Category: alcohols-buliding-blocks

Related Products of 4152-92-5, Adding some certain compound to certain chemical reactions, such as: 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4152-92-5.

A solution of 1.7 g of 2-(aminomethyl)benzyl alcohol (12. 4 mmol) and 1.76 mL of triethylamine (12. 4 mmol) was dissolved in 20 mL anhydrous methanol, 1.96 mL of ethyl trifluoroacetate (16.4 mmol) was added dropwise under argon and the reaction was stirred at 25 C for 2 hours. After the reaction, ethyl acetate (30 mL) and water (30 mL) were added to the extract. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate overnight, and the solvent was removed in vacuo to give 2-[(trifluoroacetamido)methyl]benzyl alcohol. The crude product was purified by silica gel column chromatography eluting with ethyl acetate / cyclohexane (1: 2, v / v) to give 2-[(trifluoroacetamido)methyl]benzyl alcohol (2.0 g, 8.6 mmol), 69% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4152-92-5, (2-(Aminomethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing University of Technology; Zhao, Lijiao; Sun, Guohui; Zhong, RuGang; (20 pag.)CN104031048; (2016); B;,
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Reference of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.

0.675 mol of isethionic acid sodium salt (100.0 g) and 2.02 mol benzylchloride (233 mL) were mixed in a 750 mL multi-necked flask with KPG-stirrer. The mixture was heated at 70C inside temperature (95C outside temperature) and thenTriethylamine (120 mL) was added drop wise over one hour and the outside temperature was increased to 125C and maintained. Subsequently, outside temperature increased to 140C, and the inside temperature rose to 130C. A solid clustered at the stirrer, but went back into suspension. Hydrochloric acid vapors evolved.30 mL of triethylamine was added drop wise and then reacted for 1 .5 more hours. A viscous yellowish suspension formed. The product was allowed to cool to 50C inside temperature, then 300 mL water was added and vigorously stirred for 20 minutes and the mixture was transferred to a 2L separatory funnel. Then, the flask was rinsed out with 100 mL of water.The combined aqueous phases were washed twice with 280 mL dichloromethane.The aqueous phase was held at 40C, while KCI was added to the solution until saturated (about 130 g KCI). The mixture was filtered through a fluted filter and stored overnight in a refrigerator.The remaining solid was extracted and dried, resulting in 30.85 g, yield of 17.9%. fl: OH band is present, similar to the precursor.The mother liquor was again treated with KCI and stored (at 35-40C) overnight in the refrigerator.Solid from the second precipitation with KCI was filtered off and dried, resulting in 60.0 g = 34.9 % and the fl corresponds to the desired product.Solid 1: Was boiled with 150 mL EtCH and filtered while hot.By repeated precipitating with KCI, boiling and crystallization, 32 g of the product were obtained for a yield of 19 %.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (101 pag.)WO2016/98054; (2016); A1;,
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Reference of 4249-72-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4249-72-3, name is 2-Phenoxy-1-phenylethanol, molecular formula is C14H14O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Lignin model molecule (2-phenoxy-1-phenylethanol) wassynthesized according to the method reported by Rothenberg[9]. Catalytic hydrotreating of 2-phenoxy-1-phenylethanolwas carried out in a 100ml autoclave with Tefon liner.The catalyst (50mg) was added to a solution of 2-phenoxy-1-phenylethanol (150mg) in ethanol (2ml) and H2O(8ml).The autoclave was sealed and purged with H2several times.The reaction was performed at 170C with 2MPa hydrogenpressure for 6h. Then, the reactors were cooled down toroom temperature using an ice bath, and the organic productswere extracted with ethyl acetate (5ml ¡Á 2). The organic products mixtures were analyzed by GC and chlorobenzenewas used as an external standard. Identification of mainproducts was based on GC-MS as well as by comparisonwith authentic samples. The product distribution was shownon the mole basis. In consecutive batch tests, the catalystwas recovered by magnets and washed with EtOH for threetimes. The catalyst was recycled into the autoclave with thefeedstream.

