:

POSS-containing polynorbornene with pendant perylene diimide (PPDI-POSS) has been synthesized, with alkyl-containing polynorbornene (PPDI-C10C8) as the reference The supermol. structure and photoluminescence properties were elucidated using UV-Vis absorption spectra, and one- and two-dimensional X-ray diffraction. The exptl. results reveal that PPDI-C10C8 possesses a lamellar structure with close PDI stacking to meet the requirement for min. free energy. However, the introduction of POSS cages endows PPDI-POSS with a unique hexagonal columnar structure and enhanced photoluminescence properties due to the steric hindrance of POSS cages. These results may contribute to the understanding of the structure-property relationship of the optical polymers and provide some useful information for the design of polymer materials with a controllable supramol. structure and tunable luminescence properties. In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Application of 4048-33-3

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