Category: alcohols-buliding-blocks

Related Products of 230295-16-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 230295-16-6, name is (3-Fluoro-4-(trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Step2: A mixture of [3-fluoro-4-(trifluoromethyl)phenyl]methanol (230 g, 1.18 mol) andHBr (1200 mL, 40%) was heated to reflux for 2 hours. The resulting solution was cooledand diluted with 2 L of water. The resulting solution was extracted with dichloromethane (3 x 1 L). The organic layers were combined, washed with water (1 L), aqueous sodium bicarbonate (1 L) and brine (1 L), dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 4-(bromomethyl)-2-fluoro-1-(trifluoromethyl)benzene asyellow oil.

According to the analysis of related databases, 230295-16-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CAMMARANO, Carolyn Michele; CHRISTOPHER, Matthew, P.; DINSMORE, Christopher; DOLL, Ronald, J.; FRADERA LLINAS, Francesc Xavier; LI, Chaomin; MACHACEK, Michelle; MARTINEZ, Michelle; NAIR, Latha, G.; PAN, Weidong; REUTERSHAN, Michael Hale; SHIZUKA, Manami; STEINHUEBEL, Dietrich, P.; SUN, Binyuan; THOMPSON, Christopher Francis; TROTTER, B. Wesley; VOSS, Matthew Ernst; WANG, Yaolin; YANG, Liping; PANDA, Jagannath; KURISSERY, Anthappan Tony; BOGEN, Stephane, L.; WO2014/120748; (2014); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. A new synthetic method of this compound is introduced below., Quality Control of 1-Amino-2-methylpropan-2-ol

Example 82N-(2-{[(2-hydroxy-2-methylpropyl)amino]methyl}-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamideN-(2-Formyl-1,7-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide (300 mg) obtained in Reference Example 66, 1-amino-2-methylpropan-2-ol (102 mg) and acetic acid (1.53 mL) were added to N,N-dimethylacetamide (5 mL), and the mixture was stirred at room temperature for 1 hr.Sodium triacetoxyborohydride (324 mg) was added, and the mixture was stirred at room temperature for 21 hr. 8N Aqueous sodium hydroxide solution (3.82 mL) was added dropwise at 0°C.The mixture was extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, purified by silica gel column chromatography [eluent; ethyl acetate_methanol=100:0 (volume ratio)?methyl acetate_methanol=60:40 (volume ratio)], and crystallized from ethyl acetate and diisopropyl ether to give the title compound (289 mg, yield 81percent) as a beige solid.1H NHR (300 MHz, DMSO-d6) delta: 1.10 (6 H, s), 1.59 – 2.10 (4 H, m), 2.46 (2 H, s), 2.55 (3 H, s), 3.65 – 3.74 (1 H, m), 3.76 – 3.85 (1 H, m), 3.87 (2 H, s), 3.96 – 4.12 (5 H, m), 4.13 – 4.25 (2 H, m), 6.29 (1 H, s), 6.82 (1 H, d, J=8.3 Hz), 7.05 (2 H, d, J=8.7 Hz), 7.26 (1 H, d, J=8.3 Hz), 7.98 (2 H, d, J=8.7 Hz), 9.80 (1 H, s).melting point: 197-200°Celemental analysis (C27H35N3O4*0.2H2O)Calculated: C, 69.12; H, 7.60; N, 8.96.Found: C, 69.06; H, 7.41; N, 8.83.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2854-16-2, 1-Amino-2-methylpropan-2-ol.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2522657; (2012); A1;,
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Related Products of 1883-32-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1883-32-5, name is 2,2-Diphenylethanol, molecular formula is C14H14O, molecular weight is 198.26, as common compound, the synthetic route is as follows.

(3) Preparation of 2,2-diphenylethyl methanesulfonate In a 500mL three-opening flask, 2,2-diphenyl ethanol (17g, 86mmol) was dissolved in 170mL dichloromethane. To the flask was added triethylamine (13.03g, 129mmol). The resulting mixture was stirred at 0C for half an hour. To the resulting mixture was slowly added MsCl (11.92g, 104mmol) dropwisely. The reaction was conducted at 25C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23g) in a yield of 96.78 %.

Statistics shows that 1883-32-5 is playing an increasingly important role. we look forward to future research findings about 2,2-Diphenylethanol.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; ZHANG, Hui; FAN, Mingwei; SUN, Liang; EP2703398; (2014); A1;,
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Application of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a 50 mL two-neck flask was placed 1.611 g (10 millimol) of 2-methyl-2-adamantanol and to dissolve the same, was added 10 mL of dry tetrahydrofuran. When the content in the flask was cooled with a cooling medium to minus 65C, the uniform solution turned to slurry. To the resultant slurry was added dropwise 6.25 mL (10.0 millimol, 1.6 M) of solution of n-butyllithium in hexane over a period of approximately 1 to 2 minutes with a result that the slurry turned to yellow transparent solution. Subsequently, the resultant solution was subjected to natural temperature raising to room temperature to proceed with reaction for 3 hours, and reaction liquid thus obtained was used as such for the next synthesis.

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEMITSU PETROCHEMICAL CO., LTD.; EP1398309; (2004); A1;,
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Synthetic Route of 932-01-4 , The common heterocyclic compound, 932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10399] Step 1: To a DCM (45 mE) solution of the 4,4- dimethylcyclohexanol (200 mg, 1.56 mmol) was added tnethylamine(4.9 mE, 35 mmol). The solution was cooled to 0 C. before methanesulfonyl chloride (0.324 mE, 2.34 mmol) was added dropwise. The resulting mixture was allowed to warm to RT over 13 h. The reaction was diluted with DCM and washed with water, the organic phase dried (Na2504), filtered and the filtrate concentrated in vacuo. No further purification was necessary to afford 4,4-dimethylcyclohexyl methanesulfonate.