According to the analysis of related databases, 4249-72-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Bingfeng; Li, Fengbo; Yuan, Guoqing; Catalysis Letters; vol. 147; 11; (2017); p. 2877 – 2885;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 756520-66-8

To a solution of 1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol 18 (19.00 g, 90.89 mmol) in 150 ml of CH2Cl2 was added Et3N (13.27 ml, 95.43 mmol) and catalytic amount of DMAP. The resulting solution was cooled in an ice bath and added dropwise MsCl (7.39 ml, 95.43 mmol). After complete addition of MsCl, the reaction mixture was maintained in the ice bath for 1 h and then 30 ml of water was added to the reaction mixture. The organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was pure enough for use in the next step. 1H NMR (300 MHz, CDCl3) delta 7.33 (dd, J = 4.8, 9.0 Hz, 1H), 7.12 (dd, J = 8.1, 9.0 Hz, 1H), 6.45 (q, J = 6.9 Hz, 1H), 2.91 (s, 3H), 1.84 (d, J = 6.9 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Article; Zhang, Dengyou; Ai, Jing; Liang, Zhongjie; Li, Chunpu; Peng, Xia; Ji, Yinchun; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 20; 17; (2012); p. 5169 – 5180;,
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Related Products of 395-23-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of substrate 2a2t(0.100 mmol), Cs2CO3 (24.4 mg, 75.0mol) and catalyst1d(4.8 mg, 5.00mol) inEt2O (3.00 mL)was added isobutyric anhydride (12.4L, 75.0mol)at60 C. The reaction mixture was stirred for 15 h at60 C.MeOH (2 mL) was then added to destroy unreactedisobutyricanhydride and the mixture was stirredfor 30 minasit warmedto room temperature. The resulting solution was concentratedin vacuo. The resulting mixture was passed through a short padofsilica gel(eluent: hexane/Et2O=1/1, v/v) to give the esterproduct and the unreacted alcohol,which were directly analyzed by chiralHPLC. The enantiomeric ratio (er) and enantiomeric excess (ee) values ofthe ester and the unreacted alcoholwere obtained by HPLC analysis. The conversion (C) and sfactor (s)ofkinetic resolution were calculated asfollows:52sln1C1ee0ln1C1ee0ln1C1eeln1C1eekfastkslow2eeenantiomeric excess measuredfor the starting material3ee0enantiomeric excess measuredfor the product 4Ceeeeee0100conversion 5

According to the analysis of related databases, 395-23-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Fujii, Kazuki; Mitsudo, Koichi; Mandai, Hiroki; Suga, Seiji; Bulletin of the Chemical Society of Japan; vol. 89; 9; (2016); p. 1081 – 1092;,
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Related Products of 6850-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6850-39-1, name is 3-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.17, as common compound, the synthetic route is as follows.

To a solution of 5-chloro-3-(5-fluoro-4-(methylsulfonyl)pyrimidin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine, 1a, (1.09 g, 2.34 mmol) and 3-aminocyclohexanol (0.32 g, 2.82 mmol) in THE was added DIEA (0.60 g, 4.69 mmol). The reaction mixture was heated at 130 C. in microwave for 10 min. The solvent was removed under reduced pressure and the resulting residue was purified by silica gel chromatography to afford 550 mg of the desired product, 27a.

The chemical industry reduces the impact on the environment during synthesis 6850-39-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, PAUL S; CLARK, MICHAEL P; BANDARAGE, UPUL K; BETHIEL, RANDY S; COURT, JOHN J; DENG, HONGBO; DAVIES, IOANA; DUFFY, JOHN P; FARMER, LUC J; GAO, HUAI; GU, WENXIN; JACOBS, DYLAN H; KENNEDY, JOSEPH M; LEDEBOER, MARK W; LEDFORD, BRIAN; MALTAIS, FRANCOIS; PEROLA, EMANUELE; WANG, TIAN-SHENG; WANNAMAKER, M WOODS; BYRN, RANDAL; CHOU, II; LIN, CHAO; JIANG, MIN; JONES, STEVEN; GERMANN, URSULA A; SALITURO, FRANCESCO G; KWONG, ANN DAK-YEE; (541 pag.)JP2015/38146; (2015); A;,
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Adding a certain compound to certain chemical reactions, such as: 171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (4-Bromo-1,2-phenylene)dimethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (4-Bromo-1,2-phenylene)dimethanol

General procedure: In a typical experiment, a round bottom flask containing 4-6mL of acetonitrile/water mixture (1:1) was charged with 0.5-1.0mmol of the diol, 5mol% of TetMe-IA, and oxone (2equiv). The resulting mixture was stirred at rt for benzylic diols and at 45C for aliphatic diols. At the end of the reaction, as judged from TLC analysis, little water was added to dissolve the inorganic salts, and the organic matter was extracted with EtOAc at least two times. The combined extract was dried over anhydrous Na2SO4, concentrated in vacuo to obtain the crude product, which was subjected to silica-gel column chromatography using ethyl acetate/pet ether to isolate the pure product.

The synthetic route of 171011-37-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 70; 13; (2014); p. 2286 – 2293;,
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Application of 143726-85-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 143726-85-6 as follows.

C. 4- (1, 1, 4-Trioxo-1, 2, 5-thiadiazolidin-2-ylmethyl)-benzoic acid 4-t-butoxycarbonyl- benzyl ester; A solution of the title B compound, 4- [5- (2, 4-dimethoxy-benzyl)-1, 1, 4-trioxo-1, 2,5- thiadiazolidin-2-ylmethyl]-benzoic acid (84 mg, 0.2 mmol) and 4-hydroxymethyl-benzoic acid t-butyl ester (42 mg, 0.2 mmol) in CH2CI2 (3 mL) is treated with DMAP (12 mg, 0.1 mmol) and the reaction is cooled to 5C. EDCI (39 mg, 0.2 mmol) is then added and the reaction is stirred for 16 h. The mixture is concentrated and partioned between EtOAc and 1 N aqueous HCI. The organic solution is washed with saturated aqueous NaHCO3 and brine, dried over anhydrous MgS04 and concentrated to give 4- (1, 1, 4-trioxo-1, 2, 5-thiadiazolidin-2-ylmethyl)- benzoic acid 4-t-butoxycarbonyl-benzyl ester as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,143726-85-6, its application will become more common.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2003/82841; (2003); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 23377-40-4

S13: A suspension of 3-hexadecyloxypropan-l-ol (1.58 g, 5.26 mmol) and DIPEA (0.92 mL, 5.26 mmol) in anhydrous acetonitrile (25 mL) was treated dropwise over a 10 min period with 3-((chloro(diisopropylamino)phosphino)oxy)-propanenitrile (1.2 mL, 5.26 mmol). After 18 h at rt, the mixture was quenched with sat. aq. NaHC03 (15 mL) and extracted with ethyl acetate (2 x 100 mL). The combined organic phases were concentrated by rotary evaporation, and flash chromatography (column volume 25 mm x 140 mm, 10 to 20% gradient of EtOAc in hexanes) provided S13 (1.40 g, 53%) as a white solid: 1H NMR (400 MHz, CDC13) delta 3.89 – 3.54 (m, 6H), 3.49 (t, 7= 6.3 Hz, 2H), 3.39 (t, 7= 6.7 Hz, 2H), 2.64 (t, J = 6.6 Hz, 2H), 1.87 (p, J = 6.3 Hz, 2H), 1.57 (p, J = 6.3 Hz, 2H), 1.25 (s, 26H), 1.18 (dd, J = 6.8, 3.5 Hz, 12H), 0.87 (t, J= 6.6 Hz, 3H); 31P NMR (162 MHz, CDC13) delta 147.40.

With the rapid development of chemical substances, we look forward to future research findings about 23377-40-4.

Reference:
Patent; EMORY UNIVERSITY; PAINTER, George, R.; GUTHRIE, David, B.; BLUEMLING, Gregory, R.; NATCHUS, Michael, R.; (179 pag.)WO2017/156380; (2017); A1;,
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Reference of 3391-86-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3391-86-4 as follows.

General procedure: In a Schlenk tube, 11.5 mg (4 105 mol) Na2CO310H2O wasdissolved in 4.6 mL H2O. After deoxygenation, 9.3 mg (2 105mol) [RuCl2(pta)(g6-p-cymene)] was added and the solution wasstirred for 15 min at 80 C. 310 lL (2.02 mmol) oct-1-en-3-ol wasinjected to the catalyst solution and the reaction mixture was stirredfurther at 80 C. At the end of the desired reaction time themixture was cooled and extracted with hexane under air. Theorganic phase was dried on MgSO4 and analyzed by gas chromatography.Products were identified by comparison of theirretention times to standards and the composition of the productmixture was calculated from peak areas.In recycling experiments, following extraction and phase separation,the aqueous phase was deoxygenated, heated to 80 C, anew batch of the substrate was added and the reaction was initiatedby stirring.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3391-86-4, its application will become more common.

Reference:
Article; Bolyog-Nagy, Evelin; Udvardy, Antal; Barczane-Bertok, Agnes; Joo, Ferenc; Katho, Agnes; Inorganica Chimica Acta; vol. 455; (2017); p. 514 – 520;,
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