Tag: 100-200

《Synthesis and antimicrobial resistant modulatory activity of 2,4-dinitrophenylhydrazone derivatives as agents against some ESKAPE human pathogens》 was published in Journal of Chemistry in 2020. These research results belong to Ade, Alberta; Amengor, Cedric D. K.; Brobbey, Abena; Ayensu, Isaac; Harley, Benjamin K.; Boakye, Yaw Duah. Application of 100-83-4 The article mentions the following:

A library of six novel phenylhydrazones 2,4-di-NO2C6H3NHN=CR(R1) [R = H, Ph; R1 = H, 2-OH, 3-OH, 2,4-di-OH, 3-MeO-4OH] were synthesized and evaluated for their in vitro antimicrobial and resistance modulating activity against a panel of Gram-pos., Gram-neg., and fungal species. The compounds were produced in good yields of 60-92% weight/weight and characterized using m.p., UV-visible spectroscopy, IR, and NMR (1H, 13C, and DEPT-Q) techniques. Mass spectroscopy was used to confirm the identity of one of the most active compounds, 2,4-di-NO2C6H3NHN=CR(R1) [R = H, R1 = 2-OH]. The phenylhydrazones showed activity against all the six selected microorganisms with min. inhibitory concentration (MIC) values of the most active compounds, 2,4-di-NO2C6H3NHN=CR(R1) [R = Ph, R1 = H; R = H, R1 = 2-OH], at 138μM (Klebsiella pneumoniae) and 165μM (Streptococcus pneumoniae), resp. Compound 2,4-di-NO2C6H3NHN=CR(R1) [R = Ph, R1 = H] further demonstrated a high resistance modulatory activity at 1.078μM against Streptococcus pneumoniae and Klebsiella pneumoniae. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

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Alcohol – Wikipedia,
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《Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study》 was published in Bioorganic Chemistry in 2020. These research results belong to Rahim, Fazal; Zaman, Khalid; Taha, Muhammad; Ullah, Hayat; Ghufran, Mehreen; Wadood, Abdul; Rehman, Wajid; Uddin, Nizam; Shah, Syed Adnan Ali; Sajid, Muhammad; Nawaz, Faisal; Khan, Khalid Mohammed. SDS of cas: 100-83-4 The article mentions the following:

Synthesis and biol. screening of benzimidazole-bearing bis-Schiff bases I (R1 = 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4; R2 = 3-HOC6H4, 2-O2NC6H4, 2,4-Cl2C6H3, etc.) for their α-glucosidase inhibitory activity are described. All compounds I exhibited excellent to good inhibitory potential (IC50 = 2.20 ± 0.1 to 88.60 ± 1.70μM) when compared with standard drug acarbose (IC50 = 38.45 ± 0.80μM). A structure activity relationship has been established on the basis of electronic effects and position of different substituents present on Ph ring. In order to rationalize the binding interactions of most active analogs with the active site of α-glucosidase enzyme, mol. docking study was conducted. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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《Dual Catalytic Platform for Enabling sp3 α C-H Arylation and Alkylation of Benzamides》 was published in ACS Catalysis in 2020. These research results belong to Rand, Alexander W.; Yin, Hongfei; Xu, Liang; Giacoboni, Jessica; Martin-Montero, Raul; Romano, Ciro; Montgomery, John; Martin, Ruben. Electric Literature of C6H15NO The article mentions the following:

A dual catalytic sp3 α C-H arylation and alkylation of benzamides with organic halides is described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and enantioselectivity pattern, offering a complementary reactivity mode to existing sp3 arylation or alkylations via transition metal catalysis or photoredox events. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

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Alcohol – Wikipedia,
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《Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines》 was published in Nature Communications in 2020. These research results belong to Che, Jiuwei; Niu, Li; Jia, Shikun; Xing, Dong; Hu, Wenhao. Name: (4-Bromophenyl)methanol The article mentions the following:

Here, based on a rhodium/chiral phosphoric acid cooperative catalysis, an enantioselective three-component reaction of α-diazo ketones with alcs. and 1,3,5-triazines was achieved. A dual hydrogen bonding between the chiral phosphoric acid catalyst and two distinct active intermediates was proposed to be crucial for the efficient electrophile-based enantiocontrol. A series of chiral β-amino-α-hydroxy ketones I [R = H, Et, Bn, 1-naphthylmethyl, etc.; R1 = H, Ph, 4-MeC6H4, 4-BrC6H4; R2 = Ph, 4-MeC6H4, 4-BrC6H4; R3 = Ph, 4-MeC6H4, 2-FC6H4, etc.] including those derived from simple aliphatic alcs., allylic alc., propargyl alc., complicated natural alcs. and water could all be prepared in high efficiency and enantioselectivity. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Name: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Name: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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The author of 《Stuffed Methyltransferase Catalyzes the Penultimate Step of Pyochelin Biosynthesis》 were Ronnebaum, Trey A.; McFarlane, Jeffrey S.; Prisinzano, Thomas E.; Booker, Squire J.; Lamb, Audrey L.. And the article was published in Biochemistry in 2019. Recommanded Product: 89466-08-0 The author mentioned the following in the article:

Nonribosomal peptide synthetases (NRPSs) use tailoring domains to incorporate chem. diversity into the final natural product. A structurally unique set of tailoring domains are found to be stuffed within adenylation domains and have only recently begun to be characterized. PchF is the NRPS termination module in pyochelin biosynthesis and includes a stuffed methyltransferase domain responsible for S-adenosylmethionine (AdoMet)-dependent N-methylation. Recent studies of stuffed methyltransferase domains propose a model in which methylation occurs on amino acids after adenylation and thiolation rather than after condensation to the nascent peptide chain. Herein, we characterize the adenylation and stuffed methyltransferase didomain of PchF through the synthesis and use of substrate analogs, steady-state kinetics, and onium chalcogen effects. We provide evidence that methylation occurs through an SN2 reaction after thiolation, condensation, cyclization, and reduction of the module substrate cysteine and is the penultimate step in pyochelin biosynthesis.2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 89466-08-0

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Alcohol – Wikipedia,
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In 2019,New Journal of Chemistry included an article by Anamika; Agrahari, Anand K.; Manar, Krishna K.; Yadav, Chote Lal; Tiwari, Vinod K.; Drew, Michael G. B.; Singh, Nanhai. Electric Literature of C7H9NO2. The article was titled 《Highly efficient structurally characterized novel precatalysts: di- and mononuclear heteroleptic Cu(I) dixanthate/xanthate-phosphine complexes for azide-alkyne cycloadditions》. The information in the text is summarized as follows:

Novel heteroleptic dinuclear [Cu2(L)(PPh3)4] (L = 2,6-pyridinedimethyldixanthate L1 1, 1,4-benznedimethyldixanthate L2 2, 1,4-cyclohexanedixanthate L3 3) and mononuclear [Cu(L4)(PPh3)2] 4, (L4 = piperonylxanthate) and [Cu(L5)(dppf)] (5) (L5 = methylxanthate, dppf = 1,1′-bis(diphenylphosphino)ferrocene) complexes were synthesized and characterized by elemental (C, H, and N) anal., high resolution mass spectrometry, and IR, UV-visible, 1H, 13C{1H} and 31P{1H} NMR spectroscopy. Single crystal x-ray diffraction revealed S,S-bidentate coordination of the dixanthate group in dinuclear 1-3 while 4 and 5 are mononuclear. 1-5 Adopt tetrahedral coordination geometry about the Cu atom. These precatalysts having two and one Cu(I) centers in a single mol. were applied in Cu catalyzed azide-alkyne cycloaddition (CuAAC) reactions for the synthesis of a variety of glycoconjugate triazoles using the Click approach. Particularly, the dinuclear catalyst 1, formed on the pyridyl linker based dixanthate ligand, displayed outstanding and reusable catalytic activity for this reaction. Full optimization of the reaction conditions demonstrated a Click catalytic system with low catalyst loading under mild reaction conditions.2,6-Pyridinedimethanol(cas: 1195-59-1Electric Literature of C7H9NO2) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C7H9NO2

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Alcohol – Wikipedia,
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In 2019,Dalton Transactions included an article by Wang, Danfeng; McBurney, Roy T.; Pernik, Indrek; Messerle, Barbara A.. Application of 100-55-0. The article was titled 《Controlling the selectivity and efficiency of the hydrogen borrowing reaction by switching between rhodium and iridium catalysts》. The information in the text is summarized as follows:

The catalytic alkylation of ketones with alcs. via the hydrogen borrowing methodol. (HB) has the potential to be a highly efficient approach for forming new carbon-carbon bonds. However, this transformation can result in more than one product being formed. The work reported here utilizes bidentate triazole-carbene ligated iridium and rhodium complexes as catalysts for the selective formation of alkylated ketone or alc. products. Switching from an iridium center to a rhodium center in the complex resulted in significant changes in product selectivity. Other factors – base, base loading, solvent and reaction temperature – were also investigated to tune the selectivity further. The optimized conditions were used to demonstrate the scope of the reaction across 17 ketones and 14 alcs. containing a variety of functional groups. A series of mechanistic investigations were performed to probe the reasons behind the product selectivity, including kinetic and deuterium studies. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Application of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 100-55-0

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In 2019,Catalysis Letters included an article by Hajjami, Maryam; Gholamian, Fatemeh; Hudson, Robert H. E.; Sanati, Ali Mohammad. Recommanded Product: 3-Hydroxybenzaldehyde. The article was titled 《FSM-16/AEPC-SO3H: Synthesis, Characterization and Its Application for the Catalytic Preparation of 1,8-Dioxo-octahydroxanthene and Tetrahydrobenzo[b]pyran Derivatives》. The information in the text is summarized as follows:

A new acidic mesoporous catalyst (FSM-16/AEPC-SO3H) was successfully synthesized and characterized by FT-IR, TGA, XRD, SEM, TEM, EDS and BET techniques. The FSM-16/AEPC-SO3H showed excellent catalytic activity for the synthesis of 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives The synthesized catalyst can also be recycled. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Recommanded Product: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Soheili, Majid; Mohamadnia, Zahra; Karimi, Babak published 《Switching from Ethylene Trimerization to Ethylene Polymerization by Chromium Catalysts Bearing SNS Tridentate Ligands: Process Optimization Using Response Surface Methodology》.Catalysis Letters published the findings.HPLC of Formula: 1195-59-1 The information in the text is summarized as follows:

Two types of chromium catalysts bearing pyridine and amine based SNS ligands under the title of (pyridine-SNS-alkyl/CrCl3) and (amine-SNS-alkyl/CrCl3) were synthesized. Different thiolates such as octyl, pentyl, Bu, cyclohexyl and cyclopentyl thiolates were reacted with 2,6-pyridine-dimethylene-ditosylate (PMT)/THF solution at room temperature Then, the purified pyridine-based SNS ligands (1-5) were reacted with CrCl3 (THF)3 to obtain the pyridine-SNS-alkyl/CrCl3 catalysts (6-10) in 50-70% yields. MMAO-activated pyridine-SNS-alkyl/CrCl3 catalysts were capable of oligomerizing ethylene. Statistical exptl. design was conducted using the central composite design method and surface methodol. to study of the effect of important parameters such as ethylene pressure, Al/Cr ratio, catalyst concentration and the reaction temperature on 1-C6 productivity of catalyst (7). A quadratic polynomial equation was developed to predict the 1-C6 productivity. Ethylene oligomerization using the catalyst (7) was lead to a optimized reaction conditions, including the ethylene pressure of 19.5 bar, the temperature of 58.2 °C, the MMAO co-catalyst, Al/Cr = 841 and the catalyst concentration of 8.7 μmol. The catalytic properties for ethylene oligomerization are strongly affected by reaction temperature The exptl. results indicated the reasonable agreement with the predicted values. The transformation from ethylene trimerization to ethylene polymerization of catalyst system (7) was occurred by exchanging the reaction pressure. Influence of ligand structure with different substitutions on sulfur atom on productivity and selectivity was investigated. 1-C6 with the high selectivity and productivity 4318 (g 1-C6/g Cr h) was obtained for catalyst (7). In the second part, 1-C6 was obtained with high selectivity and productivity around 141 × 103 (g 1-C6/g Cr h) for amine-based catalyst. All amine-based catalysts (14-16) showed considerably higher catalytic activities compared to pyridine-based catalysts. According to the TGA anal. the thermal stability of pyridine-based catalysts was found to be higher than the amine-based catalysts. Graphical Abstract: Chromium complexes bearing pyridine and amine based SNS ligands have been synthesized and their catalytic performance in ethylene oligomerization has been investigated. A switching from ethylene trimerization to ethylene polymerization of the catalyst (7) was obtained utilizing exchanging of the ethylene pressure. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
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《Antitubercular Triazines: Optimization and Intrabacterial Metabolism》 was written by Wang, Xin; Inoyama, Daigo; Russo, Riccardo; Li, Shao-Gang; Jadhav, Ravindra; Stratton, Thomas P.; Mittal, Nisha; Bilotta, Joseph A.; Singleton, Eric; Kim, Thomas; Paget, Steve D.; Pottorf, Richard S.; Ahn, Yong-Mo; Davila-Pagan, Alejandro; Kandasamy, Srinivasan; Grady, Courtney; Hussain, Seema; Soteropoulos, Patricia; Zimmerman, Matthew D.; Ho, Hsin Pin; Park, Steven; Dartois, Veronique; Ekins, Sean; Connell, Nancy; Kumar, Pradeep; Freundlich, Joel S.. Synthetic Route of C3H8ClNOThis research focused ontriazine antitubercular agent intrabacterial drug metabolism pharmacokinetics; Bayesian models; Mycobacterium tuberculosis; intrabacterial drug metabolism; nitrofuran; triazine. The article conveys some information:

The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clin. relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F420H2 and one or more nitroreductases in addition to Ddn. An intrabacterial drug metabolism (IBDM) platform was leveraged to demonstrate the system kinetics, evidencing formation of NO. and a des-nitro metabolite. Structure-activity relationship studies focused on improving the solubility and mouse pharmacokinetic profile of JSF-2019 and culminated in JSF-2513, relying on the key introduction of a morpholine. Mechanistic studies with JSF-2019, JSF-2513, and other triazines stressed the significance of achieving potent in vitro efficacy via release of intrabacterial NO. along with inhibition of InhA and, more generally, the FAS-II pathway. This study highlights the importance of probing IBDM and its potential to clarify mechanism of action, which in this case is a combination of NO. release and InhA inhibition. The experimental process involved the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Synthetic Route of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Synthetic Route of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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