Category: alcohols-buliding-blocks

Related Products of 3840-31-1, Adding some certain compound to certain chemical reactions, such as: 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol,molecular formula is C10H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3840-31-1.

To the solution of 3,4,5-trimethoxybenzyl alcohol (7.2 g, 36.4 mol) in dry DCM (100 mL), thionyl chloride (3.5 mL, 48.2 mmol) and pyridine (3.4 mL, 42.1 mmol) were added dropwise. The reaction mixture was stirred at RT for 1.5 h and progress was monitored by TLC (AcOEt/Hex 1:1 as mobile phase). The reaction was stopped by the addition of 100 mL H2O and extracted with 2 x 25 mL DCM. The combined organic extracts were dried over MgSO4 and evaporated in vacuo to give 87% yield. Yellow, solid.

According to the analysis of related databases, 3840-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Urbaniak, Alicja; Delgado, Magdalena; Kacprzak, Karol; Chambers, Timothy C.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2766 – 2770;,
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Application of 100751-63-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, the compound obtained in the second step to the reactor (T-3) was charged (23.6 g, 99.6 mmol) and methylene chloride (250ml). The solution was cooled to 0 , and Dess-Martin periodinane; was added in portions (DMP 42.2g, 99.6mmol) to 3 times. The mixture was stirred for a further 2 hours while returning to room temperature. The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (300 ml), then was subjected to filtration, the filtrate was extracted with ethyl acetate. The organic layers were washed with water, aqueous sodium sulfite, and washed sequentially with water and saturated brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure, the residue was purified by silica gel chromatography (eluent: toluene) to give the compound (T-4) (19.05g, 81.0mmol; 81%) was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100751-63-1, 6-Bromo-2-naphthylmethanol.

Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; GOTO, MAYUMI; TANAKA, HIROYUKI; (104 pag.)JP2016/37458; (2016); A;,
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Synthetic Route of 6214-44-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6214-44-4, name is (4-Ethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Under an argon stream, p-Ethoxybenzyl alcohol (1) (6.509, 42.7 mmol) Of anhydrous methylene chloride (90 mL), The mixed solution of anhydrous N, N-dimethylformamide (70 L) was cooled with ice, Thionyl chloride (4.0 mL, 55.7 mmol) was added, And stirred for 30 minutes. The reaction solution was concentrated and dissolved in tetrahydrofuran (30 mL) Was added dropwise to ice water (150 mL). It was extracted twice with methylene chloride (50 mL) The obtained organic layer was dried with sodium sulfate, By concentrating under reduced pressure, To give compound 2 (7.66 g) as a pale yellow liquid.

According to the analysis of related databases, 6214-44-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE; DOKKYO GAKUEN DOKKYO UNIVERSITY SCHOOL OF MEDICINE; MATSUMOTO, NOBUYUKI; ANZAI, NAOHIKO; (16 pag.)JP2018/62475; (2018); A;,
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Reference of 575-03-1, Adding some certain compound to certain chemical reactions, such as: 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin,molecular formula is C10H5F3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 575-03-1.

Similarly, the reaction of 4-nitrophthalonitrile (1.00 g, 5.78 mM) with 7-hydroxy-4-trifluoromethylcoumarin(1.33 g, 5.78 mM) was initiated in 30 mL of DMF in the presence of K2CO3 (2.30 g, 16.6 mM). The reaction mixture was heated with stirring at 90 ¡ãC under an inert nitrogen atmosphere for 24 h. Thereafter, the reaction mixture was cooled to room temperature, poured into 60 mL water, and extracted with CH3CN. The combined organic extracts were dried over sodium sulfate and filtered. The solvent was evaporated under reduced pressure and the remaining residue was added to 30percent HCl to induce precipitation. The precipitate was then repeatedly washed with water and added to hot methanol (MeOH), filtered, and dried under P2O5. Yield: 41percent; m.p. (¡ãC): 180.0?181.8; FT-IR (numax/cm?1): nu(C=O) 1729, nu(C?N) 2235, nu(C?O?C) 990, 1129; 1H NMR (ppm): 7.06 (s, 1H, H1), 7.99 (s, 1H, H2), 7.64 (d, 1H, J = 8.73 Hz, H3), 8.19 (d, 1H, J = 8.74 Hz, H4), 7.43 (s, 1H,H5), 7.28 (d, 1H, J = 8.80 Hz, H6), 7.80 (d, 1H, J = 9.01 Hz, H7); 13C NMR (ppm): 159.78, 158.74, 158.42, 156.01, 146.85, 137.01, 127.37, 124.64, 124.38, 123.44, 117.57, 117.21, 116.26, 116.11, 115.69, 110.82, 110.40, 109.04; UV?Vis [DMF, lambdamax (epsilon, M?1 cm?1)]: 443 nm (90), 318 nm (29875), 307 nm (33370). Molecular mass (m/z): Calcd: 356.25. Found: 379.03 [M + Na]+. Anal. Calcd for C18H7F3N2O3 (percent): C, 60.68; H, 1.98;N, 7.86. Found: C, 60.48; H, 2.30; N, 7.86.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chohan, Sumayya; Booysen, Irvin Noel; Mambanda, Allen; Akerman, Matthew Piers; Journal of Coordination Chemistry; vol. 68; 10; (2015); p. 1829 – 1846;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62285-58-9, name is (2,6-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2,6-Dimethylphenyl)methanol

A solution of 2,6-Dimethylbenzyl alcohol (5.25 g, 38.6 mmol) and diisopropyl azodicarboxylate (DIAD, 8.49 g, 42 mmol) in THF (30 ml) and DMF (13 ml) was added drop wise to a solution of Ethyl 3-hydroxyphenylacetate (Step A, 6.66 g, 37 mmol) and triphenylphosphine (1 Ig, 42 mmol) in THF (100 ml). The reaction mixture was stirred at room temperature for 4 hours, diluted with ether and washed with water. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash EPO chromatography on a silica gel column (hex: ethyl acetate 1:1) to give the title compound.1H NMR (270 MHz5 CDCl3): 1.2 (t, 3H); 2.4 (s, 6H); 3.5 (s, 2H); 4.1 (q, 2H); 5.1 (s, 2H); 6.9 (m, 2H); 7.15-7.35 (m, 5H).

With the rapid development of chemical substances, we look forward to future research findings about 62285-58-9.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2006/127133; (2006); A2;,
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Synthetic Route of 44565-27-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 44565-27-7, name is 4-Amino-2-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 7b (90 mg, 0.26 mmol) and 4-amino-2-methyl-butan-1-ol (40 mg, 0.26 mmol) were refluxed overnight in BuOH (2 mL). The resulting solution was poured into saturated NH4Cl solution, and extractedwith EtOAc. The organic layer was washed with saturated NaCl, and then dried over Na2SO4, evaporated under reduce pressure. The residue was purified by a silica gel column chromatography (CHCl3:MeOH=95:5) to give 3b as white powder (73 mg, 68 % yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 44565-27-7, 4-Amino-2-methylbutan-1-ol.

Reference:
Article; Hayashi, Ken-Ichiro; Kusaka, Naoyuki; Ando, Kazuki; Mitsui, Taichi; Aoyama, Takashi; Nozaki, Hiroshi; Bioorganic and Medicinal Chemistry Letters; vol. 22; 17; (2012); p. 5663 – 5667;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 1-Amino-2-methylpropan-2-ol

General procedure: A suspension of 26c (2.00 g, 5.47 mmol), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride (2.27 g, 8.21 mmol) and 1-amino-2-methylpropan-2-ol (0.585 g, 6.56 mmol) in THF (25 mL) and 2-propanol (25 mL) was stirred at room temperature for 19 h. The mixture was concentrated in vacuo, acidified with 1 N HCl, and extracted twice with EtOAc. The organic layers were combined, washed with saturated aqueous solution of NH4Cl and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane-EtOAc). The product was recrystallized from hexane-EtOAc to give 28h (2.06 g, 89percent) as a white solid.

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yamamoto, Satoshi; Tomita, Naoki; Suzuki, Yuri; Suzaki, Tomohiko; Kaku, Tomohiro; Hara, Takahito; Yamaoka, Masuo; Kanzaki, Naoyuki; Hasuoka, Atsushi; Baba, Atsuo; Ito, Mitsuhiro; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2338 – 2352;,
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Application of 2566-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Iodine (3.05 g, 24.0 mmol) and imidazole(1.63 g, 24.0 mmol) were added to a solution of triphenylphosphine(6.29 g, 24.0 mmol) in chloroform (50 mL) at 0C under anitrogen atmosphere, and the mixture was stirred at the sametemperature for 15 min. A solution of 2-cyclopropylethanol(1.72 g, 20.0 mmol) in chloroform (50 mL) was added dropwiseto the reaction mixture, and the mixture was stirred at roomtemperature for 3 h. To the reaction mixture were added saturatedaqueous sodium thiosulfate solution (60 mL) and water (60 mL), and the mixture was extracted with chloroform. Theorganic layer was concentrated under reduced pressure, andthe resulting residue was purified using a silica gel columneluted with 100% n-hexane to afford the desired product(2.14 g, 55%) as a pale yellow oil.Triphenylphosphine (2.86 g, 10.9 mmol) was added to a solutionof the above product (2.14 g, 10.9 mmol) in acetonitrile(5 mL), and the mixture was heated at reflux temperature for15 h. After cooling to room temperature, diethyl ether wasadded to the mixture, and the resulting precipitates were collectedby filtration to afford the target intermediate (3.87 g,77%) as a colorless powder. To a suspension of the above intermediate (3.83 g,8.36 mmol) in THF (60 mL) was added dropwise potassiumhexamethyldisilazane (toluene solution, 0.5 mol/L) (16.7 mL,8.36 mmol) at 0C under a nitrogen atmosphere, and the mixturewas stirred at room temperature for 1 h. After coolingto 0C, a solution of 3-fluoro-4-nitrobenzaldehyde (1.23 g,7.27 mmol) in THF (10 mL) was added dropwise to the reactionmixture, and the mixture was stirred at room temperaturefor 1 h. Saturated aqueous ammonium chloride solution wasadded to the reaction mixture, and the mixture was extractedtwice with ethyl acetate. The organic layer was washed withbrine, dried over anhydrous MgSO4, filtered, and concentratedunder reduced pressure. The resulting residue was purifiedusing a silica gel column eluted with 25% ethyl acetate-nhexaneto afford 24 (1.42 g, 88%) as a brown oil: 1H-NMR(300 MHz, CDCl3) delta: 0.07-0.21 (2H, m), 0.45-0.60 (2H, m),0.74-0.92 (1H, m), 2.14-2.30 (2H, m), 5.96-6.11 (1H, m),6.36-6.45 (1H, m), 7.12-7.31 (2H, m), 7.98-8.08 (1H, m).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2566-44-1, 2-Cyclopropylethanol.

Reference:
Article; Busujima, Tsuyoshi; Tanaka, Hiroaki; Iwakiri, A. Kanako; Shirasaki, Yoshihisa; Munetomo, Eiji; Saito, Masako; Masuko, Aiko; Kitano, Kiyokazu; Io, Fusayo; Kato, B Koji; Kamigaso, Shunsuke; Nozoe, Akiko; Sato, Nagaaki; Chemical and Pharmaceutical Bulletin; vol. 64; 3; (2016); p. 228 – 238;,
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Related Products of 62037-46-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62037-46-1, name is 1-Amino-3-chloropropan-2-ol hydrochloride, molecular formula is C3H9Cl2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A three-necked flask was charged with 1-amino-3-chloropropyl-2-ol hydrochloride (14.60 g, 100 mmol) and tetrahydrofuran(73 mL), water (73 mL), stirred and cooled to 0 to 5 C, added with dipotassium hydrogen phosphate (34.84 g, 200 mmol), stirred for 5 minAfter the clockwise drop of ethyl sulfonyl chloride (13.50g, 105mm0l), plus the temperature after warming to room temperature for 3-4 hours, the end of the reaction0.5mol / L dilute hydrochloric acid 73mL quenching reaction, stirring and dispensing, water and then extracted with ethyl acetate 35mL 2 times, combined organic saturatedAnd washed with salt (73 mL), dried over anhydrous sodium sulfate and concentrated to give N-(3-chloro-2-hydroxypropyl) ethane sulfonamide Followed by the next step (GC purity of about 92%).

According to the analysis of related databases, 62037-46-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Wu Yihua; (16 pag.)CN106946917; (2017); A;,
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Related Products of 261723-32-4 ,Some common heterocyclic compound, 261723-32-4, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To an ice-cold solution of Compound II (500 mg) in THF (5.0 mL) were added sodium hydride (160 mg, 55% contents) and methyl iodide (608 muL), and the resulting mixture was stirred at room temperature overnight. To the reaction mixture was added water, and the mixture was concentrated under reduced pressure. The residue was diluted with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1) to give Compound III (426 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 261723-32-4, (3-Bromo-2-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAINIPPON SUMITOMO PHARMA CO., LTD.; US2012/225876; (2012); A1;,
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