Category: alcohols-buliding-blocks

Reference of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

In a 250 mL three-necked flask, 0.03 mol of dibenzofuran-3-amine, 0.04 mol of 2-(2-bromophenyl)propan-2-ol, and 150 mL of toluene were stirred and mixed under a nitrogen atmosphere.Then adding 0.05 mol of sodium t-butoxide, 0.0015 mol of Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, heating to 115 C, refluxing reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C).Passing through a neutral silica gel column to give 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

The chemical industry reduces the impact on the environment during synthesis 7073-69-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (37 pag.)CN108203427; (2018); A;,
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Related Products of 698-87-3, Adding some certain compound to certain chemical reactions, such as: 698-87-3, name is 1-Phenyl-2-propanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 698-87-3.

General procedure: The solution of ionic-liquid-supported DMI 7 (2.2 mmol) in[bmim]PF6 (2 mL) was added to oxalyl chloride (2.0 mmol), andthe mixture was stirred at 60 ¡ãC for 2 h. The mixture was then added to the appropriate alcohol (1.5 mmol), and the resultingmixture was stirred at r.t. overnight. Finally, the mixture wasextracted with hexane 10 mL x 3, and the organic layer wasconcentrated.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 698-87-3, 1-Phenyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Koguchi, Shinichi; Shibuya, Yuga; Igarashi, Yusuke; Takemura, Haruka; Synlett; vol. 30; 8; (2019); p. 943 – 946;,
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Adding a certain compound to certain chemical reactions, such as: 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

[00100] In a 50 mL round-bottom flask equipped with stir bar, 5-carboxyphthalaldehydic acid (116 mg, 0.60 mmol), 2,3,6,7-tetrahydro-lH,5H-pyrido[3,2,l-ij]quinolin-8-ol (238 mg, 1.25 mmol) and trifluoroethanol (25 mL). Oxygen was allowed to bubble through the solution for 5 minutes. The resulting dark brown solution was gently warmed up under oxygen atmosphere to 75C and stirred vigorously for 21 hours. The solvent was concentrated in vacuo, and dark blue residue was purified by silica gel chromatography (0? 60% MeOH/DCM) to provide 279 mg (87% yield) of 5-ROX as a dark blue solid. l NMR (300 MHz, CD2Cl2-TFIP-c delta 8.77 (d, J= 1.6 Hz, 1H), 8.28 (dd, J= 7.9, 1.8 Hz, 1H), 7.40 (d, J = 8.0 Hz, 1H), 6.66 (s, 2H), 3.55 – 3.42 (m, 8H), 3.11 (t, J= 6.3 Hz, 4H), 2.70 (t, J = 6.0 Hz, 4H), 2.19 – 2.09 (m, 4H), 2.03 – 1.94 (m, 4H); 1 C NMR (75 MHz, CD2Cl2-TFIP-c delta 174.0, 171.2, 155.9, 153.4, 152.6, 139.4, 135.90, 134.1, 133.4, 132.9, 132.1, 126.8, 125.5, 113.7, 106.6, 51.9, 51.4, 28.2, 21.4, 20.8, 20.5; HRMS (ESI+) calc’d for C33H3iN205+ [M+H]+ 535.2227 found 535.2228.

The synthetic route of 41175-50-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PROMEGA CORPORATION; DWIGHT, Stephen, J.; LEVIN, Sergiy; (38 pag.)WO2017/59308; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol

A method of synthesizing the silybin phenolic ether derivatives as shown in Formula I-d is as follows:1) Add 8.00 g (0.20 mol) NaOH, 80 ml water to a 250 ml three-necked flask.Stir to dissolve it evenly. 24.96 g (0.12 mol) of tetraethylene glycol monomethyl ether was added to 50 ml of THF to be uniformly dissolved, then added to the above-mentioned three-necked flask and uniformly mixed with the NaOH solution.The mixture was stirred in an ice bath at 0 55 C. and thoroughly deoxygenated with nitrogen. 22.88 g (0.12 mol) of p-toluenesulfonyl chloride and 40 ml of THF were mixed well, and then slowly added dropwise to the above three-necked flask. The dropping process kept the temperature of the reaction liquid. After exceeding 10C, the reaction was continued for 6 hours after completion of the dropwise addition to stop the reaction.The reaction solution was extracted three times with diethyl ether, and the ether extract was washed with water until neutral and then dried over anhydrous magnesium sulfate. After filtration and rotary evaporation, the ether was removed.This gave 40.83 g (yield: 94%) of the corresponding p-toluenesulfonate of formula III-b,

The synthetic route of 23783-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Zhao Yuxia; He Ru; Wu Feipeng; (18 pag.)CN105037337; (2018); B;,
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Electric Literature of 2516-33-8 , The common heterocyclic compound, 2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

b) 5-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid Sodium hydride (4.83 g, 0.12 mol) was added into cyclopropanemethanol (CAN 2516-33- 8, 30 g) at 0 C and the mixture was stirred at 0 C for 1 h. Then to the mixture was added5 methyl 5-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester (3 g, 12.75 mmol). The obtained solution was heated to 90 C for 2 h. Then the mixture was evaporated to dryness, the residue was dissolved in 40 mL of water, and adjusted to pH = 4 with hydrochloric acid (3 N), and extracted with ethyl acetate (3 x 30 mL). The combined organic layer was washed with water (2 x 30 mL) and brine (2 x 50 mL) then evaporated to dryness to obtain10 the product as a white solid (2.5 g, 76.7%); MS (El): mle = 272.0 [MH?i.

The synthetic route of 2516-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FREI, Beat; GOBBI, Luca; GRETHER, Uwe; KIMBARA, Atsushi; NETTEKOVEN, Matthias; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHULZ-GASCH, Tanja; WO2014/86705; (2014); A1;,
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Reference of 629-30-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-30-1, name is 1,7-Heptanediol, molecular formula is C7H16O2, molecular weight is 132.2, as common compound, the synthetic route is as follows.

7- bromoheptane-l-ol1 (2): Heptane- 1,7-diol (36.0 g, 272 mmol; Alfa Aesar) and aq. 48% HBr (38 mL, 0.9 equiv.) were heated under reflux in benzene (400 mL) with water removal using a Dean-Stark apparatus. After 16 h, all volatiles were removed in vacuo and the residue was purified by Si02 column chromatography using a gradient of 10-30% EtOAc/hexanes as eluent to give 7-bromoheptan-l-ol (26.22 g, 62%) as a colorless oil. TLC: 50% EtOAc/hexanes, Rf ~ 0.40; NMR (400 MHz, CDC13) delta 3.61 (t, 2H, J = 7.1 Hz), 3.39 (t, 2H, J= 6.8 Hz), 1.80- 1.88 (m, 2H), 1.52-1.58 (m, 2H), 1.30-1.46 (m, 6H).

The chemical industry reduces the impact on the environment during synthesis 629-30-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MCW RESEARCH FOUNDATION, INC.; IMIG, John, David; CAMPBELL, William, B.; FALCK, John, Russell; WO2012/138706; (2012); A1;,
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Reference of 115-20-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115-20-8 as follows.

Preparation of 12′- (2, 2,2-Trichloroethylcarbonyl) vinblastine Trifluoroacetate [00125] Carbon monoxide was bubbled through a solution of 12′- iodovinblastine (53 mg, 0.057 mmol), triethylamine (57 mg, 0.565 mmol) and bis (triphenylphosphine) palladium (II) dichloride (8 mg, 0.011 mmol) in a mixture of DMF/2,2, 2-trichloroethanol (2 mL, 1 : 1) for 5 min, then the reaction mixture was heated at 50 C for 9 h under one atmosphere of carbon monoxide (balloon). The solution was diluted with ethyl acetate (15 mL) then washed with saturated aqueous NaHC03 (2 x 5 mL) and brine (5 mL), dried over MgS04 and evaporated to dryness in vacuo. The residue was purified by reverse phase chromatography (C18, acetonitrile/water, 0.05% trifluoroacetic acid) to provide 12′- (2, 2,2- trichloroethylcarbonyl) vinblastine trifluoroacetate (33 mg, 48%) as a white powder after lyophilization

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.

Reference:
Patent; AMR TECHNOLOGY, INC.; WO2005/55939; (2005); A2;,
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Application of 617-94-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 617-94-7, name is 2-Phenyl-2-propanol. A new synthetic method of this compound is introduced below.

To sodium hydride (60% dispersion in mineral oil, 280 mg, 7.00 mmol, 0.5 equiv) in anhydrous diethyl ether (28 mL) was added freshly distilled 2-phenyl-2-propanol (4.20 g, 30.8 mmol, 2.2 equiv) at 0 C and the mixture was stirred for 1 h at room temperature. The reaction mixture was cooled to 0 C, 2,2,2-trichloroacetonitrile (2.80 mL, 28.0 mmol, 2.0 equiv) were added slowly and stirring was continued for 3 h at ambient temperature. The solvent was removed under reduced pressure and the residue re-dissolved in PE (7.0 mL), anhydrous MeOH (283 pL, 7.00 mmol, 0.5 equiv) was added and the solution was stirred for 10 min at room temperature. The mixture was filtered through a plug of Celite eluting with PE and the filtrate was concentrated in vacuo to give the crude imidate. To a suspension of Fmoc-Ala-OH (4.36 g, 14.0 mmol, 1.0 equiv) in CH CI (80 mL) was added a solution of the imidate in CH CI (15 mL) and the mixture was stirred for 16 h at room temperature. The reaction mixture was filtered through a plug of Celite eluting with CH CI , the solvent was removed in vacuo, and the residue was purified by column chromatograph (S O , PE/EtOAc 4:1) to give Fmoc-Ala-OCumyl (55) (6.00 g, 14.0 mmol, quant yield) contaminated with small amounts of 2-phenyl-2-propanol (~85:15 by 1H N MR) as a pale-yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,617-94-7, 2-Phenyl-2-propanol, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF WARWICK; SHIPMAN, Michael; (96 pag.)WO2019/186174; (2019); A1;,
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Related Products of 2566-44-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.

a) 500 mg (2.01 mmol) 6-Hydroxy-3,4-dihydro-1 H-isoquinoline-2-carboxylicacid tertbutyl ester, 173 mg (2.01 mmol) 2-cyclopropylethanol and 526 mg (2.01 mmol) triphenylphosphine in 5 mL THF are stirred at 000 under inert gas atmosphere. Then420 iL (2.01 mmol) diisopropylazodicarboxylate are added slowly and the reaction mixture is stirred at r.t. over night. After that time, the reaction mixture is filtered, concentrated and the residue purified by H PLC. 019 H27 N 03ES I-MSR (H PLC):(M = 317.4g/mol) 318 [M+H]1.12 mm (method A)

Statistics shows that 2566-44-1 is playing an increasingly important role. we look forward to future research findings about 2-Cyclopropylethanol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; HAEBEL, Peter Wilhelm; HEIMANN, Annekatrin; HEINE, Niklas; (172 pag.)WO2016/41845; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-90-0, blongs to alcohols-buliding-blocks compound. Recommanded Product: Diethylene Glycol Monoethyl Ether

Example 89b; Sodium hydride (60% in oil, 40 mg) was added to a mixture of 2-chloro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidine-5-carbaldehyde (150 mg) obtained in Example 89a), 2-(2-ethoxyethoxy)ethanol (134 mg) and N,N-dimethylformamide (3 ml), and the resulting mixture was stirred for one hour at room temperature. Furthermore, 2-(2-ethoxyethoxy)ethanol (134 mg) and sodium hydride (60% in oil, 40 mg) were sequentially added thereto, and the resulting mixture was stirred for 15 hours at 100 C. The reaction mixture was returned to room temperature, and then the solvent was distilled off under reduced pressure. The residue was diluted with ethyl acetate, and the dilution was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by chromatography, and was recrystallized from a mixed solvent of ethyl acetate/hexane. Thus, the title compound (85 mg) was obtained as a white powder.1H NMR (300 MHz, CHLOROFORM-d) delta ppm 1.18 (3H, t, J=8.2 Hz), 3.36-3.52 (6H, m), 3.68 (2H, dd, J=5.7, 3.8 Hz), 4.40 (2H, q, J=8.2 Hz), 4.45-4.52 (2H, m), 6.33-6.41 (1H, m), 7.04(2H, d, J=9.1 Hz), 7.17-7.25 (3H, m), 9.51 (1H, br. s.).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; Suzuki, Hideo; Fujimoto, Takuya; Yamamoto, Takeshi; US2010/190747; (2010); A1;,
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