Category: alcohols-buliding-blocks

Xue, Da-quan published the artcileSynthesis of dapoxetine hydrochloride, Product Details of C19H18O2, the publication is Hecheng Huaxue (2010), 18(5), 647-649, database is CAplus.

Dapoxetine hydrochloride was synthesized from 3-chloropropiophenone by catalytic asym. reduction, alkylation, O-methylsulfonylation, and dimethylamination, as well as salt formation in an overall yield of 39.9%.

Hecheng Huaxue published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C10H15ClO3S, Product Details of C19H18O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

McCulloch, Iain published the artcilePolymerizable liquid crystalline organic semiconductors and their fabrication in organic field effect transistors, Computed Properties of 239075-02-6, the publication is Journal of Materials Chemistry (2003), 13(10), 2436-2444, database is CAplus.

The performance of the semiconducting component in organic field effect transistors (OFETs) is a key parameter in the advancement of organic electronic devices. New semiconductors are required, which can be solution processed, possess high mobility and current modulation, and are stable in ambient conditions. This work provides the first demonstration of working field effect transistor devices fabricated from novel solution processible, polymerizable, small mol. liquid crystalline semiconductors, referred to as reactive mesogens. The design, synthesis, and performance of these materials in transistor devices are reported. The relationship between liquid crystal mol. structure, its corresponding phase behavior and elec. performance is examined Mol. design methodol. was employed to control the liquid crystalline morphol., in an attempt to optimize organization and packing. Alignment of the mols. in large homeotropic domains was achieved through surface treatment techniques, and the highly ordered mesophase was preserved by polymerization of the reactive end groups, creating a crosslinked network.

Journal of Materials Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sui, Rui published the artcileSilver based single atom catalyst with heteroatom coordination environment as high performance oxygen reduction reaction catalyst, HPLC of Formula: 80-09-1, the publication is Nano Research (2022), 15(9), 7968-7975, database is CAplus.

Ag is a potential low-cost oxygen reduction reaction (ORR) catalyst in alk. condition, which is important for the zinc-air batteries. Here, we report that an Ag based single atom catalyst with heteroatom coordination. Ag₁-h-NPClSC, has been synthesized and shown much improved performance towards ORR by manipulating the coordination environment of the Ag center. It shows a high half wave potential (0.896 V) and a high turnover frequency (TOF) (5.9 s^-1) at 0.85 V, which are higher than the previously reported Ag based catalysts and com. Pt/C. A zinc-air battery with high peak power d. of 270 mW·cm^-2 is fabricated by using the Ag₁-h-NPClSC as air electrode. The high performance is attributed to (1) the hollow structure providing good mass transfer; (2) the single atom metal center structure providing high utility of the Ag; (3) heteroatom coordination environment providing the adjusted binding to the ORR intermediates. D. functional theory (DFT) calculations show that the energy barrier for the formation of OOH*, which is considered as the rate determine step for ORR on Ag nanoparticles, is lowered on Ag₁-h-NPClSC, thus improving the ORR activity. This work demonstrates that the well manipulated Ag based single atom catalysts are promising in electrocatalysis.

Nano Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C13H10F2, HPLC of Formula: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yanrong published the artcileA further understanding on the strength development of cement pastes in the presence of triisopropanolamine used in CRTS III slab track, Synthetic Route of 122-20-3, the publication is Construction and Building Materials (2022), 125743, database is CAplus.

Accelerators are commonly used in the self-compacting concrete of CRTS III slab track to advance its strength development in cold areas. Triisopropanolamine (TIPA) is a known accelerator, and its influences on the strength development of hardened cement pastes (HCPs) were discussed based on a further understanding of cement hydration and microstructure. The results show that the addition of TIPA visibly heightens hydration degree at each age because it triggers the reaction of C4AF and gently promotes C3S hydration. At low dosages, more hydrates deposited in capillary pores facilitate a refined pore structure and therefore, significantly increase the early and late strengths. On the contrary, a high dosage of TIPA results in a loose and porous structure at an early age owing to the emergence of numerous AFm platelets and the reduction of Ca(OH)₂ crystals, so that the heightened hydration degree only slightly increases the early compressive and flexural strengths. At a later age, high dosages of TIPA cause an increase in the volume of harmful pores (greater than 50 nm), which may result from the appearance of some pores full of fractional AFm and the changed morphol. of Ca(OH)₂. Therefore, the late compressive strength of HCPs remains almost unchanged under the pos. effect of the heightened hydration degree coupled with the neg. effect of the increased volume of the harmful pores. In contrast, the late flexural strength sharply decreases, which is ascribed to both of the increased volume of the pores larger than 50 nm and the morphol. changes of hydration products.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C24H20Ge, Synthetic Route of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Rongchang published the artcileOscillographic titration with sodium tetraphenylboron for pharmaceutical and metallurgical analyses, Computed Properties of 3818-50-6, the publication is Fenxi Ceshi Xuebao (2002), 21(2), 39-41, database is CAplus.

An oscillog. titrimetric method with sodium tetraphenylboron was described for pharmaceutical and metallurgical analyses. Since the proposed method was based on the visual display of a sharp oscillog. end-point and was not affected by the colors of the solution, precipitate and excipient, it can be used to replace gravimetric anal., non-aqueous titration, and extraction-photometric anal. The method was used in the determination of alkaloid and quaternary ammonium salt with the RSD 0.03-0.06% and the results consistent with those obtained by pharmacopoeia method. Some metallurgical samples were determined with the RSD 0.15- 0.40%, the recovery 98.7-100% and the results consistent with those obtained by standard method. The method was accurate, rapid, simple and cheap, and hence had large potential for extensive application.

Fenxi Ceshi Xuebao published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C7H11N, Computed Properties of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Pianpian published the artcileMass production of a single-atom cobalt photocatalyst for high-performance visible-light photocatalytic CO₂ reduction, Formula: C9H21NO3, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2021), 9(46), 26286-26297, database is CAplus.

The photocatalytic reduction of carbon dioxide (CO₂RR) into value-added chem. products is a promising way to enrich energy supply and reduce CO₂ emission. The proposal of a high-efficiency, low-cost and easy-to-operate photocatalyst is an essential segment for promoting the CO₂RR from small-scale laboratory examination to large-scale industrial application. Herein, we first come up with a Co photocatalyst with isolated Co single atoms anchored on a com. super conductive carbon black (Co-SA@SP-800) and employ it to effectively boost the photocatalytic CO₂ reduction reaction. Large scale production of the Co-SA@SP-800 catalyst can be achieved by a simple and practical adsorption-pyrolysis method. The as-prepared Co-SA@SP-800 catalyst presents remarkable photoactivity and CO selectivity with a CO production yield of 1.64 x 104μmol g^-1 and a CO selectivity of 84.2% after 2 h of UV illumination in a heterogeneous system, and significantly outperforms other reference samples and most of the other efficient photocatalysts reported recently toward the conversion of CO₂. In situ diffuse reflectance IR Fourier transform (DRIFT) spectroscopy was carried out to investigate the reaction intermediates during the photocatalytic CO₂RR. Control experiments and theor. calculations revealed that the isolated single at. Co-N₄ sites greatly lower the energy barrier for the desorption of CO* during CO₂-to-CO conversion, while suppressing H₂ evolution in the competing water splitting reaction. This work provides valuable new insights for rationally designing and synthesizing high-performance single atom catalysts for photocatalytic CO₂ reduction with ease of large-scale production

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C5H6N2O2, Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ting published the artcileSelective hydroconversion of 2-methylfuran to pentanols on MWNT-supported Pt catalyst at ambient temperature, Application In Synthesis of 111-29-5, the publication is Rare Metals (Beijing, China) (2022), 41(3), 889-900, database is CAplus.

The selective hydrogenolysis of C-O bond in furfural and its derivatives provides a sustainable route for transforming biomass-derived feedstocks into valued chems. Currently, the development of efficient catalysts which can effectively cleavage C-O bond under mild conditions remains a critical challenge. The present work reports Pt catalysts supported on multi-walled carbon nanotubes (MWNT) which are active in 2-methylfuran (2-MF) hydrogenolysis to form pentanols in liquid phase under mild conditions. The impact of various catalyst supports, active metals and reaction conditions in terms of metal loadings, solvent, time, pressure, etc. were explored. The 5 wt% Pt/MWNT catalyst demonstrated an excellent activity and selectivity with 100% 2-MF conversion and 53% pentanols (POLs) yield under 1 MPa H2 at an exceptional low temperature of 25°C. The reaction mechanism was studied combing both the reactivity tests and characterization results, and it is found that the better catalytic performances of Pt/MWNT were correlated closely to the size of Pt nanoparticles and their interactions with the underlying MWNT support. Accordingly, a reaction pathway involving the adsorption of 2-MF parallel to the Pt nanoparticles and its subsequently selective C-O hydrogenolysis was proposed. This work showcases a promising catalyst for room-temperature biofuel production

Rare Metals (Beijing, China) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C13H10N2S, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, H.-L. published the artcileEnantioselective synthesis of enantiopure chiral alcohols using carbonyl reductases screened from Yarrowia lipolytica, Recommanded Product: 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, the publication is Journal of Applied Microbiology (2019), 126(1), 127-137, database is CAplus and MEDLINE.

