Category: alcohols-buliding-blocks

Ryba, O. published the artcileAntioxidants and stabilizers. IV. Influence of structure on polarographic half-wave potentials of alkylated hydroquinones, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Collection of Czechoslovak Chemical Communications (1965), 30(3), 843-52, database is CAplus.

cf. CA 60, 6772f, 7429d; 61, 5545d. E_1/2 values were determined with a dropping Hg electrode for hydroquinone and for its 21 alkyl derivatives in acetate buffer solutions in 50% EtOH, and were tabulated. The slope of the polarographic waves corresponded to a reversible 2-electron oxidation Substitution in the 2-or 2,5-positions caused a shift of E_1/2 towards neg. values; this shift is a linear function of the sum of steric substitution constants With substitution in the 2,6-positions, the influence of individual substituents is not additive. 37 references.

Collection of Czechoslovak Chemical Communications published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kochansky, Jan published the artcileScreening additional antibiotics for efficacy against American foulbrood, Category: alcohols-buliding-blocks, the publication is Journal of Apicultural Research (2005), 44(1), 24-28, database is CAplus.

The sensitivity of Paenibacillus larvae larvae (American foulbrood, AFB) to 35 antibiotics and synthetic antimicrobials, including two previously reported, was investigated. All compounds but one are currently approved by the US Food and Drug Administration for agricultural uses. The most active approved antibiotics screened were pirlimycin, tiamulin, and the polyether ionophores, particularly narasin, lasalocid, salinomycin, laidlomycin, and maduramicin. Pirlimycin and tiamulin show high activity in vitro, but share the mode of action of tylosin and lincomycin (inhibition of ribosomal peptide synthesis), and therefore have no advantage over it. While the ionophores have high in vitro activity and a completely different mode of action (interference with cation transport across cell membranes) and therefore seemed to represent potential alternative treatments for AFB, they were inactive in the field.

Journal of Apicultural Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ramurthy, Savithri published the artcileDiscovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors, Computed Properties of 371-99-3, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(4), 126930, database is CAplus and MEDLINE.

Glycogen synthase kinase-3 plays an essential role in multiple biochem. pathways in the cell, particularly in regards to energy regulation. As such, Glycogen synthase kinase-3 is an attractive target for pharmacol. intervention in a variety of disease states, particularly non-insulin dependent diabetes mellitus. However, due to homol. with other crucial kinases, such as the cyclin-dependent protein kinase CDC2, developing compounds that are both potent and selective is challenging. A novel series of derivatives of 5-nitro-N2-(2-(pyridine-2-ylamino)ethyl)pyridine-2,6-diamine were synthesized and potently inhibit glycogen synthase kinase-3 (GSK3). Potency in the low nanomolar range was obtained along with remarkable selectivity. The compounds activate glycogen synthase in insulin receptor-expressing CHO-IR cells and in primary rat hepatocytes, and have acceptable pharmacokinetics and pharmacodynamics to allow for oral dosing. The x-ray co-crystal structure of human GSK3-β in complex with compound 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one is reported and provides insights into the structural determinants of the series responsible for its potency and selectivity.

Bioorganic & Medicinal Chemistry Letters published new progress about 371-99-3. 371-99-3 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2-((2,2,2-Trifluoroethyl)amino)ethanol, and the molecular formula is C4H8F3NO, Computed Properties of 371-99-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zeng, Zhuo published the artcilePolyfluoroalkyl, Polyethylene Glycol, 1,4-Bismethylenebenzene, or 1,4-Bismethylene-2,3,5,6-Tetrafluorobenzene Bridged Functionalized Dicationic Ionic Liquids: Synthesis and Properties as High Temperature Lubricants, Quality Control of 129301-42-4, the publication is Chemistry of Materials (2008), 20(8), 2719-2726, database is CAplus.

A new class of geminal dicationic ionic liquids was formed with a bridging moiety, such as a polyalkyl ether, polyfluoroalkyl, 1,4-bismethylenebenzene, or 1,4-bismethylene-2,3,5,6-tetrafluorobenzene link, between alkyl-substituted imidazolium rings. Their properties were modified by varying the linker chains and/or alkyl substituents on the imidazolium ring. The polyfluoroalkyl bridged dicationic ionic liquids exhibit the highest densities and viscosities. Although m.ps. are directly proportional to the length of the alkyl substituent, the densities decrease concomitantly. With 1,4-bismethylene-2,3,5,6-tetrafluorobenzene as the linking chain and with longer alkyl substituents on the imidazolium rings, the nonpolar character of the ionic liquid greatly increases, e.g., the solubilities in toluene of dicationic ionic liquids 36 and 37, where the ring substituents are C₁₀H₂₁ and C₁₄H₂₉, increase markedly. Some of the salts exhibit higher conductivities than an equimolar tetrabutylammonium iodide solution in acetonitrile/toluene. These new ionic liquids (except with PF₆^– as anion) display outstanding tribol. properties in temperature ramp tests by performing very well at 300 °C, thus meeting one criterion for high-temperature lubricants.

Chemistry of Materials published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C2H4ClNO, Quality Control of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Adeshra, Shreya D. published the artcileDevelopment and validation of three novel UV spectrophotometric methods for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture and its comparison using ANOVA, SDS of cas: 111011-76-8, the publication is Journal of Medicinal and Chemical Sciences (2021), 4(2), 145-153, database is CAplus.

Efonidipine hydrochloride ethanolate and telmisartan combination is used for to treat hypertension treatment and under clin. phase 4 study. It is necessary to develop suitable quality control methods for rapid and accurate determination of these drugs. Three simple, accurate, sensitive, precise and economical UV spectrophotometric methods (A, B and C) have been developed for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture Method (A) is based on the first order derivative spectrophotometric method at zero crossing wavelength. In this method the zero crossing zero-crossing point of efonidipine hydrochloride ethanolate is 326 nm and for telmisartan is 272 nm. The linearity was obtained in the concentration range of 8-20 μg/mL for efonidipine hydrochloride ethanolate and 16-40 μg/mL for telmisartan using methanol as a solvent. Method (B) is based on absorbance correction method, method; it was performed at 347 nm for efonidipine hydrochloride ethanolate and at 296 nm for telmisartan. Method (C) is based on dual wavelength method developed using absorbance difference at 242.5 nm and 257.5 nm for efonidipine hydrochloride ethanolate and 244.5 nm and 287 nm for telmisartan. The accuracy and precision of the methods were determined assessed and validated statistically. All the methods showed revealed good reproducibility and recovery. The three methods were compared using one way ANOVA. All methods were found to be rapid, specific, precise and accurate and these methods require no preliminary separation and found no interferences from the tablet excipients so it can be used for routine anal. of both drugs in quality control laboratories

Journal of Medicinal and Chemical Sciences published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rastogi, Supriya published the artcileAllergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis, COA of Formula: C11H24O3, the publication is Journal of the American Academy of Dermatology (2018), 79(6), 1028-1033.e6, database is CAplus and MEDLINE.

Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications that might predispose a person toward developing allergic contact dermatitis. To determine the predictors of allergic contact dermatitis and relevant allergens in AD. A retrospective chart review was performed for 502 adults (age ≥18 years) who were patch tested to an expanded allergen series during 2014-2017. Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with and without current AD had similar proportions of any pos. (+, ++, or +++ 80 [74.1%] vs 254 [64.5%], resp., chi-squared P = .06); strong-pos. (++ and +++ 34 [31.5%] vs 102 [25.9%], resp., P = .25); and irritant (56 [51.9%] vs 188 [47.7%], resp., P = .45) patch-test reactions. AD patients had significantly higher rates of pos. reactions to ingredients in their personal care products and topical medications, including fragrance mix II (P = .04), lanolin (P = .03), bacitracin (P = .04), cinnamal (P = .02), budesonide (P = .01), tixocortol (P = .02), and chlorhexidine (P = .001); relevance was established in >90% of these reactions. Polysensitization occurred more commonly in patients with AD than without (35 [32.4%] vs 75 [19.0%]; P = .01). Study was performed at a single center. AD patients had more pos. patch-test reactions to ingredients in their personal care products, topical steroids, and antibiotics.

Journal of the American Academy of Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Rashmin B. published the artcileBox-Behnken Experimental Design Aided Optimization of Stability Indicating HPTLC-Based Assay Method: Application in Pharmaceutical Dosage form Containing Model Drugs-Roxithromycin and Ambroxol Hydrochloride, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Analytical Chemistry Letters (2019), 9(6), 816-834, database is CAplus.

