Category: alcohols-buliding-blocks

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 124-68-5

General procedure: A microwave tube was charged with 2i (1 mmol), NaOH (120 mg, 3 mmol), and EtOH (10 mL). The tube was sealed, placed in a microwaveoven and heated (T = 135 C; t = 10 min). After release, Boc2O(655 mg, 3 mmol) was added at r.t. and the reaction mixture wasstirred for 2 h at 40 C. H2O (10 mL) and Et2O (20 mL) were added andthe layers were separated. The aqueous phase was extracted withEt2O (2 ¡Á 20 mL) and the combined organic layers were dried overMgSO4, filtered, and the solvent was removed in vacuo. The crude residuewas purified on silica gel chromatography (cyclohexane-EtOAc,95:5 to 40:60) to afford the desired N-Boc-protected amino alcohol 4.

With the rapid development of chemical substances, we look forward to future research findings about 124-68-5.

Reference:
Article; Boukattaya, Fatma; Caille, Julien; Ammar, Houcine; Rouzier, Florian; Boeda, Fabien; Pearson-Long, Morwenna S. M.; Bertus, Philippe; Synthesis; vol. 48; 6; (2016); p. 906 – 916;,
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Synthetic Route of 2077-19-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below.

1.1 4-[4-(1-Hydroxy-1-methyl-ethyl)-benzoyl]-piperidine-1-carboxylic acid tert- butyl ester To a solution of 2-(4-bromo-phenyl)-propan-2-ol (5.00 g; 22.78 mmol) in THF (100 mL) under nitrogen atmosphere, n-butyl lithium (23 % in hexanes) (13.92 ml; 50.12 mmol) was added dropwise at -78 C and stirred for 15 min at the same temperature. A solution of 4-(methoxy-methyl-carbamoyl)-piperidine-1- carboxylic acid tert-butyl ester (6.96 g; 25.06 mmol) in THF ( 00 mL) was added dropwise at -78 C and stirred for 2 h at -78 C. The reaction mixture was stirred for 4 h at -78 C and quenched with saturated NH4CI solution (100 mL). The reaction mixture was extracted with ethyl acetate (2 x 100 mL). The combined extracts were washed with water (200 mL), brine solution (100 mL), dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography using silica gel (60-120) and petrol ether – ethyl acetate (1 :1) as gradient elution to afford the title compound (2.30 g; 29 %) as a pale yellow oil; H NMR (400 MHz, CDCI3) delta 7.92 (d, J = 8.48 Hz, 2H), 7.60 (d, J = 8.52 Hz, 2H), 5.18 (s, 1 H), 3.96 (d, J = 12.56 Hz, 2H), 3.63-3.57 (m, 1 H), 2.90 (s, 2H), 1.74 (d, J = 11.52 Hz, 2H), 1.43-1.38 (m, 17H); LC/MS (B), Rt: 4.50 min; (M+H-BOC) 248.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2077-19-2, 2-(4-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK PATENT GMBH; DORSCH, Dieter; BUCHSTALLER, Hans-Peter; WO2015/14442; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., name: 2-(Diethylamino)ethanol

Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device were placed 12.8 g (0.1 mol) of adipic anhydride, 35.1 g (0.3 mol) of N, N-diethylaminoethanol,0.8gTitanyl sulfate, 20 mlXylene, stirring heated to 145 C refluxing reaction 3h, until the separation of 1.8g (0.1mol) water, remove the catalyst filter (direct reuse), the filtrate into another 250ml three bottles, vacuum distillation of solvent ), An excess amount of diethylaminoethanol (used for recovery), and a low boiling point substance were added, and 3.0 g of activated clay was added thereto. The mixture was stirred for 30 minutes, and the temperature was lowered to 80 C or less, and filtered to obtain a yellow oily liquid bisdiethylaminoethyl adipate 31.34 G, and the yield was 91.1%. And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed heated to 120 C, the citric acid after melting, stirring cooling crystallization salt, that is a white powder solid product adipic acid bis Diethylamino ethanolate citrate. Its melting point: 117 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
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Application of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

Into a dry 500 mL distillation flask there was placed 91 mL (1.14 mole) of aziridineethanol to which there was added 495 mg of NaH (60% dispersion in mineral oil). The mixture was stirred for 30 min and the flask was vented. Dimethyl adipate (48 mL, 0.29 mole) was added to the mixture and the flask was connected to a distillation column. The resulting mixture was then heated and methanol was removed at reduced pressure during a period of one hour. Excess aziridineethanol was then removed by heating the mixture to 70 C at a pressure of 0.15 mm Hg. The desired product was then distilled off from the mixture at 130 C at a pressure of 0.15 mm Hg to obtain 49 g (0.18 mole, 60% yield) of di[2-(1-aziridinyl)ethyl]adipate as a colorless oil having the following analysis: 1H NMR (400 MHz, DMSOd6) delta=1.10-1.11(m, 4H, CH2). 1.51-1.55(m, 8H, CH2), 2.28-2.35(m, 8H, CH2), 4.09(t, J=4.0 Hz, 4H, CH2) ppm. 3C NMR (100 MHz, DMSOd6) delta=24.6; 27.0; 33.8; 59.7; 64.2; 173.3 ppm IR: 3064.42; 2952.38; 1731.46; 1454.54; 1264.33; 1174.82 cm-1

According to the analysis of related databases, 1072-52-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gianolio, Diego A.; Calias, Pericles; Miller, Robert J.; US2005/222081; (2005); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29908-11-0, name is (1,4-Dioxan-2-yl)methanol, the common compound, a new synthetic route is introduced below. Formula: C5H10O3

[0284] An oven dried multineck round bottom flask equipped with a condenser and an inlet septum under N2 is loaded with NaH (1.25 equiv., 60% in mineral oil) and dry THF (2.67 mL/mmol). An alcohol (1.2 equiv.) is added dropwise and the resulting mixture is stirred at room temperature for 20 min and subsequently heated at 50 C for 20 min. Then 4-chloro-6,7-dihydrobenzo[a]quinolizin-2-one derivative is added (1.0 equiv.) as a dry solid to the alkoxide mixture (any material that can not be transferred as such is dissolved in dry THF (1.3 mL/mmol) and added to the mixture). The mixture is briefly purged with N2 and heated at 70 C until all starting material is consumed. The mixture is cooled down to room temperature and quenched with saturated aq. NaHCO3. The mixture is then concentrated in vacuo and partitioned between DCM and brine. The aqueous layer is extracted once with DCM and combined organics are dried over Na2SO4 and concentrated to dryness. The crude product is dissolved in MeCN and refluxed for 15 min. The mixture is cooled down to room temperature and the precipitate is separated by filtration. The precipitate is discarded and the filtrate is washed with pentane. The MeCN phase is concentrated to dryness affording the desired product.

The synthetic route of 29908-11-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; DOYON, Julien, Georges, Pierre-Olivier; CLAES, Pieter, Isabelle, Roger; ALLART, Brigitte; DE WACHTER, Maxim, Maria, Paul; TRICARICO, Giovanni, Alessandro; (168 pag.)WO2016/169911; (2016); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Diethylamino)ethanol

General procedure: 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carboxylate hydrochlorides 7a-7f were synthesized as described above for 6a-6e from 7 mmol of amino alcohol 5a-5f and 1.87 g (7 mmol) of acid chloride 3 in the presence of 0.7 g (7 mmol) of triethylamine. A solution of 1.3 g (5 mmol) of acid chloride 3 in 30 mL of anhydrous benzene was added with shaking to a mixture of 5 mmol of diamine 4a-4e and 0.5 g (5 mmol) of triethylamine in 50 mL of anhydrous benzene. The mixture was left to stand for 2 h at room temperature and was then refluxed for 10 h. After cooling, the mixture was treated with 3 mL of 15% aqueous sodium hydroxide with shaking, and the organic layer was separated, washed with water until neutral reaction, and dried. The solvent was distilled off, the residue was dissolved in diethyl ether, and a solution of dry HCl in diethyl ether was added. The precipitate was filtered off and recrystallized from ethanol.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Article; Arustamyan, Zh. S.; Markaryan; Aghekyan; Nazaryan; Hakobyan; Paronikyan; Minasyan; Russian Journal of Organic Chemistry; vol. 55; 6; (2019); p. 796 – 799; Zh. Org. Khim.; vol. 55; 6; (2019); p. 896 – 900,5;,
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Synthetic Route of 303043-91-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.303043-91-6, name is 3-Fluoro-2-methoxybenzenemethanol, molecular formula is C8H9FO2, molecular weight is 156.1543, as common compound, the synthetic route is as follows.

a 1-(Chloromethyl)-3-fluoro-2-methoxy-benzene A solution of 3-fluoro-2-methoxy-benzenemethanol (WO 20000419) (0.50 g) and thionyl chloride (0.47 ml) in dichloromethane (30 ml) was stirred for 2 hours then concentrated in-vacuo to give the subtitled compound, which was used directly in the next step.

The chemical industry reduces the impact on the environment during synthesis 303043-91-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bonnert, Roger; Gardiner, Stewart; Hunt, Fraser; Walters, Iain; US2003/55250; (2003); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C3H9NO2

To a solution of compound 1 (20.0 g) in H20 (100 mL) were added Na2C03 (78 g) and compound 2 (21.5 g). The reaction mixture was stirred at rt for 16 h. Compound 3 (15.0 g, yield 58%) was obtained after standard work up procedure as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SYNBLIA THERAPEUTICS, INC.; XIE, Yinong; BABISS, Lee, E.; (89 pag.)WO2019/89422; (2019); A1;,
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Reference of 583-03-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.583-03-9, name is 1-Phenylpentan-1-ol, molecular formula is C11H16O, molecular weight is 164.24, as common compound, the synthetic route is as follows.

At room temperature, in a 50 ml round-bottom flask is sequentially added in the 1 – benzene amyl alcohol (0.164 g, 1 mmol), benzoic acid (0.183g, 1.5 mmol), NBS (0.356g, 2 mmol) and 1, 4 – dioxane (2 ml). In the 60 C stirring 1 hour, then adding DBU (0.304 g, 2 mmol), continue to reaction 4 hours (TLC detection reaction). Then, stopping the reaction, concentrated under reduced pressure, to obtain crude product. Finally petroleum ether and ethyl acetate mixed eluent flushing, rapid column chromatography (silica gel column) to obtain the corresponding product alpha – acyloxy ketone compound (yellow liquid 0.260g, yield 92%).

The chemical industry reduces the impact on the environment during synthesis 583-03-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Qufu Normal University; Wang, Hua; Wei, Wei; Zhu, Minghui; Cui, Huanhuan; (19 pag.)CN106518663; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 62037-46-1, 1-Amino-3-chloropropan-2-ol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 62037-46-1, blongs to alcohols-buliding-blocks compound. Computed Properties of C3H9Cl2NO

The reaction flask was charged with 116.8 g of compound II (0.80 mol)191.8 g of Boc2O (0.88 mol) and 1500 ml of methanol, stirred,And 1200 ml of an aqueous solution containing 80.6 g of sodium hydrogencarbonate (0.96 mol)And then reacted at room temperature for 3 hours. After the reaction was complete, the methanol was removed by concentration,The residue was extracted with 2000 ml of methylene chloride and the dichloromethane layer was washed with water,And finally dried over anhydrous sodium sulfate; filtered, the filtrate was concentrated to dryness,174.3 g of an oil was obtained, and 1200 ml of petroleum ether was added to the oil to freeze the crystals,The filter cake was washed with petroleum ether to give 161.7 g of the white solid, compound III; mp 48-51 C, molar yield: 96.71% (calculated as compound II).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62037-46-1, its application will become more common.

Reference:
Patent; Changzhou Ruibo Biological Technology Co., Ltd.; Wei Feng; Wu Zongquan; Ge Erpeng; (12 pag.)CN104292222; (2017); B;,
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