Aims : We aimed to explore Yarrowia lipolytica carbonyl reductases as effective biocatalysts and to develop efficient asym. reduction systems for chiral alc. synthesis. Methods and Results : Yarrowia lipolytica carbonyl reductase genes were obtained via homologous sequence amplification strategy. Two carbonyl reductases, YaCRI and YaCRII, were identified and characterized, and used to catalyze the conversion of 2-hydroxyacetophenone (2-HAP) to optically pure (S)-1-phenyl-1,2-ethanediol. Enzymic assays revealed that YaCRI and YaCRII exhibited specific activities of 6·96 U mg^-1 (99·8% e.e.) and 7·85 U mg^-1 (99·9% e.e.), resp., and showed moderate heat resistance at 40-50°C and acid tolerance at pH 5·0-6·0. An efficient whole-cell two-phase system was established using reductase-expressing recombinant Escherichia coli. The conversion of 2-HAP (20·0 g l^-1) conversion with the solvent of di-Bu phthalate was approx. 70-fold higher than in water. Furthermore, the two recombinant E. coli displayed biocatalyst activity and enantioselectivity towards several different carbonyl compounds, and E. coliBL21 (DE3)/pET-28a-yacrII showed a broad substrate spectrum. Conclusions : A new whole-cell recombinant E. coli-based bioreduction system for enantiopure alc. synthesis with high enantioselectivity at high substrate concentrations was developed. Significance and Impact of the Study : We proposed a promising approach for the efficient preparation of enantiopure chiral alcs.

Journal of Applied Microbiology published new progress about 1310357-40-4. 1310357-40-4 belongs to alcohols-buliding-blocks, auxiliary class Benzenes, name is 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, and the molecular formula is C24H12, Recommanded Product: 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ting published the artcileThe underlying rationality of Chinese medicine herb pair Coptis chinensis and Dolomiaea souliei: From the perspective of metabolomics and intestinal function, COA of Formula: C8H8O3, the publication is Journal of Ethnopharmacology (2022), 115065, database is CAplus and MEDLINE.

The combination of Coptis chinensis (RC) and Dolomiaea souliei (VR) has long been used as a classic herb pair for the treatment of gastrointestinal diseases, but the underlying mechanisms remain unknown. In this study, the rationality of evidence-based RC and VR combination was explored from the perspective of metabolism, gut microbiota and gastrointestinal function. After 5 wk treatment, VR extracts (700 mg/kg) and RC alkaloids (800 mg/kg) showed no toxic effect on mice. However, RC administration significantly decreased the body weight of mice. Gastric emptying, gastrointestinal motility function and the absorption of FITC dextran were retarded in the mice of RC group, taking RC along with low dose VR (RC-VRL) and high dose VR (RC-VRH) reversed the impaired gastrointestinal function caused by RC. RC administration significantly increased villus height/crypt depth value. Notably, VR administration increased the number of crypts in mice ileum and reduced villus height/crypt depth value in VR and RC combination group. RC treatment significantly increased the expression of occludin compared to NC group; RC-VRL treatment reversed this tendency. While, VR administration increased ZO1 expression by 99.4% compared to NC mice. As for gut microbiota, RC gavage decreased the gut microbiota diversity, but gut microbiota in VR group was similar to NC group, and VR and RC combination increased gut microbiota diversity. RC administration obviously increased the proportion of Akkermansia muciniphila, Bacteroides thetaiotaomicron, Parabacteroides distasonis, and Escherichia coli, compared to NC mice. VR treatment increased the richness of Bacteroides thetaiotaomicron, Parabacteroides distasonis. RC-VRL and RC-VRH treatment dose-dependently increased the richness of Rikenellaceae RC9, Lactobacillus, and decreased the abundance of Psychrobacter, Bacteroides and Ruminococcus in mice. Serum metabolomic anal. revealed that RC gavage significantly down regulated 76 metabolites and up regulated 31 metabolites. VR treatment significantly down regulated 30 metabolites and up regulated 12 metabolites. Weight loss caused by RC may attribute to the elevated methylxanthine level in mice. The potential adverse effects caused by high dose RC intake may partially alleviate by high serum contents of adenosine, inosine and urolithin A resulted from VR coadministration. VR may alleviate RC caused “fluid retention” via normalizing gastrointestinal function, gut microbiota and modulating the perturbed metabolism

Journal of Ethnopharmacology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H4FNO3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Zhiwen published the artcileHighly selective oxidation of organosilanes with a reusable nanoporous silver catalyst, COA of Formula: C6H16OSi, the publication is Catalysis Communications (2014), 53-56, database is CAplus.

Room temperature highly selective oxidation of organosilanes to organosilanols and organosilyl ethers is achieved in liquid-phase with dealloyed nanoporous silver catalysts. In both cases, aromatic and aliphatic silanes can be effectively converted into the corresponding silanols and silyl ethers by using water and alcs. as oxidant, resp. Moreover, hydrogen gas is the only byproduct and the catalyst can be recycled for several times without evident loss of activity and selectivity.

Catalysis Communications published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, COA of Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts