Category: alcohols-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 2002-24-6

9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine 7-Methoxy-1-nitro-9-phenoxyacridine (0.69 g) is dissolved in phenol (20 g). Ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 100 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether (100 ml), slowly poured into dry ether (300 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed twice with ether and crystallized from absolute methanol-ether to give 9-(2′-hydroxyethylamino)-7-methoxy-1-nitroacridine monohydrochloride (0.58 g, 83% yield), m.p. 220 C. (decomp.) 1H NMR (d6DMSO): delta3.45 (t, 2 H, H-2′), 3.65 (t, 2 H, H-1′), 3.80 (s, 3 H, OCH3), 7.30 (dd, 1 H, J1=9.3 Hz, J2=2.5 Hz, H-6), 7.35 (d, 1 H, J=2.5 Hz, H-8), 7.40 (d, 1 H, J=9.3 Hz, H-5), 7.7 (m, 2 H, H-3, H-4), 7.87 (m, 1H, H-2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2002-24-6, 2-Aminoethanol hydrochloride.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
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Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8. 100-37-8

EXAMPLE 24D 5-[6-[3-(2-Diethylamino-ethoxy)-phenyl]-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic Acid Tert-Butyl Ester To a solution of the product of Example 24C (0.1 g, 0.26 mmol) and N,N-diethylethanolamine (Aldrich, 87 mL, 0.65 mmol) in 10 mL CH2Cl2 at 0 C. was added polymer-supported triphenylphosphine (Aldrich, 3 mmol/gram, 0.65 mmol, 0.22 g). The diisopropyl azodicarboxylate (DIAD, Aldrich, 0.13 mL, 0.65 mmol) was added dropwise via syringe and, following the addition, the ice-bath was removed and the reaction mixture stirred at ambient temperature for 2 h. The mixture was then filtered, concentrated and purified via column chromatography (SiO2, 1% NH4OH:9% CH3OH:90% CH2Cl2) to give 0.12 g of the title compound (0.25 mmol, 96% yield). MS (DCI/NH3) m/z 482 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 100-37-8.

Reference:
Patent; Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; US2005/65178; (2005); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. 612-16-8

1.02 g (7.38 mmol, 1.0 eq) compound 13c was dissolved in 40 ml CH2Cl2, then 0.84 ml (8.90 mmol, 1.2 eq) PBr3 was added under the condition of ice water bath. After reacting for an hour, a little saturated sodium bicarbonate solution was added to wash the organic phase followed by twice wash with saturated sodium chloride solution, then dried over anhydrous sodium sulfate and desolventizing to gain 1.15 g reddish colored oily material (Compound 8-2c), yield 77.5%. The crude product was used without purification in the next step directly. Compound 8-2a, 8-2b, and 8-2d can be obtained in the same way from compound 13a, 13b, and 13d.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Patent; Fudan University; YE, Deyong; LI, Yali; ZHOU, Lu; WANG, Penghui; CHU, Yong; GONG, Haojun; HUANG, Qi; CHEN, Yan; ZHANG, Zhikuan; (40 pag.)EP3196191; (2017); A1;,
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2615-15-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1.In a 50 mL three-necked flask, add TsCl (6.05 g, 31.9 mmol),Hexaethylene glycol (3.81 g, 12.8 mmol), a catalytic amount of 4-dimethylaminopyridine (20 mg) and 20 mL of CH2Cl2,Under an ice-salt bath, triethylamine (6.55 g, 64.8 mmol) was added dropwise using a constant pressure dropping funnel.After stirring at room temperature for 12h, the reaction was stopped and washed with 1M HCl solution (30mL ¡Á 3).Wash with saturated sodium bicarbonate solution (30 mL ¡Á 3), wash with saturated brine (30 mL ¡Á 3), and dry with anhydrous sodium sulfate. Filter and spin dry.Column chromatography separation: CH2Cl2 ? CH2Cl2: EA = 1: 1, red compound A was obtained as a viscous liquid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; Changzhou University; Xiao Tangxin; Zhou Ling; Wu Kehui; Li Zhengyi; Sun Xiaoqiang; (6 pag.)CN110372682; (2019); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 6338-55-2

A solution of the amino alcohol (620) (313.6 g, 2.1mol) in THF (3.5 L) was treated, portion- wise, with N-(Benzyloxycarbonyloxy)succinimide (621) (550 g, 2.21mol). Once the reaction was complete (18 h) the THF was removed under reduced pressure and the residue dissolved in CH2Cl2 (2.5 L), then washed with an equal volume of HCl (1 M), NaHCO3 (Sat. Aq.), H2O and brine. The organic extract was dried (MgSO4), filtered and concentrated. The crude material (600g) was subjected to chromatography (4kg silica; 1-12% CH3OH-CH2Cl2) to yield HO- Trig-NHZ (622) (468g, 78%) as a clear-yellow viscous oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; GENEVANT SCIENCES GMBH; HEYES, James; HOLLAND, Richard J.; JUDGE, Adam; LAM, Kieu Mong; (0 pag.)WO2020/93061; (2020); A1;,
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1777-82-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1777-82-8, name is (2,4-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 0.5 mmol substrate, 1.5 mmol NH4OAc, 0.15 mmol TEMPO, 2 mL AcOH and 0.15 mmol HNO3 weresuccessively added to a dried 45 mL tube filled with 1atm oxygen. Then the reaction tube was sealed andplaced in a constant-temperature oil bath to perform the reaction for 12 h. Once the reaction time wasreached, the mixture was cooled to room temperature. Then the mixture was alkalized to pH 7-8 with sodiumhydroxide aqueous solution. GC analysis of organic phase provided the GC yields of the products.Subsequently, the crude product from another parallel experiment was purified by column chromatography,and identified by 1H-NMR, 1C-NMR or GC-MS

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1777-82-8, (2,4-Dichlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Bo; Ren, Yun-Lai; Ren, Fangping; Tian, Xinzhe; Zhao, Shuang; Letters in Organic Chemistry; vol. 15; 7; (2018); p. 627 – 632;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 455-01-6, name is 2-(3-(Trifluoromethyl)phenyl)ethanol, the common compound, a new synthetic route is introduced below. 455-01-6

General procedure: DIAD (0.65mL, 3.31mmol) was added dropwise to 12a or 12b (500mg, 2.21mmol), PPh3 (869mg, 3.31mmol) and appropriate alcohol [2-phenylethanol (0.27mL, 2.21mmol, 2e; or 0.17mL, 1.46mmol, 2k), 2-(3-methoxyphenyl)ethanol (0.31mL, 2.21mmol, 2f; 0.20mL, 1.46mmol, 2l), or 2-(3-trifluoromethylphenyl)ethanol (0.33mL, 2.21mmol, 2g and 2m] in THF (10mL), and the mixture was stirred for 18h. Drying, evaporation and chromatography (PE/EtOAc 20:1) gave the esters 2e-g, k-m. Spectroscopic data for these compounds are given in the Supporting information.

Statistics shows that 455-01-6 is playing an increasingly important role. we look forward to future research findings about 2-(3-(Trifluoromethyl)phenyl)ethanol.

Reference:
Article; Yevglevskis, Maksims; Nathubhai, Amit; Wadda, Katty; Lee, Guat L.; Al-Rawi, Suzanne; Jiao, Tingying; Mitchell, Paul J.; James, Tony D.; Threadgill, Michael D.; Woodman, Timothy J.; Lloyd, Matthew D.; Bioorganic Chemistry; vol. 92; (2019);,
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Adding some certain compound to certain chemical reactions, such as: 3973-18-0, name is Propynol ethoxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3973-18-0. 3973-18-0

A solution of 1.7 g of lib and 3 ml of triethyl amine in 20 ml of diethyl ether was treated at O0C with 1.5 ml of methanesulfonyl chloride. The mixture was stirred for an additional 30 min and then diluted with 35 ml of water and extracted with ethyl acetate. The combined organic layers were washed with IM aq. K2CO3 solution and water, dried and concentrated, to provide 2.45 of lie as a colorless oil; Rf 0.45 (heptane/ethyl acetate 1/1).NMR (CDCl3) delta 2.48 (t, 1, acetylene-H), 3.08 (s, 3, CH3SO2), 3,82 (m, 2, CH2), 4.03( d, 2, CH2), 4.41 (m, 2, CH2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3973-18-0.

Reference:
Patent; N.V. ORGANON; LOOZEN, Hubert, Jan, Jozef; TIMMERS, Cornelis, Marius; STOCK, Herman, Thijs; WO2011/12600; (2011); A1;,
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355-80-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. A new synthetic method of this compound is introduced below.

General rocedure: 5.5 ml of aq. solutions of KBr (0.55 mol/dm3), 20 ml MeCN, TEMPO (0.12 g, 0.00077 mol), and 2,2,3-trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-trifluoromethoxy-propoxy)-propan-1-ol (2a) (10 g, 0.0275 mol) were placed in the flask. 14% aq. NaOCl (48 ml) buffered by NaHCO3 (5.2 g) were added via the dropping funnel in 3 portions during two days of stirring in a room temperature (slight exothermic effect). The progress of reaction was monitored by 19F NMR spectroscopy. Then concentrated sulfuric acid followed by water was added. After extraction with diethyl ether, the organic phases were dried over magnesium sulfate. The solvent was evaporated to give a colorless liquid, which was distilled.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, and friends who are interested can also refer to it.

Reference:
Article; Ignatowska, Jolanta; Shyshkov, Oleg; Zipplies, Tilman; Hintzer, Klaus; Roeschenthaler, Gerd-Volker; Journal of Fluorine Chemistry; vol. 141; (2012); p. 35 – 40;,
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349-95-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 349-95-1, name is (4-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

B. Into another reactor, the concentration is 35%Aqueous hydrochloric acid 150kg and p-trifluoromethyl benzyl alcohol 50kg,Stir and heat to reflux, keep reaction for 24h,Cool to room temperature, layer, take organic layer,Dehydrated with anhydrous sodium sulfate,Distillation under vacuum gives a pairTrifluoromethyl benzyl chlorideThe content is 98.8%. Step B of equation (2) is as follows:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 349-95-1, (4-(Trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Bandung Technology Co., Ltd.; Wu Yongcai; (5 pag.)CN107793292; (2018); A;,
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