The synthetic route of 932-01-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVIRA THERAPEUTICS, INC.; Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; (76 pag.)US2016/151375; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 27489-62-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 27489-62-9

Example 140; 5 -((R)-2-(5-fluoro-2-methoxypyridin-3 -yDpyrrolidin- 1-y l)-N-((trans)-4- hvdroxycvclohexyDpyrazolor 1 ,5-a1pyrimidine-3-carboxamide; To a solution of (R)-5-(2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-l- yl)pyrazolo[l,5-a]pyrimidine-3-carboxylic acid (Preparation K, 30 mg, 0.084 mmol) in anhydrous CH2Cl2 (2 mL) was added HOBt (34 mg, 0.25 mmol) followed by EDCI (48 mg, 0.25 mmol). The solution was stirred for 30 minutes, then treated with (trans)-4- aminocyclohexanol (29 mg, 0.25 mmol) followed by triethylamine (35 muL, 0.25 mmol). After stirring at ambient temperature for 5 hours, the reaction mixture was diluted with EtOAc, washed with saturated NH4Cl (20 mL), saturated NaHCO3, and brine, then dried (Na2SO4), filtered and concentrated. The crude material was purified by silica chromatography (4% MeOH/CH2Cl2) to yield the final product as white solid (23 mg, 60%). LCMS (apci) m/z = 455.1 (M+H).

The synthetic route of 27489-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob; WO2011/6074; (2011); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-82-9, name is 3-Aminoadamantan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 702-82-9

To a solution of 9 (2.0 g, 4.6 mmol) in DMF (20 mL) at room temperature, 3-amino-l- adamantanol (0.76 g, 4.5 mmol) and K2CO3 (1.2 g, 8.7 mmol) were added. The resulting mixture was stirred at 90 0C overnight then was cooled to room temperature and was diluted with ethyl acetate and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with 1:1 hexanes:ethyl acetate, 3:7 hexanes:ethyl acetate, ethyl acetate and 9: 1 ethyl acetate: methanol to give 10 (1.8 g, 74% yield) as an off-white solid

With the rapid development of chemical substances, we look forward to future research findings about 702-82-9.

Reference:
Patent; ENCYSIVE PHARMACEUTICALS INC.; WO2009/53895; (2009); A2;,
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Adding a certain compound to certain chemical reactions, such as: 60211-57-6, 3,5-Dichlorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 60211-57-6, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Example 24 1-[2-{N-Ethyl-N-(4-(1-piperidinomethyl)benzyl)amino}ethyl]-3-(3,5-dichlorobenzyl)-2-imidazolidinylidenepropanedinitrile (Compound 24) Compound (X) (0.20 g) obtained in Reference Example 10, 0.35 ml of 3,5-dichlorobenzyl alcohol, 0.53 g of triphenylphosphine, and 0.46 g of di-tert-butyl azodicarboxylate were allowed to react in 10 ml of tetrahydrofuran as described in Example 23 to give 0.25 g (89%) of Compound 24 as a pale yellow oily substance. 1H NMR (270 MHz, CDCl3) delta: 7.35-7.19 (5H, m), 7.17 (2H, d), 4.68 (2H, s), 3.61 (2H, t), 3.56-3.48 (4H, m), 3.45 (2H, s), 3.33-3.26 (2H, m), 2.74 (2H, t), 2.61 (2H, q), 2.37 (4H, m), 1.56 (4H, m), 1.43 (2H, m), 1.13 (3H, t).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60211-57-6, its application will become more common.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US6469002; (2002); B1;,
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Reference of 66582-32-9 , The common heterocyclic compound, 66582-32-9, name is 3-(Benzyloxy)-2,2-dimethylpropan-1-ol, molecular formula is C12H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[00510] 3-(Benzyloxy)-2,2-dimethylpropan-l-ol 160 (2.5 g, 12.9 mmol) was dissolved in dichloromethane (50 mL). Triethylamine (2.61 g, 25.8 mmol) and methane sulfonyl chloride (1.79 g, 15.5 mmol) were added at 0 C and the reaction mixture was stirred at 0 C for 2 h. The reaction mixture was transferred into iced water and extracted with dichloromethane (40 mL X 3). The combined organic layers were washed with brine, dried over anhydrous Na2S04, and concentrated under reduced pressure to give crude 3 -(benzyl oxy)-2,2- dimethylpropyl methanesulfonate 161, which was purified by silica gel chromatography (17% ethyl acetate/petroleum ether) to give 3.2 g of 3-(benzyloxy)-2,2-dimethylpropyl methanesulfonate 3 (91% yield). LCMS: m/z 294.9 [M+Na]+, tK = 1.78 min.

The synthetic route of 66582-32-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; MCCAULEY, Dilara; LANDESMAN, Yosef; GOLAN, Gali; KALID, Ori; SHECHTER, Sharon; WO2015/42414; (2015); A1;,
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Related Products of 83647-43-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a flask charged with (3-bromo-2- methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M TFA solution of thallium trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. Analysis by TLC showed no starting material remaining. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added palladium(II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and MeOH (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a CELITE pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford title compound. 1H-NMR (500 MHz, CDCI3) delta ppm 7.71 (d, J = 8.0 Hz, 1H), 7.58 (d, J = 8.0 Hz, 1H), 5.25 (s, 2H), 2.37 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83647-43-2, (3-Bromo-2-methylphenyl)methanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DING, Fa-Xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; TANG, Haifeng; WU, Zhicai; YU, Yang; SUZUKI, Takao; WO2014/18764; (2014); A1;,
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