The objective of this study was to apply Design of Experiment (DoE) concept for development of stability indicating high-performance thin-layer chromatog. (HPTLC) method for assay of model drugs (Roxithromycin (ROXTM) and Ambroxol hydrochloride (AMBRX)) in marketed tablet formulations followed by validation of developed HPTLC method as per ICHQ2(R1). Box-Behnken exptl. design was applied to optimize chromatog. conditions and their effects on retardation factor (Rf) value. The developed HPTLC method was validated for specificity, linearity, accuracy, precision, and robustness. The ROXTM (Rf 0.42) and AMBRX (Rf 0.75) were well separated (Rs 2.06) from each other and from their resp. degradation products on HPTLC plate using optimized chromatog. conditions. The developed method was successfully validated and statistical anal. proved that the method is sensitive, specific (peak purity > 0.9999 for both ROXTM and AMBRX), accurate (98.59-101.14% and 99.96-101.76%, ROXTM and AMBRX, resp.) and precise (% RSD >1.0 for both ROXTM and AMBRX). The developed HPTLC method have advantages over reported methods in being robust and able to determine the model drugs and degradation products with sensitivity, selectivity and short anal. time using simple mobile phase.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bleehen, S. S. published the artcileDepigmentation of skin with 4-sisopropylcatechol, mercaptoamines, and other compounds, Computed Properties of 1139-46-4, the publication is Journal of Investigative Dermatology (1968), 50(2), 103-17, database is CAplus and MEDLINE.

Thirty-three compounds including thiols, mercaptoamines, catechol, catechol derivatives, and quinones were tested for their depigmenting potency and irritant effect on the skin of guinea pigs. These compounds, in concentrations ranging from 1 to 10%, were applied topically to the epilated skin of the back and the unepilated skin of the ear of black guinea pigs; 4-isopropylcatechol (4-IPC) was the most potent depigmenting agent, and the depigmentation occurred only in the treated areas. When used in low concentrations (1-3%), 4-IPC did not irritate the skin. Evidence obtained by light and electron microscopy indicated that 4-IPC markedly reduced the population of the melanocytes in the epidermis. The few remaining melanocytes were rendered degenerative, and those found had only a few melanized melanosomes. Cutaneous depigmentation by 4-IPC apparently results from a selective action on melanocytes; they are either destroyed or inactivated.

Journal of Investigative Dermatology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Computed Properties of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Agarwal, Sameer published the artcileDiscovery of a Potent and Orally Efficacious TGR5 Receptor Agonist, SDS of cas: 23351-09-9, the publication is ACS Medicinal Chemistry Letters (2016), 7(1), 51-55, database is CAplus and MEDLINE.

TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5 EC₅₀ = 57 pM, mTGR5 = 62 pM) with a favorable pharmacokinetic profile. The compound 6g was found to have potent glucose lowering effects in vivo during an oral glucose tolerance test in DIO C57 mice with ED₅₀ of 7.9 mg/kg and ED₉₀ of 29.2 mg/kg.

ACS Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gollapelli, Krishna Kumar published the artcileRh(I)-catalyzed stereoselective desymmetrization of prochiral cyclohexadienones via highly exo-selective Huisgen-type [3 + 2] cycloaddition, COA of Formula: C9H12O, the publication is Chemical Science (2021), 12(4), 1544-1550, database is CAplus and MEDLINE.

A Rh(I)-catalyzed highly stereoselective desymmetrization of 2-alkynylbenzaldehyde-tethered cyclohexadienones triggered by intramol. Huisgen-type [3 + 2] cycloaddition was developed. This method enables convergent construction of complex epoxy-bridged polycyclic ring systems with five contiguous stereocenters with excellent exo-selectivity and broad substrate scope. The highly atom-economical process involves 6-endo-dig cyclization of carbonyl oxygen onto an activated alkyne resulting in a highly reactive metal-benzopyrylium intermediate, which readily undergoes intramol. [3 + 2] annulation/hydration. Asym. induction was also achieved for the first time in Rh(I)-catalyzed 1,3-dipolar cycloaddition using an easily accessible chiral diene as the ligand.

Chemical Science published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts