Category: alcohols-buliding-blocks

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Aminopropane-1,3-diol

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes.. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours.. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate.. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8 Hz), 7.41 (2H, t, J=8 Hz), 7.22 (2H, t, J=7 Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7 Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; Sankyo Company, Limited; US6673804; (2004); B1;,
Alcohol – Wikipedia,
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Reference of 27489-62-9, Adding some certain compound to certain chemical reactions, such as: 27489-62-9, name is trans-4-Aminocyclohexanol,molecular formula is C6H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27489-62-9.

Preparation of trans-4-(3-(5,6,7-trimethoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazin-6-ylamino)cyclohexanol To a solution of 6-chloro-3-(5,6,7-trimethoxybenzo[b]thiophen-2-yl)imidazo[1,2-b]pyridazine (50 mg, 0.133 mmol, 1.0 equiv) in DMSO (2.0 mL) was added p-toluene sulfonic acid monohydrate (25 mg, 0.144 mmol, 1.0 equiv) and amine (0.532 mmol, 4.0 equiv) and heated to 100 C. for 24 h. The reaction mixture was diluted with water and extracted with ethyl acetate. Purification by column chromatography using 5% methanol in dichloromethane elution 36 mg of the brown solid, 60%. Compound 179 was physically characterized by electrospray ionization mass spectrometry. Structures and molecular masses are given below in Table 35-b.

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
Alcohol – Wikipedia,
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Related Products of 111-45-5 , The common heterocyclic compound, 111-45-5, name is 2-(Allyloxy)ethanol, molecular formula is C5H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10072] In a one-liter flask equipped with a stirring device, a dimroth condenser, a thermometer and a dropping thnnel, put were 38.25 g (0.375 mol) of ethylene glycol monoallyl ether represented by the following formula (7) and 100 g oftoluene, and heated to 70 degrees C. 0.38 Gram of a solution of a catalyst, complex of alkali-neutralized chloroplatinic acid with vinyl siloxane, in toluene, containing 0.5% of platinum, was added in the flask. Then, 185 g (0.25 mol) of the compound represented by the aforesaid formula (6) was added dropwise in the flask with the dropping funnel over one hout The reaction mixture was held at 100 degrees C. for one hour and, then, analyzed in GC. The peak of the compound represented by the aforesaid formula (6) disappeared, which means that the reaction completed. 100 Grams of ion exchanged water were added to the reaction mixture with stirring to wash it and, then, lefi standing to cause phase separation. The aqueous phase containing the excessive ethylene glycol monoallyl ether was removed. The organic phase was similarly washed twice with each 100 g of ion exchanged water and, then, the toluene in the organic phase was stripped off under a reduced pressure to obtain 193.7 g (0.23 mol) of a colorless and transparent liquid, silicone compound representedby the following formula (8). The yield was 92%. The ratio of the silicone compound represented by the following formula (8) in the obtained product was 98.1 mass %, as determined in GC.

The synthetic route of 111-45-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHIN-ETSU CHEMICAL CO., LTD.; KUDO, Muneo; US2015/361114; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol

54 g of 2-bromo-3,3,3-trifluoropropanol, 79 g of methanol, 9.7 g of activated RaneyNi catalyst and 19.3 g of potassium carbonate were charged into a 300 mL autoclave, stirred, evacuated and replaced with hydrogen After three times, pressure 5Mpa, heated to 80 C, the reaction 3.0h, stop the reaction, cooling, discharge, distillation to 3,3,3 – trifluoropropanol; Yield 95.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; Gu, Yujie; Lu, Jian; Ma, Hui; Wang, Zhixuan; Kang, Jianping; Du, Yongmei; Tu, Donghuai; Wan, Hong; Li, Yang; (5 pag.)CN105399607; (2016); A;,
Alcohol – Wikipedia,
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Electric Literature of 57772-50-6 ,Some common heterocyclic compound, 57772-50-6, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 57772-50-6, (2-Amino-3-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 32328-03-3, Diethyl 3-hydroxyglutarate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 32328-03-3, blongs to alcohols-buliding-blocks compound. Safety of Diethyl 3-hydroxyglutarate

Sodium hydroxide (0.80 g, 20 mmol) was dissolved in water (10 mL), diethyl 3-hydroxyglutarate (0.95 g, 5.0 mmol) was added thereto, and the mixture was stirred at room temperature for 1 hour. Next, after cooling the reaction solution on ice,65% nitric acid was added in an equimolar amount to sodium hydroxide and stirred for 1 hour under ice cooling. to this, An aqueous solution (0.70 mL) containing silver nitrate (1.70 g, 10 mmol) was added dropwise and the mixture was further stirred for 1 hour. Thereafter, the precipitated white precipitate was collected by filtration.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32328-03-3, its application will become more common.

Reference:
Patent; NOF CORPORATION; TAGAMI, YASUNOBU; MORISHITA, TAKEHIRO; MICHINISHI, JUNYA; (16 pag.)JP2015/107938; (2015); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 86770-74-3 ,Some common heterocyclic compound, 86770-74-3, molecular formula is C8H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

An oven-dried 200 mL round bottomed flask was charged with Biotin-NHS (1.17 g, 3.43 mmol) and 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethan-1-ol (730 mg, 3.80 mmol). The flask was subjected to three cycles of vacuum/nitrogen backfill before addition of anhydrous DMF (69 mL). To the colorless solution was added triethylamine (960 muL, 6.85 mmol) and after 45 minutes, the solution was concentrated in vacuo. The crude material was purified by flash chromatography (basic alumina: 5 % methanol in CH2Cl2) to provide the title compound as an opaque amorphous solid (1.18 g, 2.81 mmol, 82 % yield). 1H NMR (400 MHz, CDCl3) delta: 7.21 (1H, br t), 5.97 (1H, br s), 5.09 (1H, br s), 4.48 (1H, m), 4.30 (1H, m), 3.78 (1H, m), 3.70 (4H, m), 3.65-3.58 (8H, m), 3.52 (2H, m), 3.41 (2H, m), 3.13 (1H, td, J = 7.4, 4.6 Hz), 2.90 (1H, dd, J = 12.8, 5.0 Hz), 2.73 (1H, d, J = 12.8 Hz), 2.20 (2H, t, J = 7.5 Hz), 1.78 (4H, m), 1.46-1.38 (2H, m); 13C NMR (100 MHz, CDCl3) delta: 173.49, 164.17, 72.60, 70.51, 70.32, 70.17, 70.00, 69.92, 61.78, 61.41, 60.22, 55.65, 40.47, 39.08, 35.90, 28.30, 28.11, 25.69. IR numax/cm-1 (film): 3273, 3085, 2916, 2865, 1690, 1669, 1646, 1551, 1464, 1420, 1264, 1240, 1202, 1101, 869, 693. m/z HRMS (ESI): [M+ H]+ calculated for C18H33N3O6S+ = 442.1982, found 442.1962.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nottingham, Kyle G.; McNally, Andrew; McNaughton, Brian R.; Tetrahedron Letters; vol. 59; 3; (2018); p. 234 – 237;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 4152-92-5 , The common heterocyclic compound, 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

An ice-cold pyridine solution (10 mL) of compound 23 (1 mmol) is treated successively, in a dropwise fashion with acetyl chloride (1 mmol), then after 5 min with MsCl (1.1 mmol). The solution is warmed to room temperature then the solvent is removed. The residue is dissolved in EtOAc, washed with water, dried (MgS04), filtered and concentrated in vacuo. Purification by column chromatography affords pure compound 24.

The synthetic route of 4152-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ONTORII, INC.; BUTLER, David; IWAMOTO, Naoki; MEENA, Meena; SVRZIKAPA, Nenad; VERDINE, Gregory L.; ZLATEV, Ivan; WO2014/12081; (2014); A2;,
Alcohol – Wikipedia,
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Related Products of 115-20-8 ,Some common heterocyclic compound, 115-20-8, molecular formula is C2H3Cl3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirring solution of 5-chloro-2-(quinolin-6-yl)benzoic acid (0.201 g, 0.708 mmol) and TEA (0.148 ml, 1.06 mmol) in 1 ,4-dioxane (10 ml) at RT, was added DPPA (0.191 ml, 0.244 mmol). After stirring for 30 min at RT, 2,2,2-trichloroethanol (0.680 ml, 7.08 mmol) was added and the reaction was stirred with heating at 100 C for 2 h. The completed reaction was diluted with brine (10 ml) and extracted with EtOAc (3×25 ml). The combined organics were washed with 5% citric acid (10 ml), sat’d. NaHC03 (10 ml) and brine (10 ml), dried (MgSO^, concentrated in vacuo and purified by chromatography to afford 2,2,2-trichloroethyl 5-chloro-2-(quinolin-6- yl)phenylcarbamate (0.25 g, 82% yield) as a white solid. MS (ESI) m/z: 431.0 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.

Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.; WO2013/36232; (2013); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 60211-57-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60211-57-6, name is 3,5-Dichlorobenzyl alcohol. A new synthetic method of this compound is introduced below.

To a solution of 3.5 g of 3,5-dichlorobenzyl alcohol (Aldrich) in 75 mL of dichloromethane at 0C was added 1.8 mL of methane sulfonylchloride followed by 3.5 mL of triethylamine added dropwise. After 2 hours the solution was diluted to 150 mL with dichloromethane, washed with 3N HCl, saturated aqueous NaHCO3 dried with Na2SO4 and the solvents removed to yield the desired 3,5-dichlorobenzyl methanesulfonate as a yellow oil that was used without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60211-57-6, 3,5-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; ELI LILLY AND COMPANY; EP951466; (2009); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts