Tag: 100-200

《19F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo》 was published in Biomaterials Science in 2020. These research results belong to Li, Qinghua; Feng, Zujian; Song, Huijuan; Zhang, Jianhua; Dong, Anjie; Kong, Deling; Wang, Weiwei; Huang, Pingsheng. COA of Formula: C3H5F3O The article mentions the following:

The degradation behavior of hydrogel scaffolds is closely related to the controlled release of bioactive agents and matching with the proliferative demands of newly generated tissues. Here, for the first time, we presented the use of 19F magnetic resonance imaging (19F MRI) to precisely monitor the localization and quantify the degradation rate of implantable or injectable hydrogels in a real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth. The total voxel and content in the region of interest (ROI) were linearly correlated to the injection amount, providing exact 3D stereoscopic and 2D anatomical information in the meantime. Moreover, a computational algorithm was established to present the real-time degradation rate in vivo as a function of time, which was implemented directly from the 19F MRI dataset. In addition, labeling with a zwitterionic 19F contrast agent demonstrated a facile and general applicability for multiple types of materials with no influence on their original gelation properties as well as 19F NMR properties in the hydrogel matrix. Therefore, this 19F MRI method offers a new approach to non-invasively track the degradation rate of hydrogel scaffolds in vivo in a precise localization and accurate quantification way, which will suffice the need for the evaluation of implants at deep depths in large animals or human objects. In addition to this study using 3,3,3-Trifluoropropan-1-ol, there are many other studies that have used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2COA of Formula: C3H5F3O) was used in this study.

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.COA of Formula: C3H5F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2019 ,《O-H and (CO)N-H bond weakening by coordination to Fe(II)》 appeared in Dalton Transactions. The author of the article were Resa, Sandra; Millan, Alba; Fuentes, Noelia; Crovetto, Luis; Luisa Marcos, M.; Lezama, Luis; Choquesillo-Lazarte, Duane; Blanco, Victor; Campana, Araceli G.; Cardenas, Diego J.; Cuerva, Juan M.. The article conveys some information:

New N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)-ethane-1,2-diamine derivatives bearing covalently linked OH and (CO)NH groups were synthesized. The coordination of those pendant hydroxyl/amide groups to a Fe(II) metal center is demonstrated both in solution, even in the presence of chloride as the counterion, and in solid state, by x-ray diffraction crystal structures. As a result of this coordination, the exptl. bond dissociation free energies (BDFE) of O-H and (CO)N-H bonds are remarkably diminished down to 76.0 and 80.5 kcal mol-1, resp., which is also in agreement with DFT-based theor. calculations These BDFE values are in the range of commonly used hydrogen-atom donor reagents. The strategy presented here allows an unequivocal evaluation of the influence of metal coordination in X-H bond weakening in organic solvents which could be easily extended to other metal centers. The experimental process involved the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Hu; Wu, Zheng-Rong; Chu, Qing-Ru; Liang, Hong-Jie; Liu, Ying-Qian; Wu, Tian-Lin; Ma, Yue published an article in New Journal of Chemistry. The title of the article was 《Potential application value of hydroxychalcones based on isoliquiritigenin in agricultural plant diseases》.Formula: C7H6O3 The author mentioned the following in the article:

To improve the fungicidal activity of the lead compound isoliquiritigenin, 33 hydroxychalcones were designed and prepared Their in vitro antifungal activities against four pathogenic fungi (Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum) were evaluated systematically. We found the most potent agricultural fungicides to be compounds LH-4, LH-5, LH-14 and LH-15 with EC50 values in the range of 5.96 – 10.06 μg mL-1, which are superior to the lead compound isoliquiritigenin and pos. control azoxystrobin, with compound LH-4 displaying the best in vitro antifungal activity against R. solani with an EC50 value of 5.96 μg mL-1, approx. 6 times more potent than isoliquiritigenin (EC50 = 36.91 μg mL-1). Moreover, the preliminary antifungal mechanism of compound LH-4 illustrated that it could affect the hyphal morphol. and ultrastructure feature of R. solani; its antifungal activity can be associated with the hyphal distortion that results from the disruption of the cell membrane integrity. Besides, SAR studies revealed that the chalcones with few hydroxyls on the A- and B-rings exhibited noticeable antifungal activity. However, chalcones with multi-hydroxyl groups showed unsatisfactory activity. Herein, we report and discuss hydroxychalcones based on isoliquiritigenin as bioactive compounds useful in treating agricultural plant diseases.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Formula: C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Ranjbar, Sara; Khoshneviszadeh, Mehdi; Tavakkoli, Marjan; Miri, Ramin; Edraki, Najmeh; Firuzi, Omidreza published an article in Molecular Diversity. The title of the article was 《5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity》.Electric Literature of C6H7NO The author mentioned the following in the article:

In this study, a series of 49 5-oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridines I [R1 = 3-pyridylmethyl, 2-pyridylethyl, 3-pyridylpropyl, etc.; R2 = Ph, 2-furanyl, Bu, etc.; X = (CH2)n; n = 1, 2], containing different pyridine alkyl carboxylates at C3 and various aliphatic, aromatic, and heteroaromatic substitutions at the C4 position of the central core, were synthesized. The target compounds I were tested for antiproliferative effect against three human cancer cell lines including MOLT-4 (acute lymphoblastic leukemia), K562 (chronic myelogenous leukemia), and MCF-7 (breast adenocarcinoma) by MTT assay, and the effect of the most potent derivatives on cell cycle was evaluated by RNase/propidium iodide (PI) flow cytometric assay. Generally, 5-oxo-hexahydroquinoline derivatives I [R1 = 3-pyridylpropyl; R2 = Ph, 2-furanyl, Bu, etc.; n = 2] possessed superior antiproliferative activities compared to their 5-oxo-tetrahydrocyclopentapyridine counterparts I [R1 = 3-pyridylpropyl; R2 = Ph, 2-furanyl, Bu, etc.; n = 1]. 5-Oxo-hexahydroquinoline compounds bearing 2-pyridyl Pr carboxylates I [R1 = 2-pyridylpropyl; R2 = Ph, 2-furanyl, Bu, etc.; n = 2] and 3-pyridyl Pr carboxylates I [R1 = 3-pyridylpropyl; R2 = Ph, 2-furanyl, Bu, etc.; n = 2] were better antiproliferative agents than those bearing other pyridyl alkyl carboxylates. Five best compounds with IC50 values in the range of 9.5-22.9μM against MOLT-4 cells were selected for cell-cycle anal., which revealed that derivatives I [R1 = 2-pyridylpropyl; R2 = 2,3-dichlorophenyl; n = 2], I [R1 = 3-pyridylpropyl; R2 = 3-nitrophenyl, 2-nitrophenyl; n = 2] with substitutions at C4 position, may induce apoptosis in MOLT-4 cells. Mol. docking anal., which was employed to make some predictions on the interaction of the most active derivatives with the binding site of Bcl-2 and Bcl-xL proteins, suggested that the compounds may be well accommodated within the binding sites of these anti-apoptotic proteins via hydrogen-bonding and hydrophobic interactions. The findings of this study present 5-oxo-hexahydroquinolines I [R1 = 3-pyridylmethyl, 2-pyridylethyl, 3-pyridylpropyl, etc.; R2 = Ph, 2-furanyl,butyl, etc.; n = 2]. as antiproliferative agents with potential apoptosis-inducing ability in cancer cells.3-Pyridinemethanol(cas: 100-55-0Electric Literature of C6H7NO) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Electric Literature of C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Yeung, Jason; Becker, Matthias; Stephan, Douglas W. published an article in Dalton Transactions. The title of the article was 《Towards macrocyclic frustrated Lewis pairs》.Safety of 2,6-Pyridinedimethanol The author mentioned the following in the article:

Macrocycles with and without B-N bonds were prepared from reaction of C6F5BH2·SMe2 or MesBH2 with the 2,6-pyridinedimethanol derivatives Both classes of macrocycle reacted with B(C6F5)3 but were unreactive to small mols. These observations provide insights for the subsequent design of macrocyclic FLPs for multi-electron reactions. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Yuan; Liu, Guoqiang; Lv, Tong; He, Xianzhe; Wei, Yen; Pan, Ruihao; Yang, Lei; Tao, Lei published an article in 2022. The article was titled 《Antioxidant Polymers via the Ugi Reaction for In Vivo Protection of UV-Induced Oxidative Stress》, and you may find the article in Chemistry of Materials.HPLC of Formula: 627-18-9 The information in the text is summarized as follows:

Small-mol. antioxidants perform poorly in vivo in combating oxidative stress because of their low bioavailability. Water-soluble polymeric antioxidants can overcome the limitations of small mol. antioxidants (instability, poor water solubility, fast metabolism, etc.), but there are only a few efficient synthesis methods to prepare safe and effective polymeric antioxidants. In this study, we develop a series of antioxidant polymers containing ferrocene and/or indole moieties through the Ugi four-component reaction and simple free radical polymerization These polymers are screened using different criteria to find a biocompatible antioxidative polymer that effectively inhibits the lethal and teratogenic effects of UV-induced oxidative damage on zebrafish embryos. This study identifies a strategy to use antioxidative polymers in vivo, demonstrates the value of multicomponent reactions in interdisciplinary areas, and provides the underlying insights to guide the design of antioxidant polymeric biomaterials. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9HPLC of Formula: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.HPLC of Formula: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sagha, Mohsen; Mousaei, Fatemeh; Salahi, Mahtab; Razzaghi-Asl, Nima published an article in 2022. The article was titled 《Synthesis of new 2-aminothiazolyl/benzothiazolyl-based 3,4-dihydropyrimidinones and evaluation of their effects on adenocarcinoma gastric cell migration》, and you may find the article in Molecular Diversity.Safety of 3-Hydroxybenzaldehyde The information in the text is summarized as follows:

A number of new 2-aminothiazolyl/benzothiazolyl derivatives of 3,4-dihydropyrimidinones I [R = 4-FC6H4, 4-ClC6H4, 4-O2NC6H4] and II [R1 = Ph, 3-HOC6H4, 3-BrC6H4] were synthesized and structurally identified, and then their effects on the migration behavior of human AGS cells (gastric cancer cells) were investigated. Mol. docking and mol. dynamics (MD) simulations were applied to explore binding potential and realistic binding model of the assessed derivatives through identification of key amino acid residues within L5/α2/α3 allosteric site of kinesin 5 (Eg5) as a validated microtubule-dependent target for monastrol as a privileged DHPM derivative In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cetinkaya, Sidika; Yurdakal, Sedat published an article in 2021. The article was titled 《Partial photocatalytic oxidations of 3-pyridinemethanol and 3-picoline by TiO2 prepared in HCl, HNO3 and H2SO4 at different temperatures》, and you may find the article in Catalysis Today.COA of Formula: C6H7NO The information in the text is summarized as follows:

Home prepared TiO2 photocatalysts were prepared from TiCl4 precursor in the absence and presence of HCl (1-6 M), HNO3 (1 M) or H2SO4 (1 M) at room temperature (RT), 60 or 100°C. The TiO2 catalysts were characterized by XRD, BET, SEM and TGA techniques. TiO2 catalyst could not form at low temperature (up to 60°C) in the presence of H2SO4. Just rutile phase was obtained for all TiO2 samples prepared at RT and 60°C in HCl or HNO3. At 100°C mainly both brookite and rutile phases were obtained in the presence of HCl or HNO3, while mainly anatase phase appeared in the presence of H2SO4. Nanorod structured TiO2 was formed in the presence of 1 M HCl or HNO3 at RT and 60°C. The prepared TiO2 catalysts were used for partial oxidation of 3-pyridinemethanol to 3-pyridinemethanal and vitamin B3 in water under UVA irradiation Moreover, photocatalytic oxidation of 3-picoline, precursor of 3-pyridinemethanol, was also performed, but much lower product selectivity values were obtained with respect to 3-pyridinemethanol oxidation However, selective 3-picoline oxidation could be performed at pH 2 with low activity. Degussa P25 was used for comparison and almost all home prepared catalysts showed a higher selectivity, but they showed to be less active than Degussa P25. The high selectivity of the home prepared samples was not due to the type of TiO2 phase, but mainly to the hydrophilicity of the TiO2 surface which allowed desorption of valuable products instead of their over-oxidation After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0COA of Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseinmardi, Soosan; Scheurer, Andreas; Heinemann, Frank W.; Kuepper, Karsten; Senft, Laura; Waldschmidt, Pablo; Ivanovic-Burmazovic, Ivana; Meyer, Karsten published an article in 2021. The article was titled 《Evaluation of Manganese Cubanoid Clusters for Water Oxidation Catalysis: From Well-Defined Molecular Coordination Complexes to Catalytically Active Amorphous Films》, and you may find the article in ChemSusChem.Application In Synthesis of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

With a view to developing multimetallic mol. catalysts that mimic the oxygen-evolving catalyst (OEC) in Nature′s photosystem II, the synthesis of various dicubanoid manganese clusters is described and their catalytic activity investigated for water oxidation in basic, aqueous solution Pyridinemethanol-based ligands are known to support polynuclear and cubanoid structures in manganese coordination chem. The chelators 2,6-pyridinedimethanol (H2L1) and 6-methyl-2-pyridinemethanol (HL2) were chosen to yield polynuclear manganese complexes; namely, the tetranuclear defective dicubanes [MnII2MnIII2(HL1)4(OAc)4(OMe)2] and [MnII2MnIII2(HL1)6(OAc)2] (OAc)2·2 H2O, as well as the octanuclear-dicubanoid [MnII6MnIII2(L2)4(O)2(OAc)10(HOMe/OH2)2]·3MeOH·MeCN. In freshly prepared solutions, polynuclear species were detected by electrospray ionization mass spectrometry, whereas X-band ESR studies in dilute, liquid solution suggested the presence of divalent mononuclear Mn species with g values of 2. However, the magnetochem. investigation of the complexes solutions by the Evans technique confirmed a haphazard combination of manganese coordination complexes, from mononuclear to polynuclear species. Subsequently, the newly synthesized and characterized manganese mol. complexes were employed as precursors to prepare electrode-deposited films in a buffer-free solution to evaluate and compare their stability and catalytic activity for water oxidation electrocatalysis. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《N-Directed fluorination of unactivated Csp3-H bonds》 was published in Chemical Science in 2020. These research results belong to Pinter, Emily N.; Bingham, Jenna E.; AbuSalim, Deyaa I.; Cook, Silas P.. Recommanded Product: 4048-33-3 The article mentions the following:

Leveraging insights gained from both computations and experimentation, author enabled the use of the ubiquitous amine functional group as a handle for the directed C-H fluorination of Csp3-H bonds. By converting primary amines to adamantoyl-based fluoroamides, site-selective C-H fluorination proceeds under the influence of a simple iron catalyst in 20 min. Computational studies revealed a unique reaction coordinate for the catalytic process and offer an explanation for the high site selectivity. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Recommanded Product: 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts