Tag: 100-200

《CaCl2-Promoted Dehydroxytrifluoromethylselenolation of Alcohols with [Me4N][SeCF3]》 was published in Organic Letters in 2020. These research results belong to Wu, Shuai; Jiang, Tian-Hao; Zhang, Cheng-Pan. Formula: C7H9NO2 The article mentions the following:

A direct trifluoromethylselenolation of alcs. with the readily accessible [Me4N][SeCF3] salt has been reported. The reaction is significantly promoted by CaCl2 and proceeds smoothly through unprecedented carbonoselenoate intermediates to form the corresponding alkyl trifluoromethyl selenoethers in good yields. This protocol is also applicable to the late-stage dehydroxytrifluoromethylselenolation of complex alcs. owing to its mildness, good compatibility, high efficiency, and broad functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Formula: C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Highly efficient oxidation of alcohols to carboxylic acids using a polyoxometalate-supported chromium(III) catalyst and CO2》 was published in Green Chemistry in 2020. These research results belong to Wang, Ying; Wu, ZhiKang; Yu, Han; Han, Sheng; Wei, Yongge. Recommanded Product: (4-Bromophenyl)methanol The article mentions the following:

Direct catalytic oxidation of alcs. to carboxylic acids is very attractive, but economical catalysis systems have not yet been well established. Here, we show that a pure inorganic ligand-supported chromium compound, (NH4)3[CrMo6O18(OH)6] (simplified as CrMo6), could be used to effectively promote this type of reaction in the presence of CO2. In almost all cases, oxidation of various alcs. (aromatic and aliphatic) could be achieved under mild conditions, and the corresponding carboxylic acids can be achieved in high yield. The chromium catalyst 1 can be reused several times with little loss of activity. Mechanism study and control reactions demonstrate that the acidification proceeds via the key oxidative immediate of aldehydes. In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
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The author of 《SO3H-dendrimer functionalized magnetic nanoparticles (Fe3O4@D-NH-(CH2)4-SO3H): Synthesis, characterization and its application as a novel and heterogeneous catalyst for the one-pot synthesis of polyfunctionalized pyrans and polyhydroquinolines》 were Maleki, Behrooz; Reiser, Oliver; Esmaeilnezhad, Ehsan; Choi, Hyoung Jin. And the article was published in Polyhedron in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

In this study, novel SO3H-dendrimer functionalized magnetic nanoparticles (Fe3O4@D-NH-(CH2)4-SO3H) were prepared and characterized by using FT-IR, X-ray diffraction patterns, SEM, transmission electron microscopy, thermogravimetry anal., and energy-dispersive X-ray spectroscopy. The synthesized nanosized catalyst was successfully applied to the synthesis of highly substituted pyrans and polyhydroquinolines via a straightforward one-pot multicomponent condensation reaction. The key advantages are the short reaction time, high yields, simple workup, and purification of products by simple recrystallization from ethanol. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Tailoring the degradation and mechanical properties of poly(e-caprolactone) incorporating functional e-caprolactone-based copolymers》 were Xu, Mi; Guo, Cuili; Dou, Haozhen; Zuo, Yi; Sun, Yawei; Zhang, Jinli; Li, Wei. And the article was published in Polymer Chemistry in 2019. Recommanded Product: 27489-62-9 The author mentioned the following in the article:

A series of functional block copolymers (COPs) was synthesized through the ring-opening polymerization of ε-caprolactone (CL) and γ-(carbamic acid benzyl ester)-ε-caprolactone (CABCL) monomers at different ratios, and then the effects of the COP additives on the hydrolytic and oxidative degradation and mech. properties of PCL/COP samples were studied. From characterization using DSC, POM, AFM, WAXD, SAXS, etc., it was demonstrated that the content and distribution of pendant side chains in the COPs can alter the nucleation of macromol. chains, and then modulate the lamellar thickness and crystallinity of the PCL/COP samples. Such variations of the macromol. structures result in distinct changes in the mech. properties during degradation These results provide useful guidance for the development of ideal materials for biodegradable polymer stents with tunable degradation rates and the desirable evolution of the mech. properties. In the part of experimental materials, we found many familiar compounds, such as trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 27489-62-9

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Alcohol – Wikipedia,
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The author of 《Dendron-functionalized surface: Efficient strategy for enhancing the capture of microvesicles》 were Jiang, Jian-Qiao; Chanseau, Christel; Alves, Isabel D.; Nlate, Sylvain; Durrieu, Marie-Christine. And the article was published in iScience in 2019. Product Details of 4048-33-3 The author mentioned the following in the article:

Microvesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated anal. including morphol., quant., and compositional studies is most desirable for the clin. application of MV detection; however, such integration is limited by the currently available anal. techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic mols. with PS-binding sites at the periphery. PS-dendron binding was studied at the mol. level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Product Details of 4048-33-3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Molecules included an article by Nakamae, Ikuko; Morimoto, Tsumoru; Shima, Hiroki; Shionyu, Masafumi; Fujiki, Hisayo; Yoneda-Kato, Noriko; Yokoyama, Takashi; Kanaya, Shigehiko; Kakiuchi, Kiyomi; Shirai, Tsuyoshi; Meiyanto, Edy; Kato, Jun-ya. Synthetic Route of C7H6O3. The article was titled 《Curcumin derivatives verify the essentiality of ROS upregulation in tumor suppression》. The information in the text is summarized as follows:

Curcumin has been shown to exert pleiotropic biol. effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties. Thirty-nine derivatives exhibited anti-proliferative activity toward human cancer cell lines, including CML-derived K562 leukemic cells, in a manner sensitive to an antioxidant, N-acetyl-cysteine (NAC). Some compounds exhibited lower GI50 values than curcumin, some efficiently induced cell senescence, and others markedly increased ROS levels, efficiently induced cell death and suppressed tumor formation in a xenograft mouse model, without any detectable side effects. A clustering anal. of the selected compounds and their measurement variables revealed that anti-tumorigenic activity was most well-correlated with an increase in ROS levels. Pulldown assays and a mol. docking anal. showed that curcumin derivatives competed with co-enzymes to bind to the resp. ROS metabolic enzymes and inhibited their enzymic activities. The anal. of novel curcumin derivatives established the importance of ROS upregulation in suppression of tumorigenesis, and these compounds are potentially useful for the development of an anti-cancer drug with few side effects. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ACS Omega included an article by Waiba, Satyadeep; Das, Animesh; Barman, Milan K.; Maji, Biplab. Formula: C6H7NO. The article was titled 《Base Metal-Catalyzed Direct Olefinations of Alcohols with Sulfones》. The information in the text is summarized as follows:

Herein, a base-metal nickel-catalyzed direct olefination of alcs. with sulfones is reported. The reaction operates under low catalyst loading and does not require an external redox reagent. A wide range of trans-stilbenes and styrenes were synthesized in good yields and selectivities. Biol. active stilbene DMU-212 could also be synthesized in a single step under these conditions. Mechanistic studies involving kinetic isotope effect, deuterium labeling experiments, and catalytic and stoichiometric reactions with possible catalytic intermediates were performed to elucidate a plausible mechanism. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Synthesis included an article by Kawano, Teruhiro; Watari, Ryo; Kayaki, Yoshihito; Ikariya, Takao. SDS of cas: 100-55-0. The article was titled 《Catalytic Hydrogenation of Carboxamides with a Bifunctional Cp*Ru Catalyst Bearing an Imidazol-2-ylidene with a Protic Aminoethyl Side Chain》. The information in the text is summarized as follows:

Synthesis of a Cp*Ru complex bearing an NH2-functionalized N-heterocyclic carbene (C-NH) I (R = CH3) was achieved by treatment of Cp*RuBr(isoprene) with an equimolar amount of a silver complex, which was generated from Ag2O and 1-(2-aminoethyl)-3-methylimidazolium bromide, in CH3CN at room temperature The new Cp*RuBr(C-NH) complex I showed a higher catalytic performance than the related Cp*RuCl(P-NH) and Cp*RuCl(N-NH) complexes. In the reaction of N-arylcarboxamides R1C(O)NR2R3 (R1 = H, C6H5, pyridin-3-yl; R2 = R3 = CH3; R2 = H, R3 = C6H5; R2R3 = -C(O)(CH2)3-, etc.), the amine products R2R3NH were obtained in satisfactory yields under mild temperature conditions. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0SDS of cas: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Green Chemistry included an article by Wei, Zheyu; Ru, Shi; Zhao, Qixin; Yu, Han; Zhang, Gang; Wei, Yongge. Category: alcohols-buliding-blocks. The article was titled 《Highly efficient and practical aerobic oxidation of alcohols by inorganic-ligand supported copper catalysis》. The information in the text is summarized as follows:

The oxidation of alcs. to aldehydes or ketones is a highly relevant conversion for the pharmaceutical and fine-chem. industries, and for biomass conversion, and is commonly performed using stoichiometric amounts of highly hazardous oxidants. The aerobic oxidation of alcs. with transition metal complex catalysts previously required complicated organic ligands and/or nitroxyl radicals as co-catalysts. Herein, we report an efficient and eco-friendly method to promote the aerobic oxidation of alcs. using an inorganic-ligand supported copper catalyst 1, (NH4)4[CuMo6O18(OH)6], with O2 (1 atm) as the sole oxidant. Catalyst 1 is synthesized directly from cheap and commonly available (NH4)6Mo7O24·4H2O and CuSO4, which consists of a pure inorganic framework built from a central CuII core supported by six MoVIO6 inorganic scaffolds. The copper catalyst 1 exhibits excellent selectivity and activity towards a wide range of substrates in the catalytic oxidation of alcs., and can avoid the use of toxic oxidants, nitroxyl radicals, and potentially air/moisture sensitive and complicated organic ligands that are not com. available. Owing to its robust inorganic framework, catalyst 1 shows good stability and reusability, and the catalytic oxidation of alcs. with catalyst 1 could be readily scaled up to gram scale with little loss of catalytic activity, demonstrating great potential of the inorganic-ligand supported Cu catalysts in catalytic chem. transformations. The experimental process involved the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Category: alcohols-buliding-blocks)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Category: alcohols-buliding-blocks It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Rapacz, Anna; Waszkielewicz, Anna M.; Panczyk, Katarzyna; Pytka, Karolina; Koczurkiewicz, Paulina; Piska, Kamil; Pekala, Elzbieta; Budziszewska, Boguslawa; Starek-Swiechowicz, Beata; Marona, Henryk published 《Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols》.MedChemComm published the findings.Name: trans-4-Aminocyclohexanol The information in the text is summarized as follows:

New derivatives of N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated via rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indexes were evaluated for analgesic activity using the formalin test for neurogenic pain. They were also evaluated for their influence on cytotoxic activity using in vitro cellular models (HepG2 and CRL-2534 cell lines). Experiments performed using MTT and neutral red cytotoxicity assays showed that all evaluated compounds were safe for normal, glial cells (astrocytes) and did not induce hepatotoxic effects. Based on the results from the in vitro studies, the safety of the evaluated compounds was inferred. The most promising compound in this research was 1-{2-[2-(2,3-dimethylphenoxy)ethoxy]ethyl}piperidin-3-ol hydrochloride. Addnl., in silico metabolism prediction for the compound has been performed. The results came from multiple reactions, including the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Name: trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Name: trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts